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Two-photon MINFLUX with doubled localization precision

eLight 2022年第1期2卷 58-67页

作者： Kun Zhao Xinzhu Xu Wei Ren Dayong Jin Peng Xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlanta30332 GeorgiaUSA UTS‑SUStech Joint Research Centre for Biomedical Materials&Devices Department of Biomedical EngineeringCollege of EngineeringSouthern University of Science and TechnologyShenzhenGuangdong 518055China National Biomedical Imaging Center Peking UniversityBeijing 100871China

Achieving localization with molecular precision has been of great interest for extending fluorescence microscopy to *** pioneers this transition through point spread function(PSF)engineering,yet its performance is primarily limited by the signal-to-background *** we demonstrate theoretically that two-photon MINFLUX(2p-MINFLUX)could double its localization precision through PSF engineering by nonlinear ***ér-Rao Bound(CRB)is studied as the maximum localization precision,and CRB of two-photon MINFLUX is halved compared to single-photon MINFLUX(1p-MINFLUX)in all three ***,in order to achieve same localization precision with 1p-MINFLUX,2p-MINFLUX requires only 1/4 of fluorescence *** simultaneous two-photon excitation of multiple fluorophore species,2p-MINFLUX may have the potential for registration-free nanoscopy and multicolor tracking.

关键词： Super-resolution microscopy Single-molecule localization MINFLUX Two-photon microscopy

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Versatile Ti_(3)C_(2)T_(x)MXene for free-radical scavenging

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Nano Research 2022年第3期15卷 2558-2566页

作者： Jiang Liu Wei Lu Xifeng Lu Lu Zhang Haifeng Dong Yingchun Li Flexible Printed Electronics Technology Center and School of Science Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Department of Physiology Health Science CenterShenzhen UniversityShenzhen 518055China Marshall Laboratory of Biomedical Engineering Research Center for Biosensor and NanotheranosticSchool of Biomedical EngineeringShenzhen UniversityShenzhen 518055China

MXene,as an emerging two-dimensional(2D)material with ultrathin structure and fascinating physiochemical properties,has been widely explored in broad *** functions of MXenes are continuously *** work presents distinctive feature of MXene-Ti_(3)C_(2)T_(x)nanosheets for free-radical(FRs)scavenging that never reported *** demonstrated the mechanism and equation in regard to the reaction between Ti_(3)C_(2)T_(x)and H_(2)O_(2),which was applied to design colorimetric H_(2)O_(2)strip assay with good *** good FRs scavenging capability of Ti_(3)C_(2)T_(x),including a series of reactive oxygen species(ROS)and reactive nitrogen species(RNS),was systemically *** antioxidation capability of Ti_(3)C_(2)T_(x)for protecting cells from oxidative damage was demonstrated using the oxidative damage model of alpha mouse liver 12(AML-12)*** original work provides huge opportunities for MXenes in FR-related biomedical applications.

关键词： MXene hydrogen peroxide colorimetric sensor reactive oxygen species anti-oxidative damage

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SpyStapler-mediated assembly of nanoparticle vaccines

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Nano Research 2023年第2期16卷 2821-2828页

作者： Songzi Kou Weitao Chen Chenbo Sun Fei Sun Biomedical Research Institute Shenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Greater Bay Biomedical Innocenter Shenzhen Bay LaboratoryShenzhen 518132China Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has wreaked havoc around the globe,with no end in *** rapid emergence of viral mutants,marked by rapid transmission and effective immune evasion,has also posed unprecedented challenges for vaccine development,not least in its speed,mass production,and *** we report a versatile“plug-and-display”strategy for creating protein vaccines,including those against malaria parasites and SARS-CoV-2,through the combined use of the intrinsically disordered protein ligase SpyStapler and computationally designed viral-like *** resulting protein nanoparticles harboring multiple antigens induce potent neutralizing antibody responses in mice,substantially stronger than those induced by the corresponding free *** modular vaccine design enabled by SpyStapler furnishes us with a new weapon for combatting infectious diseases.

关键词： subunit vaccine SpyTag SARS-CoV-2 malaria

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Biomechanical Evaluation of the Effect of MIS and COS Surgical Techniques on Patients with Spondylolisthesis using a Musculoskeletal Model

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Journal of biomedical Physics and engineering 2025年第1期15卷 49-66页

作者： Azizi, Sajad Nikkhoo, Mohammad Rostami, Mostafa Cheng, Chih-Hsiu Department of Biomedical Engineering Faculty of Medical Sciences and Technologies Science and Research Branch Islamic Azad University Tehran Iran School of Physical Therapy and Graduate Institute of Rehabilitation Science College of Medicine Chang Gung University Taoyuan Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Linkou Taiwan Department of Biomedical Engineering Amirkabir University of Technology Tehran Iran

Background: The biomechanical impacts of Conventional Open Surgery (COS) versus Minimally Invasive Surgery (MIS) fusion techniques on adjacent segments and their potential role in developing Adjacent Segment Disease (ASD) remain uncertain for spondylolisthesis. Objective: This study aimed to investigate the impact of MIS and COS fusion surgeries on adjacent spinal segments for spondylolisthesis, through on muscle injury and developing ASD. Material and Methods: This prospective and non-randomized controls study used a validated musculoskeletal model to compare the biomechanical effects of COS and MIS L4 /L5 fusion surgery on patients with spondylolisthesis. The model incorporated kinematic data from 30 patients who underwent each surgery. A sitting task was simulated to model post-operative muscle atrophy, and the analysis focused on changes in biomechanics of adjacent spinal segments. Results: Lumbar flexion was significantly greater (201%) in MIS vs. COS, despite similar pelvic tilt. Consequently, Lumbopelvic Rhythm (LPR) also increased in MIS (133%). Both techniques altered inter-segmental moments. While inter-joint load was higher in COS, only the lower joint’s compressive load was significantly greater (67%). Additionally, MIS required lower overall muscle force with reduced loads and passive moment on spinal joints compared to COS. Conclusion: This study demonstrates that MIS fusion preserves physiological LPR better than COS. MIS maintains normal spinal curvature and maintains lumbar lordosis. While open surgery can lead to abnormal curvature and increased muscle forces to compensate for spinal stability. The study emphasizes the importance of paraspinal muscles in influencing spinal load distribution during MIS compare to COS. © Journal of biomedical Physics and engineering.

关键词： Transplantation (surgical)

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Early Detection and Treatment of Skin Diseases Using Advanced Image Preprocessing and Machine Learning Techniques 4

Early Detection and Treatment of Skin Diseases Using Advance...

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4th International Conference on Ubiquitous Computing and Intelligent Information Systems, ICUIS 2024

作者： Pandian, Jeswin Paul Jegan, R. Jerlinkasmir, R. Jose, P. Subha Hency Raj, P. Anantha Christu Karunya Institute of Technology and Science Division of Biomedical Engineering Coimbatore India Karunya Institute of Technology and Science Department of Mathematics Coimbatore India Karunya Institute of Technology and Science Division of Robotics and Automation Engineering Coimbatore India

ISBN: (纸本)9798331529635

This research aims to develop a more accurate and efficient system for classifying skin diseases, including both malignant and non-cancerous conditions. The study utilizes a comprehensive dataset encompassing various skin diseases, including melanomas, basal cell carcinomas, and benign conditions like nevi and warts. To address the challenge of class imbalance with a higher number of melanoma images, the researchers employ techniques like SMOTE (Synthetic Minority Oversampling Technique) to create synthetic data for under-represented classes. The pre-processing stage involves crucial steps like image scaling, augmentation, normalization, and data cleaning to ensure the quality and consistency of the data. Following pre-processing, feature extraction and model training will be conducted. This research has the potential to significantly contribute to the field of dermatology by enabling faster and more precise diagnosis of skin diseases through the use of advanced pre-processing techniques and a diversified dataset. © 2024 IEEE.

关键词： Lung cancer

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Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer’s disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay

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Nano Research 2023年第5期16卷 7459-7469页

作者： Liding Zhang Ying Su Xiaohan Liang Kai Cao Qingming Luo Haiming Luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology(HUST)Wuhan 430074China MoE Key Laboratory for Biomedical Photonics School of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Biomedical Engineering of Hainan Province School of Biomedical EngineeringHainan UniversityHaikou 570228China Research Unit of Multimodal Cross Scale Neural Signal Detection and Imaging Chinese Academy of Medical SciencesHUST-Suzhou Institute for BrainsmaticsJiangsu Industrial Technology Research Institute(JITRI)Suzhou 215123China

Phosphorylation of tau at Ser(396,404)(p-tau^(396,404))is one of the earliest phosphorylation events,plasma p-tau^(396,404) level appears to be a potentially promising biomarker of Alzheimer’s disease(AD).The low abundance and easy degradation of p-tau in the plasma make the lateral flow assay(LFA)a suitable choice for point-of-care detection of plasma p-tau^(396,404) ***,based on our screening of a pair of p-tau^(396,404)-specific antibodies,we developed a colorimetric and surface-enhanced Raman scattering(SERS)dual-readout LFA for the rapid,highly sensitive,robust detection of plasma p-tau^(396,404) *** LFA realized a detection limit of 60 pg/mL by the naked eye or 3.8 pg/mL by SERS without cross-reacting with other tau *** importantly,LFA rapidly and accurately differentiated AD patients from healthy controls,suggesting that it has the potential for clinical point-of-care application in AD *** dual-readout LFA has the advantages of simple operation,rapid,ultra-sensitive detection,providing a new way for early AD diagnosis and intervention,especially in primary and community AD screening.

关键词： Alzheimer’s disease p-tau^(396,404) plasma detection surface-enhanced Raman scattering lateral flow assay

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Isolation and culture of human primary osteoblasts:Comparing the effects of differences in method details on osteoblast characteristics

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Genes & Diseases 2024年第2期11卷 546-549页

作者： Fei Chen Yan Zhang Pai Peng Xiao-Ting Huang Zi-Han Qiu Bao-Cheng Liu Tie-Lin Yang Bo Yang Yan Guo Key Laboratory of Biomedical Information Engineering of Ministry of Education Biomedical Informatics & Genomics CenterSchool of Life Science and TechnologyXi'an Jiaotong UniversityXi'anShaanxi 710049China Department of Orthopaedics Shannxi Provincial People's Hospital (The Third Affiliated Hospital of Xi'an Jiaotong University)Xi'anShaanxi 710068China

Osteoblasts are essential in the maintenance of human bone homeostasis.1 The abnormal formation and impaired differentiation ability of osteoblasts are pivotal factors leading to bone-related diseases,suggesting that an indepth study of osteoblasts can provide novel treatment strategies for these diseases.2 Human primary osteoblasts are precious experimental models in bone-related research.3 However,the isolation and culture of human primary osteoblasts still have some difficulties and ***,we refined a method to isolate and culture human primary osteoblasts by taking cancellous bone through a bone tissue sampler and pre-digesting it with pancreatin,which makes the process easier,cheaper,and more ***,we compared the effects of the subtle changes in isolation and culture methods on the phenotype of human primary osteoblasts and examined the differences in morphology,proliferation,and differentiation between micro-explants cultured osteoblasts(MECOBs)and explants cultured osteoblasts(EC-OBs).

关键词： impaired culture details

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A Hybrid EEG-EMG Framework for Humanoid Control using Deep Learning Transformers

A Hybrid EEG-EMG Framework for Humanoid Control using Deep L...

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2024 IEEE International Conference on robotics and Biomimetics, ROBIO 2024

作者： Olikkal, Parthan Pillai, Branesh M. Suthakorn, Jackrit Ali, Habib Vinjamuri, Ramana University of Maryland Baltimore County Vinjamuri lab Department of Computer Science and Electrical Engineering BaltimoreMD21220 United States Mahidol University Center for Biomedical and Robotics Technology Nakorm Pathom Salaya Thailand

ISBN: (纸本)9781665481090

Brain-computer interfaces (BCIs) offer promising solutions for upper limb rehabilitation. Despite advancements in deep learning, traditional models for motor rehabilitation using electroencephalography (EEG) or electromyography (EMG) to control assistive devices require enhancement. This study aims to enhance motor control capabilities by integrating EEG and EMG signals using a Transformer-based deep learning model. Ten able-bodies subjects performed center-out tasks on a low-cost upper limb rehabilitation table, capturing 2D kinematic data, EEG, and EMG signals simultaneously. The tasks varied in complexity across four levels. Preprocessed EEG and EMG signals were fused and given as input to the proposed model, which was evaluated using three performance metrics. Results showed that the EEG-EMG combined model achieved 87.27% accuracy across all the four levels. Furthermore, the model's output successfully controlled a humanoid robot to replicate similar movements. These findings highlight the efficacy of combined EEG-EMG data in improving accuracy and performance in BCI applications, advancing assistive technologies and neurorehabilitation interventions. © 2024 IEEE.

关键词： Anthropomorphic robots

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The Role of Uric Acid to Reduce the Corrosion of Co-Cr-Mo Alloy as Joint in Presence of Ca and Vitamin D3

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Journal of Bio- and Tribo-Corrosion 2023年第4期9卷 1-14页

作者： Maged, Saja A. Abdul Anaee, Rana A. Mathew, Mathew T. Department of Materials Engineering University of Technology Baghdad Iraq Nanotechnology and Advanced Materials Research Center University of Technology Baghdad Iraq Department of Biomedical Sciences University of Illinois at Chicago Chicago United States

The effect of increasing uric acid which is biologically undesirable had a positive effect on reducing the corrosion of Co-Cr-Mo alloy that used in artificial joint. This investigation was done by the electrochemically study through addition 8 mg/dL uric acid to simulated body fluid (Ringer’s solution) at pH = 7.4 and Temp. 37 °C in the absence and presence two concentrations of each Calcium (1500 and 2500 mg/L) and Vitamin D3 (100 and 600 mg/L) representing a normal and mega dose of each drug. The results of corrosion showed that all experimental addition behave as inhibitors by adsorption these molecules on metallic surface to form a layer of coordination complexes (Co2+-uric acid and Co2+-uric acid) supported by accumulation of organic molecules of D3 to get inhibition efficiency ranged from 98.05 to 99.46%. The characteristic methods were used to support the results of corrosion, where the scanning electron microscopy showed the fully coverage by uric acid molecules and calcium salt as well as D3 molecules with lower defects on the surface of base alloy, atomic force microscopy indicated the adsorption of uric acid, calcium carbonate and cholecalcifero molecules with increasing in maximum height and depth compared with blank as well as increasing in surface roughness that reach to 14.17, 21.53 and 16.76 nm in the presence uric acid alone, uric acid-2500 mg/L Ca and uric acid-600 mg/L D3 respectively compared with 3.107 nm for blank without additives. © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

关键词： Cobalt alloys

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Revised in-depth meta-analysis on the efficacy of robot-assisted versus traditional free-hand pedicle screw insertion

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第4期7卷 155-165页

作者： Sorayouth Chumnanvej Branesh M.Pillai Jackrit Suthakorn Siriluk Chumnanvej Neurosurgery Division Department of SurgeryFaculty of Medicine Ramathibodi HospitalMahidol UniversityBangkokThailand Center for Biomedical and Robotics Technology(BART LAB) Faculty of EngineeringMahidol UniversityBangkokThailand Department of Anesthesiology and Operating Room Phramongkutklao HospitalBangkokThailand

Objective:Robot-assisted pedicle screw insertion has recently emerged as an alternative to the traditional free-hand ***,discrepancies in the accuracy of screw placement between the 2 methods have been highlighted by some comparative *** meta-analysis was conducted to synthesize evidence comparing these ***:Searches were conducted in 5 electronic databases adhering to specific eligibility criteria for randomized and observational *** data were analyzed using RevMan software and the results are presented as odds ratios(ORs),mean differences,or standard mean differences(SMDs)with 95%confidence intervals(CIs).Our analysis included 12 studies(7 randomized trials and 5 observational studies,involving 883 patients and 4903 screws).Results:The results demonstrated a higher rate of Grade A Gertzbein and Robbins pedicle placement score(OR:1.77;95%CI:1.10e2.87),a lower rate of revision surgeries(OR:0.21;95%CI:0.09e0.52),and a shorter radiation exposure duration(SMD?1.38,95%CI:2.32 to0.44)in the robot-assisted group compared with the free-hand ***,the length of hospital stay,volume of intraoperative blood loss,postoperative visual analogue scale scores for back pain,and rate of wound infection were similar between the 2 *** heterogeneity was observed in some ***:Compared with the free-hand method,the robot-assisted technique provides greater accuracy and reduced radiation *** efficacy of the robot-assisted technique is expected to improve further as experience with its use in surgery grows.

关键词： Robotic surgery Pedicle screw placement Free-hand Fluoroscopy Meta-analysis

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