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Method for the extraction of circulating nucleic acids based on MOF reveals cell-free RNA signatures in liver cancer

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National science Review 2024年第1期11卷 94-106页

作者： Yuqing Sun Haixin Yu Shaoqing Han Ruoxi Ran Ying Yang Yongling Tang Yuhao Wang Wenhao Zhang Heng Tang Boqiao Fu Boshi Fu Xiaocheng Weng Song-Mei Liu Hexiang Deng Shuang Peng Xiang Zhou College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers-Ministry of Education Wuhan University Department of Digestive Surgical Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Clinical Laboratory Center for Gene Diagnosis and Program of Clinical Laboratory Zhongnan Hospital of Wuhan University College of Chemistry and Materials Science Hubei Engineering University Department of Pharmacology School of Pharmacy China Medical University Taikang Center for Life and Medical Sciences Wuhan University Department of Hematology Zhongnan Hospital of Wuhan University

Cell-free RNA(cf RNA) allows assessment of health, status, and phenotype of a variety of human organs and is a potential biomarker to non-invasively diagnose numerous diseases. Nevertheless, there is a lack of highly efficient and bias-free cf RNA isolation technologies due to the low abundance and instability of cf ***, we developed a reproducible and high-efficiency isolation technology for different types of cell-free nucleic acids(containing cf RNA and viral RNA) in serum/plasma based on the inclusion of nucleic acids by metal-organic framework(MOF) materials, which greatly improved the isolation efficiency and was able to preserve RNA integrity compared with the most widely used research kit method. Importantly, the quality of cf RNA extracted by the MOF method is about 10-fold that of the kit method, and the MOF method isolates more than three times as many different RNA types as the kit method. The whole transcriptome mapping characteristics of cf RNA in serum from patients with liver cancer was described and a cf RNA signature with six cf RNAs was identified to diagnose liver cancer with high diagnostic efficiency(area under curve = 0.905 in the independent validation cohort) using this MOF method. Thus, this new MOF isolation technique will advance the field of liquid biopsy, with the potential to diagnose liver cancer.

关键词： MOF circulating cell-free RNA biomarker liver cancer diagnosis

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Dynamic Surrogate Optimization of Vertically Stacked Nanosheet FET Based on Gaussian Process Regression

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IEEE Access 2025年 13卷 95730-95738页

作者： Christofer N. Yalung Doldet Tantraviwat Doctor of Philosophy Program in Nanoscience and Nanotechnology (International Program/Interdisciplinary) Materials Science Research Center Faculty of Science Chiang Mai University Chiang Mai Thailand Department of Electrical Engineering Faculty of Engineering Chiang Mai University Chiang Mai Thailand Center of Excellence in Materials Science and Technology Faculty of Science Chiang Mai University Chiang Mai Thailand

While speed improvements are pivotal for advancing modern transistor technologies and ensuring faster computational performance, the tradeoffs with other critical electrical properties, such as threshold voltage ( $V_{T}$ ) and off-current ( $I_{OFF}$ ), are often overlooked. These tradeoffs can significantly impact the overall device performance. The design of vertically stacked n-type and p-type nanosheet FETs (NSFETs) was applied using a dynamic surrogate optimization-gaussian process regression (DSO-GPR) with batch assessment and halting conditions. A vertically stacked silicon-based system is created and refined. Source extension ( $S_{ext}$ ), drain extension ( $D_{ex\mathrm {t}}$ ), gate length ( $L_{g}$ ), nanosheet height (NSh), nanosheet width (NSw), and number of fin (nfin) make up the input variables. In addition to applying normalization to make the weight assignment to the goal functions easier, a penalty component was incorporated to manage the $V_{T}$ . This study demonstrates the effectiveness of the DSO-GPR framework in optimizing NSFET-based inverter designs by balancing speed, $I_{OFF}$ and $V_{T}$ . Among the three evaluated cases, case 1 achieved the fastest propagation delay (1.05 ps) due to higher $I_{ON}$ and lower $V_{T}$ , albeit with increased $I_{OFF}$ and $V_{T}$ mismatch. Case 2 provided a balanced trade-off, significantly reducing $I_{OFF}$ while maintaining a competitive delay of 1.25 ps and achieving $V_{T}$ matching at 0.11 V for both n-type and p-type NSFETs. The optimum parameters for n-type are ${L} _{g}$ = 5 nm, $N_{Sh} = 9$ nm, $N_{Sw} = 42$ nm, $S_{ext} = 3$ nm and $D_{ext} = 4$ nm, nfin = 5; for p-type, $L_{g} = 7$ nm, $N_{Sh} = 10$ nm, $N_{Sw} = 42$ nm, $S_{ext} = 3$ nm and $D_{ext} = 3$ nm, nfin = 5. Case 3 minimized leakage at the cost of delay, highlighting the trade-off between power and performance. These results validate the framework’s adaptability and automation, with performance-based stopping criteria that balance

关键词： Optimization Logic gates Ions Silicon Performance evaluation Linear programming Gaussian processes Field effect transistors Accuracy Machine learning

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Renewable energy application of pulsed laser annealing perovskite quantum dots materials

Renewable energy application of pulsed laser annealing perov...

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Nanoscale and Quantum materials: From Synthesis and Laser Processing to Applications 2025

作者： Lin, Yen-Ting Hsieh, Jui-Ting Tsai, Meng-Lin Yang, Chan-Shan Institute and Undergraduate Program of Electro-Optical Engineering National Taiwan Normal University Taipei Taiwan Department of Materials Science and Engineering National Taiwan University of Science and Technology Taipei Taiwan Micro/Nano Device Inspection and Research Center National Taiwan Normal University Taiwan Applied High Entropy Technology Center National Cheng Kung University Tainan Taiwan

ISBN: (纸本)9781510684522

With the advancement of the global economy and technology, energy demand has become an urgent issue, prompting heightened attention to environmental friendliness and sustainable development. Solar energy, as a significant renewable resource, has garnered widespread attention despite facing challenges in conversion efficiency. Perovskite materials, due to their cubic crystal structure exhibiting excellent optoelectronic properties and a broad spectrum response, along with low manufacturing costs, have emerged as a recent research focus. These materials have shown remarkable potential in solar cells, light-emitting devices, and photodetectors, offering high efficiency, tunable bandgaps, and scalable fabrication processes. This study enhances the optical performance and stability of perovskite quantum dots through femtosecond pulse laser annealing technology, thereby improving their quantum yield. Advanced optical systems are employed for analysis, fully leveraging the advantages of perovskite materials in photovoltaic conversion. This research not only provides foundational solutions to pressing energy challenges but also promotes the transition of society towards cleaner and more sustainable energy technologies. Moreover, it contributes to the advancement of more efficient solar technologies, promoting innovation and development in future energy sources, and effectively reducing dependence on non-renewable energy. This is of significant importance for environmental protection, ensuring a better living environment for the future generations. © 2025 SPIE.

关键词： Nanocrystals

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Design of Mixed-Dimensional QDs/MoS2/TiO2 Heterostructured Resistive Random-Access Memory with Interfacial Analog Switching Characteristics for Potential Neuromorphic Computing

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ACS Applied Electronic materials 2024年第3期6卷 1581-1589页

作者： Tang, Shin-Yi Shih, Yu-Chuan Shen, Ying-Chun Cyu, Ruei-Hong Chen, Chieh-Ting Yang, Tzu-Yi Chaudhary, Mayur Peng, Yu-Ren Kuo, Yao-Ren Miao, Wen-Chien Yu, Yi-Jen Lee, Ling Kuo, Hao-Chung Chueh, Yu-Lun Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan College of Semiconductor Research National Tsing Hua University Hsinchu30013 Taiwan Semiconductor Research Center Hon Hai Research Institute Taipei11492 Taiwan Ph. D. Program in Prospective Functional Materials Industry National Tsing Hua University Hsinchu30013 Taiwan Department of Electrophysics College of Science National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Instrument Center National Tsing Hua University Hsinchu30013 Taiwan Department of Photonics Institute of Electro-Optical Engineering National Yang-Ming Chiao Tung University Hsinchu30010 Taiwan Department of Physics National Sun Yat-Sen University Kaohsiung80424 Taiwan Department of Materials Science and Engineering Korea University Seoul02841 Korea Republic of

Resistive random-access memory (RRAM) is one of the most promising candidates for next-generation nanoscale nonvolatile memory devices and neuromorphic computing applications. In this study, we developed a novel mixed-dimensional design for RRAM devices, incorporating zero-dimensional quantum dots (QDs), two-dimensional MoS2, and a TiO2 switching layer to achieve prominent interfacial switching behaviors. Compared with typical filamentary RRAM devices, the proposed heterostructure featured a light-sensitive QDs/MoS2 layer that allowed for bias-controllable resistive changes during the set and reset processes without abrupt switching. This was endowed by effective electron-hole pair separations upon excitation and the generation of a thin molybdenum oxide (MoOx) layer due to the accumulation of oxygen ions at the interface between MoS2 and TiO2. The ITO/QDs/MoS2/TiO2/Pt RRAM device exhibited an on/off ratio of 10 with improved endurance under 515 nm laser illumination and wavelength-dependent resistive switching behavior, making it useful for multilevel storage. Furthermore, the heterostructured device demonstrated synaptic characteristics with enhanced potentiation and depression nonlinearities and asymmetry factors, revealing its potential for future neuromorphic applications. © 2024 American Chemical Society.

关键词： Titanium dioxide

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Non-Hermitian Mott Skin Effect

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Physical Review Letters 2024年第7期133卷 076502-076502页

作者： Tsuneya Yoshida Song-Bo Zhang Titus Neupert Norio Kawakami Department of Physics Institute for Theoretical Physics Hefei National Laboratory Hefei Anhui 230088 China International Center for Quantum Design of Functional Materials (ICQD) Department of Materials Engineering Science Fundamental Quantum Science Program TRIP Headquarters

We propose a novel type of skin effects in non-Hermitian quantum many-body systems that we dub a “non-Hermitian Mott skin effect.” This phenomenon is induced by the interplay between strong correlations and the non-Hermitian point-gap topology. The Mott skin effect induces extreme sensitivity to the boundary conditions only in the spin degree of freedom (i.e., the charge distribution is not sensitive to boundary conditions), which is in sharp contrast to the ordinary non-Hermitian skin effect in noninteracting systems. Concretely, we elucidate that a bosonic non-Hermitian chain exhibits the Mott skin effect in the strongly correlated regime by closely examining an effective Hamiltonian. The emergence of the Mott skin effect is also supported by numerical diagonalization of the bosonic chain. The difference between the ordinary non-Hermitian skin effect and the Mott skin effect is also reflected in the time evolution of physical quantities; under the time evolution spin accumulation is observed while the charge distribution remains spatially uniform.

关键词： Bosons Strong interaction Topological insulators

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In situ interphase engineering for all-solid-state Li batteries: a case study on the LiNi0.5Mn1.5O4/Li0.33La0.55TiO3 composite cathode guided by ab initio calculations

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Journal of materials Chemistry A 2024年第16期12卷 9438-9453页

作者： Lin, Che-An Ihrig, Martin Kung, Kuan-Chen Chen, Hsiang-Ching Finsterbusch, Martin Guillon, Olivier Lin, Shih-Kang Department of Materials Science and Engineering National Cheng Kung University Tainan70101 Taiwan Department of Chemical Engineering National Taiwan University of Science and Technology Taipei106 Taiwan Forschungszentrum Jülich GmbH Jülich52425 Germany Research Center National Cheng Kung University Tainan70101 Taiwan Program on Smart and Sustainable Manufacturing Academy of Innovative Semiconductor and Sustainable Manufacturing National Cheng Kung University Tainan70101 Taiwan Core Facility Center National Cheng Kung University Tainan70101 Taiwan

The sinterability and interfacial stability issues in the composite cathode have been the main bottlenecks of oxide-based all-solid-state Li battery development. The interfacial reaction between the electrode and electrolyte plays an important role in the sinterability and interfacial stability of a composite cathode. A suitable interfacial reaction can not only improve the sinterability by providing an additional driving force for chemical bond formation, but it can also stabilize the electrode/electrolyte interface by forming interfacial reaction products which remain stable during operation of the cell. In this work, a suitable dopant that can induce the formation of the desired interphase between the LiNi0.5Mn1.5O4 cathode and Li0.33La0.55TiO3 electrolyte was obtained through ab inito computational screening. Experimental verification was carried out by field-assisted sintering technology/spark plasma sintering (FAST/SPS) for obtaining mechanically stable composite cathode pellets and heat treatment for inducing the interfacial reaction. The dopant identified by computation was proven to induce the in situ formation of a stable protective layer. A successful method of simultaneously improving sinterability and interfacial stability in an oxide-based composite cathode is demonstrated in this work. © 2024 The Royal Society of Chemistry.

关键词： Spark plasma sintering

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Te-hybridized zeolitic imidazolate frameworks-derived core-shell design toward dendrite-free Zn anode for long-term aqueous zinc-ion batteries

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Journal of Colloid and Interface science 2023年 649卷 471-480页

作者： Fu, Yu-Chieh Lin, Tuan-Yue Chen, Yu-Ze Department of Materials Science and Engineering National Cheng Kung University Tainan City70101 Taiwan Program on Key Materials Academy of Innovative Semiconductor and Sustainable Manufacturing National Cheng Kung University Tainan City70101 Taiwan Program on Semiconductor Packaging and Testing Academy of Innovative Semiconductor and Sustainable Manufacturing National Cheng Kung University Tainan City70101 Taiwan

Hypothesis: Aqueous zinc-ion batteries (AZIBs) have received considerable attention owing to their safety, low cost, and environmental benignity. However, the side reactions of hydrogen evolution revolution and Zn dendrite growth reduce the Coulombic efficiency and life span of AZIBs. To address these issues, we designed an artificial protective layer of a Te-hybridized core–shell zeolitic imidazolate framework (ZIF). Experiments: A core–shell structure of ZIF-8@ZIF-67 was first developed as a protecting layer on the Zn anode. To improve the poor conductivity of ZIF and its affinity for Zn, the core–shell structure was hybridized with zincophilic Te to increase the surface area and reduce the charge-transfer resistance. Findings: By incorporating metallic Te into ZIF-8 and ZIF-67, the nucleation potential and charge-transfer resistance were significantly reduced, enhancing the ion reaction kinetics and electron migration. Benefiting from the Te-hybridized ZIF-8@ZIF-67-derived nitrogen-doped porous carbon (Te-hybridized ZIF-8@ZIF-67/NC) layer, a full cell of Zn coated with Te-hybridized ZIF-8@ZIF-67/NC//MnO2 exhibited an excellent rate performance of 214 mAh g−1 at an ultrahigh current density of 10 A g−1 and ultralong cycle life (3200 cycles) without the formation of Zn dendrites. © 2023 Elsevier Inc.

关键词： Anodes

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Investigation of structural, optical, antibacterial, and dielectric properties of sol-gel and biosynthesized TiO₂ nanoparticles

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Heliyon 2024年第23期10卷 e40776页

作者： Moyeen, Abdullah Al Mahmud, Raiyana Mashfiqua Mazumder, Durjoy Datta Ghosh, Sondip Datta, Orchi Molla, Anik Begum, M. Esmotara Department of Glass & Ceramic Engineering Rajshahi University of Engineering & Technology (RUET) Rajshahi 6204 Bangladesh Department of Materials Science & Engineering Rajshahi University of Engineering & Technology (RUET) Rajshahi 6204 Bangladesh

This study explored the structural, optical, antibacterial, and dielectric properties of TiO2 nanoparticles synthesized using two distinct approaches: sol-gel and biosynthesis. Density functional tight binding (DFTB+)... 详细信息

This study explored the structural, optical, antibacterial, and dielectric properties of TiO₂ nanoparticles synthesized using two distinct approaches: sol-gel and biosynthesis. Density functional tight binding (DFTB+) and density functional theory (DFT) calculations were employed alongside experimental techniques to gain a comprehensive understanding of the electronic-property relationships. Allium sativum peel extract was utilized for the biosynthesis method. X-ray diffraction (XRD) affirmed the anatase phase formation for both nanoparticles. Rietveld technique was employed for a detailed structural analysis. The FESEM analysis revealed the diminutive particle size of TiO₂ nanoparticles with a comparable size distribution for both variants. However, the biosynthesized variant exhibited smaller average particle size (26.74 nm) than the sol-gel variant (32.22 nm). Optical studies showed an absorption redshift for the biosynthesized variant (352 nm) relative to the sol-gel variant (347 nm). The band gap energy is higher for the sol-gel variant (3.17 eV) compared to the biosynthesized variant (3.02 eV). The biosynthesized nanoparticles showed strong antibacterial activity, with inhibition zones of 15 mm against E. coli and S. flexneri bacteria. Dielectric analysis revealed that the sol-gel synthesized nanoparticles exhibited a higher dielectric permittivity of 27.80 and a lower dielectric loss of 0.37 at 1 kHz, compared to the biosynthesized nanoparticles, which showed a dielectric permittivity of 19.48 and a dielectric loss of 0.69. © 2024 The Authors

关键词： Allium sativum Antibacterial activity Band gap Biosynthesis Dielectric properties Sol-gel

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Bright Cyan Emission in Eu-Doped Borosilicate Glasses by Optimizing Reduction of Eu3+ to Eu2+ in Ambient Atmosphere

SSRN

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SSRN 2024年

作者： Cui, Jiuzhi Sun, Xin-Yuan Wen, Yufeng Chen, Runchuan Cheng, Xi Yu, Meidong Liu, Jiandi Hu, Zuofu He, Jiajun Xiao, Zhuohao Department of Physics Jinggangshan University Ji'An343009 China School of Materials Science and Engineering Jingdezhen Ceramic University Jiangxi Jingdezhen333403 China

Although substantial strides have been made in exploring the blue and red emissions of amorphous glass under near-ultraviolet excitation for LEDs purpose, the lack of the cyan emission heavily hinders the full spectra LED towards high-quality application. Addressing this cyan gap in white-light LED technology calls for the doping of Eu2+ as the luminescent center, presenting a promising solution. However, Eu3+ as an oxidation state of europium ions poses a critical challenge in effectively reducing to its reduction state. A popular method for reduction involves using mixed gases such as N2/H2 or CO gas in a reaction container, yet this approach brings about environmental pollution and increased production costs. In this work, we proposed a novel method that bright cyan emission can be achieved in Eu-doped borosilicate glasses by optimizing reduction of Eu3+ to Eu2+ in ambient atmosphere. Through variations in Eu ion concentrations, we observed a gradual increase in the band emission associated with Eu2+ and a concurrent decrease in the peak linked with Eu3+ with higher Si3N4 content. We have investigated the effect of both melting temperature and time on reduction revealed that either longer melting times or higher temperatures diminished the efficient reduction of Eu3+ to Eu2+ ions. Expanding on the Si3N4 reduction method, we employed an external bamboo charcoal approach to produce Eu-doped borosilicate glass under varying melting times. The outcomes showcased that longer melting times enhanced the reduction effect. Notably, the best cyan luminescent glass sample has an emission wavelength of 486 nm, a transmittance of 85%, and a quantum yield of 37.97%. Through these inquiries, a solid way was paved to prepare Eu2+-doped borosilicate glasses with bright cyan-emitting. © 2024, The Authors. All rights reserved.

关键词： Silicon compounds

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Atomic-scale Origin of the Low Grain-boundary Resistance in Perovskite Solid Electrolyte Li0.375Sr0.4375Ta0.75Zr0.25O3

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 1267-1269页

作者： Lee, Tom Qi, Ji Gadre, Chaitanya A. Huyan, Huaixun Ko, Shu-Ting Zuo, Yunxing Du, Chaojie Li, Jie Aoki, Toshihiro Wu, Ruqian Luo, Jian Ong, Shyue Ping Pan, Xiaoqing Department of Materials Science and Engineering University of California at Irvine Irvine CA United States Materials Science and Engineering Program University of California San Diego La Jolla CA United States Department of Physics and Astronomy University of California at Irvine Irvine CA United States Department of NanoEngineering University of California San Diego La Jolla CA United States Irvine Materials Research Institute University of California at Irvine Irvine CA United States

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