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Front Cover: chemically Tuned Intracellular Gene Delivery by Core-Shell Nanoparticles: Effects of Proton Buffering, Acid Degradability, and Membrane Disruption (ChemMedChem 7/2022)

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ChemMedChem 2022年第7期17卷

作者： Dr. Soo Kyung Cho Rebecca T. Lee Prof. Yoon-Hwae Hwang Prof. Young Jik Kwon Crystal Bank PNU Pusan National University 2222 Nano Building Samnangjin-ro Miryang Gyeongsangnam-do 50463 Republic of Korea Department of Biomedical Engineering and Medical Scientist Training Program University of California Irvine B200 Sprague Hall Irvine CA 92697-3958 USA Department of Nano Energy Engineering Pusan National University Pusandaehak-ro 63 beon-gil 2 Jangjeon-dong Geumjung-gu Busan 46241 (Republic of Korea) Departments of Pharmaceutical Science Chemical and Biomolecular Engineering Biomedical Engineering and Molecular Biology and Biochemistry University of California Irvine 132 Sprague Hall Irvine CA 92697-3958 USA

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A non-metal single atom nanozyme for cutting off the energy and reducing power of tumors

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Angewandte Chemie 2024年第16期136卷

作者： Junjie Cheng Li Li Duo Jin Yajie Zhang Wenxin Yu Jiaji Yu Jianhua Zou Yi Dai Yang Zhu Manman Liu Miya Zhang Yongfu Sun Yangzhong Liu Xiaoyuan Chen Department of Chemistry Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China Hefei 230026 China Hefei National Research Center for Physical Sciences at Microscale University of Science and Technology of China Hefei 230026 China Central Laboratory Department of Biobank Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Nanjing 210022 China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive Proteos Singapore 138673 Singapore College of Pharmaceutical Sciences Anhui Xinhua University Hefei 230088 China

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Front Cover: Pyromellitic-Diimide-Based Liquid Material Forming an Exciplex with Naphthalene (ChemPhotoChem 6/2023)

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ChemPhotoChem 2023年第6期7卷

作者： Yuya Tanabe Hiroki Tsutsui Dr. Shinya Matsuda Dr. So Shikita Prof. Takuma Yasuda Dr. Kyosuke Isoda Program in Advanced Materials Science Faculty of Engineering and Design Kagawa University 2217-20 Hayashi-cho Takamatsu Kagawa 761-0396 Japan Department of Applied Chemistry Graduate School of Engineering Kyushu University 744 Motooka Nishi-ku Fukuoka 819-0395 Japan Institute for Advanced Study Kyushu University 744 Motooka Nishi-ku Fukuoka 819-0395 Japan Health Research Institute National Institute of Advanced Industrial Science and Technology (AIST) 2217-14 Hayashi-cho Takamatsu Kagawa 761-0395 Japan Organic Materials Chemistry Group Sagami Chemical Research Institute 2743-1 Hayakawa Ayase Kanagawa 252-1193 Japan

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Tumor microenvironment responsive nano-PROTAC for BRD4 degradation enhanced cancer photo-immunotherapy

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Biomaterials 2025年 322卷 123387-123387页

作者： Li, Zheng Ren, Guodong Wang, Xuewei Li, Xiaowan Ding, Lingwen Zhu, Jianwei Zhang, Yajie Zhang, Chengwu Zou, Jianhua Chen, Xiaoyuan Departments of Diagnostic Radiology Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore School of Basic Medical Sciences Shanxi Medical University Taiyuan030001 China Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Yong Loo Lin School of Medicine National University of Singapore 11 Biopolis Way Helios Singapore 138667 Singapore 61 Biopolis Drive Proteos Singapore 138673 Singapore Department of Pharmacy and Pharmaceutical Sciences National University of Singapore Lower Kent Ridge Road 4 Science Drive 2 117544 Singapore

Proteolysis Targeting Chimeras (PROTAC) technology has garnered great attention due to its advantages in targeted protein degradation, promising its potential for treating malignant cancer. Nevertheless, the inherent drawbacks of PROTAC technology hinder its clinical translation. The integration of nanotechnology with PROTAC molecules to create nano-PROTACs for combined therapy offers a promising solution. Among the various cancer treatment methods, phototherapy is considered the optimal choice to integrate with specific PROTACs due to its proven effectiveness and non-invasive nature. Herein, a nano-PROTAC formulation (ARV@PEG-ICG) consisting of a phototherapeutic agent named indocyanine green functionalized polyethylene glycol (PEG-ICG) and a BRD4 degrader (ARV-825) was fabricated for cancer photo-immunotherapy. Activated by acidic tumor microenvironment (TME), ARV@PEG-ICG nanoparticles (NPs) will decompose rapidly for ARV delivery. PEG-ICG generated abundant ROS with laser irradiation, downregulating the expression of Bcl-xL and inducing the cleavage of PARP to stimulate cell apoptosis. Furthermore, the degradation of BRD4, a transcriptional cofactor, inhibited nitric oxide synthase (iNOS) generation to improve phototherapeutic efficacy. In a 4T1 breast tumor model, dying 4T1 cells released tumor associated antigens (TAAs) to serve as the immunogenic cell death (ICD) inducer, facilitating DC maturation and T cell activation and amplifying systemic immune response. The distant tumor growth can also be inhibited due to the activation of long-term immune response. Overall, the current study aims to combine typical PROTAC with functional nanomaterials to form nano-PROTAC with high performance for PROTAC delivery mediated cancer treatment. © 2025 Elsevier Ltd

关键词： Nanocomposites

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Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides

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Nature communications 2023年第1期14卷 7589页

作者： Liam Hudson Jeremy W Mason Matthias V Westphal Matthieu J R Richter Jonathan R Thielman Bruce K Hua Christopher J Gerry Guoqin Xia Heather L Osswald John M Knapp Zher Yin Tan Praveen Kokkonda Ben I C Tresco Shuang Liu Andrew G Reidenbach Katherine S Lim Jennifer Poirier John Capece Simone Bonazzi Christian M Gampe Nichola J Smith James E Bradner Connor W Coley Paul A Clemons Bruno Melillo C Suk-Yee Hon Johannes Ottl Christoph E Dumelin Jonas V Schaefer Ann Marie E Faust Frédéric Berst Stuart L Schreiber Frédéric J Zécri Karin Briner Chemical Biology and Therapeutics Science Program Broad Institute 415 Main Street Cambridge MA 02142 USA. Novartis Institutes for BioMedical Research 181 Massachusetts Avenue Cambridge MA 02139 USA. Department of Chemistry The Scripps Research Institute 10550 North Torrey Pines Road La Jolla CA 92037 USA. Department of Chemistry and Chemical Biology Harvard University 12 Oxford Street Cambridge MA 02138 USA. Department of Chemical Engineering MIT Cambridge MA 02139 USA. Novartis Institutes for BioMedical Research Novartis Pharma AG Novartis Campus CH-4002 Basel Switzerland. Novartis Institutes for BioMedical Research 181 Massachusetts Avenue Cambridge MA 02139 USA. frederic.zecri@***.

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Interactive Protocols for Classically-Verifiable Quantum Advantage

arXiv

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arXiv 2021年

作者： Zhu, Daiwei Kahanamoku-Meyer, Gregory D. Lewis, Laura Noel, Crystal Katz, Or Harraz, Bahaa Wang, Qingfeng Risinger, Andrew Feng, Lei Biswas, Debopriyo Egan, Laird Gheorghiu, Alexandru Nam, Yunseong Vidick, Thomas Vazirani, Umesh Yao, Norman Y. Cetina, Marko Monroe, Christopher Joint Quantum Institute Departments of Physics and Electrical and Computer Engineering University of Maryland College ParkMD20742 United States Joint Center for Quantum Information and Computer Science NIST University of Maryland College ParkMD20742 United States Department of Physics University of California BerkeleyCA94720 United States Materials Sciences Division Lawrence Berkeley National Laboratory BerkeleyCA94720 United States Department of Computing and Mathematical Sciences California Institute of Technology CA91125 United States Division of Physics Mathematics and Astronomy California Institute of Technology CA91125-0001 United States Duke Quantum Center Department of Physics Duke University DurhamNC27708 United States Department of Electrical and Computer Engineering Duke University DurhamNC27708 United States IonQ Inc. College ParkMD20740 United States Institute for Theoretical Studies ETH Zürich CH 8001 Switzerland Chemical Physics Program Institute for Physical Science and Technology University of Maryland College ParkMD20742 United States Departments of Electrical and Computer Engineering University of Maryland College ParkMD20742 United States

Interaction is a powerful resource for quantum computation. It can be utilized in applications ranging from the verification of quantum algorithms all the way to verifying quantum mechanics itself. Here, we present the first implementation of interactive protocols for proofs of quantumness — which when suitably scaled promise the efficient verification of quantum computational advantage. The key feature that distinguishes these protocols from existing demonstrations of quantum advantage is that the classical verification is efficient and scales polynomially rather than exponentially with the number of qubits. The experimental implementation of such interactive protocols requires the ability to independently measure subsets of qubits in the middle of a quantum circuit and to continue coherent evolution afterwards. This is achieved by spatially isolating target qubits via shuttling, and opens the door to a range of quantum interactive protocols as well as new information processing architectures. Copyright © 2021, The Authors. All rights reserved.

关键词： Qubits

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Biomineral tablets for long-acting IL-2 immunotherapy

Nature cancer

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Nature cancer 2025年 2025 Jun 10页

作者： Jianping Liu Xiaoyuan Chen Department of Diagnostic Radiology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore. Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore. Department of Diagnostic Radiology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Department of Chemical and Biomolecular Engineering College of Design and Engineering National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Department of Biomedical Engineering College of Design and Engineering National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Department of Pharmacy and Pharmaceutical Sciences Faculty of Science National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Theranostics Center of Excellence (TCE) Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) Singapore Singapore. chen.shawn@nus.edu.sg.

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A Hybrid Supramolecular Polymeric Nanomedicine for Cascade-Amplified Synergetic Cancer Therapy

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Angewandte Chemie 2022年第27期134卷

作者： Kai Yang Dr. Shaolong Qi Dr. Xinyang Yu Dr. Bing Bai Xueyan Zhang Prof. Dr. Zhengwei Mao Prof. Dr. Feihe Huang Prof. Dr. Guocan Yu Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology Department of Chemistry Tsinghua University Beijing 100084 P. R. China State Key Laboratory of Chemical Engineering Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University Hangzhou 310027 P. R. China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215 P. R. China Green Catalysis Center and College of Chemistry Zhengzhou University Zhengzhou 450001 P. R. China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province the Second Affiliated Hospital School of Medicine MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 P. R. China

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Shear-induced polydomain structures of nematic lyotropic chromonic liquid crystal disodium cromoglycate

arXiv

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arXiv 2020年

作者： Baza, Hend Turiv, Taras Li, Bing-Xiang Li, Ruipeng Yavitt, Benjamin M. Fukuto, Masafumi Lavrentovich, Oleg D. Department of Physics Kent State University OH United States Advanced Materials and Liquid Crystal Institute Kent State University OH United States Materials Science Graduate Program Kent State University OH United States National Synchrotron Light Source II Brookhaven National Laboratory UptonNY United States Department of Material Science and Chemical Engineering Stony Brook University Stony BrookNY United States

Lyotropic chromonic liquid crystals (LCLCs) represent aqueous dispersions of organic disk-like molecules that form cylindrical aggregates. Despite the growing interest in these materials, their flow behavior is poorly understood. Here, we explore the effect of shear on dynamic structures of the nematic LCLC, formed by 14wt% water dispersion of disodium cromoglycate (DSCG). We employ in-situ polarizing optical microscopy (POM) and small-angle and wide-angle X-ray scattering (SAXS/WAXS) to obtain independent and complementary information on the director structures over a wide range of shear rates. The DSCG nematic shows a shear-thinning behavior with two shear-thinning regions (Region I at γ −1 and Region III at γ > 10 s−1) separated by a pseudo-Newtonian Region II (1 s−1 −1). The material is of a tumbling type. In Region I, γ −1, the director realigns along the vorticity axis. An increase of γ above 1 s-1 triggers nucleation of disclination loops. The disclinations introduce patches of the director that deviates from the vorticity direction and form a polydomain texture. Extension of the domains along the flow and along the vorticity direction decreases with the increase of the shear rate to 10 s−1. Above 10 s−1, the domains begin to elongate along the flow. At γ > 100 s−1, the texture evolves into periodic stripes in which the director is predominantly along the flow with left and right tilts. The period of stripes decreases with an increase of γ. The shear-induced transformations are explained by the balance of the elastic and viscous energies. In particular, nucleation of disclinations is associated with an increase of the elastic energy at the walls separating nonsingular domains with different director tilts. The uncovered shear-induced structural effects would be of importance in the further development of LCLC applications. Copyright © 2020, The Authors. All rights reserved.

关键词： Shear deformation

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Phase imaging with computational specificity (PICS) for measuring dry mass changes in sub-cellular compartments

arXiv

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arXiv 2020年

作者： Kandel, Mikhail E. He, Yuchen R. Lee, Young Jae Chen, Taylor Hsuan-Yu Sullivan, Kathryn Michele Aydin, Onur Saif, Taher M.A. Kong, Hyunjoon Sobh, Nahil Popescu, Gabriel Beckman Institute University of Illinois at Urbana-Champaign UrbanaIL United States Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign UrbanaIL United States Neuroscience Program University of Illinois at Urbana-Champaign UrbanaIL United States Department of Bioengineering University of Illinois at Urbana-Champaign UrbanaIL United States Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign UrbanaIL United States Chemical and Biomolecular Engineering University of Illinois at Urbana-Champaign UrbanaIL United States Carl Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign UrbanaIL United States

Due to its specificity, fluorescence microscopy (FM) has become a quintessential imaging tool in cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit FM’s utility. Recently, it has been shown that artificial intelligence (AI) can transform one form of contrast into another. We present PICS, a combination of quantitative phase imaging and AI, which provides information about unlabeled live cells with high specificity. Our imaging system allows for automatic training, while inference is built into the acquisition software and runs in real-time. Applying the computed fluorescence maps back to the QPI data, we measured the growth of both nuclei and cytoplasm independently, over many days, without loss of viability. Using a QPI method that suppresses multiple scattering, we measured the dry mass content of individual cell nuclei within spheroids. In its current implementation, PICS offers a versatile quantitative technique for continuous simultaneous monitoring of individual cellular components in biological applications where long-term label-free imaging is desirable. Copyright © 2020, The Authors. All rights reserved.

关键词： Fluorescence microscopy

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