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arXiv 2023年

作者： Abe, K. Abe, S. Aguasca-Cabot, A. Agudo, I. Alvarez Crespo, N. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Baxter, J. Becerra González, J. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Carrasco, M.S. Cassol, F. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Gasbarra, C. Gasparrini, D. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Herrera Llorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Ioka, K. Iori, M. Ishio, K. Jimenez Martinez, I. Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lainez, M. Lamanna, G. Lamastra, A. Le Flour, T. Linhoff, M. Longo, F. López-Coto, R. López-Oramas, A. Loporchio, S. Lorini, A. Lozano Bahilo, J. Luque-Escamilla, P.L. Department of Physics Tokai University Japan Institute for Cosmic Ray Research University of Tokyo Japan Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain IPARCOS-UCM Instituto de Física de Partículas y del Cosmos EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Campus UAB Bellaterra Barcelona08193 Spain Univ. Savoie Mont Blanc CNRS Laboratoire d'Annecy de Physique des Particules - IN2P3 Annecy74000 France Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain CIEMAT Spain Department of Physics TU Dortmund University Germany INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy INFN Sezione di Trieste Università degli Studi di Udine Italy University of Geneva Département de Physique Nucléaire et Corpusculaire Switzerland INFN Sezione di Catania Italy Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari Università di Bari Italy INFN Sezione di Torino Italy Palacky University Olomouc Faculty of Science Czech Republic University of Alcalá UAH Spain Port d'Informació Científica Spain University of Rijeka Department of Physics Croatia Institute for Theoretical Physics and Astrophysics Universität Würzburg Germany Institut für Theoretische Physik Lehrstuhl IV:

The next-generation ground-based gamma-ray Cherenkov Telescope Array Observatory (CTAO) will consist of imaging atmospheric Cherenkov telescopes (IACTs) of three different sizes distributed in two sites. The Large-Sized Telescopes will cover the low-energy end of the CTA energy range, starting at about 20 GeV. After its first years of operation at the CTA northern site, the Large-Sized Telescope prototype (LST-1) is in the final stage of its commissioning phase, having collected a significant amount of scientific data to date. In this contribution, we present the physics performance of the telescope using low-zenith Crab Nebula observations and Monte Carlo simulations fine-tuned accordingly. We show performance figures of merit such as the energy threshold, effective area, energy and angular resolution, and sensitivity based on the standard Hillas-parameters approach and following the source-independent and dependent analysis methods. The analysis threshold is estimated at 30 GeV. The energy resolution is around 30%, and the angular resolution is 0.3 degrees at 100 GeV. The best integral sensitivity of LST-1 is about 1.1% of the Crab Nebula flux above 250 GeV for 50 hours of observations. We also show the spectral energy distribution and light curve from Crab Nebula observations, which agree with results from other IACTs and link smoothly with Fermi-LAT when considering statistical and systematic uncertainties near the energy threshold. © 2023, CC BY-NC-ND.

关键词： Telescopes

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ABis-(carbone) Pincer Ligand and Its Coordinative Behavior toward Multi-Metallic Configurations

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Angewandte Chemie 2022年第24期134卷

作者： Bamlaku Semagne Aweke Dr. Cheng-Han Yu Minna Zhi Dr. Wen-Ching Chen Glenn P. A. Yap Prof. Lili Zhao Prof. Tiow-Gan Ong Institute of Chemistry Academia Sinica Taipei Taiwan ROC Department of Applied Chemistry National Yang Ming Chiao Tung University Hsinchu Taiwan ROC Sustainable Chemical Science and Technology (SCST) Taiwan International Graduate Program (TIGP) Academia Sinica Taipei Taiwan ROC Institute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University Nanjing China Department of Chemistry and Biochemistry University of Delaware Newark DE USA Department of Chemistry National Taiwan University Taipei Taiwan ROC Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung Taiwan ROC

Carbones are divalent carbon(0) species that contain two lone pairs of electrons. Herein, we have prepared the first known stable and isolable free bis -(carbone) pincer framework with a well-defined solid-state structure. This bis -(carbone) ligand is an effective scaffold for forming monometallic (Ni and Pd) and trinuclear heterometallic complexes with Au−Pd−Au, Au−Ni−Au, and Cu−Ni−Cu configurations. Sophisticated quantum-theoretical analyses found that the metal–metal interactions are too weak to play a significant role in upholding these multi-metallic configurations; rather, the four lone pairs of electrons within the bis -(carbone) framework are the main contributors to the stability of the complexes.

关键词： Bis-(Carbone) Heterometallic Coordination Metal–Metal Interactions Pincer Ligands

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Imaging Atmospheric Cherenkov Telescopes pointing determination using the trajectories of the stars in the field of view

arXiv

引用

arXiv 2023年

作者： Abe, K. Abe, S. Aguasca-Cabot, A. Agudo, I. Alvarez Crespo, N. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Baxter, J. Becerra González, J. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Carrasco, M.S. Cassol, F. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, Mykhailo Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Gasbarra, C. Gasparrini, D. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heckmann, L. Heller, Matthieu Herrera Llorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Ioka, K. Iori, M. Ishio, K. Jimenez Martinez, I. Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lainez, M. Lamanna, G. Lamastra, A. Le Flour, T. Linhoff, M. Longo, F. López-Coto, R. López-Oramas, A. Loporchio, S. Lorini, A. Lozano Bahilo, J. Department of Physics Tokai University Japan Institute for Cosmic Ray Research University of Tokyo Japan Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department and IPARCOS Universidad Complutense de Madrid Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy Max-Planck-Institut für Physik Germany INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Spain LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello Spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain CIEMAT Spain Department of Physics TU Dortmund University Germany INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy INFN Sezione di Trieste Università degli Studi di Udine Italy University of Geneva Département de Physique Nucléaire et Corpusculaire 24 quai Ernest-Ansermet Genève Switzerland INFN Sezione di Catania Italy Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari Università di Bari Italy INFN Sezione di Torino Italy Palacky University Olomouc Faculty of Science Czech Republic University of Alcalá UAH Spain Port d'Informació Científica Spain University of Rijeka Department of Physics Croatia Institute for Theoretical Physics and Astrophysics Universität Würzburg Germany Institut für Theoretische Physik Lehrstuhl IV: Plasma-Astroteilchenphysik Ruhr-Universität Bochum Germany INFN Sezione di Roma La Sapienza Italy ILANCE CNRS France Physics Program Graduate School of Advanced Science and E

We present a new approach to the pointing determination of Imaging Atmospheric Cherenkov Telescopes (IACTs). This method is universal and can be applied to any IACT with minor modifications. It uses the trajectories of the stars in the field of view of the IACT's main camera and requires neither dedicated auxiliary hardware nor a specific data taking mode. The method consists of two parts: firstly, we reconstruct individual star positions as a function of time, taking into account the point spread function of the telescope;secondly, we perform a simultaneous fit of all reconstructed star trajectories using the orthogonal distance regression method. The method does not assume any particular star trajectories, does not require a long integration time, and can be applied to any IACT observation mode. The performance of the method is assessed with commissioning data of the Large-Sized Telescope prototype (LST-1), showing the method's stability and remarkable pointing performance of the LST-1 telescope. © 2023, CC BY-NC-ND.

关键词： Trajectories

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Halogen bonding interactions: Revised benchmarks and a new assessment of exchange vs. Dispersion

arXiv

引用

arXiv 2018年

作者： Anderson, Lindsey N. Aquino, Fredy W. Raeber, Alexandra E. Chen, Xi Wong, Bryan M. Department of Chemical and Environmental Engineering and Materials Science and Engineering Program University of California-Riverside RiversideCA92521 United States

We present a new analysis of exchange and dispersion effects for calculating halogen-bonding interactions in a wide variety of complex dimers (69 total) within the XB18 and XB51 benchmark sets. Contrary to previous work on these systems, we find that dispersion plays a more significant role than exact exchange in accurately calculating halogen-bonding interaction energies, which are further confirmed by extensive SAPT analyses. In particular, we find that even if the amount of exact exchange is non-empirically tuned to satisfy known DFT constraints, we still observe an overall improvement in predicting dissociation energies when dispersion corrections are applied, in stark contrast to previous studies (J. Chem. Theory Comput. 2013, 9, 1918-1931). In addition to these new analyses, we correct several (14) inconsistencies in the XB51 set, which is widely used in the scientific literature for developing and benchmarking various DFT methods. Together, these new analyses and revised benchmarks emphasize the importance of dispersion and provide corrected reference values that are essential for developing/parameterizing new DFT functionals specifically for complex halogen-bonding interactions. Copyright © 2018, The Authors. All rights reserved.

关键词： Dispersions

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Inconsistencies in the electronic properties of phosphorene nanotubes: New insights from large-scale DFT calculations

arXiv

引用

arXiv 2018年

作者： Allec, Sarah I. Wong, Bryan M. Department of Chemical and Environmental Engineering and Materials Science and Engineering Program University of California-Riverside RiversideCA92521 United States

Contrary to recent reports, we show that the electronic properties of phosphorene nanotubes are surprisingly rich and much more complex than previously assumed. We find that all phosphorene nanotubes exhibit an intricate direct-to-indirect bandgap transition as the nanotube diameter decreases a unique property not identified in any prior studies (which claimed either direct or indirect band gaps only) that we uncover with large-scale DFT calculations. We address these previous inconsistencies by detailed analyses of orbital interactions, which reveal that the strain associated with decreasing the nanotube diameter causes a transition from a direct to an indirect band gap for all of the phosphorene nanotubes. We show that our findings are completely general, and extensive calculations across several exchange-correlation functionals verify our conclusions. Most importantly, our results and analyses resolve a long-standing question on the electronic properties of phosphorus nanotubes and brings closure to previously conflicting findings in these unique nanostructures. Copyright © 2018, The Authors. All rights reserved.

关键词： Nanotubes

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Unusual bandgap oscillations in template-directed φ-conjugated Porphyrin Nanotubes

arXiv

引用

arXiv 2018年

作者： Sarah, I. Allec Niranjan, V. Ilawe Bryan, M. Wong Department of Chemical and Environmental Engineering and Materials Science Engineering Program University of California-Riverside RiversideCA92521 United States

Using large-scale DFT calculations (up to 1,476 atoms and 18,432 orbitals), we present the first detailed analysis on the unusual electronic properties of recently synthesized porphyrin nanotubes. We surprisingly observe extremely large oscillations in the bandgap of these nanostructures as a function of size, in contradiction to typical quantum confinement effects (i.e., the bandgap increases with size in several of these nanotubes). In particular, we find that these intriguing electronic oscillations arise from a size-dependent alternation of aromatic/non-Aromatic characteristics in these porphyrin nanotubes. Our analyses of band structures and orbital diagrams indicate that the electronic transitions in these nanostructures are direct-bandgap, optically active "bright" states that can be readily observed in photoelectron spectroscopic experiments. Most importantly due to their unusual bandgap oscillations, we find that both type I and type II donor-Acceptor p-n heterojunctions are possible in these template-directed, "bottom-up synthesized" porphyrin nanotubes a unique property that is not present in conventional carbon nanotubes. Copyright © 2018, The Authors. All rights reserved.

关键词： Nanotubes

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Accurate electron affinities and orbital energies of anions from a non-empirically tuned range-separated density functional theory approach

arXiv

引用

arXiv 2018年

作者： Anderson, Lindsey N. Belen Oviedo, M. Wong, Bryan M. Department of Chemical Environmental Engineering and Materials Science Engineering Program University of California-Riverside RiversideCA92521 United States

The treatment of atomic anions with Kohn-Sham density functional theory (DFT) has long been controversial since the highest occupied molecular orbital (HOMO) energy, EHOMO, is often calculated to be positive with most approximate density functionals. We assess the accuracy of orbital energies and electron affinities for all three rows of elements in the periodic table (H-Ar) using a variety of theoretical approaches and customized basis sets. Among all of the theoretical methods studied here, we find that a non-empirically tuned range-separated approach (constructed to satisfy DFT-Koopmans theorem for the anionic electron system) provides the best accuracy for a variety of basis sets even for small basis sets where most functionals typically fail. Previous approaches to solve this conundrum of positive EHOMO values have utilized non-self-consistent methods;however electronic properties, such as electronic couplings/gradients (which require a self-consistent potential and energy), become ill-defined with these approaches. In contrast, the non-empirically tuned range-separated procedure used here yields well-defined electronic couplings/gradients and correct EHOMO values since both the potential and resulting electronic energy are computed self-consistently. Orbital energies and electron affinities are further analyzed in the context of the electronic energy as a function of electronic number (including fractional numbers of electrons) to provide a stringent assessment of self-interaction errors for these complex anion systems. Copyright © 2018, The Authors. All rights reserved.

关键词： Density functional theory

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Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions

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细胞研究（英文版） 2020年第10期30卷 833-853页

作者： Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti Bhargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich Department of NanoEngineering University of California San Diego 9500 Gilman Drive La Jolla CA 92093 USA Division of Regenerative Medicine Department of MedicineUniversity of California San Diego La Jolla CA 92037 USA Sanford Consortium for Regenerative Medicine 2880 Torrey Pines Scenic Drive La Jolla CA 92037 USA School of Life Sciences Westlake University Hangzhou Zhejiang 310024 China Key Laboratory of Growth Regulation and Translation Research of Zhejiang Province School of Life Sciences Westlake University Hangzhou Zhejiang 310024 China Institute of Basic Medical Sciences Westlake Institute for Advanced Study Hangzhou Zhejiang 310024 China Department of Pathology Case Western University Cleveland OH USA Department of Cellular and Molecular Medicine Cleveland Clinic Lerner Research Institute Cleveland OHUSA Department of Cellular & Molecular Medicine School of Medicine University of California San Diego La Jolla CA 92093 USA Department of Pediatrics/Rady Children's Hospital San Diego School of Medicine University of California San Diego ka Jolla CA 92093 USA The Department of Chemistry and The Skaggs Institute for Chemical Biology The Scripps Research Institute La Jolla CA 92037 USA Materials Science and Engineering Program University of California San Diego 9500 Gilman Drive La Jolla CA 92093 USA Department of Pathology and Center for Cancer Research Massachusetts General Hospital and Harvard Medical School Boston MA 02114 USA Division of Biological Sciences University of California San Diego La Jolla CA 92093 USA Kavli Institute for Brain and Mind University of California San Diego La JollaCA 92093 USA Center for Academic Research and Training in Anthropogeny (CARTA) La Jolla CA 92093 USA Department of Bioengineering University of California San Diego 9500 Gilman Drive La Jolla CA 92093 USA Department of Neurosciences School of Medicine University of California San Diego La Jolla CA 92037 USA

Brain tumors are dynamic complex ecosystems with multiple cell *** model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional (3D) bioprinting method to construct clinically relevant biomimetic tissue *** recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor *** parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells (GSCs) alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without *** constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug ***-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere *** bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a speciesmatched neural environment.

关键词： Cancer microenvironment Cancer stem cells CNS cancer

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Comparative analyses for plant virus-based cancer immunotherapy drug development

Cell Biomaterials

引用

Cell Biomaterials 2025年

作者： Anthony O. Omole Hannah S. Newton Edward Cedrone Kimia Nematpour Shaojun Xie Yongmei Zhao Bao Tran Marina A. Dobrovolskaia Nicole F. Steinmetz Aiiso Yufeng Li Family Department of Chemical and Nano Engineering University of California San Diego La Jolla San Diego CA 92093 USA Shu and K.C. Chien and Peter Farrell Collaboratory University of California San Diego La Jolla San Diego CA 92093 USA Center for Nano-ImmunoEngineering University of California San Diego La Jolla San Diego CA 92093 USA Moores Cancer Center University of California San Diego La Jolla San Diego CA 92093 USA Nanotechnology Characterization Lab Cancer Research Technology Program Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute Frederick MD 21702 USA Sequencing Facility Bioinformatics Group Biomedical Informatics and Data Science Directorate Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute Frederick MD 21702 USA CCR Sequencing Facility Cancer Research Technology Program Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute Frederick MD 21702 USA Department of Bioengineering University of California San Diego La Jolla San Diego CA 92093 USA Department of Radiology University of California San Diego La Jolla San Diego CA USA Institute for Materials Discovery and Design University of California San Diego La Jolla San Diego CA 92093 USA Center for Engineering in Cancer Institute of Engineering Medicine University of California San Diego La Jolla San Diego CA 92093 USA

Cowpea mosaic virus (CPMV) is a plant virus with potent anti-tumor efficacy. Intratumoral CPMV, but not cowpea chlorotic mottle virus (CCMV), reprograms the tumor microenvironment priming durable, systemic anti-tumor immunity. Here, we performed a side-by-side mechanism of action comparison between CPMV and CCMV. Through immune-multiplexing and trafficking studies we observed that CPMV and CCMV are taken up by innate immune cells at similar rates but are processed differently. While CCMV induces proinflammatory interleukins 22, 23, and 27, CPMV is a strong inducer of type I, II, and III interferons, which contribute to the activation and enhancement of immune cell function. We observed that CPMV RNAs activate Toll-like receptor (TLR) 7 upon delivery—and not CCMV RNAs; CPMV RNAs persist longer within cells compared with CCMV. Taken together, this work identifies determinants for CPMV’s unique mechanism for intratumoral immunotherapy. It also broadens our understanding of the utility of plant viruses for biomedical applications.

关键词： plant viruses intratumoral immunotherapy cowpea mosaic virus cowpea chlorotic mottle virus cancer nanotechnology

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In-situ electric field control of THz non-reciprocal directional dichroism in the multiferroic Ba2CoGe2O7

arXiv

引用

arXiv 2021年

作者： Vít, J. Viirok, J. Peedu, L. Rõõm, T. Nagel, U. Kocsis, V. Tokunaga, Y. Taguchi, Y. Tokura, Y. Kézsmárki, I. Balla, P. Penc, K. Romhányi, J. Bordács, Sandor Department of Physics Budapest University of Technology and Economics Budapest1111 Hungary Institute of Physics Ascr Na Slovance 2 Prague 8182 21 Czech Republic Faculty of Nuclear Science and Physical Engineering Czech Technical University Břehová 7 Prague 1115 19 Czech Republic National Institute of Chemical Physics and Biophysics Akadeemia tee 23 Tallinn12618 Estonia Wako351-0198 Japan Department of Advanced Materials Science University of Tokyo Kashiwa277-8561 Japan Department of Applied Physics Tokyo College University of Tokyo Tokyo113-8656 Japan Experimental Physics v Center for Electronic Correlations and Magnetism University of Augsburg Augsburg86135 Germany Institute for Solid State Physics and Optics Wigner Research Centre or Physics PO Box. 49 BudapestH-1525 Hungary Department of Physics and Astronomy University of California Irvine 4129 Frederick Reines Hall IrvineCA United States Hungarian Academy of Sciences Premium Postdoctor Program Budapest1051 Hungary

Non-reciprocal directional dichroism, also called the optical-diode effect, is an appealing functional property inherent to the large class of non-centrosymmetric magnets. However, the in-situ electric control of this phenomenon is challenging as it requires a set of conditions to be fulfilled: Special symmetries of the magnetic ground state, spin-excitations with comparable magnetic- and electricdipole activity and switchable electric polarization. We demonstrate the isothermal electric switch between domains of Ba2CoGe2O7 possessing opposite magnetoelectric susceptibilities. Combining THz spectroscopy and multiboson spin-wave analysis, we show that unbalancing the population of antiferromagnetic domains generates the non-reciprocal light absorption of spin excitations. Copyright © 2021, The Authors. All rights reserved.

关键词： Electric fields

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