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3D micropattern force triggers YAP nuclear entry by transport across nuclear pores and modulates stem cells paracrine

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National Science Review 2023年第8期10卷 180-193页

作者： Yan Li Zhenyu Zhong Cunjing Xu Xiaodan Wu Jiaqi Li Weiyong Tao Jianglin Wang Yingying Du Shengmin Zhang Advanced Biomaterials and Tissue Engineering Center Huazhong University of Science and Technology Department of Biomedical Engineering Huazhong University of Science and Technology Research Base of Regulatory Science for Medical Devices National Medical Products Administration&Institute of Regulatory Science for Medical Devices Huazhong University of Science and Technology

Biophysical cues of the cellular microenvironment tremendously influence cell behavior by mechanotransduction. However, it is still unclear how cells sense and transduce the mechanical signals from 3D geometry to regulate cell function. Here, the mechanotransduction of human mesenchymal stem cells(MSCs) triggered by 3D micropatterns and its effect on the paracrine of MSCs are systematically investigated. Our findings show that 3D micropattern force could influence the spatial reorganization of the cytoskeleton, leading to different local forces which mediate nucleus alteration such as orientation,morphology, expression of Lamin A/C and chromatin condensation. Specifically, in the triangular prism and cuboid micropatterns, the ordered F-actin fibers are distributed over and fully transmit compressive forces to the nucleus, which results in nuclear flattening and stretching of nuclear pores, thus enhancing the nuclear import of YES-associated protein(YAP). Furthermore, the activation of YAP significantly enhances the paracrine of MSCs and upregulates the secretion of angiogenic growth factors. In contrast, the fewer compressive forces on the nucleus in cylinder and cube micropatterns cause less YAP entering the *** skin repair experiment provides the first in vivo evidence that enhanced MSCs paracrine by 3D geometry significantly promotes tissue regeneration. The current study contributes to understanding the in-depth mechanisms of mechanical signals affecting cell function and provides inspiration for innovative design of biomaterials.

关键词： bioactive materials tissue regeneration 3D micropattern force paracrine mechanotransduction

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Interaction between Duty Ratio and Eye Movement for Motion Artifacts

Interaction between Duty Ratio and Eye Movement for Motion A...

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International Symposium, Seminar, and Exhibition, Display Week 2024

作者： Han, Chang-Yeong Choe, Seonggyu Kim, Hyosun Kwon, Oh-Sang Department of Biomedical Engineering UNIST Ulsan Korea Republic of Samsung Display Research Center Frontier Technology Team Korea Republic of

Previous research compared the motion artifacts under tracking and fixating conditions with moving stimulus and suggested that shorter duty ratios resulted in enhanced display quality by minimize motion blur in tracking condition (Hoffman et al, 2014). However, in real-world, interactions between eye movements and stimulus motion are more intricate than their experimental setups. We investigated the interaction further by employing various eye movement and stimulus motion combinations: A. Smooth Pursuit + Moving stimulus, B. Smooth Pursuit + Stationary stimulus, C. Fixation + Moving stimulus, D. Saccade + Stationary stimulus, and E. Saccade + Moving stimulus. Participants compared short duty ratio (10%) and a long duty ratio (90%) stimuli at 60 Hz to a reference stimulus of a 100% duty ratio at 1440 Hz. Participants perceived the short duty ratio stimulus as more closely resembling the reference stimulus in condition A as in the previous study. Interestingly, in conditions B and E, participants reported the long-duty ratio stimulus is more similar to the reference stimulus. There was no significant difference between short and long duty ratios in conditions C and D. These findings challenge the conventional assumption that less motion blur (associated with short duty ratio) is inherently more natural and suggest that even strong motion blur (associated with long duty ratio) can be perceived as more natural under specific conditions. This study underscores the importance of considering the complex interactions between eye movements, duty ratio, and stimulus motion when evaluating display image quality. © 2024, John Wiley and Sons Inc. All rights reserved.

关键词： Duty Ratio Eye Movement Image Quality Motion Artifacts Movie Quality

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Targeted nanosensitizer-augmented sono-immunotherapy with STING agonist to remodel the immune microenvironment in hepatocellular carcinoma

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Acta Biomaterialia 2025年 199卷 387-397页

作者： Yang, Huajing Li, Rui Jin, Shiyang Tian, Yuhang Wang, Chunyue Sun, Yucao Dai, Zhifei Cheng, Wen Department of Ultrasound Harbin Medical University Cancer Hospital Heilongjiang Province Harbin150081 China Department of Biomedical Engineering College of Future Technology National Biomedical Imaging Center Peking University Beijing100871 China Department of Gastrointestinal Surgery Harbin Medical University Cancer Hospital Heilongjiang Province Harbin150081 China

Hepatocellular carcinoma (HCC) is the most common primary malignant disease of the liver. Although immunotherapy offers new opportunities for treating advanced HCC, its therapeutic effect is still limited by the immunosuppressive tumor microenvironment (TME). Herein, a nanosensitizer RGD@Ce6@MSA-2@Liposome (RCM-Lip) is synthesized to specifically initiate the HCC tumor immune microenvironment through sonodynamic therapy (SDT)-triggered immunogenic cell death (ICD) and MSA-2-activated cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. RCM-Lip consists of a sonosensitizer (Chlorin e6, Ce6) with a STING agonist (MSA-2) and a tumor targeting peptide RGD inserted on the outer liposome surface. Under ultrasound irradiation, RCM-Lip generates reactive oxygen species that induce cytotoxicity and apoptosis of tumor cells. Meanwhile, tumor antigens released by apoptosis are taken up by dendritic cells (DCs), while STING is activated in the DCs by MSA-2. Moreover, DC maturation is stimulated, further enhancing the systematic anti-tumor immune responses. Sono-immunotherapy mediated by RCM-Lip promotes DCs maturation and tumor infiltration of CD8+ T cells, increasing inflammatory cytokine secretion. Consequently, the immunologically "cold" TME of HCC is successfully turned into a "hot" one, leading to a significant tumor suppression effect with good bio-safety. These results suggest a promising method for precise tumor targeting and synergistic cancer sono-immunotherapy. Statement of significance: Our study addressed the therapeutic dilemma of hepatocellular carcinoma (HCC) as an immunological "cold" tumor by the synergistic application of sonodynamic therapy (SDT) and STING agonist. The cGAS-STING signaling pathway plays a pivotal role in innate immunity against cancer, but the clinical application of STING agonists were hampered by inflammatory responses due to off-target activation. Our innovative solution introduces RGD-targeted peptide to encapsu

关键词： Immune system

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Preparation and Structure-Property Regulation Mechanism of Reversible Thermochromic Polydiacetylene

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Chinese Journal of Polymer Science 2024年第8期42卷 1111-1121页

作者： Zhi-Qing Ge Shuo Yan Zu-Xiong Pan Shan Lei Xuan-Zhi Mao Chu Zhao Mo-Zhen Wang Xue-Wu Ge Key Laboratory of Precision and Intelligent Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Marshall Laboratory of Biomedical Engineering International Cancer CenterLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

The thermochromic mechanism and the structure-property regulation principle of reversible thermochromic polydiacetylene(PDA)materials have always been a challenging *** this work,a series of diacetylene monomers(m-PCDA)containing phenyl and amide or carboxyl groups were synthesized from 10,12-pentacosadiynoic acid(PCDA)through the esterification or amidation *** effects of the number and the distribution of the functional groups in m-PCDA molecules on their solid-state polymerization capability,and the thermochromic mechanism of their corresponding polymers(m-PDA)were investigated and discussed in *** results show that the m-PCDA monomers containing both benzene ring and groups that can form hydrogen bonding interactions have strong intermolecular interaction,and are easy to carry out the solid phase polymerization under 254-nm UV irradiation to obtain the corresponding new thermochromic m-PDA *** thermochromic behavior of m-PDA depends on its melting *** initial color-change temperature(blue to red)is determined by the onset melting tem perature,and the temperature range in which reversible color recovery can be achieved by repeat heating-cooling treatment is determined by its melting *** to the proposed thermochromic mechanism of PDA,various new PDA materials with precise thermochromic temperatu res and reversible thermochromic temperature ra nges can be designed and synthesized through the appropriate introduction of benzene ring and groups that can form hydrogen bonding interactions into the molecular structure of linear diacetylene *** work provides a perspective to the precise molecular structure design and the property regulation of the reversible thermochromic PDA materials.

关键词： Polydiacetylene Thermochromism Hydrogen bonding Chemical modification

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The Effect of Graying Process on The Mechanical and Chemical Properties of Human Hair: An Experimental Study 31

The Effect of Graying Process on The Mechanical and Chemical...

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31st National and 9th International Iranian Conference on biomedical engineering, ICBME 2024

作者： Eskandari, Farzaneh Rahimtoroghi, Elham Eskandari, Faezeh Shahid Beheshti University Protein Research Center Tehran Iran Amirkabir University of Technology Department of Biomedical Engineering Tehran Iran

ISBN: (纸本)9798331529710

Aging significantly impacts the form and function of the human body. One of the most obvious signs of aging is scalp hair graying which often encourages people to use hair dyes. Investigating the chemical and physical properties of black and white hair could lead to improve the quality of cosmetic products. Therefore, the current study aimed to analyze the changes in the structural, mechanical, and chemical properties of human hair fibers due to the graying process. White and black hair fibers were collected from West-Asian females, and their morphology, chemical structure, and mechanical properties were studied using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and uniaxial tensile tests. The results revealed that the morphological properties of black and white hairs did not significantly differ (p>0.05). Additionally, FTIR analysis indicated that black hair exhibited a higher peak around 3350 cm-1 compared to white hair, possibly due to melanin content. Furthermore, mechanical tests demonstrated that white hair samples were significantly stiffer that black hair samples (p © 2024 IEEE.

关键词： Tensile testing

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Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

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Bioactive Materials 2024年第2期32卷 66-97页

作者： Min Jun Ko Sunhong Min Hyunsik Hong Woojung Yoo Jinmyoung Joo Yu Shrike Zhang Heemin Kang Dong-Hyun Kim Department of Radiology Feinberg School of MedicineNorthwestern UniversityChicagoIL60611USA Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea Department of Biomedical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan44919Republic of Korea Division of Engineering in Medicine Department of MedicineBrigham and Women’s Hospital Harvard Medical SchoolCambridgeMA02139USA College of Medicine Korea UniversitySeoul02841Republic of Korea Department of Biomedical Engineering University of IllinoisChicagoIL60607USA Robert H.Lurie Comprehensive Cancer Center Northwestern UniversityChicagoIL60611USA Department of Biomedical Engineering McCormick School of EngineeringNorthwestern UniversityEvanstonIL60208USA

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment *** effective use as a cancer therapy requires a precisely targeted approach,which can be facilitated by using nanoparticles and nanomedicine,and their use to enhance ferroptosis is indeed a growing area of *** a few review papers have been published on iron-dependent mechanism and inducers of ferroptosis cancer therapy that partly covers ferroptosis nanoparticles,there is a need for a comprehensive review focusing on the design of magnetic nanoparticles that can typically supply iron ions to promote ferroptosis and simultaneously enable targeted ferroptosis cancer ***,magnetic nanoparticles can locally induce ferroptosis and combinational ferroptosis with diagnostic magnetic resonance imaging(MRI).The use of remotely controllable magnetic nanocarriers can offer highly effective localized image-guided ferroptosis cancer ***,recent developments in magnetically manipulable nanocarriers for ferroptosis cancer nanomedicine with medical imaging are *** review also highlights the advantages of current state-of-the-art image-guided ferroptosis cancer ***,image guided combinational ferroptosis cancer therapy with conventional apoptosis-based therapy that enables synergistic tumor therapy is discussed for clinical translations.

关键词： Magnetic nanoparticles Ferroptosis cancer therapy Diagnostic imaging Magnetic resonance imaging Synergistic cancer imaging and therapy

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Brain Tumor Classification by Ensemble Learning Utilizing Wavelet Transformation-based Statistical Features 2

Brain Tumor Classification by Ensemble Learning Utilizing Wa...

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2nd International Conference on Power, Electrical, Electronics and Industrial Applications, PEEIACON 2024

作者： Akter, Sharmin Talukder, Md. Simul Hasan Enam, Sadia Khanam, Farzana Jashore University of Science and Technology Department of Biomedical Engineering Jashore Bangladesh Dhaka University of Engineering & Technology Electrical and Electronic Engineering Gazipur Bangladesh Bangabandhu Sheikh Mujibur Rahman Digital University Internet of Things and Robotics Engineering Gazipur Bangladesh

ISBN: (纸本)9798331517984

Brain tumors are regarded as highly dangerous and severe conditions, frequently leading to a substantial reduction in life expectancy. Accurate identification of brain tumors is essential for developing successful therapies that can increase patients' chances of survival. The process of manually examining and interpreting extensive MRI data can be both complex and labor-intensive. As a result of this, there is a pressing need for a trustworthy machine-learning method for accurately identifying brain tumors, and during the last decade, many approaches have been implemented. This research presents a novel method to identify as abnormal any given MR brain image. The proposed method begins with the application of DWT to extract features from images. To find the most pertinent features, PCA is then applied as a feature selection method. These selected features are classified using both a SVM with a polynomial kernel and an Ensemble of Decision Trees (EoDT), with k-fold cross-validation employed to improve the model's generalizability. Our proposed methods demonstrate enhanced performance, with the EoDT model attaining the maximum classification accuracy of 99.95%. The SVM model obtains an accuracy of 90.61%, while the combined model reaches an accuracy of 94.20%. The experimental data indicate that the method is both effective and efficient, making it suitable for brain tumor classification. It can assist doctors in diagnosing whether a patient is normal or abnormal to varying degrees. © 2024 IEEE.

关键词： Discrete wavelet transforms

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A Segmentation-based Deep Learning Method for Automatic Atrial Fibrillation Detection Using RR Intervals 24

A Segmentation-based Deep Learning Method for Automatic Atri...

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9th International Conference on biomedical Signal and Image Processing, ICBIP 2024

作者： Feng, Xiaoli Lin, Fan Li, Qiang Zhang, Peng Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology China MoE Key Laboratory for Biomedical Photonics Collaborative Innovation Center for Biomedical Engineering School of Engineering Sciences Huazhong University of Science and Technology China Division of Cardiology Department of Internal Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology China

ISBN: (纸本)9798400717970

Accurate and reliable automatic detection of atrial fibrillation (AF) in long-term dynamic electrocardiogram (ECG) recording is crucial for diagnosing the disease, tracking its progression, and assisting doctors in developing personalized care plans. Many automatic AF detection methods have been proposed, however, these methods regarded AF detection as a classification task, which limited the detection resolution. Moreover, most of them were developed and evaluated based on public datasets that included limited patients data. In this study, we regarded AF detection as a segmentation task and proposed a one-dimensional UNet-based model for AF segmentation using RR intervals data. For evaluating our method, we built an in-house dataset of 200 24-hour 12-lead Holter recordings for training and testing it in the intra-dataset manner, and further tested our method on a publicly available dataset of 23 10-hour 2-lead Holter recordings in the inter-dataset manner for evaluating its generalization ability. Our method obtained 95.5% sensitivity, 97.5% specificity, and 97.0% accuracy on the in-house dataset, and outperformed state-of-the-art methods on the public AFDB dataset, indicting high performance and good generalization ability. Therefore, our method has good potential in real clinical practice of AF detection. © 2024 Copyright held by the owner/author(s).

关键词： Deep learning

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Taguchi and ANN approaches for predicting the FSW parameters to analyse the mechanical properties

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Interactions 2024年第1期245卷 1-12页

作者： Manickam, Selvaraj Kavitha, N. Rao, N. Srinivasa Indira, K.P. Pydi, Hari Prasadarao Cheepurupalli, N. Rao Department of Automation and Robotics IMPACT College of Engineering and Applied Sciences Bangalore India Department of Physics NPR College of Engineering and Technology Tamilnadu Natham Dindigul624 401 India Department of Mechanical Engineering Shri Vishnu Engineering College for Women Bhimavaram India Department of Biomedical Engineering Saveetha School of Engineering SIMATS Chennai Kuthambakkam India Department of Mechanical Engineering College of Engineering and Technology Bule Hora University Bule Hora Ethiopia Department of Mineral Processing and Metallurgical Engineering Faculty of Mines Aksum University Aksum Ethiopia

Taguchi design utilized to execute mathematical analysis to assess friction stir welding factors on the mechanical properties like ultimate tensile strength (UTS) and Hardness (BHN). Tool rotational speed (TO), pin depth of tool (PI) and welding speed (WE) were selected. The collected experimental data were used to train ANN model using the LM backpropagation algorithm, aiming to achieve accurate predictions of the maximize the mechanical properties. The optimized ANN was structured as a multilayer perceptron with a feed-forward architecture, consisting of 3 input nodes, 10 neurons in the hidden layer, and 2 output node (3-10-3 structure). The developed model accurately which predicted UTS and BHN values, with an overall R of 0.99335 which indicates a high level of accuracy. The optimal settings for UTS at the highest and lowest levels in Exp. No 8 and Exp. No 3 are identified as TO3-WE2-PI1(1600 rpm, 200 mm/min, and 0.3 mm) and TO1-WE3-PI3 (1200 rpm, 250 mm/min, and 0.9 mm). © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.

关键词： Aluminum alloys

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Hydrogels for ameliorating osteoarthritis:Mechanical modulation,anti-inflammation,and regeneration

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BMEMat(biomedical engineering Materials) 2024年第2期2卷 34-60页

作者： Xuwei Jiang Yuxiang Sun Yuanning Lyu Heemin Kang Jianyang Zhao Kunyu Zhang Liming Bian School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhouChina National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhouChina Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhouChina Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhouChina Department of Materials Science and Engineering Korea UniversitySeoulRepublic of Korea

Osteoarthritis(OA)is a chronic and degenerative disease with limited clinical options for effective ***,significant endeavors have been explored to reveal its pathogenesis and develop treatments against ***,designed with a striking resemblance to the extracellular matrix,offer a biomimetic interaction with biological tissues,presenting a promising avenue for OA *** a result,biocompatible hydrogels have been erected incorporating on-demand bioactivities to optimize the intra-articular microenvironment,thereby alleviating OA symptoms and fostering the eventual regeneration of articular *** review highlights the collaborative objectives underlying the establishment of this tissue microenvironment,encompassing mechanical modulation,anti-inflammation,and tissue ***,we consolidate recent advances in hydrogel-based biomaterials,serving as the tissue engineering scaffolds to replicate the lubrication properties of natural joints or the bioactive agent-loaded vehicles to combat localized ***,hydrogels function as cell scaffolds to facilitate the maintenance of cellular homeostasis and contribute to the advancement of cartilage ***,this review outlines the prospective directions for hydrogel-mediated OA therapies.

关键词： cargo-delivery cellular induction hydrogels lubrication osteoarthritis

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