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Real-time magnetic resonance visualization of tumor acidosis as a precognition indicator of therapeutic efficacy

Bioactive Materials 2025年 52卷 63-72页

作者： Mu, Mengyao Zhang, Mengmeng Liu, Jie Ren, Ke Liu, Hui Yip, Lixian Guo, Kai Teng, Feifei Dong, Jian Xu, Xueli Leong, David Tai Sun, Xiao School of Science Shandong Jianzhu University Jinan 250101 China Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan 250000 China Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 Singapore

Traditional antitumor strategies often require sufficient time to assess the effectiveness according to changes in tumor structure. Once ineffective, patients may miss the critical window for pursuing alternative treatment options. Herein, a manganese sulfide nanoplatform loaded with proton pump inhibitor (PPI) is developed. This nanoplatform is designed for visualizing tumor acidosis degree by magnetic resonance imaging (MRI), achieving real-time therapeutic efficacy precognition. The nanoplatform releases PPI, H₂S, and Mn²⁺ within the acidic lysosome of tumor cells. PPI inhibits V-ATPase expression, leading to an increase in intracellular H⁺ levels. H₂S accelerates glucose consumption of tumor cells, producing more lactic acid and further inducing tumor acidosis. Tumor acidosis in turn accelerates the nanoplatform's degradation, achieving higher tumor MRI. As the tumor acidosis degree correlates positively with tumor regression, real-time visualization of acidosis degree effectively predicts future therapeutics. Interestingly, tumor acidosis achieves efficient tumor metastasis suppression rather than increases it. Overall, this work presents a nanoplatform capable of visualizing tumor acidosis in real-time and precisely predicting future therapeutics. © 2025 The Authors

关键词： Molecular imaging MRI visualization PPI Predicting therapy Tumor acidosis

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Recent advances in single-atom catalysts for electrocatalytic synthesis of hydrogen peroxide

Green Energy and Resources

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Green Energy and Resources 2023年第3期1卷

作者： Huang, Helai Sun, Mingze Li, Mei Tang, Lei Zhang, Shengbo State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University Beijing 100084 China Key Laboratory for Green Chemical Technology of the Ministry of Education School of Chemical Engineering and Technology Collaborative Innovation Center of Chemical Science and Engineering Tianjin University Tianjin 300072 China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Singapore 117585 Singapore

The electro-synthesis of hydrogen peroxide has attracted extensive research interest and is expected to replace conventional chemical processes as a mild and safe approach. Single-atom catalysts (SACs) have been applied in a wide variety of thermo- and electro-chemical reactions due to their high atom utilization and highly tunable electronic structure. Herein, an in-depth discussion on recent advances of SACs in the field of hydrogen peroxide electro-synthesis is summarized, specifically on the surface structure and electronic effects that enable high activity and selectivity of SACs. Different synthesis and modification strategies of SACs are discussed in detail, emphasizing the remarkable versatility of SACs utilization in this field. Finally, the opportunities and challenges of SACs for electrocatalytic synthesis of hydrogen peroxide are summarized in terms of rational design, controlled synthesis, and the stability of operation at high current densities of SACs to meet practical requirements. © 2023 The Author(s)

关键词： Activity and selectivity Electro-synthesis Hydrogen peroxide Single-atom catalysts Structure regulation

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Enhanced Cuproptosis via Metabolic Reprogramming Using Copper-Delivering Co-N-C Single-Atom Nanozyme

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ACS nano 2025年第24期19卷 2025 Jun 11页

作者： Kang Kim Jaewoo Lee Ok Kyu Park Hyochul Lee Taekyu Jang Jungho Kim Bowon Lee Jeong Hyun Kim Jaeho Moon Seoin Back Nohyun Lee Seung Hong Choi Taeghwan Hyeon Center for Nanoparticle Research Institute for Basic Science (IBS) Seoul 08826 Republic of Korea. School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National University Seoul 08826 Republic of Korea. Department of Radiology Seoul National University College of Medicine Seoul 03080 Republic of Korea. Interdisciplinary Program in Cancer Biology Seoul National University College of Medicine Seoul 03080 Republic of Korea. Department of Chemical and Biomolecular Engineering Sogang University Seoul 04107 Republic of Korea. KU-KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea. Department of Integrative Energy Engineering Korea University Seoul 02841 Republic of Korea. School of Advanced Materials Engineering Kookmin University Seoul 02707 Republic of Korea.

Cuproptosis, a copper-dependent cell death, has shown promise as a cancer therapy characterized by mitochondrial protein aggregation. However, this distinct feature makes its efficacy highly dependent on the metabolic state of cancer cells, yielding poor outcomes in hypoxic tumors with a reduced mitochondrial activity. Herein, we construct a Cu-delivering vehicle with catalase-like activity using oxygen-rich cobalt single-atom nanozymes (Cu@CoNC(O)) to reprogram metabolism while delivering copper. By introduction of oxygen-containing functional groups onto carbon supports, Cu@CoNC(O) exhibits significantly improved loading efficiency of Cu ions compared to its oxygen-deficient counterpart. Simultaneously, the outstanding catalase-like activity of Cu@CoNC(O) alleviates hypoxia, switching metabolism from glycolysis to mitochondrial respiration through the inhibition of lactate metabolism and activation of the pyruvate dehydrogenase complex. The synergistic effect of the metabolic shift and efficient Cu delivery promotes cuproptosis even under hypoxic conditions, leading to enhanced therapeutic effects. This study demonstrates the potential of single-atom nanozymes as catalytic ion delivery vehicles capable of concurrently performing catalytic functions and delivering metal ions, presenting an effective strategy to enhance cuproptosis through metabolic modulation.

关键词： catalase-like activity cuproptosis hypoxia relief ion delivery metabolic reprogramming single-atom nanozymes

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A Review of Rechargeable Zinc-Air Batteries:Recent Progress and Future Perspectives

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Nano-Micro Letters 2024年第7期16卷 358-401页

作者： Ghazanfar Nazir Adeela Rehman Jong-Hoon Lee Choong-Hee Kim Jagadis Gautam Kwang Heo Sajjad Hussain Muhammad Ikram Abeer AAlObaid Seul-Yi Lee Soo-Jin Park Department of Nanotechnology and Advanced Materials Engineering Hybrid Materials Research Center(HMC)Sejong UniversitySeoul 05006Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea Department of Chemistry Inha UniversityIncheon 22212Republic of Korea Solar Cell Applications Research Lab Department of PhysicsGovernment College University LahoreLahore 54000 PunjabPakistan Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia

Zinc-air batteries(ZABs)are gaining attention as an ideal option for various applications requiring high-capacity batteries,such as portable electronics,electric vehicles,and renewable energy *** offer advantages such as low environmental impact,enhanced safety compared to Li-ion batteries,and cost-effectiveness due to the abundance of ***,early research faced challenges due to parasitic reactions at the zinc anode and slow oxygen redox *** advancements in restructuring the anode,utilizing alternative electrolytes,and developing bifunctional oxygen catalysts have significantly improved *** have achieved battery reversibility over thousands of cycles,introduced new electrolytes,and achieved energy efficiency records surpassing 70%.Despite these achievements,there are challenges related to lower power density,shorter lifespan,and air electrode corrosion leading to performance *** review paper discusses different battery configurations,and reaction mechanisms for electrically and mechanically rechargeable ZABs,and proposes remedies to enhance overall battery *** paper also explores recent advancements,applications,and the future prospects of electrically/mechanically rechargeable ZABs.

关键词： Zinc-air batteries Energy storage Affordability Reversibility

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Effect of pyrolysis temperature on characteristics of tunable magnetic biochar synthesized from watermelon rind and its tetracycline adsorption performance

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Journal of the Taiwan Institute of chemical Engineers 2024年 160卷

作者： Thairattananon, Phisit Le, Giang T.T. Matsumura, Yukihiko Wu, Kevin C.W. Charinpanitkul, Tawatchai Department of Chemical Engineering Faculty of Engineering Center of Excellence in Particle and Material Processing Technology Chulalongkorn University Bangkok10330 Thailand Institute of Fundamental and Applied Sciences Duy Tan University Ho Chi Minh700000 Viet Nam Faculty of Environmental and Chemical Engineering Duy Tan University Da Nang550000 Viet Nam Mechanical Engineering Program Graduate School of Advanced Science and Engineering Kagamiyama Hiroshima Higashi-Hiroshima739-8527 Japan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Chung-Li Taoyuan Taiwan Research Network of NANOTEC-KU on Nanocatalyst and Nanomaterials for Sustainable Energy and Environment Bangkok10900 Thailand

Background: Tetracycline is an emerging contaminant in water reservoirs, causing undesirable influences on human society. The promising usage of magnetic biochar (MBC) derived from watermelon rind has been explored in the adsorption of various contaminants owing to its high specific surface area and separability;however, the temperature-dependent changes of MBC and its sorption ability toward antibiotics have not been widely examined. Method: Tunable MBCs could be synthesized via simple pyrolysis of watermelon rind impregnated with FeCl3 at different temperatures (700–900 °C). The as-synthesized MBCs were characterized using scanning electron microscopy (SEM), an elemental analyzer, N2 adsorption/desorption, Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray diffractometry (XRD), and vibrating sample magnetometry (VSM). Then Tetracycline, an emerging contaminant in water reservoirs, was employed as the target contaminant, while adsorption kinetics, isotherm, the effect of pH, and reusability were investigated. Significant findings: The tunability of as-synthesized MBCs could be observed by their distinct changes in structural characteristics when varying pyrolysis temperature. MBC synthesized at 900 °C (MBC900) possessed a high-specific surface area (401 m2.g−1) and saturation magnetization (55.29 emu.g−1), resulting in a greater amount of sorption sites. Tetracycline adsorption by MBCs followed a pseudo-second-order kinetic model and fitted well with the Freundlich model. MBC900 is an excellent adsorbent with a maximum adsorption capacity of 77.6 mg.g−1 and could be used for at least five cycles with an insignificant decrease in the adsorption capacity. © 2024 Taiwan Institute of chemical Engineers

关键词： Adsorption

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Cobalt-containing covalent organic frameworks for visible light-driven hydrogen evolution

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science China Chemistry 2020年第2期63卷 192-197页

作者： Jian Wang Jian Zhang Shing Bo Peh Guoliang Liu Tanay Kundu Jinqiao Dong Yunpan Ying Yuhong Qian Dan Zhao Department of Chemical and Biomolecular Engineering National Universityof SingaporeSingapore 117585Singapore School ofChemistry and Materials Science Jiangsu Normal UniversityXuzhou 221116China

Covalent organic frameworks(COFs) have recently emerged as a new class of ***,integrated design is crucial to maximizing the performance of COF-incorporating photocatalytic ***,we compare two strategies of installing earth-abundant metal-based catalytic centers into the matrice of a 2 D COF named *** to NUS-55(Co)prepared from the post-synthetic metalation of coordination sites within the COF,the molecular co-catalyst impregnated NUS-55/[Co(bpy)3]Cl2 achieves a seven-fold improvement in visible light-driven H2 evolution rate to 2,480 μmol g^-1h^-1,with an apparent quantum efficiency(AQE) of 1.55% at 450 *** results show that the rational design of molecular anchoring sites in COFs for the introduction of catalytic metal sites can be a viable strategy for the development of highly efficient photocatalysts with enhanced stability and photocatalytic activities.

关键词： covalent organic frameworks(COFs) photocatalytic H2 evolution non-precious-metal post-synthetic modification Co(Ⅱ)-cooperation

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Interfacial Diffusion Manipulation by Amphiphilic Cellulose Nanocrystal Having Antibacterial Property for Asymmetric Polyamide Layer

SSRN

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SSRN 2023年

作者： Seo, Huiran Shin, Huiseob Kong, Saerom Jung, Kyung Hwa Kim, Mun Hyeon Kim, Jae Jun Lee, Changha Kim, Hee Joong Lee, Jong-Chan Department of Chemical and Biological Engineering Institute of Chemical Processes Seoul National University 1 Gwanak-ro Seoul08826 Korea Republic of Department of Polymer Science and Engineering & Program in Environmental and Polymer Engineering Inha University Incheon22212 Korea Republic of

Polyamide (PA) thin-film composite (TFC) membranes, fabricated by interfacial polymerization (IP) process, have been widely used for the desalination process due to high water permeability with high water/salt selectivity. A number of advanced PA TFC membranes have been developed as more efficient alternatives to further improve separation performance, scalability, and address the surface contamination problem of commercial membranes. Here, we utilized amphiphilic functionalized cellulose nanocrystal (f-CNC) having antibacterial property as a nanofiller material for the preparation of an advanced PA membrane system, featuring improved water permeability with high salt rejection ability. This strategy is inexpensive, scalable, environmentally friendly, and practically relevant, given that typical IP process with a renewable nanofiller was employed. The amphiphilic f-CNC manipulates interfacial diffusion of monomers upon IP process, thereby decreasing the effective PA layer thickness by 30 % and increasing water permeability by 44 %. In addition, the PA membrane with f-CNC showed improved antibacterial and antifouling properties due to the specific nature of f-CNC. This study provides insights for the development of thin, effective, and antibacterial, yet more green and scalable PA membrane alternatives to the conventional desalination membranes. © 2023, The Authors. All rights reserved.

关键词： Cellulose

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Enhanced Capacitance in Surfactant Mediated Ion Complexes

arXiv

引用

arXiv 2023年

作者： Chen, Jihua Espera, Alejandro Carrillo, Jan Michael Y. Advincula, Rigoberto Center for Nanophase Materials Science Oak Ridge National Laboratory United States Engineering Fundamentals Tickle College of Engineering The University of Tennessee Knoxville United States Department of Chemical and Biomolecular Engineering University of Tennessee Knoxville United States

Ion complexes hold the key for various energy transfer and communication systems in nature and industries. Achieving controllable mechanical and electrical properties in these complex systems is highly desirable but remains challenging. In this work, we propose the use of amphiphilic molecules to mediate salt crystallization. The resultant ionic interfaces can be tunable through reduced surface tensions of crystal facets, an additional intermolecular modifier, and the diffusion-limited crystallization during controlled solvent evaporation. Specifically, we utilized the ionic surfactant Sodium Lauryl sulfoacetate (SLSA) to mediate the crystallization of sodium chloride. Citric acid (CA) was adopted as a hydrogen-bond modifier. Systems mediated by SLSA exhibited the highest capacitance, and a significant enhancement of capacitance was also observed in systems with both SLSA and CA. The substantially increased capacitance of these ionic complexes can be attributed to changes in interfacial and crystalline grain structures. Transmission electron microscopy (TEM), optical microscopy (OM), and Finite Element Analysis (FEA) were used to study the effects of surfactant molecules in these ionic complexes. Understanding the role of ionic complexation in defining the thermodynamic and kinetic process of the crystallization process will contribute to better optimization in nucleation and scalability of organic and inorganic crystal production. © 2023, CC BY.

关键词： Hydrogen bonds

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Hydrate-Based Energy Storage: Studying Mixed Ch4/1,3-Dioxane Hydrates Via Thermodynamic Modeling, In-Situ Raman Spectroscopy, and Macroscopic Kinetics

SSRN

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SSRN 2024年

作者： Sun, Jiyue Zhang, Ye Bhattacharjee, Gaurav Li, Xiaosen Jiang, Lei Linga, Praveen Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou510640 China Institute of Deep-sea Science and Engineering Chinese Academy of Sciences Sanya572000 China Department of Chemical and Biomolecular Engineering National University of Singapore Singapore117585 Singapore

The global demand for natural gas (NG) is anticipated to rise in the upcoming decades. Solidified Natural Gas (SNG) provides an alternative solution for the storage and transportation of NG, boasting high energy density and efficiency. Fundamental experiments and modeling endeavors are undertaken herein, focusing on diverse concentrations of 1,3-dioxane, a low-toxicity promoter, and L-tryptophan for investigating mixed sII hydrate formation. The equilibrium data and dissociation enthalpies for mixed CH4/dioxane hydrate are obtained. A van der Waals and Platteeuw (vdW–P) based thermodynamic model is developed for accurate prediction of equilibrium data, yielding an average absolute deviation ranging from 1.7% to 3.9% The quantitative analysis of the in-situ Raman spectra reveals a two-stage growth mechanism for mixed CH4/dioxane hydrates. A high gas uptake of 91.1 (±0.5) v/v is achieved using a 5.56 mol% dioxane solution at 287.15 K and 10.0 MPa. Additionally, the incorporation of 1000 ppm L-tryptophan reduces the time to reach 90% uptake (t90) to 19.9 (±1.8) minutes. The findings obtained contribute to the development of a commercially viable NG storage system. © 2024, The Authors. All rights reserved.

关键词： Raman spectroscopy

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Hydrogenation of Bio-Oil Oxygenates at Ambient Conditions via a Two-Step Redox Cycle

SSRN

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SSRN 2023年

作者： Ruan, Chongyan Akutsu, Ryota Yang, Kunran Zayan, Noha M. Dou, Jian Liu, Junchen Bose, Arnab Brody, Leo Lamb, H. Henry Li, Fanxing Department of Chemical and Biomolecular Engineering North Carolina State University RaleighNC United States Chemistry and Materials Division Department of Textile Science and Technology Shinshu University Japan

A key challenge in upgrading bio-oils to renewable fuels and chemicals resides in developing effective and versatile hydrogenation systems. Herein, we report a two-step solar thermochemical hydrogenation process that sources hydrogen directly from water and concentrated solar radiation for furfural and bio-oils upgrading. Superior catalytic performance was achieved at room temperature and atmospheric pressure, with up to two orders of magnitude higher H2 utilization efficiency compared to state-of-the-art catalytic hydrogenation. A metal or reduced metal oxide, obtainable from solar thermal or electrochemical reduction, provides the active sites for furfural adsorption and H2O dissociation. Fundamentally different from conventional hydrogenation, the in situ generated reactive H atoms hydrogenate furfural and biomass-derived oxygenates, eliminating the barriers for H2 dissolution and mass transfer in the reaction medium and the subsequent dissociation at the catalyst surface. The hydrogenation selectivity can be conveniently mediated by solvents with different polarity and metal/reduced metal oxide catalysts with varying oxophilicity, adding extra dimensions in manipulating the product distribution. This work provides an efficient and versatile strategy for bio-oils upgrading and a promising pathway for renewable energy storage. The generalized approach is also shown to be extendable to catalytic upgrading of other platform compounds with similar functional groups. © 2023, The Authors. All rights reserved.

关键词： Hydrogenation

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