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arXiv 2019年

作者： Afzal, Mohammad Atif Faiz Hachmann, Johannes Schrödinger Inc. PortlandOR97204 United States Department of Chemical and Biological Engineering University at Buffalo State University of New York BuffaloNY14260 United States Computational and Data-Enabled Science and Engineering Graduate Program University at Buffalo The State University of New York BuffaloNY14260 United States New York State Center of Excellence in Materials Informatics BuffaloNY14203 United States

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Covalent Adaptable Networks: Toward Stimuli‐Responsive Dynamic Thermosets through Continuous Development and Improvements in Covalent Adaptable Networks (CANs) (Adv. Mater. 20/2020)

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Advanced Materials 2020年第20期32卷

作者： Maciej Podgórski Benjamin D. Fairbanks Bruce E. Kirkpatrick Matthew McBride Alina Martinez Adam Dobson Nicholas J. Bongiardina Christopher N. Bowman Department of Chemical and Biological Engineering University of Colorado UCB 596 Boulder CO 80309 USA Department of Polymer Chemistry Faculty of Chemistry Maria Curia‐Sklodowska University pl. Marii Curie‐Sklodowskiej 5 Lublin 20‐031 Poland Medical Scientist Training Program School of Medicine University of Colorado Aurora CO 80045 USA Materials Science and Engineering Program University of Colorado Boulder CO 80309 USA

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Bovine Bone Charcoal as Support Material for Immobilization of <em>Bacillus firmus</em>Strain 37 and Production of Cyclomaltodextrin Glucanotransferase by Batch Fermentation in a Fluidized Bed

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Advances in chemical engineering and science 2018年第1期8卷 11-25页

作者： Larissa Albunio Silva Bruno Cesar Bieli Osvaldo Valarini Junior Graciette Matioli Gisella Maria Zanin Flavio Faria Moraes Chemical Engineering Department State University of MaringaMaringáBrazil Graduate Program of Food Science Universidade Estadual de MaringáMaringáBrazil Pharmaceutical Sciences Department State University of MaringaMaringáBrazil

The process described in the present work uses air supplementation in a fluidized bed reactor containing Bacillus firmus strain 37 immobilized on active bovine bone charcoal, to produce by batch fermentation the enzyme CGTase (cyclomaltodextrin-glucanotransferase). Three different aeration rates were evaluated. The maximum CGTase activity was achieved after 120 hours of fermentation with aeration rate of 2 vvm and was equal to 2.48 U/mL. When 0.5 and 1 vvm were used the enzymatic activities achieved 1.1 and 0.57 U/mL, respectively. Bovine bone charcoal was characterized in terms of surface area, pore size and volume. To the best of our knowledge, the immobilization of microorganism cells in bovine bone charcoal for CGTase production has not been reported in the literature. Our results showed that fluidized bed reactor allows retaining high concentration of biomass, improving biomass-substrate contact and operation at low residence times, which resulted in improved enzyme production. Therefore, the process as proposed has great potential for industrial development.

关键词： Bacillus firmus Bone Charcoal Matrix Cell Immobilization Microbial Enzyme Cyclomaltodextrin Glucanotransferase

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Adaptive in vivo Device for Theranostics of Inflammation by Monitoring of Cytokine Interferon-γ and Its Triggered Aspirin Release

SSRN

引用

SSRN 2019年

作者： Cao, Chaomin Jin, Ronghua Wei, Hui Liu, Zhongning Ni, Shengnan Chen, Xin Young, Howard A. Liu, Guojun Liu, Guozhen International Joint Research Center for Intelligent Biosensor Technology and Health Central China Normal University Wuhan430079 China School of Chemical Engineering and Technology Shanxi Key Laboratory of Energy Chemical Process Intensification Institute of Polymer Science in Chemical Engineering Xi’an Jiao Tong University Xi’an710049 China Department of Prosthodontics Peking University School and Hospital of Stomatology National Clinical Research Center for Oral Diseases National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology Beijing100081 China Australian Nuclear Science and Technology Organization New Illuwarra Road Lucas HeightsNSW2234 Australia Graduate School of Biomedical Engineering ARC Centre of Excellent for Nanoscale Bipphotonics Faculty of Engineering University of New South Wales SydneyNSW2052 Australia Cancer and Inflammation Program Center for Cancer Research National Cancer Institute at Frederick FrederickMD21702 United States

Cytokines mediate and control immune and inflammatory responses. Complex interactions exist between cytokines, inflammation and the adaptive responses in maintaining homeostasis, health, and well being. On-demand, local delivery of anti-inflammatory drug molecules to target tissues provides a means for effective drug dosing while reducing the adverse effects of systemic drug delivery. This work demonstrates a proof-of-concept theranostic approach for inflammation based on analyte-kissing induced signaling, whereby a drug (in this report, aspirin) can be released upon detection of a target level of a proinfammatory cytokine(i.e. Interferon-γ (IFN-γ)) in real time. The structure-switching aptamer based biosensor described here is capable of quantitatively and dynamically detecting IFN-γ both in vitro and in vivo with a sensitivity of 10 pg mL-1. Moreover, the released aspirin triggered by the inflammatory cytokine IFN-γ is able to inhibit inflammation in the inflammatory rat model, and the releasing of aspirin can be quantitatively controlled. Herein research provides a novel and promising strategy for in vivo detection of proinflammatory cytokines and the subsequent therapeutic delivery of anti-inflammatory molecules. This universal theranostic platform is expected to achieve great potentials on personalized medicine towards treatment of various of diseases and health conditions. © 2019, The Authors. All rights reserved.

关键词： Pathology

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Macroscopic Assembled Graphene for Silicon Mid-Infrared Photodetectors

Research Square

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Research Square 2020年

作者： Gao, Chao Peng, Li Du, Sichao Liu, Lixiang Bodepudi, Srikrishna Chanakya Li, Lingfei Liu, Wei Cong, Xin Lai, Runchen Fang, Wenzhang Cao, Xiaoxue Liu, Xinyu Abid, Muhammad Lv, Jianhang Liu, Junxue Jin, Shengye Wu, Kaifeng Zhou, Qiaohui Zhu, Haiming Lin, Miao-Ling Tan, Ping-Heng Xiong, Qihua Wang, Xiaomu Hu, Weida Duan, Xiangfeng Yu, Bin Yin, Wenyan Xu, Zhen Xu, Yang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China Colleges of ISEE and Microelectronics State Key Laboratories of Modern Optical Instrumentation and Silicon Materials Hangzhou Global Scientific and Technological Innovation Center ZJU-UIUC Joint Institute Zhejiang University Hangzhou310027 China State Key Laboratory of Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences Beijing100083 China State Key Laboratory of Molecular Reaction Dynamics and Dynamics Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian116023 China Department of Chemistry Zhejiang University Hangzhou310027 China Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University 637371 Singapore National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructure School of Electronic Science and Engineering Nanjing University Nanjing210093 China National Laboratory for Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai200083 China Department of Chemistry and Biochemistry California Nanosystems Institute University of California Los Angeles90095 United States

Graphene with linear energy dispersion and weak electron-phonon interaction is highly anticipated to harvest hot-electrons in a broad wavelength range from ultraviolet to terahertz1,2. However, the limited absorption (~2.3%) and serious backscattering of hot-electrons associated with single-layer graphene result in inadequate quantum yields3-5, impeding their practically broadband photodetection, especially in the mid-infrared range. Here, we report a macroscopic assembled graphene (MAG)/silicon heterojunction for ultrafast mid-infrared photodetection. The highly crystalline 2-inch scale MAG with tunable thickness from 10 to 60 nm is produced by scalable wet-assembly of commercial graphene oxide followed by thermal annealing. The MAG/Si Schottky diode exhibits broadband photodetection capability in 1-10 μm at room temperature with fast response (120-130 ns, 4 mm2 window) and high detectivity (1011 to 106 Jones), outperforming single-layer graphene/Si photodetectors by 2 to 8 orders in transient photocurrent. This optoelectronic performance is attributed to the superior advantages of MAG (~40% of light absorption, ~23 ps of carrier relaxation time, and high quasi-equilibrated hot-carrier-multiplication gain), atomic-scale contact interface of MAG and silicon, and impact-ionization avalanche gain (~102 times) from silicon. The MAG provides a long-range platform to understand the hot-carrier dynamics in stacked 2D materials, leading to next-generation broadband silicon-based image sensors. © 2020, CC BY.

关键词： Graphene

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Back Cover: Prodrug Activation by Gold Artificial Metalloenzyme-Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination (Angew. Chem. Int. Ed. 22/2021)

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Angewandte Chemie International Edition 2021年第22期60卷

作者： Dr. Tsung-Che Chang Dr. Kenward Vong Dr. Tomoya Yamamoto Prof. Katsunori Tanaka Biofunctional Synthetic Chemistry Laboratory RIKEN Cluster for Pioneering Research RIKEN 2-1 Hirosawa Wako-shi Saitama 351-0198 Japan GlycoTargeting Research Laboratory RIKEN Baton Zone Program RIKEN 2-1 Hirosawa Wako-shi Saitama 351-0198 Japan Department of Chemical Science and Engineering School of Materials and Chemical Technology Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo 152-8552 Japan Biofunctional Chemical Laboratory A. Butlerov Institute of Chemistry Kazan Federal University 18 Kremlyovskaya Street 420008 Kazan Russia

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Prodrug Activation by Gold Artificial Metalloenzyme-Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination

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Angewandte Chemie 2021年第22期133卷

An emerging approach in the field of targeted drug delivery is the establishment of abiotic metal-triggered prodrug mechanisms that can control the release of bioactive drugs. Currently, the design of prodrugs that use abiotic metals as a trigger relies heavily on uncaging strategies. Here, we introduce a strategy based on the gold-catalyzed activation of a phenanthridinium-based prodrug via hydroamination under physiological conditions. To make the prodrug strategy biocompatible, a gold artificial metalloenzyme (ArM) based on human serum albumin, rather than the free gold metal complex, was used as a trigger for prodrug activation. The albumin-based gold ArM protected the catalytic activity of the bound gold metal even in the presence of up to 1 mM glutathione in vitro. The drug synthesized via the gold ArM exerted a therapeutic effect in cell-based assays, highlighting the potential usefulness of the gold ArM in anticancer applications.

关键词： antitumor agents gold catalysts metalloenzymes phenanthridinium prodrugs

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Rücktitelbild: Prodrug Activation by Gold Artificial Metalloenzyme-Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination (Angew. Chem. 22/2021)

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Angewandte Chemie 2021年第22期133卷

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Carbon nanotubes from large-scale dft calculations

arXiv

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arXiv 2018年

作者： Pari, Sangavi Cuellar, Abigail Wong, Bryan M. Department of Chemical Environmental Engineering and Materials Science Engineering Program University of California-Riverside RiversideCA92521 United States Rialto High School RialtoCA92376 United States

Using large-scale DFT calculations, we have investigated the structural and electronic properties of both armchair and zigzag graphdiyne nanotubes as a function of size. To provide insight in these properties, we present new detailed calculations of the structural relaxation energy, effective electron/hole mass, and size-scaling of the bandgap as a function of size and chirality using accurate screened-exchange DFT calculations. These calculations provide a systematic evaluation of the structural and electronic properties of the largest graphdiyne nanotubes to date up to 1,296 atoms and 23,328 basis functions. Our calculations find that zigzag graphdiyne nanotubes (GDNTs) are structurally more stable compared to armchair GDNTs of the same size. Furthermore, these large-scale calculations allow us to present simple analytical formulae to guide future experimental efforts for estimating the fundamental bandgaps of these unique nanotubes as a function of chirality and diameter. While the bandgaps for both the armchair and zigzag GDNTs can be tuned as a function of size, the conductivity in each of these two different chiralities is markedly different. Zigzag GDNTs have wider valence and conduction bands and are expected to have a higher electron-and hole-mobility than their armchair counterparts. Copyright © 2018, The Authors. All rights reserved.

关键词： Nanotubes

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Dual‐Phase Thermally Activated Delayed Fluorescence Luminogens: A Material for Time‐Resolved Imaging Independent of Probe Pretreatment and Probe Concentration

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Angewandte Chemie 2020年第19期132卷

作者： Xuping Li Gleb Baryshnikov Longjiang Ding Xiaoyan Bao Xin Li Jianjun Lu Miaoqing Liu Shen Shen Mengkai Luo Man Zhang Hans Ågren Xudong Wang Liangliang Zhu Key Laboratory of Coal Science and Technology Ministry of Education and Shanxi Province Taiyuan University of Technology Taiyuan 030024 China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University Shanghai 200438 China Division of Theoretical Chemistry and Biology School of Biotechnology KTH Royal Institute of Technology 10691 Stockholm Sweden Department of Chemistry Fudan University Shanghai 200438 China College of Chemistry and Chemical Engineering Department of Chemistry Henan University Kaifeng Henan 475004 P. R. China

Developing luminescent probes with long lifetime and high emission efficiency is essential for time‐resolved imaging. However, the practical applications usually suffer from emission quenching of traditional luminogens in aggregated states, or from weak emission of aggregation‐induced emission type luminogens in monomeric states. Herein, we overcome this dilemma by a rigid‐and‐flexible alternation design in donor–acceptor–donor skeletons, to achieve a thermally activated delayed fluorescence luminogen with high emission efficiency both in the monomeric state (quantum yield up to 35.3 %) and in the aggregated state (quantum yield up to 30.8 %). Such a dual‐phase strong and long‐lived emission allows a time‐resolved luminescence imaging, with an efficiency independent of probe pretreatment and probe concentration. The findings open opportunities for developing luminescent probes with a usage in larger temporal and spatial scales.

关键词： Dualphasenemission Kontrastmittel Lumineszenz Selbstassemblierung Thermisch aktivierte verzögerte Fluoreszenz

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