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Dynamic microphysiological system chip platform for high-throughput,customizable,and multi-dimensional drug screening

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Bioactive Materials 2024年第9期39卷 59-73页

作者： Yuxuan Zhu Deming Jiang Yong Qiu Xin Liu Yuhan Bian Shichao Tian Xiandi Wang K.Jimmy Hsia Hao Wan Liujing Zhuang Ping Wang Biosensor National Special Laboratory Key Laboratory of Biomedical Engineering of Ministry of EducationDepartment of Biomedical EngineeringZhejiang UniversityHangzhouZhejiang310027China Schools of Mechanical&Aerospace Engineering of Chemical&Biomedical EngineeringNanyang Technological University639798Singapore Cancer Center Binjiang Institute of Zhejiang UniversityHangzhou310027China The MOE Frontier Science Center for Brain Science&Brain-machine Integration Zhejiang UniversityHangzhou310027China State Key Laboratory of Transducer Technology Chinese Academy of SciencesShanghai200050China

Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug *** employing diverse types of spheroids or organoids,it is feasible to establish microphysiological systems that enhance the precision of disease modeling and offer more dependable and comprehensive drug ***-throughput microphysiological systems that support optional,parallel testing of multiple drugs have promising applications in personalized medical treatment and drug ***,establishing such a system is highly challenging and requires a multidisciplinary *** study introduces a dynamic Microphysiological System Chip Platform(MSCP)with multiple functional microstructures that encompass the mentioned *** developed a high-throughput lung cancer spheroids model and an intestine-liverheart-lung cancer microphysiological system for conducting parallel testing on four anti-lung cancer drugs,demonstrating the feasibility of the *** microphysiological system combines microscale and macroscale biomimetics to enable a comprehensive assessment of drug efficacy and side ***,the microphysiological system enables evaluation of the real pharmacological effect of drug molecules reaching the target lesion after absorption by normal organs through fluid-based physiological *** MSCP could serves as a valuable platform for microphysiological system research,making significant contributions to disease modeling,drug development,and personalized medical treatment.

关键词： Microphysiological system Organ-on-a-chip Biomimetics High throughput Multidimensional drug screening

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Tunning the bandgap of MnO_(2)homojunction by building active high-index facet to achieve rapid electron transfer for enhanced photocatalytic sterilization

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Journal of Materials Science & technology 2024年第1期168卷 265-275页

作者： Tao Zhang Bo Li Chaofeng Wang Shuilin Wu Shengli Zhu Hui Jiang Yufeng Zheng Zhaoyang Li Zhenduo Cui Yu Zhang Paul K Chu Xiangmei Liu Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer MaterialsMinistry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsSchool of Materials Science and Engineering Hubei UniversityWuhan 430062China School of Health Science&Biomedical Engineering Hebei University of TechnologyTianjin 300401China School of Materials Science&Engineering Peking UniversityBeijing 100871China School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjin 300072China Department of Orthopedics Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Physics Department of Materials Science and Engineering and Department of Biomedical EngineeringCity University of Hong KongHong Kong 999077China

Photocatalysis has been a research hotspot in recent years,and the design and modification of photocat-alysts have been the key *** methods for designing photocatalysts,including constructing heterojunctions and homojunctions,have been developed on the basis of *** this study,two homojunctions of manganese dioxide(MnO_(2)),including a high-index crystal plane homojunction and a general homojunction,are prepared using a stepwise hydrothermal *** a capping agent,the high-index crystal surface of the MnO_(2)is *** is found that the electron transport efficiency be-tween the two components of the homojunction with high-index planes is higher and the adsorption capacity of the oxygen is stronger,which leads to higher photocatalytic *** addition,the newly designed high-index homojunction is used for the treatment of bacterial infections,and it kills Staphy-lococcus aureus(***)and Escherichia coli(***)at rates of 99.95%±0.04%and 99.31%±0.25%,*** also has excellent therapeutic effects on mouse wounds,which implies superb practical application *** work provides a new strategy for the improved design of homojunctions and the application of photocatalytic materials.

关键词： Photocatalysis Homojunction Bandgap High-index facet Antibacterial

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Mechanical performance and cyocompatibility of PU/PLCL nanofibrous electrospun scaffolds for skin regeneration

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Engineered Regeneration 2022年第1期3卷 53-58页

作者： Xiang Gao Meiling Wen Yang Liu Tian Hou Meiwen An Institute of Biomedical Engineering College of Biomedical EngineeringTaiyuan University of TechnologyShanxi Key Laboratory of Material Strength&Structural ImpactTaiyuanShanxi030024China Research Center for Nano-Biomaterials&Regenerative Medicine Department of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Skin tissue engineering with considerable skin regeneration capability is an urgent need for the wound *** current challenge for researchers is to develop a bionic scaffold that imitates the extracellular matrix for the regeneration of the damaged *** our study,poly(L-lactide-co-caprolactone)(PLCL)was blended with polyurethane(PU)to obtain nanofibrous scaffolds via *** electrospun fibers with 50%PLCL content had a certain number of intersections and jointing points,and exhibited significantly enhanced mechani-cal properties combined with suitable ***,cell activities demonstrated that PU/PLCL membranes had significantly biological advantages in enhanced growth of human skin fibroblasts with spreading morphology compared with PU membranes,indicating good cytocompatibility of composite *** findings proved that PU/PLCL electrospun membranes have great potential in applications of skin tissue engineering.

关键词： Electrospun membranes Poly(L-lactide-co-caprolactone) Polyurethane Human skin fibroblasts Skin tissue engineering

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Explorations of using a convolutional neural network to understand brain activations during movie watching

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Psychoradiology 2024年第1期4卷 187-195页

作者： Wonbum Sohn Xin Di Zhen Liang Zhiguo Zhang Bharat B.Biswal Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJ 07102USA Rutgers Biomedical and Health Sciences Rutgers School of Graduate StudiesNewarkNJ 07039USA School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen51806China School of Computer Science and Technology Harbin Institute of TechnologyShenzhen518060China

Background Naturalistic stimuli,such as videos,can elicit complex brain ***,the intricate nature of these stimuli makes it challenging to attribute specific brain functions to the resulting activations,particularly for higher-level processes such as social *** We hypothesized that activations in different layers of a convolutional neural network(VGG-16)would correspond to varying levels of brain activation,reflecting the brain's visual processing ***,we aimed to explore which brain regions would be linked to the deeper layers of the *** This study analyzed functional MRI data from participants watching a cartoon *** a pre-trained VGG-16 convolutional neural network,we mapped hierarchical features of the video to different levels of brain *** maps from various kernels and layers were extracted from video frames,and the time series of average activation patterns for each kernel were used in a voxel-wise model to examine brain *** Lower layers of the network were primarily associated with activations in lower visual regions,although some kernels also unexpectedly showed associations with the posterior cingulate *** layers were linked to more anterior and lateral regions of the visual cortex,as well as the supramarginal *** This analysis demonstrated both the potential and limitations of using convolutional neural networks to connect video content with brain functions,providing valuable insights into how different brain regions respond to varying levels of visual processing.

关键词： convolutional neural network deep learning default mode network lateral occipital complex naturalistic condition supramarginal gyrus visual cortex

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ForceLAB Simulator Update: A Study on the Positive Cooperativity of Cross-Bridge Formation in Ventricular Myocyte 9th

ForceLAB Simulator Update: A Study on the Positive Cooperati...

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： de Camargo, Matheus Leonardo Alves Bassani, José Wilson Magalhães Bassani, Rosana Almada da Silva, Robson Rodrigues Research and Technology Center University of Mogi das Cruzes Mogi das Cruzes Brazil LabNECC Center for Biomedical Engineering University of Campinas Campinas Brazil Department of Biomedical Engineering School of Electrical and Computing Engineering University of Campinas Campinas Brazil

ISBN: (纸本)9783031494000

Cardiovascular diseases are one of the leading causes of death in the world. Understanding the mechanisms that control heart contraction is essential to deal with this problem. As auxiliary tools, mathematical models have been used to describe these phenomena at the cellular level. Electrical and mechanical models of ventricular myocytes have been implemented in computer simulators for analysis. One of them is ForceLAB, in which two of the main models of contraction force were implemented: Rice et al. (1999) (RWH) and Negroni & Lascano (2008) (NL). The objective of this paper is to present an updated version of the ForceLAB tool, to which additional features were added, among which the values of important variables, as one of the outputs. The new version of ForceLAB was implemented using App Designer for the development of the new interfaces. As an application, the influence of the positive crossbridge cooperativity on the unusual behavior of the Ca2+-force relationship simulated with the RWH was tested. The waveforms of twitch transient of cytosolic Ca2+ concentration ([Ca2+]i), developed force and the force versus pCa curve (where pCa = −log [Ca2+]i) were simulated. The simulation results showed that the non-paralel shift of the force versus pCa curve upon variation of myofilament Ca2+ was not corrected by the absence of the positive cooperativity mechanism did in the RWH model formulation. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Cardiac myocyte Contraction Crossbridge cooperativity In silico experiments Mathematical model

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Longitudinal study of the mechanical properties of rat abdominal aortas incubated in ex vivo conditions

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Journal of Biorheology 2023年第2期37卷 36-43页

作者： Sugita, Shukei Kawai, Hinase Ujihara, Yoshihiro Nakamura, Masanori Department of Electrical and Mechanical Engineering Graduate School of Engineering Nagoya Institute of Technology Nagoya Japan Center of Biomedical Physics and Information Technology Nagoya Institute of Technology Nagoya Japan Department of Nanopharmaceutical Sciences Nagoya Institute of Technology Nagoya Japan

Aortic disease is often associated with tissue degradation. However, the changes in the mechanical properties of the aorta occurring in accordance with tissue degradation remain unclear. This study explored the time course of the natural decay of aortic tissues in terms of mechanical and histological properties. Aortas excised from mice were incubated under ex vivo conditions, and their mechanical properties were assessed using a pressure– diameter test. Two linear lines were fitted to the pressure– diameter curve;the pressure at which the lines crossed was defined as the "collagen recruitment pressure". During incubation, the aortas suddenly changed in stiffness, and the collagen recruitment pressure dropped abruptly. These rapid changes occurred significantly earlier under an intraluminal pressure of 0 than 100 mmHg. Histological examination revealed the loss of elastic laminas (ELs) and smooth muscle cells in the aorta, coinciding with the changes in mechanical properties. Thus, the rapid change was caused by sudden structural failure of the ELs, in which damage accumulated at the microscopic level over the incubation period. Additionally, the tissue degradation rate was dependent on the mechanical environment. These findings provide insight into the etiology of aortic diseases. © Japanese Society of Biorheology 2023.

关键词： Biomechanics

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A Novel IoT-Enabled Oxygen Delivery System with Neural Network-Based Predictive Control 4

A Novel IoT-Enabled Oxygen Delivery System with Neural Netwo...

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4th International Conference on Ubiquitous Computing and Intelligent Information Systems, ICUIS 2024

作者： Sivalingam, Vijai Jayaraj, Jayakumar Paul, Subha Hency Jose Yadav, Geetika Rajasekaran, K. Raj, P. Anantha Christu Karunya Institute of Technology and Sciences Division of Biomedical Engineering Coimbatore India Karunya Institute of Technology and Sciences Division of Electrical and Electronics Engineering Coimbatore India Indian Council for Medical Research New Delhi India Kpr Institute of Engineering and Technology Department of Biomedical Engineering Coimbatore India Karunya Institute of Technology and Sciences Division of Robotics Engineering Coimbatore India

ISBN: (纸本)9798331529635

In this research study, a hardware is designed to monitor and control oxygen delivery based on physiological parameters, blood Oxygen saturation, and heart rate for real time applications. The development and evaluation of an intelligent portable Oxygen Concentrator system that integrates a Sensor, Motor driver Controller, and ESP8266 microcontroller. The controller measures SPO2 and heart rate. Data from these sensors are processed by neural network model implemented on the ESP8266 which predicts the optimal Oxygen flow rate constrained internet of things (IoT) applications such as wireless sensor networks. Therefore, in this paper, the design steps to build a model in NodeMCU ESP8266 using an artificial neural network (ANN) are presented. Controller is used in our study and NodeMCU ESP8266 is chosen because it is suitable to be used as a sensor node or sink in WSN applications. ANN with a Levenberg Marquardt algorithm is used as it can model the non - linearity with high accuracy. This intelligent system effectively manages Oxygen delivery, optimizing patient care, and has demonstrated high accuracy MSE of 0.0588 in predicting Oxygen flow requirements using a dataset of 1178 data points. For physiological metrics like SPO2, heart rate, respiration rate, and temperature, combining neural networks with data sets can help lower mistakes and increase the precision of predictions generated using these methods. © 2024 IEEE.

关键词： Physiological models

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Effect of elastin on delamination strength in the porcine aortic tunica media

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Journal of Biorheology 2023年第2期37卷 120-129页

作者： Kurihara, Genki Ujihara, Yoshihiro Nakamura, Masanori Sugita, Shukei Department of Electrical and Mechanical Engineering Graduate School of Engineering Nagoya Institute of Technology Nagoya Japan Center of Biomedical Physics and Information Technology Nagoya Institute of Technology Nagoya Japan Department of Nanopharmaceutical Sciences Nagoya Institute of Technology Nagoya Japan

Aortic dissection (AD) is a disease in which the tunica media is separated into two layers and blood flows in the newly created lumen. To elucidate the etiology of AD, we investigated the effect of the decrease in elastin, which occurs in actual AD, on the delamination strength of the aorta. Healthy porcine aortas were purchased, and half specimens were immersed in an elastase solution, for elastin digestion. The delamination test was performed on the specimens in both the circumferential θ and longitudinal z directions. The area fractions of elastin and collagen were measured via a histological analysis, such as Elastica–Masson and Azan stains. In healthy specimens, the delamination strength in the z-direction tended (albeit insignificantly) to be higher than that in the θ-direction. Conversely, in elastase-treated specimens, the delamination strengths in both directions were almost the same and were significantly lower than those recorded in the healthy specimens. The area fraction of elastin, but not of collagen, was significantly lower in elastase-treated specimens compared with control specimens. These results indicate that a decrease in elastin causes a reduction in the delamination strength, especially in the z-direction, which may result in dissection propagation in that direction in AD. © Japanese Society of Biorheology 2023.

关键词： Elastin

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loT based Patient Monitoring System towards Improving quality of life for Patients with Mild Respiratory Failure

loT based Patient Monitoring System towards Improving qualit...

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International Conference on Computer Vision and Internet of Things 2023, ICCVIoT 2023

作者： Vijai, S. Jayakumar, J. Jose, P. Subha Hency Sekaran, K. Raja Raj, P. Anantha Christu Division of Biomedical Engineering Karunya Institute of Technology and Sciences Coimbatore India Division of Electrical and Electronics Engineering Karunya Institute of Technology and Sciences Coimbatore India Division of Biomedical Engineering Karunya Institute of Technology and science Coimbatore India Department of Biomedical Engineering KPR Institute of Engineering and Technology Coimbatore India Division of Robotics Engineering Karunya Institute of Technology and Sciences Coimbatore India

ISBN: (纸本)9781839539848

Internet of things (loT) it is a network of several devices recognizable items are linked to the web and mobile app. Patient Monitoring devices accumulate healthcare information such as Body parameters Heart rate (BPM), Oxygen saturation level(SpO2). Healthcare providers receive data from Patients through loT devices. There need patient health monitoring regularly and collecting data will need a stay at home. Patients are spending less time in hospitals because to remote patient monitoring. Healthcare prices have decreased as treatment quality has increased. Using information from of the loT-enabled devices, patients and healthcare professionals can see patient data that is collected by an loT device and delivered to a software program. The data may be analyzed and therapy recommendations are made using algorithms. Any abnormality in a person's everyday activities will trigger an alarm mechanism that will notify care takers and medical professional. The sensor data is delivered to cloud through a ESP 8266 WiFi module and Arduino uno board that allows the health care system to operate efficiently. © The Institution of engineering & technology 2023.

关键词： Patient treatment

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Configurable Dynamics of Electromagnetic Suspension by Fuzzy Takagi-Sugeno Controller 21st

Configurable Dynamics of Electromagnetic Suspension by Fuzzy...

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21st Polish Control Conference, PCC 2023

作者： Pilat, Adam Krzysztof Milanowski, Hubert Bieszczad, Rafal Sikora, Bartiomiej Faculty of Electrical Engineering Automatics Computer Science and Biomedical Engineering Department of Automatic Control and Robotics AGH-University of Science and Technology Krakow Poland

ISBN: (纸本)9783031351693

This elaboration presents the synthesis of the Takagi-Sugeno type Fuzzy Logic controller realizing the programmable parameters of the state feedback controller together with the steady state current for the active magnetic levitation system. Closed-loop dynamics was calculated precisely with respect to the requested dynamics. Two cases were considered: fixed-and variable-closed-loop dynamics. The Fuzzy Logic Controller was considered under four scenarios with linear, nonlinear, and constant in-range output. The study was supported by simulations and experimental investigations. The position of the levitating sphere stands as an illustration of the system in operation. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.

关键词： Dynamics

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