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SSRN 2020年

作者： Grasso, Michael Bond, Gavin J. Kim, Ye-Jin Alwan, Katherine B. Boyd, Stefanie Dzebo, Maria Matson Valenzuela, Sebastian Tsang, Tiffany Schibrowsky, Natalie A. Matthews, Megan L. Burslem, George M. Wittung-Stafshede, Pernilla Winkler, Duane D. Blackburn, Ninian J. Marmorstein, Ronen Brady, Donita C. Department of Chemistry School of Arts and Sciences University of Pennsylvania PhiladelphiaPA19104 United States Abramson Family Cancer Research Institute Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104 United States Biochemistry Major Program College of Arts and Sciences University of Pennsylvania PhiladelphiaPA19104 United States Department of Cancer Biology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104 United States Department of Chemical Physiology and Biochemistry School of Medicine Oregon Health and Science University PortlandOR97239 United States Department of Biological Sciences University of Texas at Dallas RichardsonTX75080 United States Department of Biology and Biological Engineering Chalmers University of Technology Gothenburg412 96 Sweden Cell and Molecular Biology Graduate Group Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104 United States Department of Biochemistry and Molecular Biophysics Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104 United States

Normal physiology relies on the precise coordination of intracellular signal transduction pathways that respond to nutrient availability to balance cell growth and cell death. We recently established a critical mechanistic function for the redox-active micronutrient copper (Cu) in the canonical mitogen activated protein kinase (MAPK) pathway at the level of MEK1 and MEK2. Here we report the X-ray crystal structure of Cu-MEK1 and reveal active site chemical ligands and oxidation state specificity for MEK1 Cu coordination. Mechanistically, the Cu chaperone CCS selectively bound to and facilitated Cu transfer to MEK1. Mutations in MEK1 that disrupt Cu(I) affinity or a CCS small molecule inhibitor reduced Cu-stimulated MEK1 kinase activity. These atomic and molecular level data provide the first mechanistic insights of Cu kinase signaling and could be exploited for the development of novel MEK1/2 inhibitors that either target the Cu structural interface or blunt dedicated Cu delivery mechanisms via CCS. © 2020, The Authors. All rights reserved.

关键词： Cell death

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Large-scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop

Journal of Extracellular Biology

引用

Journal of Extracellular Biology 2022年第10期1卷 e63页

作者： Paolini, Lucia Monguió-Tortajada, Marta Costa, Marta Antenucci, Fabio Barilani, Mario Clos-Sansalvador, Marta Andrade, André Cronemberger Driedonks, Tom A. P. Giancaterino, Sara Kronstadt, Stephanie M. Mizenko, Rachel R. Nawaz, Muhammad Osteikoetxea, Xabier Pereira, Carla Shrivastava, Surya Boysen, Anders Toftegaard van de Wakker, Simonides Immanuel van Herwijnen, Martijn J. C. Wang, Xiaoqin Watson, Dionysios C. Gimona, Mario Kaparakis-Liaskos, Maria Konstantinov, Konstantin Lim, Sai Kiang Meisner-Kober, Nicole Stork, Michiel Nejsum, Peter Radeghieri, Annalisa Rohde, Eva Touzet, Nicolas Wauben, Marca H. M. Witwer, Kenneth W. Bongiovanni, Antonella Bergese, Paolo Department of Molecular and Translational Medicine University of Brescia Brescia Italy Center for Colloid and Surface Science (CSGI) Department of Chemistry University of Florence Sesto Fiorentino (FI) Italy Department of Medical and Surgical Specialties Radiological Sciences and Public Health University of Brescia Brescia Italy CREC Research Program Health Science Research Institute Germans Trias i Pujol (IGTP) Badalona Spain Heart Institute (iCor) Cardiology Department Germans Trias i Pujol University Hospital Badalona Spain iBET Instituto de Biologia Experimental e Tecnológica Oeiras Portugal Instituto de Tecnologia Química e Biológica António Xavier Universidade Nova de Lisboa Oeiras Portugal Department of Veterinary and Animal Sciences University of Copenhagen Copenhagen Denmark Laboratory of Regenerative Medicine ‒ Cell Factory Department of Transfusion Medicine and Hematology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy REMAR-IGTP Group Germans Trias i Pujol Research Institute (IGTP) & Nephrology Department University Hospital Germans Trias i Pujol (HUGTiP) Catalonia Badalona (Barcelona) Spain Department of Cell Biology Physiology and Immunology Universitat Autònoma de Barcelona (UAB) Bellaterra Spain Experimental and Clinical Cell Therapy Institute (ExCT) Spinal Cord Injury and Tissue Regeneration Center Paracelsus Medical University Salzburg Austria CDL Research University Medical Center Utrecht Utrecht University Utrecht Netherlands Department of Molecular and Comparative Pathology Johns Hopkins School of Medicine Baltimore MD United States Department of Civil Chemical Environmental and Materials Engineering Alma Mater Studiorum University of Bologna Bologna Italy Fischell Department of Bioengineering University of Maryland College Park MD United States Department of Biomedical Engineering University of California Davis CA United States Department of Rheumatology and Inflammation Research Institute of Medicine

Extracellular vesicles (EVs) large-scale production is a crucial point for the translation of EVs from discovery to application of EV-based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET-OPEN projects, “The Extracellular Vesicle Foundry” (evFOUNDRY) and “Extracellular vesicles from a natural source for tailor-made nanomaterials” (VES4US), organized a workshop entitled “massivEVs” to discuss the potential challenges for translation of EV-based products. This report gives an overview of the topics discussed during “massivEVs”, the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field. © 2022 The Authors. Journal of Extracellular Biology published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.

关键词： EV-based products extracellular vesicles ISEV workshop large-scale production manufacturing processing regulatory issues

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MoS2/C @ polyurethane composite sponges for synergistic high-rate solar steaming and mercury removal

arXiv

引用

arXiv 2018年

作者： Li, Weigu Tekell, Marshall C. Huang, Yun Bertelsmann, Karina Lau, Max Fan, Donglei Department of Mechanical Engineering University of Texas at Austin AustinTX78712 United States Department of Chemical Engineering University of Texas at Austin AustinTX78712 United States Materials Science and Engineering Program Texas Materials Institute University of Texas at Austin AustinTX78712 United States

Solar steam generation, a sustainable water-purification technology, holds substantial promises in resolving the global issue of shortage of drinkable water. Here, we report the design, fabrication, and performance of an innovative three-dimensional (3-D) solar steamer, offering synergistic high-rate steaming and heavy metal removal functions. The device is made of synthesized carbon-molybdenum-disulfide microbeads electrostatically assembled on a 3-D polyurethane sponge. The mesoporous composite sponge also serves as a freestanding water reservoir that avoids one-side contact to bulk water, effectively suppressing the commonly observed parasitic heat loss, and offering a high energy efficiency of 88%. When being sculptured into a 3-D spoke-like structure, the composite sponge achieves one of the highest evaporation rates of 1.95 kg m-2 h-1 at 1 sun. The solar steamer is demonstrated for water treatment, i.e. decontamination of metal ions, disinfection, and reducing alkalinity and hardness of river water. Particularly, the strong mercury adsorption of MoS2 reduces Mercury from 200 to 1ppb, meeting the stringent standard set by the Environmental Protection Agency, which is the first demonstration of mercury-removal powered by solar energy. The unique design, fabrication, water-handling strategy, and mercury-removal function of this high-performance solar steamer could inspire new paradigms of water treatment technologies. Copyright © 2018, The Authors. All rights reserved.

关键词： Molybdenum compounds

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Basic Framework of Regional Model for Disaster Waste Estimation and Distribution by Using Spatial Approach in Central Java-Indonesia

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IOP Conference Series: Earth and Environmental science 2019年第1期396卷

作者： M Maryono K Seruningtyas A D Roynaldi Sudarno Hadiyanto Department of Urban and Regional Planning Faculty of Engineering Diponegoro University Indonesia Center for Green Infrastructure Resilience and Development (C-Greinde) Master Program of Environmental Science School of Postgraduate Diponegoro University Indonesia Department of Environmental Engineering Faculty of Engineering Diponegoro University Indonesia Department of Chemical Engineering Faculty of Engineering Diponegoro University Indonesia

Disaster are becoming more frequent around the world and more intense in urban areas. Central Java is the province with the largest number of disasters in Indonesia. Disaster create amount of disaster waste and sometime very huge, many times comparing to daily municipal waste generation. Government and local citizen sometimes are unable to handling disaster waste. Since effective implementation of disaster waste management (DWM) will lead quick and better recovery of living and avoid more environmental risk, high level regional government such as provincial should help. To make effective support, it is important that provincial government develop a model to monitor disaster waste generation in each regency and cities. This study aims to develop basic framework of regional model for disaster waste estimation and distribution in provincial level. This study used Central Java Province as a case study. To estimate disaster waste in Central Java, this study developed an index system as a basic model. It is about basic comparison of disaster waste generation in all central java regencies or cities. Disaster waste is associated with total disaster events. This study utilized GIS tools to express model and system. This study developed of regional model disaster waste estimation in Central Java, divided by 3 sub decades. Study result shown that in first decade 1990-1999 the highest index of disaster waste estimation is Brebes Regency. Second decade 2000-2009 the highest index of disaster waste estimation is Semarang Regency and the third decade 2010-2018 the highest index of disaster waste estimation in Cilacap Regency.

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The influence of micro plastic to Chlorella growth in difference aquatic systems

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AIP Conference Proceedings 2020年第1期2197卷

作者： Mohammad Muslihuddin Hadiyanto Fuad Muhammad Adian Khoironi Norma Afiati 1Center of Biomass and Renewable Energy Chemical Engineering Department Diponegoro University Indonesia 2Master Program of Environmental Sciences School of Postgraduate Studies Diponegoro University Indonesia 3Biology Department Faculty of Science and Mathematics Diponegoro University Indonesia 4Faculty of Fisheries and Marines Sciences Diponegoro University Indonesia

Plastic waste is harmful to human health and became climacteric problem for our environment. In year 2010, 275 million metric tons (MT) of plastic waste was emerge in 192 coastal countries. Micro plastic with size range around 1-5mm also affecting microorganism such as microalgae, Chlorella Pyrenoidosa which one of many species of microalgae is no exception. This microalga commonly used for foodstuff as the source of protein and lipid, also can be used as materials to make biodiesel since it also rich with lipid and can be processed with either esterification, trans-esterification or both. 500mg micro plastic of polyethylene terephthalate (PET) is added in 25ml Chlorella Pyrenoidosa on peak of its growth. Additional amount of diluted nutrients in 250ml freshwater and brackish also being added as controls with different salinity. Since control experiment also being made without the presence of PET micro plastic, the growth rate shown in Chlorella Pyrenoidosa which being add with PET micro plastic is more than the growth rate Chlorella Pyrenoidosa without micro plastic. This difference could be due utilization of micro plastic as carbon source by Chlorella Pyrenoidosa.

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Pyrolysis: An effective technique for degradation of COVID-19 medical wastes

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Chemosphere 2021年 275卷 130092页

作者： Selvakumar Dharmaraj Veeramuthu Ashokkumar Rajesh Pandiyan Heli Siti Halimatul Munawaroh Kit Wayne Chew Wei-Hsin Chen Chawalit Ngamcharussrivichai (Deemed to be University) Chennai 603112 Tamil Nadu India. Center of Excellence in Catalysis for Bioenergy and Renewable Chemicals (CBRC) Faculty of Science Chulalongkorn University Bangkok 10330 Thailand. Electronic address: rvashok2008@***. Department of Biochemistry Karpagam Academy of Higher Education (formerly Karpagam University) Pollachi Main Road Eachanari Post Coimbatore Tamil Nadu India. Chemistry Study Program Department of Chemistry Education Faculty of Mathematics and Science Education Universitas Pendidikan Indonesia Jl. Dr. Setiabudhi 229 Bandung 40154 Indonesia. School of Energy and Chemical Engineering Xiamen University Malaysia Jalan Sunsuria Bandar Sunsuria 43900 Sepang Selangor Malaysia College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 Fujian China. Department of Aeronautics and Astronautics National Cheng Kung University Tainan 701 Taiwan Research Center for Smart Sustainable Circular Economy Tunghai University Taichung 407 Taiwan Department of Mechanical Engineering National Chin-Yi University of Technology Taichung 411 Taiwan. Center of Excellence in Catalysis for Bioenergy and Renewable Chemicals (CBRC) Faculty of Science Chulalongkorn University Bangkok 10330 Thailand Center of Excellence on Petrochemical and Materials Technology (PETROMAT) Chulalongkorn University Pathumwan Bangkok 10330 Thailand. Electronic address: Chawalit.Ng@chula.ac.th.

COVID-19 has led to the enormous rise of medical wastes throughout the world, and these have mainly been generated from hospitals, clinics, and other healthcare establishments. This creates an additional challenge in medical waste management, particularly in developing countries. Improper managing of medical waste may have serious public health issues and a significant impact on the environment. There are currently three disinfection technologies, namely incineration, chemical and physical processes, that are available to treat COVID-19 medical waste (CMW). This study focuses on thermochemical process, particularly pyrolysis process to treat the medical waste. Pyrolysis is a process that utilizes the thermal instability of organic components in medical waste to convert them into valuable products. Besides, the technique is environmentally friendly, more efficient and cost-effective, requires less landfill capacity, and causes lower pollution. The current pandemic situation generates a large amount of plastic medical wastes, which mainly consists of polyethylene, polypropylene, polystyrene, polyethylene terephthalate, and nylon. These plastic wastes can be converted into valuable energy products like oil, gas and char through pyrolysis process. This review provides detailed information about CMW handling, treatment, valuable product generation, and proper discharge into the open environment.

关键词： COVID-19 medical waste Disinfection techniques Energy conversion Medical waste management Pyrolysis

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Bleifreie Halogenid‐Perowskit‐Nanokristalle: Kristallstrukturen, Synthese, Stabilitäten und optische Eigenschaften

引用

Angewandte Chemie 2019年第3期132卷

作者： Qianqian Fan Gill V. Biesold‐McGee Jianzhong Ma Qunna Xu Shuang Pan Juan Peng Zhiqun Lin College of Bioresources Chemical and Materials Engineering Shaanxi University of Science & Technology Xi'an 710021 P. R. China School of Materials Science and Engineering Georgia Institute of Technology Atlanta GA 30332 USA State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University Shanghai 200438 P. R. China

In den letzten Jahren gab es rasante Fortschritte bei der Synthese von Bleihalogenid‐Perowskit‐Nanokristallen (NCs) für den Einsatz in Solarzellen, Leuchtdioden, Lasern und Photodetektoren. Sie besitzen eine Reihe faszinierender optischer, excitonischer und Ladungstransporteigenschaften, einschließlich hervorragender Photolumineszenz‐Quantenausbeuten (PLQY) und abstimmbaren optischen Bandlücken. Die notwendige Verwendung von Blei, einem toxischen Element, gibt jedoch Anlass zu ernsthafter Besorgnis über die zukünftige kommerzielle Entwicklung. Um das Problem der Toxizität zu lösen, wurden in jüngster Zeit intensive Forschungsarbeiten zur Entwicklung bleifreier Halogenid‐Perowskit(LFHP)‐NCs durchgeführt. In diesem Aufsatz geben wir einen Überblick über die derzeit erforschten LFHP‐NCs mit den Schwerpunkten Kristallstruktur, Synthese, optische Eigenschaften und Umgebungsstabilität (z. B. UV‐, Wärme‐ und Feuchtigkeitsbeständigkeit). Darüber hinaus werden Strategien zur Verbesserung der optischen Eigenschaften und Stabilitäten von LFHP‐NCs sowie deren neueste Anwendungen diskutiert.

关键词： Bleifreie Perowskite Nanokristalle Optische Eigenschaften

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Table drainage and press dewatering when cellulose nanofibers are applied on the wet end

Table drainage and press dewatering when cellulose nanofiber...

引用

Paper Conference and Trade Show: Renew, Rethink, Redefine the Future, PaperCon 2017

作者： Bousfield, Doug Paradis, Mark Johnson, Donna Bilodeau, Michael Process Development Center Paper Surface Science Program Department of Chemical and Biological Engineering University of Maine OronoME United States

ISBN: (纸本)9781510847286

Before cellulose nanofibers (CNF) can be used in paper furnishes or as a surface layer, the drainage characteristics of pulps that contain CNF must be determined. In addition, the influence of CNF addition on pressing needs to be understood. CNF was added to pulp furnishes at various levels and also applied as a curtain to the just formed web on the drainage table on a pilot paper machine. The couch solids and the final press solids, for various nip pressures is obtained. The final press solids is also predicted from an equation in the literature. In some cases, CNF addition is found to increase press solids instead of decreasing it.

关键词： Presses (machine tools)

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Multifunctional stimuli responsive polymer-gated iron and gold-embedded silica nano golf balls:Nanoshuttles for targeted on-demand theranostics

引用

Bone Research 2017年第4期5卷 343-356页

作者： Liping Wang Grace Jang Deependra Kumar Ban Vrinda Sant Jay Seth Sami Kazmi Nirav Patel Qingqing Yang Joon Lee Woraphong Janetanakit Shanshan Wang Brian P Head Gennadi Glinsky Ratneshwar Lai School of Biomedical Engineering Shanghai Jiaotong UniverityShanghaiChina Department of Mechanical and Aerospace Engineering La JollaCAUSA Materials Science and Engineering Program La JollaCAUSA Department of Nanoengineering La JollaCAUSA Department of Chemical Engineering University of California San DiegoLa JollaCAUSA Departrnenf of Bioengineering La JollaCAUSA Department of Anesthesiology La JollaCAUSA Veterans Affairs San Diego Healthcare System San DiegoCAUSA Institute of Engineering in Medicine La JollaCAUSA

Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles （NP）-embedded silica nanoshuttles （MGNSs） with nanopores on their surface. Fluorescently labeled Doxombicin （DOX）, a cancer drug, was loaded in the MGNSs as a payload. DOX loaded MGNSs were encapsulated in heat and pH sensitive polymer P（NIPAM-co- MAA） to enable controlled release of the payload. Magnetically-guided transport of MGNSs was examined in：（a） a glass capillary tube to simulate their delivery via blood vessels; and （b） porous hydrogels to simulate their transport in composite human tissues, including bone, cartilage, tendon, muscles and blood-brain barrier {BBB）. The viscoelastic properties of hydrogels were examined by atomic force microscopy （AFM）. Cellular uptake of DOX- loaded MGNSs and the subsequent pH and temperature-mediated release were demonstrated in differentiated human neurons derived from induced pluripotent stem cells （iPSCs） as well as epithelial HeLa cells. The presence of embedded iron and gold NPs in silica shells and polymer-coating are supported by SEM and TEM. Fluorescence spectroscopy and microscopy documented DOX loading in the MGNSs. Time-dependent transport of MGNSs guided by an external magnetic field was observed in both glass capillary tubes and in the porous hydrogel. AFM results affirmed that the stiffness of the hydrogels model the rigidity range from soft tissues to bone. pH and temperature-dependent drug release analysis showed stimuli responsive and gradual drug release. Cells＇ viability MTT assays showed that MGNSs are non-toxic. The cell death from on-demand DOX release was observed in both neurons and ep

关键词： Multifunctional stimuli responsive polymer-gated iron

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Bandgap in orthorhombic thin lead halide perovskite (CsPbBr3) nanosheets measured from STEM-EELS

arXiv

引用

arXiv 2020年

作者： Brescia, Rosaria Toso, Stefano Ramasse, Quentin Manna, Liberato Downing, Clive Calzolari, Arrigo Bertoni, Giovanni Electron Microscopy Facility Istituto Italiano di Tecnologia Via Morego 30 Genova16163 Italy Nanochemistry Department Istituto Italiano di Tecnologia Via Morego 30 Genova16163 Italy International Doctoral Program in Science Universita Cattolica del Sacro Cuore Brescia25121 Italy SuperSTEM SciTech Daresbury Science and Innovation Campus Keckwick Lane DaresburyWA4 4AD United Kingdom School of Chemical and Process Engineering & School of Physics University of Leeds LeedsLS29JT United Kingdom CRANN and AMBER Research Centers Trinity College Dublin Dublin 2 Ireland School of Chemistry Trinity College Dublin Dublin 2 Ireland CNR - Istituto Nanoscienze Via Campi 213/A Modena41125 Italy

Inorganic lead halide perovskites are promising candidates for optoelectronic applications, due to their bandgap tunability, high photoluminescence quantum yield, and narrow emission line widths. In particular, they offer the possibility to vary the bandgap as a function of the halide composition and dimension/shape of the crystals at the nanoscale. Here we present an aberration-corrected scanning transmission microscopy (STEM) study of extended nanosheets of CsPbBr3 directly demonstrating their orthorhombic crystal structure and their lateral termination with Cs-Br planes. The bandgaps from individual nanosheets are measured by monochromated electron energy loss spectroscopy (EELS). We find an increase of the bandgap starting at thicknesses below 10 nm, confirming the less dramatic effect of 1D confinement in nanosheets compared to the 3D confinement observed in quantum dots, as predicted by density functional theory calculations and optical spectroscopy data from ensemble measurements. Copyright © 2020, The Authors. All rights reserved.

关键词： Nanosheets

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