检索结果-内蒙古大学图书馆

Impedimetric identification of heteroMOFs modified porous nickel foam self-supports as robust electrodes for CA 19-9 pancreatic tumor marker in human serum

引用

Applied Materials Today 2024年 40卷

作者： Sathyadevi Palanisamy Priya Vijayaraghavan Tsu-Yin Cheng Sarin Kumar Kappithottam Duraisamy Senthil Raja Xiao-Qi Chen Tsai-Te Lu Chiao-Yun Chen Yun-Ming Wang Institute of Biomedical Engineering National Tsing Hua University Hsinchu 300 Taiwan Department of Biological Science and Technology Institute of Molecular Medicine and Bioengineering Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Institute of Biotechnology Department of Life Sciences National Tsing Hua University Hsinchu 300 Taiwan Department of Chemical Engineering National Tsing Hua University Hsinchu 300 Taiwan Department of Chemistry National Tsing Hua University Hsinchu 300 Taiwan Department of Chemistry Chung Yuan Christian University Taoyuan 320 Taiwan Department of Medical Imaging Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan School of Post-Baccalaureate Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung 807 Taiwan School of Dentistry College of Dental Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan

An impedance-based electrochemical immunosensor for direct and binder-free target recognition of carbohydrate antigen (CA 19-9) tumor biomarker for the early diagnosis of pancreatic cancer was reported. This study uses an in situ solvothermal process to develop a simple method for the one-pot construction of Ni-Fe heteroMOFs (HFNMOFs,) self-supported on conductive nickel foam (NicFm). Utilizing HFNMOFs@NicFm developed in this study, the electrochemical performance of the biosensor was studied for the first time. The as-prepared mixed MOFs decorated NicFm electrodes displayed potential electrochemical outputs. They demonstrated the potential for developing binder-free non-enzymatic immunosensors with wide linear limits, high selectivity, stability, and excellent sensitivity. The bifunctional MOFs exhibit improved electrochemical conductivity owing to the highly exposed metal sites and hierarchical porosity. The changes in the charge transfer resistance present a linear response against increasing target concentrations. The immunosensor developed in this study exhibited its detection limit of 2.56 U/mL. Further, the bioelectrodes produced were validated against real human spiked serum with good results of percentage recovery, indicating the immunosensor is well-suitable to be tested in real-time analysis.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Swelling-Induced Symmetry Breaking: A Versatile Approach to the Scalable Production of Colloidal Particles with a Janus Structure

引用

Angewandte Chemie 2021年第23期133卷

作者： Dr. Jichuan Qiu Dr. Zitao Chen Dr. Miaofang Chi Prof. Dr. Younan Xia The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta Georgia 30332 USA Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA School of Chemistry and Biochemistry School of Chemical and Biomolecular Engineering Georgia Institute of Technology Atlanta Georgia 30332 USA

Janus particles are widely sought for applications related to colloidal assembly, stabilization of emulsions, and development of active colloids, among others. Here we report a versatile route to the fabrication of well-controlled Janus particles by simply breaking the symmetry of spherical particles with swelling. When a polystyrene (PS) sphere covered by a rigid shell made of silica or polydopamine is exposed to a good solvent for PS, a gradually increased pressure will be created inside the shell. If the pressure becomes high enough to poke a hole in the shell, the spherical symmetry will break while pushing out the swollen PS through the opening to generate a Janus particle comprised of two distinct components. One of the components is made of PS and its size is controlled by the extent of swelling. The other component is comprised of the rigid shell and remaining PS, with its overall diameter determined by the original PS sphere and the rigid shell. This solution-based route holds promises for the scalable production of complex Janus particles with a variety of compositions and in large quantities.

关键词： asymmetric structure colloid Janus particle swelling symmetry breaking

来源：评论

学校读者我要写书评

暂无评论

Molecular and Serologic Diagnostic Technologies for SARS-CoV-2

arXiv

引用

arXiv 2022年

作者： Rando, Halie M. Brueffer, Christian Lordan, Ronan Dattoli, Anna Ada Manheim, David Meyer, Jesse G. Mundo, Ariel I. Perrin, Dimitri Mai, David Wellhausen, Nils Gitter, Anthony Greene, Casey S. Department of SystemsPharmacology and Translational Therapeutics University of Pennsylvania PhiladelphiaPA United States Department of Biochemistry and MolecularGenetics University of Colorado School of Medicine AuroraCO United States Center for Health AI University of Colorado School of Medicine AuroraCO United States Department of Clinical Sciences Lund University Lund Sweden Institute for TranslationalMedicine and Therapeutics Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104-5158 United States Department of Medicine Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104 United States Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104 United States Department of Pathology Laboratory Medicine The Children’s Hospital of Philadelphia PhiladelphiaPA United States Department of Systems Pharmacology & Translational Therapeutics Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States 1DaySooner Delaware United States Communication Research Center School of Public Health University of Haifa Haifa Israel Technion Israel Institute of Technology Haifa Israel Department of Biochemistry Medical College of Wisconsin MilwaukeeWI United States Department of Biomedical Engineering University of Arkansas FayettevilleAR United States School of Computer Science Queensland University of Technology Brisbane Australia Centre for Data Science Queensland University of Technology Brisbane Australia Department of Bioengineering University of Pennsylvania PhiladelphiaPA United States Center for Cellular Immunotherapies Perelman School of Medicine Parker Institute for Cancer Immunotherapy University of Pennsylvania PhiladelphiaPA United States Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania PhiladelphiaPA United States Department of Biostatistics Medical

The COVID-19 pandemic has presented many challenges that have spurred biotechnological research to address specific problems. Diagnostics is one area where biotechnology has been critical. Diagnostic tests play a vital role in managing a viral threat by facilitating the detection of infected and/or recovered individuals. From the perspective of what information is provided, these tests fall into two major categories, molecular and serological. Molecular diagnostic techniques assay whether a virus is present in a biological sample, thus making it possible to identify individuals who are currently infected. Additionally, when the immune system is exposed to a virus, it responds by producing antibodies specific to the virus. Serological tests make it possible to identify individuals who have mounted an immune response to a virus of interest and therefore facilitate the identification of individuals who have previously encountered the virus. These two categories of tests provide different perspectives valuable to understanding the spread of SARS-CoV-2. Within these categories, different biotechnological approaches offer specific advantages and disadvantages. Here we review the categories of tests developed for the detection of the SARS-CoV-2 virus or antibodies against SARS-CoV-2 and discuss the role of diagnostics in the COVID-19 pandemic. © 2022, CC BY.

关键词： SARS

来源：评论

学校读者我要写书评

暂无评论

Classification of Major Depressive Disorder Using Vertex-Wise Brain Sulcal Depth, Curvature, and Thickness with a Deep and a Shallow Learning Model

arXiv

引用

arXiv 2023年

作者： Goya-Maldonado, Roberto Erwin-Grabner, Tracy Zeng, Ling-Li Ching, Christopher R.K. Aleman, Andre Amod, Alyssa R. Basgoze, Zeynep Benedetti, Francesco Besteher, Bianca Brosch, Katharina Bülow, Robin Colle, Romain Connolly, Colm G. Corruble, Emmanuelle Couvy-Duchesne, Baptiste Cullen, Kathryn Dannlowski, Udo Davey, Christopher G. Dols, Annemiek Ernsting, Jan Evans, Jennifer W. Fisch, Lukas Fuentes-Claramonte, Paola Gonul, Ali Saffet Gotlib, Ian H. Grabe, Hans J. Groenewold, Nynke A. Grotegerd, Dominik Hahn, Tim Hamilton, J. Paul Han, Laura K.M. Harrison, Ben J. Ho, Tiffany C. Jahanshad, Neda Jamieson, Alec J. Karuk, Andriana Kircher, Tilo Klimes-Dougan, Bonnie Koopowitz, Sheri-Michelle Lancaster, Thomas Leenings, Ramona Li, Meng Linden, David E.J. MacMaster, Frank P. Mehler, David M.A. Meinert, Susanne Melloni, Elisa Mueller, Bryon A. Mwangi, Benson Nenadić, Igor Ojha, Amar Okamoto, Yasumasa Oudega, Mardien L. Penninx, Brenda W.J.H. Poletti, Sara Pomarol-Clotet, Edith Portella, Maria J. Pozzi, Elena Radua, Joaquim Rodríguez-Cano, Elena Sacchet, Matthew D. Salvador, Raymond Schrantee, Anouk Sim, Kang Soares, Jair C. Solanes, Aleix Stein, Dan J. Stein, Frederike Stolicyn, Aleks Thomopoulos, Sophia I. Toenders, Yara J. Uyar-Demir, Aslihan Vieta, Eduard Vives-Gilabert, Yolanda Völzke, Henry Walter, Martin Whalley, Heather C. Whittle, Sarah Winter, Nils Wittfeld, Katharina Wright, Margaret J. Wu, Mon-Ju Yang, Tony T. Zarate, Carlos Veltman, Dick J. Schmaal, Lianne Thompson, Paul M. Georg-August University Göttingen Germany College of Intelligence Science and Technology National University of Defense Technology Changsha410073 China Imaging Genetics Center Mark & Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California Marina del ReyCA90274 United States Department of Biomedical Sciences of Cells and Systems University Medical Center Groningen University of Groningen Groningen Netherlands Department of Psychiatry & Mental Health Neuroscience Institute University of Cape Town Cape Town South Africa Department of Psychiatry and Behavioral Science University of Minnesota Medical School MinneapolisMN United States Division of Neuroscience IRCCS Scientific Institute Ospedale San Raffaele Milano Italy Department of Psychiatry and Psychotherapy Jena University Hospital Jena Germany Department of Psychiatry and Psychotherapy University of Marburg Rudolf Bultmann Str. 8 Marburg35039 Germany Institute for Radiology and Neuroradiology University Medicine Greifswald Greifswald Germany MOODS Team CESP INSERM U1018 Faculté de Médecine Univ Paris-Saclay Le Kremlin Bicêtre94275 France Service Hospitalo Universitaire de Psychiatrie de Bicêtre Hôpitaux Universitaires Paris-Saclay Assistance Publique-Hôpitaux deParis Hôpital de Bicêtre Le Kremlin BicêtreF-94275 France Department of Biomedical Sciences Florida State University TallahasseeFL United States Sorbonne University Paris Brain Institute - ICM CNRS Inria Inserm AP-HP Hôpital de la Pitié Salpêtrière ParisF-75013 France Institute for Molecular Bioscience the University of Queensland St LuciaQLD Australia Institute for Translational Psychiatry University of Münster Münster Germany Melbourne Neuropsychiatry Centre Department of Psychiatry the University of Melbourne ParkvilleVIC Australia Department of Psychiatry Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam Neuroscience Amsterdam Public Health Research Institute Am

Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD, likely due to the heterogeneity of this disorder. The application of deep learning tools to neuroimaging data, capable of capturing complex non-linear patterns, has the potential to provide diagnostic and predictive biomarkers for MDD. However, previous attempts to demarcate MDD patients and healthy controls (HC) based on segmented cortical features via linear machine learning approaches have reported low accuracies. In this study, we used globally representative data from the ENIGMA-MDD working group containing 7,012 participants from 30 sites (N=2,772 MDD and N=4,240 HC), which allows a comprehensive analysis with generalizable results. Based on the hypothesis that integration of vertex-wise cortical features can improve classification performance, we evaluated the classification of a DenseNet and a Support Vector Machine (SVM), with the expectation that the former would outperform the latter. As we analyzed a multi-site sample, we additionally applied the ComBat harmonization tool to remove potential nuisance effects of site. We found that both classifiers exhibited close to chance performance (balanced accuracy DenseNet: 51%;SVM: 53%), when estimated on unseen sites. Slightly higher classification performance (balanced accuracy DenseNet: 58%;SVM: 55%) was found when the cross-validation folds contained subjects from all sites, indicating site effect. In conclusion, the integration of vertex-wise morphometric features and the use of the non-linear classifier did not lead to the differentiability between MDD and HC. Our results support the notion that MDD classification on this combination of features and classifiers is unfeasible. Future studies are needed to determine whether more sophisticated integration of information from ot

关键词： Support vector machines

来源：评论

学校读者我要写书评

暂无评论

Immune Profiling Reveals Distinct Features of Multiple Myeloma Subtypes Defined By Multi-Omics Network Analysis

引用

Blood 2024年 144卷 4658-4658页

作者： Junia Vieira Alison S Park Edgar Gonzalez-Kozlova David Melnekoff Sherry Bhalla Chaitanya Acharya Mark Hamilton George Mulligan Immune Atlas Network Hearn Jay Cho Li Ding Sacha Gnjatic Ioannis S Vlachos Manoj Bhasin Sundar Jagannath Samir Parekh Alessandro Lagana Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York NY Icahn School of Medicine at Mount Sinai New York MSSM New York Mount Sinai Hospital New York NY MMRF Norwalk CT Multiple Myeloma Research Foundation Norwalk CT MMRF Norwalk Department of Medicine Hematology and Medical Oncology Tisch Cancer Institute Tisch Cancer Institute New York NY WUSTL St Louis Icahn School of Medicine at Mount Sinai New York NY Beth Israel Deaconess Medical Center Boston MA Department of Biomedical Engineering Georgia Institute of Technology Johns Creek GA Mount Sinai Medical Center New York NY Department of Medicine Hematology and Medical Oncology Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York

Introduction : Multiple myeloma (MM) has a highly heterogeneous genomic landscape, challenging patient stratification and clinical management. By combining bulk tumor profiling with single-cell data of the tumor microenvironment (TME), we aimed to create a comprehensive multi-omics network model to dissect inter-tumor heterogeneity, which enabled us to characterize the immune cell landscape and correlate it with patient subgroups identified through multi-omics analysis of bulk tumor data, revealing significant features within each subgroup. Methods : We analyzed 185 samples collected at diagnosis from newly-diagnosed MM (NDMM) patients in MMRF CoMMpass, included in both our previous MM-PSN model (Bhalla et al, 2021) and the MMRF Immune Atlas (Pilcher et al, 2023). The CD138- fraction underwent 10X 3' single cell RNA seq (scRNA-seq), yielding 776,859 cells. Our dataset included 107,884 myeloid cells, 407,895 NK/T cells, 162,630 B/ erythroid cells, and 85,147 plasma cells. The analysis was performed using the R packages Seurat, CellphoneDB, pySCENIC, MOVICS and MOGONET. Results : We stratified 185 patients in the Immune Atlas cohort according to our multi-omics patient similarity network MM-PSN into the following groups: (i) hyperdiploidy (HD) and t(8;14) translocation of MYC (tMYC) (group 1, n = 105); (ii) translocations t(4;14) of MMSET (tMMSET) and t(14;16) of MAF (tMAF) (group 2, n = 46); and (iii) translocation t(11;14) of CCND1 (tCCND1) (group 3, n = 33). The overall cohort had a median progression-free survival (PFS) of 1082 days. The subgroups had the following median PFS: HD, 1094 days; tMMSET/tMAF, 634 days; and tCCND1, 1236 days. Group 1 had higher frequencies of hematopoietic stem cells (HSCs), plasmacytoid dendritic cells (pDCs) and B naïve cells (p<0.05), compared to groups 2 and 3. This suggests HD and tMYC may be associated with TME changes, influencing cytokine and growth factor production, as indicated by IL4R (B naïve) and GZMB (pDC) enriched signat

关键词：

来源：评论

学校读者我要写书评

暂无评论

Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane curvature and deformability (vol 115, pg E4377, 2018)

引用

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2018年第27期115卷 E6385-E6385页

作者： Smith, Alyson S. Nowak, Roberta B. Zhou, Sitong Giannetto, Michael Gokhin, David S. Papoin, Julien Ghiran, Ionita C. Blanc, Lionel Wan, Jiandi Fowler, Velia M. Department of Molecular Medicine The Scripps Research Institute La Jolla CA 92037 Department of Molecular Medicine The Scripps Research Institute La Jolla CA 92037 Microsystems Engineering Rochester Institute of Technology Rochester NY 14623 Department of Biomedical Engineering University of Rochester Rochester NY 14623 Center for Translational Neuromedicine University of Rochester Medical Center Rochester NY 14623 Microsystems Engineering Rochester Institute of Technology Rochester NY 14623 Department of Biomedical Engineering University of Rochester Rochester NY 14623 Center for Translational Neuromedicine University of Rochester Medical Center Rochester NY 14623 Department of Molecular Medicine The Scripps Research Institute La Jolla CA 92037 Center for Autoimmune Musculoskeletal and Hematopoietic Diseases The Feinstein Institute for Medical Research Manhasset NY 11030 Department of Medicine Beth Israel Deaconess Medical Center Boston MA 02115 Center for Autoimmune Musculoskeletal and Hematopoietic Diseases The Feinstein Institute for Medical Research Manhasset NY 11030 Department of Molecular Medicine Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Hempstead NY 11030 Department of Pediatrics Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Hempstead NY 11030 Microsystems Engineering Rochester Institute of Technology Rochester NY 14623 Department of Biomedical Engineering University of Rochester Rochester NY 14623 Center for Translational Neuromedicine University of Rochester Medical Center Rochester NY 14623 Department of Molecular Medicine The Scripps Research Institute La Jolla CA 92037

The biconcave disk shape and deformability of mammalian RBCs rely on the membrane skeleton, a viscoelastic network of short, membrane-associated actin filaments (F-actin) cross-linked by long, flexible spectrin tetramers. Nonmuscle myosin II (NMII) motors exert force on diverse F-actin networks to control cell shapes, but a function for NMII contractility in the 2D spectrin-F-actin network of RBCs has not been tested. Here, we show that RBCs contain membrane skeleton-associated NMIIA puncta, identified as bipolar filaments by superresolution fluorescence microscopy. MgATP disrupts NMIIA association with the membrane skeleton, consistent with NMIIA motor domains binding to membrane skeleton F-actin and contributing to membrane mechanical properties. In addition, the phosphorylation of the RBC NMIIA heavy and light chains in vivo indicates active regulation of NMIIA motor activity and filament assembly, while reduced heavy chain phosphorylation of membrane skeleton-associated NMIIA indicates assembly of stable filaments at the membrane. Treatment of RBCs with blebbistatin, an inhibitor of NMII motor activity, decreases the number of NMIIA filaments associated with the membrane and enhances local, nanoscale membrane oscillations, suggesting decreased membrane tension. Blebbistatin-treated RBCs also exhibit elongated shapes, loss of membrane curvature, and enhanced deformability, indicating a role for NMIIA contractility in promoting membrane stiffness and maintaining RBC biconcave disk cell shape. As structures similar to the RBC membrane skeleton exist in many metazoan cell types, these data demonstrate a general function for NMII in controlling specialized membrane morphology and mechanical properties through contractile interactions with short F-actin in spectrin-F-actin networks.

关键词： actomyosin contractility cytoskeleton erythrocyte deformability cell shape TIRF microscopy

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Thermo-responsive triple-function nanotransporter for efficient chemo-photothermal therapy of multidrug-resistant bacterial infection

引用

Nature communications 2025年第1期16卷 4003页

作者： Guangchao Qing Xianxian Zhao Ningqiang Gong Jing Chen Xianlei Li Yaling Gan Yongchao Wang Zhen Zhang Yuxuan Zhang Weisheng Guo Yang Luo Xing-Jie Liang Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants College of Bioengineering Chongqing University Chongqing 400044 P. R. China. Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 P. R. China. Department of Materials and Energy Southwest University No. 2 Tiansheng Street Beibei District Chongqing 400715 P. R. China. University of Chinese Academy of Sciences Beijing 100049 P. R. China. Department of Clinical Laboratory Medicine Southwest Hospital Army Medical University Chongqing 400038 P. R. China. Translational Medicine Center Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences & The Second Affiliated Hospital Guangzhou Medical University Guangzhou 510260 P.R. China. tjuguoweisheng@***. Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants College of Bioengineering Chongqing University Chongqing 400044 P. R. China. luoy@***. Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province Department of Nuclear Medicine the Affiliated Hospital of Southwest Medical University Sichuan 646000 P. R. China. luoy@***. Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 P. R. China. liangxj@***. University of Chinese Academy of Sciences Beijing 100049 P. R. China. liangxj@***.

来源：评论

学校读者我要写书评

暂无评论

Highly accelerated EPI with wave encoding and multi-shot simultaneous multi-slice imaging

arXiv

引用

arXiv 2021年

作者： Cho, Jaejin Liao, Congyu Tian, Qiyuan Zhang, Zijing Xu, Jinmin Lo, Wei-Ching Poser, Benedikt A. Stenger, V. Andrew Stockmann, Jason Setsompop, Kawin Bilgic, Berkin Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital BostonMA United States Harvard Medical School BostonMA United States Radiological Sciences Laboratory Stanford University Palo AltoCA United States State Key Laboratory of Modern Optical Instrumentation College of Optical Science and Engineering Zhejiang University Hangzhou China Siemens Medical Solutions BostonMA United States Maastricht Brain Imaging Centre Maastricht University Maastricht Netherlands MR Research Program Department of Medicine John A. Burns School of Medicine University of Hawai'i HI United States Harvard-MIT Health Sciences and Technology Massachusetts Institute of Technology CambridgeMA United States

Purpose: To introduce wave encoded acquisition and reconstruction techniques for highly accelerated echo planar imaging (EPI) with reduced g-factor penalty and image artifacts. Method: Wave-EPI involves playing sinusoidal gradients during the EPI readout while employing interslice shifts as in blipped-CAIPI acquisitions. This spreads the aliasing in all spatial directions, thereby taking better advantage of 3D coil sensitivity profiles. The amount of voxel spreading that can be achieved by the wave gradients during the short EPI readout period is constrained by the slew rate of the gradient coils and peripheral nerve stimulation (PNS) monitor. We propose to use a "half-cycle" sinusoidal gradient to increase the amount of voxel spreading that can be achieved while respecting the slew and stimulation constraints. Extending wave-EPI to multi-shot acquisition minimizes geometric distortion and voxel blurring at high in-plane resolution, while structured low-rank regularization mitigates shot-to-shot phase variations without additional navigators. We propose to use different point spread functions (PSFs) for the k-space lines with positive and negative polarities, which are calibrated with a FLEET-based reference scan and allow for addressing gradient imperfections. Results: Wave-EPI provided whole-brain single-shot gradient echo (GE) and multi-shot spin echo (SE) EPI acquisitions at high acceleration factors and was combined with g-Slider slab encoding to boost the SNR level in 1mm isotropic diffusion imaging. Relative to blipped-CAIPI, wave-EPI reduced average and maximum g-factors by up to 1.21- and 1.37-fold, respectively. Conclusion: Wave-EPI allows highly accelerated single- and multi-shot EPI with reduced g-factor and artifacts and may facilitate clinical and neuroscientific applications of EPI by improving the spatial and temporal resolution in functional and diffusion imaging. Copyright © 2021, The Authors. All rights reserved.

关键词： Signal encoding

来源：评论

学校读者我要写书评

暂无评论

P116 Increased airflow limitation during nocturnal respiratory events is associated with increased psychomotor vigilance task lapses in obstructive sleep apnoea patients

引用

Sleep Advances 2022年第SUPPLEMENT_1期3卷 A67–A67页

作者： Staykov, E Mann, D Duce, B Kainulainen, S Leppänen, T Töyräs, J Sands, S Terrill, P School of Information Technology and Electrical Engineering The University of Queensland Brisbane Australia Institute for Social Science Research The University of Queensland Brisbane Australia Department of Respiratory & Sleep Medicine Princess Alexandra Hospital Brisbane Australia Institute of Health and Biomedical Innovation Queensland University of Technology Brisbane Australia Department of Applied Physics University of Eastern Finland Kuopio Finland Diagnostic Imaging Center Kuopio University Hospital Kuopio Finland Science Service Center Kuopio University Hospital Kuopio Finland Division of Sleep and Circadian Disorders Department of Medicine Brigham & Women's Hospital & Harvard Medical School Boston USA

来源：评论

学校读者我要写书评

暂无评论

Bioactivity,in-vitro corrosion behavior,and antibacterial activity of silver-zeolites doped hydroxyapatite coating on magnesium alloy

引用

Transactions of Nonferrous Metals Society of China 2018年第8期28卷 1553-1562页

作者： H.R.BAKHSHESHI-RAD E.HAMZAH A.F.ISMAIL M.AZIZ E.KARAMIAN N.IQBAL Advanced Materials Research Center Department of Materials EngineeringNajafabad Branch Islamic Azad University Department of Materials Manufacturing and Industrial EngineeringFaculty of Mechanical Engineering Universiti Teknologi Malaysia Advanced Membrane Technology Research Center (AMTEC) Universiti Teknologi Malaysia Department of Biomedical Engineering University of Engineering and TechnologyLahore Pakistan

Mg-based alloys received significant attention for temporary implant applications while, their applications have been limited by high degradation rate. Therefore, silver-zeolite doped hydroxyapatite（Ag-Zeo-HAp） coating was synthesized on Ti O2-coated Mg alloy by physical vapour deposition（PVD） assisted electrodeposition technique to decrease the degradation rate of Mg alloy. X-ray diffraction（XRD） analysis and field emission scanning electron microscopy（FE-SEM） images showed the formation of a uniform and compact layer of Ag-Zeo-HAp with a thickness of 15 μm on the Ti O2 film with a thickness of 1 μm. The potentiodynamic polarization（PDP） and electrochemical impedance spectroscopy（EIS） tests indicated that corrosion resistance of Mg-Ca alloy was considerably increased by the Ag-Zeo-HAp coating. The bioactivity test in the simulated body fluid（SBF） solution showed that a dense and homogeneous bonelike apatite layer was formed on the Ag-Zeo-HAp surface after 14 d. Investigation of antibacterial activity via disk diffusion and spread plate methods showed that the Ag-Zeo-HAp coating had a significantly larger inhibition zone（3.86 mm） towards Escherichia coli（E. coli） compared with the Ti O2-coated Mg alloy（2.61 mm）. The Ag-Zeo-HAp coating showed high antibacterial performance, good bioactivity, and high corrosion resistance which make it a perfect coating material for biomedical applications.

关键词： magnesium alloy zeolite coatiilg bioactivity conosion behavior antibacterial activity

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：