检索结果-内蒙古大学图书馆

Preclinical SC and IV repeat-dose toxicology of a cowpea mosaic virus – A cancer immunotherapy candidate

Toxicology Reports 2025年 14卷

作者： Stern, Stephan T. Affonso de Oliveira, Jessica Fernanda Gatus, Jamie Edmondson, Elijah Neun, Barry W. Dobrovolskaia, Marina A. Steinmetz, Nicole F. Nanotechnology Characterization Lab Cancer Research Technology Program Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute Frederick 21702 MD United States Aiiso Yufeng Li Family Department of Chemical and Nano Engineering University of California San Diego 9500 Gilman Dr. La Jolla La Jolla 92093 CA United States Shu and K.C. Chien and Peter Farrell Collaboratory University of California San Diego 9500 Gilman Dr. La Jolla 92093 CA United States Center for Nano-ImmunoEngineering University of California San Diego 9500 Gilman Dr. La Jolla 92093 CA United States Department of Bioengineering University of California San Diego 9500 Gilman Dr. La Jolla 92093 CA United States Molecular Histopathology Laboratory Laboratory of Animal Sciences Program Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute 8560 Progress Drive Frederick 21701 MD United States Department of Radiology University of California San Diego 9500 Gilman Dr. La Jolla 92093 CA United States Institute for Materials Discovery and Design University of California San Diego 9500 Gilman Dr. La Jolla 92093 CA United States Moores Cancer Center University of California San Diego 9500 Gilman Dr. La Jolla 92093 CA United States Center for Engineering in Cancer Institute of Engineering Medicine University of California San Diego 9500 Gilman Dr. La Jolla 92093 CA United States

Cancer immunotherapies focus on boosting the immune system to recognize and eliminate tumor cells. Amongst the various biologics under development for cancer immunotherapy, our team has focused on the study of plant viruses in this context. We have shown that intratumoral administration of cowpea mosaic virus (CPMV) relieves the immunosuppressive tumor microenvironment and elicits a potent, systemic and durable anti-tumor immune response. The potency of CPMV has been demonstrated in several tumor mouse models and in companion canine cancer patients. Toward clinical development, we here studied the pharmacology and safety of CPMV. The repeat-dose toxicity of CPMV was evaluated in female Sprague Dawley rats. Rats received three weekly treatments (subcutaneous or intravenous) of a fixed dose (∼20 mg/kg), and complete necropsy was performed either 24 hrs (acute toxicity group) or 14 day (recovery group) post-dose. All animals reached the scheduled euthanasia times, and no clinical abnormalities were noted during the study period. Important clinical chemistry, hematology and histopathology findings included decreased albumin/globulin ratio, leukocytosis, neutrophilia, monocytosis, and lymphoid hyperplasia (Dunnett's test, p<0.05) – these changes support the immunostimulatory mode of action for CPMV. All other changes were considered mild, within historical range for the model, and/or not biologically significant. Neither a maximum tolerated dose (MTD) nor a no-observable adverse effect level (NOAEL) was established in this study. Overall, data indicate a good safety profile for the CPMV cancer immunotherapy candidate. © 2025 The Authors

关键词： Cowpea mosaic virus (CPMV) Pharmacology Plant viruses Toxicology

来源：评论

学校读者我要写书评

暂无评论

Plasmonic bacteria on a nanoporous mirror via hydrodynamic trapping for rapid identification of waterborne pathogens

引用

Light(Science & Applications) 2018年第1期7卷 359-367页

作者： Keumrai Whang Jong-Hwan Lee Yonghee Shin Wooju Lee Young Wan Kim Dongchoul Kim Luke P.Lee Taewook Kang Department of Chemical and Biomolecular Engineering Sogang UniversitySeoul 04107Korea Berkeley Sensor and Actuator Center Departments of BioengineeringElectrical Engineering and Computer ScienceBiophysics Graduate ProgramUniversity of CaliforniaBerkeleyBerkeleyCA 94720USA Department of Mechanical Engineering Sogang UniversitySeoul 04107Korea

A rapid,precise method for identifying waterborne pathogens is critically needed for effective disinfection and better ***,conventional methods,such as culture-based counting,generally suffer from slow detection times and low ***,we developed a rapid detection method for tracing waterborne pathogens by an innovative optofluidic platform,a plasmonic bacteria on a nanoporous mirror,that allows effective hydrodynamic cell trapping,enrichment of pathogens,and optical signal *** designed and simulated the integrated optofluidic platform to maximize the enrichment of the bacteria and to align bacteria on the nanopores and plasmonic mirror via hydrodynamic cell *** nanoparticles are self-assembled to form antenna arrays on the surface of bacteria,such as Escherichia coli and Pseudomonas aeruginosa,by replacing citrate with hydroxylamine hydrochloride in order to amplify the signal of the plasmonic optical *** to the synergistic contributions of focused light via the nanopore geometry,self-assembled nanoplasmonic optical antennas on the surface of bacteria,and plasmonic mirror,we obtain a sensitivity of detecting *** as low as 102 cells/ml via surface-enhanced Raman *** believe that our label-free strategy via an integrated optofluidic platform will pave the way for the rapid,precise identification of various pathogens.

关键词： mirror trapping precise

来源：评论

学校读者我要写书评

暂无评论

Bioelectrical Interfaces Beyond Cellular Excitability: Cancer, Aging, and Gene Expression Reprogramming

arXiv

引用

arXiv 2025年

作者： Cadinu, Paolo Burgess, Matthew Jones, Catarina Franco Luciani, Titouan Iarossi, Marzia Schröter, Manuel Nakatsuka, Nako Djamgoz, Mustafa B.A. Gonçalves, Gil Sanjuán-Alberte, Paola Mendes, Paula M. Rawson, Frankie J. Nair, Malavika Levin, Michael Moreddu, Rosalia Program in Cellular and Molecular Medicine Boston Children’s Hospital BostonMA02115 United States Department of Microbiology Blavatnik Institute Harvard Medical School BostonMA02115 United States Institute of Biomedical Engineering Department of Engineering Science University of Oxford Oxford United Kingdom Department of Bioengineering Institute for Bioengineering and Biosciences Instituto Superior Técnico University of Lisbon Lisbon Portugal Associate Laboratory i4HB Institute for Health and Bioeconomy Instituto Superior Técnico Universidade de Lisboa Lisbon Portugal Department of Neuroscience Institut Pasteur Paris75015 France Department of Biomedical Engineering Technion Israel Institute of Technology Haifa Israel ETH Zurich Department of Biosystems Science and Engineering Basel Switzerland Laboratory of Chemical Nanotechnology Neuro-X Institute EPFL Genève1202 Switzerland Department of Life Sciences Imperial College London United Kingdom Department of Mechanical Engineering University of Aveiro Aveiro3810-193 Portugal Guimarães4800-058 Portugal School of Chemical Engineering University of Birmingham Birmingham United Kingdom Bioelectronics Laboratory Division of Regenerative Medicine and Cellular Therapies School of Pharmacy Biodiscovery Institute University of Nottingham Nottingham United Kingdom Allen Discovery Centre Tufts University Tufts University MedfordMA United States Wyss Institute for Bioinspired Engineering Harvard University BostonMA United States School of Electronics and Computer Science University of Southampton Southampton United Kingdom Institute for Life Sciences University of Southampton Southampton United Kingdom

Bioelectrical interfaces represent a significant evolution in the intersection of nanotechnology and biophysics, oRering new strategies for probing and influencing cellular processes. These systems capitalize on the subtle but powerful electric fields within living matter, potentially enabling applications beyond cellular excitability, ranging from targeted cancer therapies to interventions in genetic mechanisms and aging. This perspective article envisions the translation, development and application of next-generation solid-state bioelectrical interfaces and their transformative impact across several critical areas of medical research. © 2025, CC BY.

关键词： Medical nanotechnology

来源：评论

学校读者我要写书评

暂无评论

Artificial confocal microscopy for deep label-free imaging

arXiv

引用

arXiv 2021年

作者： Chen, Xi Kandel, Mikhail E. He, Shenghua Hu, Chenfei Lee, Young Jae Sullivan, Kathryn Tracy, Gregory Chung, Hee Jung Kong, Hyun Joon Anastasio, Mark Popescu, Gabriel Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaIL United States Department of Computer Science & Engineering Washington University in St. Louis St. LouisMO63130 United States Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign UrbanaIL United States Neuroscience Program University of Illinois at Urbana-Champaign UrbanaIL United States Department of Bioengineering University of Illinois at Urbana-Champaign UrbanaIL United States Department of Molecular and Integrative Physiology University of Illinois at Urbana-Champaign UrbanaIL United States Chemical and Biomolecular Engineering University of Illinois at Urbana-Champaign UrbanaIL United States Carl Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign UrbanaIL United States

来源：评论

学校读者我要写书评

暂无评论

Decoding Transition between Kinematics Stages for Brain-Machine Interface*

Decoding Transition between Kinematics Stages for Brain-Mach...

引用

IEEE International Conference on Systems, Man and Cybernetics

作者： Shuhang Chen Xiang Zhang Xiang Shen Yifan Huang Yiwen Wang Program of Bioengineering Hong Kong University of Science and Technology department of Electronic and Computer Engineering Hong Kong University of Science and Technology department of Chemical and Biological Engineering Hong Kong University of Science and Technology

ISBN: (纸本)9781728145709

Brain-machine interfaces (BMIs) translate the neural activity into digital command to control external devices in accomplishing movement task, which could involve multiple stages of behaviors in sequence. Previous work generally discriminates the stage labels using a classifier and uses a combination of sub-decoders designed respectively for each stage. Without considering the time dynamics of neural activity, the classifier often introduces noisy estimation in stage prediction. Brain-controlling neuro-prosthesis requires the decoder to continuously output the kinematics interpretation on brain state for each time instance, including when to start or end each stage within the task smoothly and accurately. We propose to decode the kinematic states within stages and during stage transition in one paradigm. The kinematics state vector is extended, and the time dynamics is modelled in the state-observation framework. We validate our approach on a brain-controlled lever discrimination task. The rats need to adjust the neural activity to press the correct virtual lever and drives the brain state to trigger the start of the next trial. Compared with the existing method whose mean square error is 0.8038, our results show smoother transition prediction and better decoding accuracy with less mean square error which is 0.7922. And the correction rate of holding lever and rest is above 90%. These results help the subjects do the task with even less response time (2.81s) and shorter inter-trial duration (4.5s).

关键词： Decoding Kinematics Pressing Neural activity Task analysis Rats Human factors

来源：评论

学校读者我要写书评

暂无评论

Mutational signatures and transmissibility of SARS-CoV-2 Gamma and Lambda variants

arXiv

引用

arXiv 2021年

作者： Oróstica, Karen Y. Contreras, Sebastian Mohr, Sebastian B. Dehning, Jonas Bauer, Simon Medina-Ortiz, David Iftekhar, Emil N. Mujica, Karen Covarrubias, Paulo C. Ulloa, Soledad Castillo, Andrés E. Verdugo, Ricardo A. Fernández, Jorge Olivera-Nappa, Álvaro Priesemann, Viola Santiago Chile Max Planck Institute for Dynamics and Self-Organization Am Faßberg 17 Göttingen37077 Germany Department of Chemical Engineering Biotechnology and Materials Universidad de Chile Beauchef 851 Santiago8370448 Chile Centre for Biotechnology and Bioengineering Universidad de Chile Beauchef 851 Santiago8370456 Chile Human Genetics Program Institute of Biomedical Sciences Faculty of Medicine University of Chile Santiago Chile Institute for the Dynamics of Complex Systems University of Göttingen Friedrich-Hund-Platz 1 Göttingen37077 Germany

The emergence of SARS-CoV-2 variants of concern endangers the long-term control of COVID-19, especially in countries with limited genomic surveillance. In this work, we explored genomic drivers of contagion in Chile. We sequenced 3443 SARS-CoV-2 genomes collected between January and July 2021, where the Gamma (P.1), Lambda (C.37), Alpha (B.1.1.7), B.1.1.348, and B.1.1 lineages were predominant. Using a Bayesian model tailored for limited genomic surveillance, we found that Lambda and Gamma variants’ reproduction numbers were about 5% and 16% larger than Alpha’s, respectively. We observed an overabundance of mutations in the Spike gene, strongly correlated with the variant’s transmissibility. Furthermore, the variants’ mutational signatures featured a breakpoint concurrent with the beginning of vaccination (mostly CoronaVac, an inactivated virus vaccine), indicating an additional putative selective pressure. Thus, our work provides a reliable method for quantifying novel variants’ transmissibility under subsampling (as newly-reported Delta, B.1.617.2) and highlights the importance of continuous genomic surveillance. Copyright © 2021, The Authors. All rights reserved.

关键词： SARS

来源：评论

学校读者我要写书评

暂无评论

Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury

引用

Journal of Biomedical Science 2024年第1期31卷 1页

作者： Chen, Sin-Yu Chen, Yi-Ling Li, Po-Chen Cheng, Tai-Shan Chu, Yeh-Shiu Shen, Yi-Shan Chen, Hsin-Tung Tsai, Wei-Ni Huang, Chien-Ling Sieber, Martin Yeh, Yuan-Chieh Liu, Hsiao-Sheng Chiang, Chi-Ling Chang, Chih-Hung Lee, Andrew S. Tseng, Yen-Han Lee, Ly James Liao, Hsiu-Jung Yip, Hon-Kan Huang, Chi-Ying F. Institute of Biopharmaceutical Sciences College of Pharmaceutical Sciences National Yang Ming Chiao Tung University Taipei 112304 Taiwan Division of Cardiology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 833401 Taiwan Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial Hospital Kaohsiung 833401 Taiwan Department of Orthopedic Surgery Far Eastern Memorial Hospital New Taipei City 220216 Taiwan Brain Research Center National Yang Ming Chiao Tung University Taipei 112304 Taiwan Department of Biomedical Engineering National Taiwan University Taipei 106319 Taiwan Bionet Therapeutics Taipei 114065 Taiwan Department of Traditional Chinese Medicine Chang Gung Memorial Hospital Keelung 204201 Taiwan Program in Molecular Medicine College of Life Sciences National Yang Ming Chiao Tung University Taipei 112304 Taiwan Department of Microbiology and Immunology College of Medicine National Cheng Kung University Tainan 701401 Taiwan Center for Cancer Research College of Medicine Kaohsiung Medical University Kaohsiung 807378 Taiwan Teaching and Research Center Kaohsiung Municipal Siaogang Hospital Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung 812015 Taiwan Department of Chemical and Biomolecular Engineering The Ohio State University Columbus 43210 OH United States Comprehensive Cancer Center College of Medicine The Ohio State University Columbus 43210 OH United States Graduate School of Biotechnology and Bioengineering Yuan Ze University Taoyuan 320315 Taiwan Spot Biosystems Ltd. Palo Alto 94305 CA United States Department of Chest Medicine Taipei Veterans General Hospital Taipei 112201 Taiwan Department of Medical Research Far Eastern Memorial Hospital New Taipei City 220216 Taiwan Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial Hospital Kaohsiung 833401 Taiwan Departme

Background: Acute lung injury (ALI) is a life-threatening respiratory condition characterized by severe inflammation and lung tissue damage, frequently causing rapid respiratory failure and long-term complications. The microRNA let-7a-5p is involved in the progression of lung injury, inflammation, and fibrosis by regulating immune cell activation and cytokine production. This study aims to use an innovative cellular electroporation platform to generate extracellular vesicles (EVs) carring let-7a-5p (EV-let-7a-5p) derived from transfected Wharton’s jelly-mesenchymal stem cells (WJ-MSCs) as a potential gene therapy for ALI. Methods: A cellular nanoporation (CNP) method was used to induce the production and release of EV-let-7a-5p from WJ-MSCs transfected with the relevant plasmid DNA. EV-let-7a-5p in the conditioned medium were isolated using a tangential flow filtration (TFF) system. EV characterization followed the minimal consensus guidelines outlined by the International Society for Extracellular Vesicles. We conducted a thorough set of therapeutic assessments, including the antifibrotic effects using a transforming growth factor beta (TGF-β)-induced cell model, the modulation effects on macrophage polarization, and the influence of EV-let-7a-5p in a rat model of hyperoxia-induced ALI. Results: The CNP platform significantly increased EV secretion from transfected WJ-MSCs, and the encapsulated let-7a-5p in engineered EVs was markedly higher than that in untreated WJ-MSCs. These EV-let-7a-5p did not influence cell proliferation and effectively mitigated the TGF-β-induced fibrotic phenotype by downregulating SMAD2/3 phosphorylation in LL29 cells. Furthermore, EV-let-7a-5p regulated M2-like macrophage activation in an inflammatory microenvironment and significantly induced interleukin (IL)-10 secretion, demonstrating their modulatory effect on inflammation. Administering EVs from untreated WJ-MSCs slightly improved lung function and increased let-7a-5p expression in

关键词： Acute lung injury Anti-inflammation Cellular nanoporation Extracellular vesicles Let-7a-5p Mesenchymal stem cells

来源：评论

学校读者我要写书评

暂无评论

The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: Prospects and Challenges

引用

BioDesign Research 2020年第1期2020卷 1-8页

作者： Charles DeLisi Aristides Patrinos Michael MacCracken Dan Drell George Annas Adam Arkin George Church Robert Cook-Deegan Henry Jacoby Mary Lidstrom Jerry Melillo Ron Milo Keith Paustian John Reilly Richard J.Roberts Daniel Segrè Susan Solomon Dominic Woolf Stan D.Wullschleger Xiaohan Yang Department of Biomedical Engineering and Program in Bioinformatics College of EngineeringBoston UniversityBoston MA 02215USA The NOVIM Group Kohn HallUC Santa BarbaraCA 93106USA Climate Institute WashingtonDCUSA Department of Energy WashingtonDCUSA Center for Health Law Ethics&Human Rights at the Boston University School of Public HealthSchool of MedicineBoston UniversityUSA Department of Bioengineering University of CaliforniaBerkeley CAUSA Department of Genetics Harvard Medical SchoolCambridge MAUSA School for the Future of Innovation in Society Arizona State UniversityBarrett&O’Connor Washington Center1800 I StreetNWWashingtonDC 20006USA Sloan School of Management MITCambridge MAUSA Department of Chemical Engineering University of WashingtonSeattle WashingtonUSA The Ecosystems Center of the Marine Biological Laboratory in Woods Hole MAUSA Department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovotIsrael Department of Soil and Crop Sciences Colorado State UniversityFort Collins CO 80523USA MIT Joint Program on the Science and Policy of Global Change MITCambridge MAUSA New England Biolabs Beverly MAUSA Department of Biology and Program in Bioinformatics Boston UniversityBoston MA 02215USA Department of Earth Atmospheric and Planetary SciencesMITCambridge MAUSA Soil and Crop Sciences Section School of Integrated Plant SciencesCornell UniversityIthaca NYUSA Environmental Sciences Division Oak Ridge National LaboratoryOak Ridge TNUSA Biosciences Division Oak Ridge National LaboratoryOak RidgeTNUSA

The long atmospheric residence time of CO2 creates an urgent need to add atmospheric carbon drawdown to CO2 regulatory *** and systems biology(SSB),which enables manipulation of cellular phenotypes,offers a powerful approach to amplifying and adding new possibilities to current land management practices aimed at reducing atmospheric *** participants(in attendance:Christina Agapakis,George Annas,Adam Arkin,George Church,Robert Cook-Deegan,Charles DeLisi,Dan Drell,Sheldon Glashow,Steve Hamburg,Henry Jacoby,Henry Kelly,Mark Kon,Todd Kuiken,Mary Lidstrom,Mike MacCracken,June Medford,Jerry Melillo,Ron Milo,Pilar Ossorio,Ari Patrinos,Keith Paustian,Kristala Jones Prather,Kent Redford,David Resnik,John Reilly,Richard ***,Daniel Segre,Susan Solomon,Elizabeth Strychalski,Chris Voigt,Dominic Woolf,Stan Wullschleger,and Xiaohan Yang)identified a range of possibilities by which SSB might help reduce greenhouse gas concentrations and which might also contribute to environmental sustainability and *** include,among other possibilities,engineering plants to convert CO2 produced by respiration into a stable carbonate,designing plants with an increased root-to-shoot ratio,and creating plants with the ability to self-fertilize.A number of serious ecological and societal challenges must,however,be confronted and resolved before any such application can be fully assessed,realized,and deployed.

关键词： Synthetic Roberts enable

来源：评论

学校读者我要写书评

暂无评论

Corrigendum to ‘Study of Carbon Supported CuPd Alloy Nanoparticles with Pd-Rich Surface for the Electrochemical Formate Oxidation and CO 2 Reduction’ [Electrochimica Acta, 387 (2021) 138531]

引用

Electrochimica Acta 2021年 389卷

作者： Wei Jyun Wang Sooyeon Hwang Taejin Kim Su Ha Louis Scudiero The Gene and Linda Voiland School of Chemical Engineering and Bioengineering Washington State University Wegner Hall Room 105 1505 NE Stadium Way Pullman WA 99164 Center for Functional Nanomaterial Brookhaven National Laboratory Upton NY 11973 Department of Materials Science and Chemical Engineering Stony Brook University Stony Brook NY 11794 USA Chemistry Department and Materials Science and Engineering Program Washington State University PO Box 644630 Pullman WA 99164-4630

来源：评论

学校读者我要写书评

暂无评论

Phase imaging with computational specificity (PICS) for measuring dry mass changes in sub-cellular compartments

arXiv

引用

arXiv 2020年

作者： Kandel, Mikhail E. He, Yuchen R. Lee, Young Jae Chen, Taylor Hsuan-Yu Sullivan, Kathryn Michele Aydin, Onur Saif, Taher M.A. Kong, Hyunjoon Sobh, Nahil Popescu, Gabriel Beckman Institute University of Illinois at Urbana-Champaign UrbanaIL United States Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign UrbanaIL United States Neuroscience Program University of Illinois at Urbana-Champaign UrbanaIL United States Department of Bioengineering University of Illinois at Urbana-Champaign UrbanaIL United States Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign UrbanaIL United States Chemical and Biomolecular Engineering University of Illinois at Urbana-Champaign UrbanaIL United States Carl Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign UrbanaIL United States

Due to its specificity, fluorescence microscopy (FM) has become a quintessential imaging tool in cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit FM’s utility. Recently, it has been shown that artificial intelligence (AI) can transform one form of contrast into another. We present PICS, a combination of quantitative phase imaging and AI, which provides information about unlabeled live cells with high specificity. Our imaging system allows for automatic training, while inference is built into the acquisition software and runs in real-time. Applying the computed fluorescence maps back to the QPI data, we measured the growth of both nuclei and cytoplasm independently, over many days, without loss of viability. Using a QPI method that suppresses multiple scattering, we measured the dry mass content of individual cell nuclei within spheroids. In its current implementation, PICS offers a versatile quantitative technique for continuous simultaneous monitoring of individual cellular components in biological applications where long-term label-free imaging is desirable. Copyright © 2020, The Authors. All rights reserved.

关键词： Fluorescence microscopy

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：