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CD44-targeted RIP3 gene delivery strategy for enhanced cancer therapy via necroptosis and immune modulation

Journal of controlled release : official journal of the Controlled Release Society 2025年 384卷 113872页

作者： Sang Eun Kim Soyeon Bak Jung Hee Park Ji Eun Lee Yun Ji Lee Min Seok Park Soyeon Ko Hani Choi Kyung Hee Jung Kun Na Soon-Sun Hong Department of Medicine College of Medicine and Program in Biomedical Science & Engineering Inha University 3-ga Sinheung-dong Jung-gu Incheon 22332 Republic of Korea. Department of Biotechnology The Catholic University of Korea 43 Jibong-ro Wonmi-gu Bucheon-si Gyeonggi-do 14662 Republic of Korea Department of BioMedical-Chemical Engineering The Catholic University of Korea 43 Jibong-ro Wonmi-gu Bucheon-si Gyeonggi-do 14662 Republic of Korea. Department of BioMedical-Chemical Engineering The Catholic University of Korea 43 Jibong-ro Wonmi-gu Bucheon-si Gyeonggi-do 14662 Republic of Korea. Electronic address: kna6997@catholic.ac.kr. Department of Medicine College of Medicine and Program in Biomedical Science & Engineering Inha University 3-ga Sinheung-dong Jung-gu Incheon 22332 Republic of Korea. Electronic address: hongs@inha.ac.kr.

Receptor-interacting protein kinase 3 (RIP3)-mediated necroptosis has attracted interest as a potential target for cancer therapy as it boosts tumor immunogenicity. Here, we synthesized a pH-sensitive polymer (CA) by conjugating aminopropyl imidazole (API) to chondroitin sulfate (CHS) for RIP3 gene delivery. CA can target cancer cells due to the specific binding ability of CHS to CD44 which is overexpressed in cancer cells. In addition, the introduction of API conferred pH sensitivity, facilitating efficient endosomal escape and enhancing gene delivery efficiency. Increased levels of high mobility group box-1, EEA1, and Rab5 and high activation of RIP3/mixed-lineage kinase domain-like pseudokinase signaling were observed in the CA-shielded RIP3 complex (CA-PEI/RIP3)-treated groups. Significant tumor selectivity and ablation efficacy of CA-PEI/RIP3 were confirmed in A549 xenografts and LLC1 orthotopic lung cancer mouse models. Furthermore, CA-PEI/RIP3-induced necroptotic cell death could enhance the immune response by increasing phagocytosis of dendritic cells (DCs), resulting in large numbers of CD4+ and CD8+ T cells and mature DCs infiltrating tumor tissues and lymph nodes. Collectively, CA-PEI/RIP3 showed significant potential in cancer gene therapy due to the enhanced transfection efficiency and the tumor-targeting properties of CA, providing a safe and robust strategy to activate the immune response for cancer immunotherapy.

关键词： Cancer gene therapy Gene delivery Necroptosis RIP3 pH-sensitive polymer

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Modeling and control of subcritical coal-fired power plant components for fault detection

Modeling and control of subcritical coal-fired power plant c...

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2019 Canadian Society for Civil engineering Annual Conference, CSCE 2019

作者： Agbleze, Selorme Lima, Fernando V. Pezzini, Paolo Bonilla-Alvarado, Harry Bryden, Kenneth M. Indrawan, Natarianto Panday, Rupendranath Tucker, David Shadle, Lawrence J. Department of Chemical and Biomedical Engineering West Virginia University MorgantownWV26506 United States Simulation and Decision Science Program Ames Laboratory AmesIA50011 United States Leidos Research Support Team U.S. Department of Energy National Energy Technology Laboratory 3610 Collins Ferry Road MorgantownWV26507 United States

ISBN: (纸本)9780791883747

Due to the increased penetration of renewable power sources into the electric grid, the current number of existing coalfired power plants shifting from baseload to load-following operations has also increased. This shift creates challenges especially for the power industry as coal-fired power plants were not designed for ramping situations, leading to added stress on major components of these plants. This stress causes the system to degrade over time and eventually develop faults. As boilers are still the primary component that fails and causes forced outages, accurate characterization of faults and fractures of boilers is now becoming increasingly critical to reduce plant downtime and extend the plant life during cycling operations. This work focuses on modeling sections of a subcritical coalfired power plant and proposes algorithms for fault detection in MATLAB/Simulink. The developed model simulates the process dynamics including steam and feedwater flow regulating valves, drum-boiler, and heat rate on the regulation of pressure, drum level and production of saturated steam. The model also simulates the dynamics of superheaters for increasing the energy content of steam, and a spray section for regulating the temperature of steam upstream of the high-pressure turbine to allow for power output adjustment within a given valve operating range. Furthermore, an extension to a leak detection framework proposed by co-authors in previous work is explored. The new framework includes a modification to the threshold analysis portion of the previous work. The extended framework is then applied to a subcritical coal-fired power plant model for leak detection. In particular, this framework analyzes mismatches or deviations in expected plant dynamics with an identified transfer function model. The mismatch is flagged after it exceeds a threshold. The developed algorithm thus aids in rapid detection of faults to reduce impeded plant performance. The results of this work will sup

关键词： Coal fired power plant

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Critical pore radius and transport properties of disordered hard- and overlapping-sphere models

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Physical Review E 2021年第1期104卷 014127-014127页

作者： Michael A. Klatt Robert M. Ziff Salvatore Torquato Department of Physics Princeton University Princeton New Jersey 08544 USA Institut für Theoretische Physik FAU Erlangen-Nürnberg Staudtstr. 7 91058 Erlangen Germany Center for the Study of Complex Systems and Department of Chemical Engineering University of Michigan Ann Arbor Michigan 48109 USA Department of Chemistry Princeton Institute for the Science and Technology of Materials and Program in Applied and Computational Mathematics Princeton University Princeton New Jersey 08544 USA

Transport properties of porous media are intimately linked to their pore-space microstructures. We quantify geometrical and topological descriptors of the pore space of certain disordered and ordered distributions of spheres, including pore-size functions and the critical pore radius δc. We focus on models of porous media derived from maximally random jammed sphere packings, overlapping spheres, equilibrium hard spheres, quantizer sphere packings, and crystalline sphere packings. For precise estimates of the percolation thresholds, we use a strict relation of the void percolation around sphere configurations to weighted bond percolation on the corresponding Voronoi networks. We use the Newman-Ziff algorithm to determine the percolation threshold using universal properties of the cluster size distribution. The critical pore radius δc is often used as the key characteristic length scale that determines the fluid permeability k. A recent study [Torquato, Adv. Wat. Resour. 140, 103565 (2020)] suggested for porous media with a well-connected pore space an alternative estimate of k based on the second moment of the pore size 〈δ2〉, which is easier to determine than δc. Here, we compare δc to the second moment of the pore size 〈δ2〉, and indeed confirm that, for all porosities and all models considered, δc2 is to a good approximation proportional to 〈δ2〉. However, unlike 〈δ2〉, the permeability estimate based on δc2 does not predict the correct ranking of k for our models. Thus, we confirm 〈δ2〉 to be a promising candidate for convenient and reliable estimates of the fluid permeability for porous media with a well-connected pore space. Moreover, we compare the fluid permeability of our models with varying degrees of order, as measured by the τ order metric. We find that (effectively) hyperuniform models tend to have lower values of k than their nonhyperuniform counterparts. Our findings could facilitate the design of porous media with desirable transport properties via targete

关键词： Geophysical networks Materials Patterns in complex systems

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Interdependence of Support Wettability - Electrodeposition Rate- Sodium Metal Anode and SEI Microstructure

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Angewandte Chemie 2024年第8期137卷

作者： Chang-An Lo Yixian Wang Varun R. Kankanallu Aditya Singla Dean Yen Xiaoyin Zheng Kaustubh G. Naik Bairav S. Vishnugopi Callum Campbell Vikalp Raj Chonghang Zhao Lu Ma Jianming Bai Feipeng Yang Ruipeng Li Mingyuan Ge John Watt Partha P. Mukherjee David Mitlin Yu-chen Karen Chen-Wiegart Department of Materials Science and Chemical Engineering Stony Brook University Stony Brook NY 11794 USA Materials Science and Engineering Program & Texas Materials Institute The University of Texas at Austin Austin TX 78712 USA School of Mechanical Engineering Purdue University West Lafayette IN 47907 USA National Synchrotron Light Source II Brookhaven National Laboratory Upton NY 11973 USA Center for Integrated Nanotechnologies Los Alamos National Laboratory Los Alamos NM 87545 USA

This study examines how current collector support chemistry (sodiophilic intermetallic Na 2 Te vs. sodiophobic baseline Cu) and electrodeposition rate affect microstructure of sodium metal and its solid electrolyte interphase (SEI). Capacity and current (6 mAh cm −2 , 0.5–3 mA cm −2 ) representative of commercially relevant mass loading in anode-free sodium metal battery (AF-SMBs) are analyzed. Synchrotron X-ray nanotomography and grazing-incidence wide-angle X-ray scattering (GIWAXS) are combined with cryogenic ion beam (cryo-FIB) microscopy. Highlighted are major differences in film morphology, internal porosity, and crystallographic preferred orientation e.g. (110) vs. (100) and (211) with support and deposition rate. Within the SEI, sodium fluoride (NaF) is more prevalent with Te−Cu versus sodium hydride (NaH) and sodium hydroxide (NaOH) with baseline Cu. Due to competitive grain growth the preferred orientation of sodium crystallites depends on film thickness. Mesoscale modeling delineates the role of SEI (ionic conductivity, morphology) on electrodeposit growth and onset of electrochemical instability.

关键词： sodium metal battery sodium metal anode solid electrolyte interphase (SEI) fiber texture film growth

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Sanitation and challenges in sustainable urban water management

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AIP Conference Proceedings 2023年第1期2667卷

作者： D. D. Anggoro I. Sumantri Y. S. Sari H. R. Sunoko R. Bicer 1Department of Chemical Engineering Faculty Engineering Diponegoro University Semarang Central Java 50275 Indonesia 2Doctoral Program of Environmental Science School of Postgraduate Studies Diponegoro University Semarang Central Java 50241 Indonesia 3Faculty of Theology Sakarya University Serdivan Turkey

Water and good sanitation are essential elements to support human health. Unfortunately, the fulfillment of clean water and sanitation needs has not been fully implemented in several parts of the world. Sanitation development in Indonesia refers to the Sustainable Development Goals, which in 2030 are targeted to ensure the availability and sustainable management of clean water and sanitation for all communities. The problem in this study is to determine community participation in its contribution to achieving SDGs (6) goals in the use of public toilet facilities built from local government budgets in a sustainable effort in the SANIMAS program in Bandung City West Java. The research results that have been carried out show that the use of shared toilet facilities requires participation from the community and the increasing number of residents in each urban area. Policies from the government can anticipate problems in the future, and there is a need for collaboration between the government, the private sector, and the community by paying attention to the environment both for the sustainability of water reserves from dug wells and the use of technology that can prevent river water pollution in the city, as well as the sustainability of the sanitation program for all public.

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A first-principles study on the quantum tunneling of methylhydroxycarbene isomerization in various solvents 4

A first-principles study on the quantum tunneling of methylh...

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4th Padjadjaran International Physics Symposium 2019, PIPS 2019

作者： Susanti, E.D. Rusydi, F. Puspitasari, I. Fadilla, R.N. Aisyah, N.D. Ahmad, A. Research Center for Quantum Engineering Design Faculty of Science and Technology Universitas Airlangga Jl. Mulyorejo Surabaya60115 Indonesia Department of Physics Faculty of Science and Technology Universitas Airlangga Jl. Mulyorejo Surabaya60115 Indonesia Precision Sciences and Technology and Applied Physics Graduate School of Engineering Osaka University Suita565-0871 Japan Information System Study Program Faculty of Science and Technology Universitas Airlangga Jl. Mulyorejo Surabaya60115 Indonesia School of Chemical Science and Food Technology Faculty of Science and Technology Universiti Kebangsaan Malaysia Bangi Selangor43600 Malaysia

Quantum tunneling phenomenon allows a high-barrier reaction to occur even though thermal energy is not sufficient to surmount the barrier. The phenomenon has been suggested to exist in the isomerization of methylhydroxycarbene which occured at 11 K. Here we study the quantum tunneling that occured in the isomerization of methylhydroxycarbene to acetaldehyde and to vinyl alcohol based on density functional calculations. The isomerization pathways are determined under the effect of various solvents which are modeled by polarizable continuum model (PCM). We use Wentzel-Kramers-Brillouin (WKB) approximation to calculate the tunneling probability (T) and extend the usefulness of T into isomerization rate. The results show that the solvents give a significant effect on the isomerization rate of methylhydroxycarbene to acetaldehyde but an insignificant one on the isomerization rate to vinyl alcohol. © 2020 IOP Publishing Ltd. All rights reserved.

关键词： Isomerization

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Periodicity Scoring of Time Series Encodes Dynamical Behavior of the Tumor Suppressor p53 ⁎ ⁎

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IFAC-PapersOnLine 2021年第9期54卷 488-495页

作者： Caroline Moosmüller Christopher J. Tralie Mahdi Kooshkbaghi Zehor Belkhatir Maryam Pouryahya José Reyes Joseph O. Deasy Allen R. Tannenbaum Ioannis G. Kevrekidis C. Moosmüller and C. Tralie contributed equally to this work Department of Mathematics University of California San Diego La Jolla CA 92093 USA Department of Medical Physics Memorial Sloan-Kettering Cancer Center NY USA Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore MD 21218 USA Department of Mathematics and Computer Science Ursinus College Collegeville PA USA Program in Applied and Computational Mathematics Princeton University NJ USA School of Engineering and Sustainable Development De Montfort University Leicester UK Cancer Biology and Genetics Program and Computational and Systems Biology Program Memorial Sloan-Kettering Cancer Center New York NY 10065 USA and Department of Systems Biology Harvard Medical School Boston MA 02115 USA Departments of Computer Science and Applied Mathematics & Statistics Stony Brook University NY USA

In this paper we analyze the dynamical behavior of the tumor suppressor protein p53, an essential player in the cellular stress response, which prevents a cell from dividing if severe DNA damage is present. When this response system is malfunctioning, e.g. due to mutations in p53, uncontrolled cell proliferation may lead to the development of cancer. Understanding the behavior of p53 is thus crucial to prevent its failing. It has been shown in various experiments that periodicity of the p53 signal is one of the main descriptors of its dynamics, and that its pulsing behavior (regular vs. spontaneous) indicates the level and type of cellular stress. In the present work, we introduce an algorithm to score the local periodicity of a given time series (such as the p53 signal), which we call Detrended Autocorrelation Periodicity Scoring (DAPS). It applies pitch detection (via autocorrelation) on sliding windows of the entire time series to describe the overall periodicity by a distribution of localized pitch scores. We apply DAPS to the p53 time series obtained from single cell experiments and establish a correlation between the periodicity scoring of a cell’s p53 signal and the number of cell division events. In particular, we show that high periodicity scoring of p53 is correlated to a low number of cell divisions and vice versa. We show similar results with a more computationally intensive state-of-the-art periodicity scoring algorithm based on topology known as Sw1PerS. This correlation has two major implications: It demonstrates that periodicity scoring of the p53 signal is a good descriptor for cellular stress, and it connects the high variability of p53 periodicity observed in cell populations to the variability in the number of cell division events.

关键词： Systems biology cellular systems time series modeling bioinformatics computational biology

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A Scenario for a Carbon-Neutral Ammonia-Fueled Engine Mediated by Catalytic NH3Cracking and CO2Hydrogenation

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Angewandte Chemie 2024年第8期137卷

作者： Jie Ren Hongliang Li Hao Lou Weili Zhou Feng Zeng Yu Wang Xiaokang Liu Chalachew Mebrahtu Gang Pei Jing-Pei Cao Tao Yao Zhandong Wang Jie Zeng Department of Thermal Science and Energy Engineering Hefei National Research Center for Physical Sciences at the Microscale National Synchrotron Radiation Laboratory Key Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education Institutes Department of Chemical Physics University of Science and Technology of China Hefei Anhui 230026 P. R. China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Jiangsu 211816 China SINOPEC Shanghai Research Institute of Petrochemical Technology Co. Ltd. Shanghai 201208 P. R. China Institute for Technical and Macromolecular Chemistry RWTH Aachen University Aachen 52074 Nordrhein-Westfalen Germany Jiangsu Province Engineering Research Center of Fine Utilization of Carbon Resources China University of Mining & Technology Xuzhou 221116 Jiangsu P. R. China School of Chemistry & Chemical Engineering Anhui University of Technology Ma'anshan Anhui 243002 P. R. China

Utilizing near zero-carbon NH 3 as fuel in engines is promising for carbon-neutrality. However, the application of NH 3 into the engine suffers from the intrinsic poor combustion characteristics of NH 3 and the emission of harmful NO x exhausts. Herein, we proposed and successfully confirmed a novel scenario for converting a conventional “CH 4 -fueled” engine to “NH 3 -fueled” engine. Specifically, CH 4 was used to power the internal combustion engine and release CO 2 as the exhaust. Afterwards, we put forward two routes to convert the exhaust and NH 3 into N 2 and CH 4 for enclosing the carbon cycle. The first “spatially decoupled” route splits the exhaust treatment into NH 3 cracking over Ru clusters on the calcined Mg−Al hydrotalcite (Ru/MAO) and CO 2 methanation over a commercial Ni/Al 2 O 3 . Both NH 3 and CO 2 were almost completely converted into the target products under their respective optimal conditions. The second “spatially coupled” route refers to an one-pot reaction of NH 3 and CO 2 into N 2 , CH 4 , and H 2 O. Due to the mismatch of reaction conditions and the competitive adsorption of reactants, the conversions of NH 3 and CO 2 were lowered to 80.1 % and 49.3 %, respectively, over Ru/MAO under 1 bar (CO 2 :NH 3 =3 : 8) at 550 °C.

关键词： Direct coupling CO2 hydrogenation NH3 cracking NH3-CO2 conversion Ammonia engine

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A new sterol from the Formosan soft coral Lobophytum durum

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Journal of Molecular Structure 2024年第Part2期1296卷

作者： Hung, Chia-Ling Huang, Li-Chieh Shih, Kun-Yauh Lai, Kuei-Hung Peng, Bo-Rong Hwang, Tsong-Long Chien, Su-Ying Li, Chia-Ying Chung, Hsu-Ming Department of Applied Chemistry National Pingtung University Pingtung900391 Taiwan Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei11031 Taiwan PhD Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei11031 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei11031 Taiwan Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan333323 Taiwan Research Center for Chinese Herbal Medicine Graduate Institute of Healthy Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan333324 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Department of Anesthesiology Chang Gung Memorial Hospital Taoyuan333423 Taiwan Instrumentation Center National Taiwan University Taipei106319 Taiwan

Chromatographic investigation on the ethyl acetate extract of the soft coral Lobophytum durum collected from the waters of Guishan Island in northeast Taiwan resulted in the isolation of three sterols 1–3, including one new sterol, 3β-hydroxy-25-methylene-5-cholesten-7-one (1), and two previously reported sterols, 7-oxogorgosterol (2), and (24R)-ergostane-3β,5α,6β,25-tetraol 25-monoacetate (3). The structures of sterols 1–3 were determined by extensive spectroscopic data analysis and by comparison with literatures. Additionally, the 24R-configuration of sterol 3 was identified by a single-crystal X-ray diffraction analysis and 13C chemical shifts for first time. The anti-inflammatory activities of sterols 1–3 were evaluated by examining their inhibitory effects on the generation of superoxide anions and the release of elastase against activated human neutrophils. © 2023

关键词： Spectroscopic analysis

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Designing F/P Hybrid Polymer as Ultrastable Cationic Shielding Interphase for High-Performance Lithium Metal Batteries

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Angewandte Chemie 2023年第37期135卷

作者： Shantao Han Baifei Wu Huaijiao Wang Peng Wen Lu Zhang Prof. Dr. Xinrong Lin Prof. Dr. Mao Chen State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University Shanghai 200433 China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education Yunnan Provincial Center for Research & Development of Natural Products School of Chemical Science and Technology Yunnan University Kunming 650091 P. R. China

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