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Activatable NIR-II Photothermal Lipid Nanoparticles for Improved Messenger RNA Delivery

Angewandte Chemie 2023年第25期135卷

作者： Dr. Benhao Li Dr. Mengyao Zhao Weiping Lai Dr. Xuanbo Zhang Bowei Yang Prof. Xiaoyuan Chen Prof. Qianqian Ni Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 119074 Singapore Nanomedicine Translational Research Program NUS Centre for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Contribution: Investigation (lead) Writing - original draft (lead) Contribution: Investigation (supporting) Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers and iChem Shanghai Key Laboratory of Molecular Catalysis and Innovative Material Fudan University Shanghai 200433 China Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) Singapore 138673 Singapore Contribution: Funding acquisition (equal) Supervision (equal) Writing - review & editing (equal)

Endosomal escape remains a central issue limiting the high protein expression of mRNA therapeutics. Here, we present second near-infrared (NIR-II) lipid nanoparticles (LNPs) containing pH activatable NIR-II dye conjugated lipid (Cy-lipid) for potentiating mRNA delivery efficiency via a s timulus-responsive p hotothermal-promoted e ndosomal e scape d elivery (SPEED) strategy. In acidic endosomal microenvironment, Cy-lipid is protonated and turns on NIR-II absorption for light-to-heat transduction mediated by 1064 nm laser irradiation. Then, the heat-promoted LNPs morphology change triggers rapid escape of NIR-II LNPs from the endosome, allowing about 3-fold enhancement of enhanced green fluorescent protein (eGFP) encoding mRNA translation capacity compared to the NIR-II light free group. In addition, the bioluminescence intensity induced by delivered luciferase encoding mRNA in the mouse liver region shows positive correlation with incremental radiation dose, indicating the validity of the SPEED strategy.

关键词： Endosomal Escape Lipid Nanoparticle Photothermal Effect Second Near-Infrared Window

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Characterization and ultrasound-assisted activation of Indonesian natural zeolite from Cikalong West Java Province

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IOP Conference Series: Materials science and engineering 2020年第1期771卷

作者： Regawa Bayu Pamungkas Mohamad Djaeni Bakti Jos Wancuh Department of Chemical Engineering Faculty of Engineering and Science University of Muhammadiyah Purwokerto Jl. Dukuhwaluh Raya Purwokerto 53182 Indonesia Postgraduate Program of Department of Chemical Engineering Faculty of Engineering Diponegoro University Jl Prof H. Soedharto SH Tembalang Semarang Indonesia Department of Chemical Engineering Faculty of Engineering Diponegoro University Jl Prof H. Soedharto SH Tembalang Semarang Indonesia

Natural zeolite activation from Cikalong, Tasikmalaya Regency, West Java Province, Indonesia, has been investigated experimentally. The activation process is carried out with a solution of sodium chloride (NaCl), which is utilized by ultrasound cavitation. The purposes of this research are to determine the effect of variation of process variables on the physical-chemical characteristics of zeolites. There were two variables studied, namely; sonication time and NaCl concentration. The study was conducted with the one factor at a time (OFAT) method, which is observing responses to changes in one variable at other constant. The range of sonication time of 20 - 60 minutes, while the NaCl concentration is 0.25N - 4N. Natural zeolites and activated zeolites are then characterized using SEM, XRF, FTIR, iod number, and cation exchange capacity to test their physical-chemical characteristics. Characterization results showed that activated natural zeolite had better quality than natural zeolite. The results of the SEM analysis showed the crystal type of natural zeolite minerals in the form of elongated crystals and others, which indicate the shape of quartz and mordenite. XRF analysis results prove that the elements of Ferrum, calcium, magnesium, and potassium are cations that can be exchanged with other metal elements. The results of the volumetric analysis showed an increase in iodine number and cation exchange capacity, along with an increase in sonication time and decreased along with the increasing of NaCl concentration. Based on these properties, zeolites have excellent performance as an adsorbent.

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Enhancing miso production with optimized puffed-rice koji and its biological function evaluation

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Food Bioscience 2024年 60卷

作者： Lin, Shin-Ping Chou, Yu-Chieh Chen, Chiao-En Lai, Yen-Tso Hsieh, Chen-Che Tsai, Tsung-Yu Lin, Yun-Hsin Santoso, Shella Permatasari Lin, Hui-Wen Cheng, Kuan-Chen School of Food Safety Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan Research Center of Biomedical Device Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan TMU Research Center for Digestive Medicine Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan Institute of Food Science and Technology National Taiwan University 1 Roosevelt Rd. Sec. 4 Taipei 10617 Taiwan Department of Food and Nutrition Providence University 200 Sec. 7 Taiwan Boulevard Shalu Dist. Taichung 43301 Taiwan Institute of Biotechnology National Taiwan University 1 Roosevelt Rd. Sec. 4 Taipei 10617 Taiwan Department of Food Science Fu Jen Catholic University 510 Zhongzheng Rd. Xinzhuang Dist. New Taipei City 242062 Taiwan Department of Chemical Engineering Widya Mandala Surabaya Catholic University 37 Jl. Kalijudan 37 East Java Surabaya 60114 Indonesia Collaborative Research Center for Zero Waste and Sustainability 37 Jl. Kalijudan East Java Surabaya 60114 Indonesia Department of Optometry Asia University 500 Lioufeng Rd. Wufeng Taichung 41354 Taiwan Department of Medical Research China Medical University Hospital China Medical University 91 Hsueh-Shih Road Taichung 40402 Taiwan

In order to enhance enzyme activities of koji and further improve the health benefits and nutritional value of miso, puffed rice was used to prepare koji with optimization of fermentation utilizing response surface methodology (RSM), and the optimized puffed rice koji was used to produce miso and low-salt miso. Results showed that β-glucosidase activity increased by 1.98-fold after RSM optimization. The optimized puffed rice koji also showed the highest β-amylase and protease activities (237.1 and 968.8 units/g, respectively) compared to rice koji (108.7 and 637.4 units/g, respectively). Moreover, miso made from puffed-rice koji presented a much higher polyphenol content, antioxidant activity, and aglycone conversion. These findings clarified the relationship between changes in enzyme activities in koji and the important components of miso, and also advance solid-state fermentation research and development of functional miso. © 2024

关键词： Aspergillus oryzae Koji Miso Puffed rice Solid-state fermentation β-glucosidase

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Corrigendum to ’Recent advances in flame retardant epoxy systems containing non-reactive DOPO based phosphorus additives’ [Polymer Degradation and Stability Volume 200, June 2022, 109962]

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Polymer Degradation and Stability 2022年 202卷

作者： Aurelio Bifulco Cristian-Dragos Varganici Liliana Rosu Fanica Mustata Dan Rosu Sabyasachi Gaan School of Polytechnic and Basic Sciences Department of Chemical Materials and Production Engineering (DICMaPI) University of Naples Federico II Piazzale Vincenzo Tecchio 80 Fuorigrotta Naples Campania 80125 Italy “Petru Poni” Institute of Macromolecular Chemistry 41A Gr. Ghica-Voda Alley Iasi 700487 Romania Additives and Chemistry Group Advanced Fibers EMPA Swiss Federal Laboratories for Materials Science and Technology Lerchenfeldstrasse 5 St. Gallen 9014 Switzerland

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Cover Feature: Chemo-Biological Upcycling of Poly(ethylene terephthalate) to Multifunctional Coating Materials (ChemSusChem 19/2021)

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ChemSusChem 2021年第19期14卷

作者： Prof. Hee Taek Kim Mi Hee Ryu Ye Jean Jung Sooyoung Lim Hye Min Song Prof. Jeyoung Park Prof. Sung Yeon Hwang Dr. Hoe-Suk Lee Prof. Young Joo Yeon Dr. Bong Hyun Sung Prof. Uwe T. Bornscheuer Prof. Si Jae Park Prof. Jeong Chan Joo Prof. Dongyeop X. Oh Department of Food Science and Technology Chungnam National University Daejeon 34134 (Republic of Korea Research Center for Bio-based Chemicals Korea Research Institute of Chemical Technology Daejeon 34114 & Ulsan 44429 (Republic of Korea Department of Chemical Engineering and Materials Science Graduate Program in System Health Science & Engineering Ewha Womans University Seoul 03760 (Republic of Korea Advanced Materials and Chemical Engineering University of Science and Technology (UST) Daejeon 34113 (Republic of Korea Department of Biochemical Engineering Gangneung-Wonju National University Gangneung-si Gangwon-do 25457 (Republic of Korea Synthetic Biology and Bioengineering Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 (Republic of Korea Department of Biotechnology & Enzyme Catalysis Institute of Biochemistry University of Greifswald 17487 Greifswald Germany Department of Biotechnology The Catholic University of Korea Bucheon-si Gyeonggi-do 14662 (Republic of Korea

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Engineered thumbtack needle for augmented acupuncture therapy

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Cell Biomaterials 2025年第1期1卷

作者： Ruisi Cai Sheng Zhao Ziyi Lu Jiahuan You Hao Wang Anni Xie Shiqi Wang Quanquan Han Ying Zhang Jicheng Yu Bo Chen Chunhai Fan Zhen Gu Yuqi Zhang State Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Department of General Surgery Sir Run-Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China Department of Hematology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Jinhua Institute of Zhejiang University Jinhua 321299 China Department of Burns and Wound Care Center Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Liangzhu Laboratory Zhejiang University Hangzhou 311121 China School of Acupuncture-Moxibustion and Tuina Tianjin University of Traditional Chinese Medicine Tianjin 301617 China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381 China School of Chemistry and Chemical Engineering New Cornerstone Science Laboratory Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and National Center for Translational Medicine Shanghai Jiao Tong University Shanghai 200240 China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

Acupuncture has been widely employed for treating chronic illnesses. In this work, a thumbtack needle patch is engineered with medication for transdermal drug delivery and sustained transdermal stimulation, augmenting the therapeutic effect of acupuncture therapy. The surface of the titanium needle is modified with porous nanotubes and/or assembled coatings to achieve sufficient loading of liraglutide (LRT) and diclofenac diethylamine (DDA), respectively. The LRT-loaded thumbtack needle declines the plasma glucose levels of type 2 diabetic mice to normoglycemia and reduces the insulin resistance index to ∼48.5 after daily treatment for 5 weeks, showing a significant improvement in efficiency compared with daily subcutaneously LRT injected group (∼117.6). Moreover, in an osteoarthritis (OA) rat model, the thumbtack needle loaded with DDA effectively alleviates pain hypersensitivity and reduces joint inflammation during 4 weeks of treatment. Both customized thumbtack needles have demonstrated pronounced therapeutic effects and desired biological safety in animal disease models.

关键词： drug delivery transdermal stimulation thumbtack needle chronic diseases

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Enhanced Dielectric Constant, Ultralow Dielectric Loss, and High-Strength Imide-Functionalized Graphene Oxide/Hyperbranched Polyimide Nanocomposites (vol 122, pg 6555, 2018)

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JOURNAL OF PHYSICAL CHEMISTRY C 2018年第21期122卷 11598-11598页

作者： Iqbal, Asma Lee, Seok Hwan Siddiqi, Humaira Masood Park, O. Ok Akhter, Toheed Department of Chemistry Quaid-i-Azam University Islamabad 45320 Pakistan Department of Chemical and Biomolecular Engineering (BK21+ Graduate Program) Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 305-701 Republic of Korea Department of Chemistry School of Science University of Management and Technology C-II Johar Town Lahore Pakistan

We achieved for the first time the formation of a charge-transfer complex (CTC) between a novel hyperbranched polyimide (PI) and oligo-imide-functionalized graphene oxide (FGO), aiming for enhancing the dielectric properties of resulting PI–FGO nanocomposites. This novel hyperbranched PI was derived from a new diamineN1,N1′-(4,4′-oxybis(4,1-phenylene))bis(N1-(4-aminophenyl)benzene-1,4-diamine). The imide moieties were integrated on amine-FGO via a step-by-step condensation and thermal imidization approach. This FGO exhibited excellent compatibility with hyperbranched PI because of the formation of a CTC between two domains. In viscoelastic measurements, the dynamic storage modulus and glass-transition temperature of flexible PI–FGO nanocomposites increased linearly with increasing FGO contents. The synthesized nanocomposites revealed high mechanical properties with a tensile strength as high as 1.122 GPa. Thermogravimetric analysis demonstrates that these nanocomposite films exhibit high thermal stability up to 550 °C. Remarkably, the dielectric constant increases up to 42.47 at 8 wt % FGO loading with a dielectric loss as low as 0.0018 while maintaining the breakdown strength as high as 147.3 ± 4.5 MV/m.

关键词： Electrical properties Colloids Nanocomposites Polyimides Insulators

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Synthesize palladium nanoparticles from the macroalgae Sargassum fusiforme: An eco-friendly tool in the fight against Plasmodium falciparum?

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The science of the total environment 2023年第PT 3期857卷 159517页

作者： Chinnaperumal Kamaraj Chinnasamy Ragavendran R C Satish Kumar Sarvesh Sabarathinam Cittrarasu Vetrivel Mariyappan Vaithiyalingam Guilherme Malafaia Interdisciplinary Institute of Indian System of Medicine (IIISM) Drug Testing Laboratory Directorate of Research SRM Institute Science and Technology Kattankulathur 603 203 Tamil Nadu India. Electronic address: kamarajc@srmist.edu.in. Department of Cariology Saveetha Dental College and Hospitals Chennai Tamil Nadu India. Interdisciplinary Institute of Indian System of Medicine (IIISM) Drug Testing Laboratory Directorate of Research SRM Institute Science and Technology Kattankulathur 603 203 Tamil Nadu India. Carbon Capture Lab Department of Chemical Engineering SSN College of Engineering Kalavakkam Chennai 603110 Tamil Nadu India Department of Anatomy Saveetha Dental college and Hospital. Saveetha institute of medical and Technical science ChennaiTamil N- 600 007 India. Department of Chemistry SRM Institute of Science and Technology Kattankulathur Chengalpattu 603203 Tamilnadu India. Laboratory of Toxicology Applied to the Environment Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil. Electronic address: guilhermeifgoiano@***.

Although numerous drugs are practiced to control malaria and its vectors, more recently, eco-friendly control tools have been proposed to battle its etiologic agents. Thus, using green bionanotechnology approaches, we aimed to synthesize palladium nanoparticles (Pd NPs) from the macroalgae Sargassum fusiforme (Sf), its potential antiparasitic activity against P. falciparum, as well as its possible cytotoxicity, in HeLa cells. After the biosynthesis of the PdSf NPs, their characterization was carried out by UV-Vis, FESEM, and EDX analyses, and their hydrodynamic size, zeta potential, and surface area were determined. Furthermore, the functional groups of the PdSf NPs were analyzed by FT-IR and GC-MS. While PdSf NPs had an IC of 7.68 μg/mL (Chloroquine (CQ)-s) and 16.42 μg/mL, S. fusiforme extract had an IC of 14.38 μg/mL (CQ-s) and 35.27 μg/mL (CQ-r). With an IC value of 94.49 μg/mL, PdSf NPs exhibited the least toxic effect on the HeLa cells. The Lipinski rule of five and ADMET prediction were used to assess the in silico models of caffeine acid hexoside and quercetin 7-O-hexoside for the presence of drug-like properties. Pathogenic proteins, primarily responsible for motility, binding, and disease-causing, were the target of the structurally based docking studies between plant-derived compounds and pathogenic proteins. Thus, our study pioneered promising results that support the potential antiplasmodial activity of eco-friendly synthesized PdSf NPs using S. fusiforme extract against P. falciparum, opening perspectives for further exploration into the use of these NPs in malaria therapy.

关键词： Bionanotechnology Brown algae Molecular docking PdSf NPs Plasmodium falciparum Sargassum fusiforme

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Erratum: Perspective—Mass Conservation in Models for Electrodeposition/Stripping in Lithium Metal Batteries [J. Electrochem. Soc., 168 092502 (2021)]

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Journal of The Electrochemical Society 2021年第9期168卷

作者： Lubhani Mishra Akshay Subramaniam Taejin Jang Krishna Shah Maitri Uppaluri Scott A. Roberts Venkat R. Subramanian Walker Department of Mechanical Engineering Texas Materials Institute The University of Texas at Austin Austin Texas 78712 United States of America Materials Science and Engineering Program Texas Materials Institute The University of Texas at Austin Austin Texas 78712 United States of America Department of Chemical Engineering University of Washington Seattle Washington 98195 United States of America Department of Mechanical Engineering University of Alabama Tuscaloosa Alabama 35401 United States of America Thermal/Fluid Component Sciences Department Engineering Sciences Center Sandia National Laboratories Albuquerque New Mexico 87123 United States of America

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A retinoic acid:YAP1 signaling axis controls atrial lineage commitment

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Cell Reports 2025年第5期44卷 115687页

作者： Abraham, Elizabeth Kostina, Aleksandra Volmert, Brett Roule, Thomas Huang, Ling Yu, Jingting Williams, April E. Megill, Emily Douglas, Aidan Pericak, Olivia M. Morris, Alex Stronati, Eleonora Larrinaga-Zamanillo, Arantza Fueyo, Raquel Zubillaga, Mikel Andrake, Mark D. Akizu, Naiara Aguirre, Aitor Estaras, Conchi Department of Cardiovascular Sciences Aging + Cardiovascular Discovery Center Lewis Katz School of Medicine Temple University Philadelphia 19140 PA United States Institute for Quantitative Health Science and Engineering Division of Developmental and Stem Cell Biology Michigan State University East Lansing 48824 MI United States Department of Biomedical Engineering College of Engineering Michigan State University East Lansing 48824 MI United States Raymond G. Perelman Center for Cellular and Molecular Therapeutics The Children's Hospital of Philadelphia Philadelphia 19104 PA United States Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies La Jolla 92037 CA United States Department of Child and Adolescence Psychiatry The Children's Hospital of Philadelphia Philadelphia 19104 PA United States Department of Chemical and Systems Biology Stanford University School of Medicine Stanford 94305 CA United States Cancer Epigenetics Institute Fox Chase Cancer Center Philadelphia 19111 PA United States Molecular Modeling Facility Program in Cancer Signaling and Microenvironment Fox Chase Cancer Center Philadelphia 19111 PA United States

In cardiac progenitor cells (CPCs), retinoic acid (RA) signaling induces atrial lineage gene expression and acquisition of an atrial cell fate. To achieve this, RA coordinates a complex regulatory network of downstream effectors that is not fully identified. To address this gap, we applied a functional genomics approach (i.e., scRNA-seq and snATAC-seq) to untreated and RA-treated human embryonic stem cell (hESC)-derived CPCs. Unbiased analysis revealed that the Hippo effectors YAP1 and TEAD4 are integrated with the atrial transcription factor enhancer network and that YAP1 activates RA enhancers in CPCs. Furthermore, Yap1 deletion in mouse embryos compromises the expression of RA-induced genes, such as Nr2f2, in the CPCs of the second heart field. Accordingly, in hESC-derived patterned heart organoids, YAP1 regulates the formation of an atrial chamber but is dispensable for the formation of a ventricle. Overall, our findings revealed that YAP1 cooperates with RA signaling to induce atrial lineages during cardiogenesis. © 2025 The Author(s)

关键词： atrial differentiation cardiac enhancers cardiac progenitors chamber development CP: Developmental biology heart organoids NR2F2 retinoic acid signaling SHF TEAD4 YAP1

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