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Lithium‐Ion Batteries: Cooling Induced Surface Reconstruction during Synthesis of High‐Ni Layered Oxides (Adv. Energy Mater. 43/2019)

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Advanced Energy Materials 2019年第43期9卷

作者： Ming‐Jian Zhang Xiaobing Hu Maofan Li Yandong Duan Luyi Yang Chong Yin Mingyuan Ge Xianghui Xiao Wah‐Keat Lee Jun Young Peter Ko Khalil Amine Zonghai Chen Yimei Zhu Eric Dooryhee Jianming Bai Feng Pan Feng Wang School of Advanced Materials Peking University Shenzhen Graduate School Shenzhen 518055 P. R. China Sustainable Energy Technologies Department Brookhaven National Laboratory Upton NY 11973 USA Condensed Matter Physics and Materials Science Department Brookhaven National Laboratory Upton NY 11973 USA School of Science Hebei University of Science and Technology Shijiazhuang 050018 P. R. China Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201 P. R. China National Synchrotron Light Source II Brookhaven National Laboratory Upton NY 11973 USA The Cornell High Energy Synchrotron Source Cornell University Ithaca NY 14853 USA Electrochemical Technology Program Chemical Sciences and Engineering Division Argonne National Laboratory 9700 South Cass Avenue Lemont IL 60439 USA Materials Science and Engineering Stanford University Stanford CA 94305 USA Institute for Research and Medical Consultations (IRMC) Imam Abdulrahman Bin Faisal University (IAU) Dammam 34212 Saudi Arabia

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Synthesize palladium nanoparticles from the macroalgae Sargassum fusiforme: An eco-friendly tool in the fight against Plasmodium falciparum?

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The science of the total environment 2023年第PT 3期857卷 159517页

作者： Chinnaperumal Kamaraj Chinnasamy Ragavendran R C Satish Kumar Sarvesh Sabarathinam Cittrarasu Vetrivel Mariyappan Vaithiyalingam Guilherme Malafaia Interdisciplinary Institute of Indian System of Medicine (IIISM) Drug Testing Laboratory Directorate of Research SRM Institute Science and Technology Kattankulathur 603 203 Tamil Nadu India. Electronic address: kamarajc@srmist.edu.in. Department of Cariology Saveetha Dental College and Hospitals Chennai Tamil Nadu India. Interdisciplinary Institute of Indian System of Medicine (IIISM) Drug Testing Laboratory Directorate of Research SRM Institute Science and Technology Kattankulathur 603 203 Tamil Nadu India. Carbon Capture Lab Department of Chemical Engineering SSN College of Engineering Kalavakkam Chennai 603110 Tamil Nadu India Department of Anatomy Saveetha Dental college and Hospital. Saveetha institute of medical and Technical science ChennaiTamil N- 600 007 India. Department of Chemistry SRM Institute of Science and Technology Kattankulathur Chengalpattu 603203 Tamilnadu India. Laboratory of Toxicology Applied to the Environment Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil. Electronic address: guilhermeifgoiano@***.

Although numerous drugs are practiced to control malaria and its vectors, more recently, eco-friendly control tools have been proposed to battle its etiologic agents. Thus, using green bionanotechnology approaches, we aimed to synthesize palladium nanoparticles (Pd NPs) from the macroalgae Sargassum fusiforme (Sf), its potential antiparasitic activity against P. falciparum, as well as its possible cytotoxicity, in HeLa cells. After the biosynthesis of the PdSf NPs, their characterization was carried out by UV-Vis, FESEM, and EDX analyses, and their hydrodynamic size, zeta potential, and surface area were determined. Furthermore, the functional groups of the PdSf NPs were analyzed by FT-IR and GC-MS. While PdSf NPs had an IC of 7.68 μg/mL (Chloroquine (CQ)-s) and 16.42 μg/mL, S. fusiforme extract had an IC of 14.38 μg/mL (CQ-s) and 35.27 μg/mL (CQ-r). With an IC value of 94.49 μg/mL, PdSf NPs exhibited the least toxic effect on the HeLa cells. The Lipinski rule of five and ADMET prediction were used to assess the in silico models of caffeine acid hexoside and quercetin 7-O-hexoside for the presence of drug-like properties. Pathogenic proteins, primarily responsible for motility, binding, and disease-causing, were the target of the structurally based docking studies between plant-derived compounds and pathogenic proteins. Thus, our study pioneered promising results that support the potential antiplasmodial activity of eco-friendly synthesized PdSf NPs using S. fusiforme extract against P. falciparum, opening perspectives for further exploration into the use of these NPs in malaria therapy.

关键词： Bionanotechnology Brown algae Molecular docking PdSf NPs Plasmodium falciparum Sargassum fusiforme

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Antibody‐Based Therapeutics: Ultrasensitive NIR‐SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation (Adv. Healthcare Mater. 4/2018)

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Advanced Healthcare Materials 2018年第4期7卷

作者： Homan Kang Sinyoung Jeong Ahla Jo Hyejin Chang Jin‐Kyoung Yang Cheolhwan Jeong San Kyeong Youn Woo Lee Animesh Samanta Kaustabh Kumar Maiti Myeong Geun Cha Taek‐Keun Kim Sukmook Lee Bong‐Hyun Jun Young‐Tae Chang Junho Chung Ho‐Young Lee Dae Hong Jeong Yoon‐Sik Lee Interdisciplinary Program in Nano‐Science and Technology Seoul National University Seoul 08826 Republic of Korea Department of Chemistry Education Seoul National University Seoul 08826 Republic of Korea Department of Nuclear Medicine Seoul National University Bundang Hospital Seongnam 13620 Republic of Korea School of Chemical and Biological Engineering Seoul National University Seoul 08826 Republic of Korea Department of Chemistry and MedChem Program of Life Sciences Institute National University of Singapore Singapore 117543 Singapore Laboratory of Molecular Cancer Therapeutics Scripps Korea Antibody Institute Hyoja‐2‐dong Chuncheon‐si Gangwon‐do 24341 Republic of Korea Department of Bioscience and Biotechnology Konkuk University Seoul 05029 Republic of Korea Department of Chemistry Pohang University of Science and Technology (POSTECH) Pohang 37673 Republic of Korea Cancer Research Institute Seoul National University College of Medicine Seoul 03080 Republic of Korea

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engineering chirality at wafer scale with ordered carbon nanotube architectures

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Nature communications 2023年第1期14卷 7380页

作者： Jacques Doumani Minhan Lou Oliver Dewey Nina Hong Jichao Fan Andrey Baydin Keshav Zahn Yohei Yomogida Kazuhiro Yanagi Matteo Pasquali Riichiro Saito Junichiro Kono Weilu Gao Department of Electrical and Computer Engineering Rice University Houston TX USA. Applied Physics Graduate Program Smalley-Curl Institute Rice University Houston TX USA. Department of Electrical and Computer Engineering The University of Utah Salt Lake City UT USA. Carbon Hub Rice University Houston TX USA. Department of Chemical and Biomolecular Engineering Rice University Houston TX USA. J.A. Woollam Co. Inc. Lincoln NE USA. Smalley-Curl Institute Rice University Houston TX USA. Department of Physics Tokyo Metropolitan University Tokyo Japan. Department of Chemistry Rice University Houston TX USA. Department of Materials Science and NanoEngineering Rice University Houston TX USA. Department of Physics Tohoku University Sendai Japan. Department of Physics National Taiwan Normal University Taipei Taiwan. Department of Physics and Astronomy Rice University Houston TX USA. Department of Electrical and Computer Engineering The University of Utah Salt Lake City UT USA. weilu.gao@utah.edu. Carbon Hub Rice University Houston TX USA. weilu.gao@utah.edu.

Creating artificial matter with controllable chirality in a simple and scalable manner brings new opportunities to diverse areas. Here we show two such methods based on controlled vacuum filtration - twist stacking and mechanical rotation - for fabricating wafer-scale chiral architectures of ordered carbon nanotubes (CNTs) with tunable and large circular dichroism (CD). By controlling the stacking angle and handedness in the twist-stacking approach, we maximize the CD response and achieve a high deep-ultraviolet ellipticity of 40 ± 1 mdeg nm. Our theoretical simulations using the transfer matrix method reproduce the experimentally observed CD spectra and further predict that an optimized film of twist-stacked CNTs can exhibit an ellipticity as high as 150 mdeg nm, corresponding to a g factor of 0.22. Furthermore, the mechanical rotation method not only accelerates the fabrication of twisted structures but also produces both chiralities simultaneously in a single sample, in a single run, and in a controllable manner. The created wafer-scale objects represent an alternative type of synthetic chiral matter consisting of ordered quantum wires whose macroscopic properties are governed by nanoscopic electronic signatures and can be used to explore chiral phenomena and develop chiral photonic and optoelectronic devices.

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Parameter processes and their impact on Tinospora cordifolia stem extracts for antibacterial and antioxidant materials

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Materials Today: Proceedings 2023年

作者： Ahmad Royani Muhammad Hanafi Puspa Dewi N. Lotulung Muhammad Eka Prastya Chandrabhan Verma Akram Alfantazi Azwar Manaf Postgraduate Program of Materials Science Study Department of Physics Faculty of Mathematics and Natural Sciences Universitas Indonesia Depok 16424 Indonesia Research Center for Metallurgy National Research and Innovation Agency (BRIN) Tangerang Selatan Banten 15314 Indonesia Research Center for Pharmaceutical Ingredients and Traditional Medicine National Research and Innovation Agency (BRIN) Tangerang Selatan Banten 15314 Indonesia Research Center for Chemistry National Research and Innovation Agency (BRIN) Tangerang Selatan Banten 15314 Indonesia Department of Chemical Engineering Khalifa University of Science and Technology P. O. Box 127788 Abu Dhabi United Arab Emirates

This work extracted the Tinospora cordifolia stem for antibacterial and antioxidant materials. The stems of T. cordifolia were extracted by using a simple maceration method. The effect of three independent variables (solvent ratios, temperature, and extraction time) was investigated to obtain optimal conditions. Ten grams of T. cordifolia were extracted using a mixture of methanol–water ratios 00:100, 15:85, 30:70, and 45:55 (% v/v) at 50–95 °C for 0.5 to 3 h. The total phenolic and flavonoid content in the T. cordifolia extracts was analyzed by Folin-Ciocalteu and Colorimetric-AlCl 3 methods. The antibacterial activities against Pseudomonas aeruginosa were assessed by serial dilution methods, and antioxidant properties were performed by DPPH methods. The optimum condition was achieved at methanol–water ratios of 00:100 % (v/v) at 95 °C for 2 h. The yield extraction for this condition is around 13.97%. The total phenolic and flavonoid contents for these conditions are about 6.85% and 7.07%, respectively. The minimum inhibitory concentration value against P. aeruginosa is 1024 µg/mL, and the minimum bacterial concentration is above 2048 µg/mL. Meanwhile, the antioxidant obtained is 217.55 µg/mL at a ratio of 00:100 methanol–water. The extraction process parameters significantly influenced the phytochemical (TPC and TFC), antibacterial activity, and antioxidant properties of T. cordifolia stem extracts. This work clearly shows the antibacterial potential of T. cordifolia stem extracts, suggesting that more investigation is required to isolate the bioactive compounds in this extract.

关键词： Antibacterial Antioxidant Maceration Parameter effect P. aeruginosa T. cordifolia

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Pyrolysis: An effective technique for degradation of COVID-19 medical wastes

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Chemosphere 2021年 275卷 130092页

作者： Selvakumar Dharmaraj Veeramuthu Ashokkumar Rajesh Pandiyan Heli Siti Halimatul Munawaroh Kit Wayne Chew Wei-Hsin Chen Chawalit Ngamcharussrivichai (Deemed to be University) Chennai 603112 Tamil Nadu India. Center of Excellence in Catalysis for Bioenergy and Renewable Chemicals (CBRC) Faculty of Science Chulalongkorn University Bangkok 10330 Thailand. Electronic address: rvashok2008@***. Department of Biochemistry Karpagam Academy of Higher Education (formerly Karpagam University) Pollachi Main Road Eachanari Post Coimbatore Tamil Nadu India. Chemistry Study Program Department of Chemistry Education Faculty of Mathematics and Science Education Universitas Pendidikan Indonesia Jl. Dr. Setiabudhi 229 Bandung 40154 Indonesia. School of Energy and Chemical Engineering Xiamen University Malaysia Jalan Sunsuria Bandar Sunsuria 43900 Sepang Selangor Malaysia College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 Fujian China. Department of Aeronautics and Astronautics National Cheng Kung University Tainan 701 Taiwan Research Center for Smart Sustainable Circular Economy Tunghai University Taichung 407 Taiwan Department of Mechanical Engineering National Chin-Yi University of Technology Taichung 411 Taiwan. Center of Excellence in Catalysis for Bioenergy and Renewable Chemicals (CBRC) Faculty of Science Chulalongkorn University Bangkok 10330 Thailand Center of Excellence on Petrochemical and Materials Technology (PETROMAT) Chulalongkorn University Pathumwan Bangkok 10330 Thailand. Electronic address: Chawalit.Ng@chula.ac.th.

COVID-19 has led to the enormous rise of medical wastes throughout the world, and these have mainly been generated from hospitals, clinics, and other healthcare establishments. This creates an additional challenge in medical waste management, particularly in developing countries. Improper managing of medical waste may have serious public health issues and a significant impact on the environment. There are currently three disinfection technologies, namely incineration, chemical and physical processes, that are available to treat COVID-19 medical waste (CMW). This study focuses on thermochemical process, particularly pyrolysis process to treat the medical waste. Pyrolysis is a process that utilizes the thermal instability of organic components in medical waste to convert them into valuable products. Besides, the technique is environmentally friendly, more efficient and cost-effective, requires less landfill capacity, and causes lower pollution. The current pandemic situation generates a large amount of plastic medical wastes, which mainly consists of polyethylene, polypropylene, polystyrene, polyethylene terephthalate, and nylon. These plastic wastes can be converted into valuable energy products like oil, gas and char through pyrolysis process. This review provides detailed information about CMW handling, treatment, valuable product generation, and proper discharge into the open environment.

关键词： COVID-19 medical waste Disinfection techniques Energy conversion Medical waste management Pyrolysis

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Input optics systems of the KAGRA detector during O3GK (vol 2023, 023F01, 2023)

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PROGRESS OF THEORETICAL AND EXPERIMENTAL PHYSICS 2023年第5期2023卷

作者： Akutsu, T. Ando, M. Arai, K. Arai, Y. Araki, S. Araya, A. Aritomi, N. Asada, H. Aso, Y. Bae, S. Bae, Y. Baiotti, L. Bajpai, R. Barton, M. A. Cannon, K. Cao, Z. Capocasa, E. Chan, M. Chen, C. Chen, K. Chen, Y. Chiang, C-I Chu, H. Chu, Y-K Eguchi, S. Enomoto, Y. Flaminio, R. Fujii, Y. Fujikawa, Y. Fukunaga, M. Fukushima, M. Furuhata, T. Gao, D. Ge, G-G Ha, S. Hagiwara, A. Haino, S. Han, W-B Hasegawa, K. Hattori, K. Hayakawa, H. Hayama, K. Himemoto, Y. Hiranuma, Y. Hirata, N. Hirose, E. Hong, Z. Hsieh, B-H Huang, G-Z Huang, H-Y Huang, P. Huang, Y-C Huang, Y-J Hui, D. C. Y. Ide, S. Ikenoue, B. Imam, S. Inayoshi, K. Inoue, Y. Ioka, K. Ito, K. Itoh, Y. Izumi, K. Jeon, C. Jin, H-B Jung, K. Jung, P. Kaihotsu, K. Kajita, T. Kakizaki, M. Kamiizumi, M. Kanbara, S. Kanda, N. Kang, G. Kataoka, Y. Kawaguchi, K. Kawai, N. Kawasaki, T. Kim, C. Kim, J. Kim, J. C. Kim, Ws Kim, Y-M Kimura, N. Kita, N. Kitazawa, H. Kojima, Y. Kokeyama, K. Komori, K. Kong, A. K. H. Kotake, K. Kozakai, C. Kozu, R. Kumar, R. Kume, J. Kuo, C. Kuo, H-S Kuromiya, Y. Kuroyanagi, S. Kusayanagi, K. Kwak, K. Lee, H. K. Lee, H. W. Lee, R. Leonardi, M. Li, K. L. Lin, L. C-C Lin, C-Y Lin, F-K Lin, F-L Lin, H. L. Liu, G. C. Luo, L-W Majorana, E. Marchio, M. Michimura, Y. Mio, N. Miyakawa, O. Miyamoto, A. Miyazaki, Y. Miyo, K. Miyoki, S. Mori, Y. Morisaki, S. Moriwaki, Y. Nagano, K. Nagano, S. Nakamura, K. Nakano, H. Nakano, M. Nakashima, R. Nakayama, Y. Narikawa, T. Naticchioni, L. Negishi, R. Quynh, L. Nguyen Ni, W-T Nishizawa, A. Nozaki, S. Obuchi, Y. Ogaki, W. Oh, J. J. Oh, S. H. Ohashi, M. Ohishi, N. Ohkawa, M. Ohta, H. Okutani, Y. Okutomi, K. Oohara, K. Ooi, C. Oshino, S. Otabe, S. Pan, K-C Pang, H. Parisi, A. Park, J. Arellano, F. E. Pena Pinto, I. Sago, N. Saito, S. Saito, Y. Sakai, K. Sakai, Y. Sakuno, Y. Sato, S. Sato, T. Sawada, T. Sekiguchi, T. Sekiguchi, Y. Shao, L. Shibagaki, S. Shimizu, R. Shimoda, T. Shimode, K. Shinkai, H. Shishido, T. Shoda, A. Somiya, K. Son, E. J. Sotani, H. Sugimoto, R. Suresh, J. Suzuki, T. Suzuki, T. Tagoshi, H. Takahashi, H Gravitational Wave Science Project National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Department of Physics The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Research Center for the Early Universe The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Institute for Cosmic Ray Research KAGRA Observatory The University of Tokyo 5-1-5 Kashiwa-no-Ha Kashiwa City Chiba 277-8582 Japan Accelerator Laboratory High Energy Accelerator Research Organization (KEK) 1-1 Oho Tsukuba City Ibaraki 305-0801 Japan Earthquake Research Institute The University of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo 113-0032 Japan Department of Mathematics and Physics Graduate School of Science and Technology Hirosaki University 3 Bunkyo-cho Hirosaki Aomori 036-8561 Japan Kamioka Branch National Astronomical Observatory of Japan 238 Higashi-Mozumi Kamioka-cho Hida City Gifu 506-1205 Japan The Graduate University for Advanced Studies (SOKENDAI) 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Korea Institute of Science and Technology Information 245 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea National Institute for Mathematical Sciences 70 Yuseong-daero 1689 Beon-gil Yuseong-gu Daejeon 34047 Republic of Korea International College Osaka University 1-1 Machikaneyama-cho Toyonaka City Osaka 560-0043 Japan School of High Energy Accelerator Science The Graduate University for Advanced Studies (SOKENDAI) 1-1 Oho Tsukuba City Ibaraki 305-0801 Japan Department of Astronomy Beijing Normal University Xinjiekouwai Street 19 Haidian District Beijing 100875 China Department of Applied Physics Fukuoka University 8-19-1 Nanakuma Jonan Fukuoka City Fukuoka 814-0180 Japan Department of Physics Tamkang University No. 151 Yingzhuan Road Danshui Dist. New Taipei City 25137 Taiwan Department of Physics

KAGRA, the underground and cryogenic gravitational-wave detector, was operated for its solo observation from February 25 to March 10, 2020, and its first joint observation with the GEO 600 detector from April 7 to April 21, 2020 (O3GK). This study presents an overview of the input optics systems of the KAGRA detector, which consist of various optical systems, such as a laser source, its intensity and frequency stabilization systems, modulators, a Faraday isolator, mode-matching telescopes, and a high-power beam dump. These optics were successfully delivered to the KAGRA interferometer and operated stably during the observations. The laser frequency noise was observed to limit the detector sensitivity above a few kilohertz, whereas the laser intensity did not significantly limit the detector sensitivity.

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Low‐Fouling Fluoropolymers for Bioconjugation and In Vivo Tracking

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Angewandte Chemie 2020年第12期132卷

作者： Changkui Fu Baris Demir Sheilajen Alcantara Vinod Kumar Felicity Han Hannah G. Kelly Xiao Tan Ye Yu Weizhi Xu Jiacheng Zhao Cheng Zhang Hui Peng Cyrille Boyer Trent M. Woodruff Stephen J. Kent Debra J. Searles Andrew K. Whittaker ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia Queensland 4072 Australia School of Chemistry and Molecular Biosciences and Australian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane Queensland 4072 Australia ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and Department of Microbiology and Immunology Peter Doherty Institute for Infection and Immunity The University of Melbourne Parkville Victoria 3010 Australia School of Biomedical Sciences The University of Queensland St. Lucia Queensland 4072 Australia Centre for Advanced Macromolecular Design (CAMD) and Australian Centre for NanoMedicine (ACN) School of Chemical Engineering UNSW Australia Sydney NSW 2052 Australia

The conjugation of hydrophilic low‐fouling polymers to therapeutic molecules and particles is an effective approach to improving their aqueous stability, solubility, and pharmacokinetics. Recent concerns over the immunogenicity of poly(ethylene glycol) has highlighted the importance of identifying alternative low fouling polymers. Now, a new class of synthetic water‐soluble homo‐fluoropolymers are reported with a sulfoxide side‐chain structure. The incorporation of fluorine enables direct imaging of the homopolymer by 19 F MRI, negating the need for additional synthetic steps to attach an imaging moiety. These self‐reporting fluoropolymers show outstanding imaging sensitivity and remarkable hydrophilicity, and as such are a new class of low‐fouling polymer for bioconjugation and in vivo tracking.

关键词： 19F-MRT-Bildgebung Biokonjugation In-vivo-Tracking Low-Fouling-Fluorpolymere Thermoresponsive Materialien

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Synergistic Glutathione Depletion and STING Activation to Potentiate Dendritic Cell Maturation and Cancer Vaccine Efficacy

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Angewandte Chemie 2024年第10期136卷

作者： Dr. Jianping Liu Dr. Ye Zhang Bowei Yang Dr. Yingbo Jia Prof. Rui-Tian Liu Dr. Lingwen Ding Prof. Zheyu Shen Prof. Xiaoyuan Chen Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore School of Biomedical Engineering Southern Medical of University Guangzhou Guangdong 510515 P. R. China CAS Key Laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou Jiangsu 215123 P. R. China State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 P. R. China Department of Pathology Yong Loo Lin School of Medicine National University of Singapore Singapore 119074 Singapore Clinical Imaging Research Center Center for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive Proteos Singapore 138673 Singapore

Dendritic cell (DC) maturation and antigen presentation are key factors for successful vaccine-based cancer immunotherapy. This study developed manganese-based layered double hydroxide (Mn-LDH) nanoparticles as a self-adjuvanted vaccine carrier that not only promoted DC maturation through synergistically depleting endogenous glutathione (GSH) and activating STING signaling pathway, but also facilitated the delivery of model antigen ovalbumin (OVA) into lymph nodes and subsequent antigen presentation in DCs. Significant therapeutic-prophylactic efficacy of the OVA-loaded Mn-LDH (OVA/Mn-LDH) nanovaccine was determined by the tumor growth inhibition in the mice bearing B16-OVA tumor. Our results showed that the OVA/Mn-LDH nanoparticles could be a potent delivery system for cancer vaccine development without the need of adjuvant. Therefore, the combination of GSH exhaustion and STING pathway activation might be an advisable approach for promoting DC maturation and antigen presentation, finally improving cancer vaccine efficacy.

关键词： Antigen Delivery DC Maturation GSH Depletion ROS Upregulation STING Activation

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Corrigendum to "Elucidating the crosstalk between endothelial-to-mesenchymal transition (EndoMT) and endothelial autophagy in the pathogenesis of atherosclerosis" [Vascular Pharmacology 155 (2024) 107368]

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Vascular pharmacology 2024年 155卷 107373页

作者： Bandana Singh Kui Cui Shahram Eisa-Beygi Bo Zhu Douglas B Cowan Jinjun Shi Chris A Bashur Da-Zhi Wang Zhenguo Liu Joyce Bischoff Hong Chen Vascular Biology Program Department of Surgery Harvard Medical School Boston Children's Hospital Boston MA USA. Department of Anesthesiology Perioperative and Pain Medicine Brigham and Women's Hospital Boston MA USA. Department of Biomedical Chemical Engineering and Science Florida Institute of Technology 150 West University Blvd. Melbourne FL USA. Center for Regenerative Medicine University of South Florida Health Heart Institute Morsani College of Medicine University of South Florida Tampa FL USA. Division of Cardiovascular Medicine Department of Medicine University of Missouri School of Medicine Columbia MO USA. Vascular Biology Program Department of Surgery Harvard Medical School Boston Children's Hospital Boston MA USA. Electronic address: hong.chen@childrens.harvard.edu.

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