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Toxicity assessment of SARS-CoV-2-derived peptides in combination with a mix of pollutants on zebrafish adults: A perspective study of behavioral, biometric, mutagenic, and biochemical toxicity

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The science of the total environment 2023年第PT 2期858卷 159838页

作者： Ítalo Nascimento Freitas Amanda Vieira Dourado Amanda Pereira da Costa Araújo Sindoval Silva de Souza Thiarlen Marinho da Luz Abraão Tiago Batista Guimarães Alex Rodrigues Gomes Abu Reza Md Towfiqul Islam Md Mostafizur Rahman Andrés Hugo Arias Davoodbasha Mubarak Ali Chinnasamy Ragavendran Chinnaperumal Kamaraj Guilherme Malafaia Laboratory of Toxicology Applied to the Environment Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil. Laboratory of Toxicology Applied to the Environment Goiano Federal Institute Urutaí GO Brazil. Post-Graduation Program in Environmental Sciences Federal University of Goiás Goiânia GO Brazil. Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil. Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil. Begum Rokeya University Department of Disaster Management Rangpur 5404 Bangladesh. Laboratory of Environmental Health and Ecotoxicology Department of Environmental Sciences Jahangirnagar University Dhaka 1342 Bangladesh. Instituto Argentino de Oceanografía (IADO) Universidad Nacional del Sur (UNS)-CONICET Florida 8000 Complejo CCT CONICET Bahía Blanca Edificio E1 B8000BFW Bahía Blanca Argentina. Petroleum and Chemical Engineering Faculty of Engineering Universiti Teknologi Brunei Bandar Seri Begawan BE1410 Brunei Darussalam. Department of Conservative Dentistry and Endodontics Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai India. Interdisciplinary Institute of Indian System of Medicine (IIISM) Directorate of Research and Virtual Education SRM Institute of Science and Technology (SRMIST) Kattankulathur 603203 Tamil Nadu India. Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil. Electronic address: guilhermeifgoiano@***.

The dispersion of SARS-CoV-2 in aquatic environments via the discharge of domestic and hospital sewage has been confirmed in different locations. Thus, we aimed to evaluate the possible impacts of zebrafish (Danio rerio) exposure to SARS-CoV-2 peptide fragments (PSPD-2001, 2002, and 2003) alone and combined with a mix of emerging pollutants. Our data did not reveal the induction of behavioral, biometric, or mutagenic changes. But we noticed an organ-dependent biochemical response. While nitric oxide and malondialdehyde production in the brain, gills, and muscle did not differ between groups, superoxide dismutase activity was reduced in the "PSPD", "Mix", and "Mix+PSPD" groups. An increase in catalase activity and a reduction in DPPH radical scavenging activity were observed in the brains of animals exposed to the treatments. However, the "Mix+PSPD" group had a higher IBRv2 value, with NO levels (brain), the reduction of acetylcholinesterase activity (muscles), and the DPPH radical scavenging activity (brain and muscles), the most discriminant factors for this group. The principal component analysis (PCA) and hierarchical clustering analysis indicated a clear separation of the "Mix+PSPD" group from the others. Thus, we conclude that exposure to viral fragments, associated with the mix of pollutants, induced more significant toxicity in zebrafish adults than in others.

关键词： Biomarkers COVID-19 Danio rerio Freshwater ecosystems Non-target organisms Novel coronavirus

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Influence of autapses on synchronisation in neural networks with chemical synapses

arXiv

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arXiv 2020年

作者： Protachevicz, Paulo R. Iarosz, K.C. Caldas, I.L. Antonopoulos, C.G. Batista, A.M. Kurths, J. Institute of Physics University of São Paulo São Paulo SP Brazil Faculdade de Telêmaco Borba FATEB Telêmaco Borba Paraná Brazil Graduate Program in Chemical Engineering Federal University of Technology Paraná Ponta GrossaParaná Brazil Department of Mathematical Sciences University of Essex Wivenhoe Park United Kingdom Department of Mathematics and Statistics State University of Ponta Grossa Ponta Grossa PR Brazil Department Complexity Science Potsdam Institute for Climate Impact Research Potsdam Germany Department of Physics Humboldt University Berlin Germany Centre for Analysis of Complex Systems Sechenov First Moscow State Medical University Moscow Russia

A great deal of research has been devoted on the investigation of neural dynamics in various network topologies. However, only a few studies have focused on the influence of autapses, synapses from a neuron onto itself via closed loops, on neural synchronisation. Here, we build a random network with adaptive exponential integrate-and-fire neurons coupled with chemical synapses, equipped with autapses, to study the effect of the latter on synchronous behaviour. We consider time delay in the conductance of the pre-synaptic neuron for excitatory and inhibitory connections. Interestingly, in neural networks consisting of both excitatory and inhibitory neurons, we uncover that synchronous behaviour depends on their synapse type. Our results provide evidence on the synchronous and desynchronous activities that emerge in random neural networks with chemical, inhibitory and excitatory synapses where neurons are equipped with autapses. Copyright © 2020, The Authors. All rights reserved.

关键词： Synchronization

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The Robusta coffee grounds residues to adsorb the heavy metal Lead (Pb) in the water Layout guide for using Microsoft Word

The Robusta coffee grounds residues to adsorb the heavy meta...

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2018 Workshop on Multidisciplinary and Its Applications: Applied Mathematics, Computer science, Information Systems, and Information Technology, WMA-Mathcomtech 2018

作者： Moelyaningrum, A.D. Ngibad, K. Lestari, L.P. Sunu, P. Sari, D.A. Permana, E.P. Hertina, D. Hartanto, C.F.B. Kurniasih, N. Department of Environmental Health and Occupational Health and Safety Public Health Faculty University of Jember Indonesia Medical Laboratory Program Faculty of Health Science Universitas Maarif Hasyim Latif Sidoarjo Indonesia Faculty of Animal Science Universitas Boyolali Indonesia Chemical Engineering Engineering Faculty University of Singaperbangsa Karawang Indonesia Department of Elementary School Teacher Education Faculty of Teacher Training and Education University of Nusantara PGRI Kediri Indonesia Management and Bussines Widyatama University Bandung Indonesia Nautical Science Program Akademi Pelayaran Niaga Indonesia Indonesia Faculty of Communication Sciences Library and Information Science Program Universitas Padjajaran Indonesia

Lead (Pb) were toxic. Lead found in pipes, batteries, paint, dyes ceramic glaze, gasoline, and final waste disposal. The robusta coffee grouds residues had high carbon, nitrogen etc which can adsorb heavy metal. The purpose of this study is to analyze the robusta coffee grounds residues to adsorb the Pb in the water. The method of this research is a True Experimental using completely randomized design (CRD) method. There were control groups (C) and three treatments groups (T1;T2;T3;5gram/litre;8gram/litre;10gram/litre) with six repetitions. The robusta coffee ground residues were contacted for 2 hours. Total samples were 24 samples which analyzed each parameter of the Pb with Atomic Adsorption Spectophotometry Analysis. The results showed that the more coffee ground residues that are exposed, increasingly turbid. The KS test showed that data were a normal distribution (sig = 0,324). One way ANOVA test;Turkey post Hoc showed that there was sig difference between the control and treatment (F = 4,326, Sig = 0,017). There were sig difference between control and treatment 2 and 3 (Sig = 0,019;Sig = 0,038). Robusta coffee grounds residues can reuse to adsorb the Pb pollution in the water. It can be a solution for treating the lead pollution in the water because of it easy to the application. © Published under licence by IOP Publishing Ltd.

关键词： Normal distribution

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Electronic and magnetic properties of perovskite selenite and tellurite compounds: CoSeO3, NiSeO3, CoTeO3 and NiTeO3

arXiv

引用

arXiv 2019年

作者： M. Iasir, A. Rafi Lombardi, Todd Lu, Qiangsheng Mofrad, Amir M. Vaninger, Mitchel Zhang, Xiaoqian Singh, David J. Nuclear Engineering Program University of Missouri ColumbiaMO65211 United States Department of Physics and Astronomy University of Missouri ColumbiaMO65211-7010 United States Department of Biomedical Biological and Chemical Engineering University of Missouri ColumbiaMO65211 United States Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and Engineering Nanjing University Nanjing210093 China Department of Chemistry University of Missouri ColumbiaMO65211 United States

Selenium and tellurium are among the few elements that form ABO3 perovskite structures with a four valent ion in the A site. This leads to highly distorted structures and unusual magnetic behavior. Here we investigate the Co and Ni selenite and tellurite compounds, CoSeO3, CoTeO3, NiSeO3 and NiTeO3 using first principles calculations. We find an interplay of crystal field and Jahn-Teller distortions that underpin the electronic and magnetic properties. While all compounds are predicted to show an insulating G-type antiferromagnetic ground state, there is a considerable difference in the anisotropy of the exchange interactions between the Ni and Co compounds. This is related to the Jahn-Teller distortion. Finally, we observe that these four compounds show characteristics generally associated with Mott insulators, even when described at the level of standard density functional theory. These are then dense bulk band or Slater, Mott-type insulators. Copyright © 2019, The Authors. All rights reserved.

关键词： Tellurium compounds

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Detection of the 2021 Outburst of RS Ophiuchi with the LST-1

arXiv

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arXiv 2023年

作者： Kobayashi, Yukiho Aguasca-Cabot, Arnau Martín, María Isabel Bernardos Green, David López-Coto, Rubén Abe, K. Abe, S. Aguasca-Cabot, A. Agudo, I. Alvarez Crespo, N. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Baxter, J. Becerra González, J. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Carrasco, M.S. Cassol, F. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Gasbarra, C. Gasparrini, D. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Herrera Llorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Ioka, K. Iori, M. Ishio, K. Jimenez Martinez, I. Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lainez, M. Lamanna, G. Lamastra, A. Le Flour, T. Linhoff, M. Institute for Cosmic Ray Research The University of Tokyo 5-1-5 Kashiwa-no-ha Chiba Kashiwa277-8582 Japan Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Martí i Franquès 1 Barcelona08028 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany Department of Physics Tokai University Japan Institute for Cosmic Ray Research University of Tokyo Japan Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy Max-Planck-Institut für Physik Germany INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Spain LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello Spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain CIEMAT Spain Department of Physics TU Dortmund University Germany INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy INFN Sezione di Trieste Università degli Studi di Udine Italy University of Geneva Département de Physique Nucléaire et Corpusculaire Switzerland INFN Sezione di Catania Italy Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari Università di Bari Italy INFN Sezione di Torino Italy Palacky University Olomouc Faculty of Science United States University of Alcalá UAH Spa

Novae are luminous explosions in close binaries which host a white dwarf and a companion donor star. They are triggered by a thermonuclear runaway when the white dwarf accretes a critical amount of matter from the secondary. Though novae are established as high-energy gamma-ray emitters through observations by the Fermi Large Area Telescope (LAT), the origin of the gamma-ray emission, whether it is hadronic or leptonic, had been under intense debate until very recently. RS Ophiuchi (RS Oph) is a well-known recurrent symbiotic nova with a recurrence time scale of 15 years. The most recent outburst of RS Oph in 2021 brought the first detection of very-high-energy (VHE) gamma rays from a nova ever. The first Large-Sized Telescope prototype (LST-1) of the Cherenkov Telescope Array observed this historic event along with H.E.S.S. and MAGIC. The LST-1 observations in the first days after the burst onset show a clear VHE gamma-ray signal from RS Oph. The low energy threshold of LST-1 allows us to reconstruct the RS Oph gamma-ray spectrum down to ∼30 GeV, providing the best connection of the VHE gamma-ray data to the Fermi LAT energy range. The results from the analysis of the LST-1 observations are consistent with those obtained with H.E.S.S. and MAGIC, and also support a hadronic origin for the observed gamma-ray fluxes. In this contribution, we will present the analysis results of the LST-1 observations of the 2021 outburst of RS Oph. © 2023, CC BY.

关键词： Telescopes

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Correction: Recent developments in photonic, plasmonic and hybrid nanowire waveguides

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Journal of Materials Chemistry C 2019年第12期7卷 3696-3696页

作者： Sanggon Kim Ruoxue Yan Department of Chemical and Environmental Engineering University of California Riverside USA Materials Science and Engineering Program University of California Riverside USA

Correction for ‘Recent developments in photonic, plasmonic and hybrid nanowire waveguides’ by Sanggon Kim et al., J. Mater. Chem. C, 2018, 6, 11795–11816.

Correction for ‘Recent developments in photonic, plasmonic and hybrid nanowire waveguides’ by Sanggon Kim et al., J. Mater. Chem. C, 2018, 6, 11795–11816.

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Flexible cellulose-carbon nanotube paper substrate decorated with PZT: sensor properties

Flexible cellulose-carbon nanotube paper substrate decorated...

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MRS Advances

作者： Silva, Ricardo M. Noremberg, Bruno S. Marins, Natália H. Alano, Jose H. Santana, Luiza R. Valentini, Antoninho Lukowiec, Dariusz Tański, Tomasz Carreño, Neftalí L.V. Graduate Program in Materials Science and Engineering Technology Development Center Federal University of Pelotas PelotasRS96010-000 Brazil Federal University of Ceará Department of Analytical Chemistry and Chemical Physics FortalezaCE Brazil Institute of Engineering Materials and Biomaterials Silesian University of Technology Gliwice Poland Center for Nanotechnology Silesian University of Technology Gliwice Poland

Composite of PZT (lead zirconate titanate) and PLZT (lead lanthanum zirconate titanate) along an organic, renewable, conductive, and flexible matrix have been developed. The conductive paper was obtained through the reaction between the cellulose extracted from banana stem and functionalized MWCNT. This reaction was made in the presence of hydrogen (from H2SO4), which reduced the size of the cellulose by acid hydrolysis and promotes the interaction between its hydroxyls and the carboxyl groups of nanotubes. Afterward, the PZT particles were synthesized and grown up on the conductive paper by microwaves-assisted hydrothermal synthesis (MHS). The composite material was characterized by structure and morphology. Moreover, gas-sensing in the presence of methanol and electrical resistance as a function of temperature were also investigated. In this way, a simple, low-cost and successful synthesis was reported. Also, a promising flexible was obtained using a chemical transformation process from banana residue as source of cellulose. Copyright © Materials Research Society 2018.

关键词： Cellulose

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Polymer of chitosan with ZnO addition to optimize high responsivity and sensitivity in sensor film

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AIP Conference Proceedings 2020年第1期2267卷

作者： Saisa H. Agusnar Z. Alfian I. Nainggolan 1Doctoral Program Department of Chemistry Faculty of Mathematics and Natural Science Universitas Sumatera Utara Medan 20155 North Sumatera Indonesia 2Department of Chemical Engineering Faculty of Engineering Universitas Serambi Mekkah Banda Aceh 23245 Aceh Indonesia 3Department of Chemistry Faculty of Mathematics and Natural Science Universitas Sumatera Utara Medan 20155 North Sumatera Indonesia

Coating of polymer chitosan as sensor film on copper electrode substrate (Cu) has become a concern of research development to improve responsivity, sensitivity, and economic value to detect hazardous preservatives in food, especially formalin. This study aims to enhance the activities of sensor for more responsive and higher sensitivity by adding metal oxide as an active agent. Chitosan thin film is prepared by 1.5% chitosan dissolved with 2% acetic acid and modified with active compound ZnO. The addition of ZnO NPs metal oxide is to improve sensitivity which viewed from SEM characterization results, the surface of morphology is smoother and flat on the surface of chitosan. Characterization of FT-IR showed ZnO was perfectly bound to amine bond of chitosan structure. The research method was conducted by cyclic voltammetry analysis to find out the results test of sensor sensitivity. The results showed chitosan-ZnO film sensor provides the best sensitivity on modification conditions of ZnO NPs 0.6% and 0.8%. Linearity analysis of sensor provides ideal value obtained at R-square value of 0.9886. Thus, it can be concluded that chitosan-ZnO thin-film sensor is hugely responsive to be used as an electrode sensor for detecting hazardous chemical compounds in food. Chitosan-ZnO film sensor can provide high activity as a biosensor electrode for detecting harmful compounds in foods that are sensitive, responsive, and has economic value.

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Author Correction: Battery-free, wireless soft sensors for continuous multi-site measurements of pressure and temperature from patients at risk for pressure injuries

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Nature communications 2021年第1期12卷 6827页

作者： Yong Suk Oh Jae-Hwan Kim Zhaoqian Xie Seokjoo Cho Hyeonseok Han Sung Woo Jeon Minsu Park Myeong Namkoong Raudel Avila Zhen Song Sung-Uk Lee Kabseok Ko Jungyup Lee Je-Sang Lee Weon Gi Min Byeong-Ju Lee Myungwoo Choi Ha Uk Chung Jongwon Kim Mengdi Han Jahyun Koo Yeon Sik Choi Sung Soo Kwak Sung Bong Kim Jeonghyun Kim Jungil Choi Chang-Mo Kang Jong Uk Kim Kyeongha Kwon Sang Min Won Janice Mihyun Baek Yujin Lee So Young Kim Wei Lu Abraham Vazquez-Guardado Hyoyoung Jeong Hanjun Ryu Geumbee Lee Kyuyoung Kim Seunghwan Kim Min Seong Kim Jungrak Choi Dong Yun Choi Quansan Yang Hangbo Zhao Wubin Bai Hokyung Jang Yongjoon Yu Jaeman Lim Xu Guo Bong Hoon Kim Seokwoo Jeon Charles Davies Anthony Banks Hyung Jin Sung Yonggang Huang Inkyu Park John A Rogers Center for Bio-Integrated Electronics Northwestern University Evanston IL USA. Department of Mechanical Engineering Korea Advanced Institute of Science and Technology Daejeon Republic of Korea. Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign Urbana IL USA. Department of Materials Science and Engineering University of Illinois at Urbana Champaign Urbana IL USA. Querrey Simpson Institute for Bioelectronics Northwestern University Evanston IL USA. State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology Dalian People's Republic of China. Ningbo Institute of Dalian University of Technology Ningbo People's Republic of China. Department of Biomedical Engineering Texas A&M University College Station TX USA. Department of Mechanical Engineering Northwestern University Evanston IL USA. Advanced 3D Printing Technology Development Division Korea Atomic Energy Research Institute Daejeon Republic of Korea. Qualcomm Institute La Jolla CA USA. Sibel Health Inc Niles IL USA. Department of Rehabilitation Medicine Gimhae Hansol Rehabilitation & Convalescent Hospital Gimhae Republic of Korea. Department of Planning and Development Gimhae Hansol Rehabilitation & Convalescent Hospital Gimhae Republic of Korea. Department of Rehabilitation Medicine Pusan national university hospital Busan Republic of Korea. Department of Materials Science and Engineering KAIST Institute for The Nanocentury (KINC) Korea Advanced Institute of Science and Technology Daejeon Republic of Korea. Department of Materials Science and Engineering Northwestern University Evanston IL USA. Department of Mechanical Engineering Kyung Hee University Yongin Republic of Korea. Department of Biomedical Engineering College of Future Technology Peking University Beijing People's Republic of China. School of Biomedical Engineering Korea University Seoul Republic of Korea. Interdisci

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Enhanced Drug Delivery by Dissolution of Amorphous Drug Encapsulated in a Water Unstable Metal–Organic Framework (MOF)

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Angewandte Chemie 2019年第47期131卷

作者： Kuthuru Suresh Adam J. Matzger Department of Chemistry and the Macromolecular Science and Engineering Program University of Michigan 930 North University Avenue Ann Arbor MI 48109-1055 USA

Encapsulating a drug molecule into a water‐reactive metal–organic framework (MOF) leads to amorphous drug confined within the nanoscale pores. Rapid release of drug occurs upon hydrolytic decomposition of MOF in dissolution media. Application to improve dissolution and solubility for the hydrophobic small drug molecules curcumin, sulindac, and triamterene is demonstrated. The drug@MOF composites exhibit significantly enhanced dissolution and achieves high supersaturation in simulated gastric and/or phosphate buffer saline media. This combination strategy where MOF inhibits crystallization of the amorphous phase and then releases drug upon MOF irreversible structural collapse represents a novel and generalizable approach for drug delivery of poorly soluble compounds while overcoming the traditional weakness of amorphous drug delivery: physical instability of the amorphous form.

关键词： Amorphe Wirkstoffe Metall-organische Gerüste Sofortige Wirkstofffreisetzung Stabilität Wirkstofftransport

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