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SERS-Guided Precision Resection Combined with Photothermal-Immunotherapy for Glioblastoma Recurrence Prevention

Advanced Functional Materials 2025年

作者： Xu, Qing Yu, Mengqi Guo, Jingxing Liu, Xuemeng Ding, Yinan Wang, Yuru Rui, Jiaxin Zhu, Lijun Zhou, Qingqing Zhang, Zhiqiang Zhang, Longjiang Chen, Xiaoyuan Lu, Guangming Department of Radiology Jinling Hospital Affiliated Hospital of Medical School Nanjing University Nanjing 210023 China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore School of Chemistry Chemical Engineering and Life Sciences Wuhan University of Technology Wuhan 430070 China Department of Neurosurgery Qilu Hospital Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science Shandong University Jinan 250012 China Department of Interventional Oncology Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences Hangzhou 310022 China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials Jiangsu National Synergetic Innovation Centre for Advanced Materials Nanjing University of Posts and Telecommunications Nanjing 210023 China

The poor prognosis of patients with glioblastoma (GBM) is primarily attributed to highly aggressive residual microtumors left after surgery, with nearly all patients experiencing recurrence within the narrow margins of the initially resected lesion. Effective GBM treatment necessitates both precise intraoperative guidance and effective postoperative adjuvant therapy. Here, a multifunctional nanoplatform is reported for SERS-guided GBM resection (S), photothermal therapy (P), and immunotherapy (IT) in one, namely SPIT probes. The SPIT probe comprises an AuNS core, a Raman reporter layer, and genetically overexpressed SIRPα variants derived from macrophage membranes. It exhibits a robust and unique Raman signal, enabling precise intraoperative tumor resection. After surgical resection, its photothermal effect facilitates the ablation of residual microtumor foci. Furthermore, the overexpression of SIRPα variants on the macrophage membrane effectively blocks the CD47-SIRPα pathway, enhancing macrophage-mediated tumor cell phagocytosis. In combination with photothermal therapy, this approach amplifies the antitumor immune response. Experimental results demonstrate that this combination therapy achieves superior antitumor efficacy in an in situ GBM model, significantly suppressing tumor recurrence and extending the median survival time of mice by more than two fold. This all-in-one multifunctional nanotheranostic platform holds great promise for improving GBM treatment outcomes and effectively preventing tumor recurrence. © 2025 Wiley-VCH GmbH.

关键词： cancer immunotherapy CD47/SIRPα glioblastoma nanoparticles photothermal therapy surface enhanced Raman scattering

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Interfacially stable MOF nanosheet membrane with tailored nanochannels for ultrafast and thermo-responsive nanofiltration

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Nano Research 2020年第11期13卷 2973-2978页

作者： Wei Jia Baohu Wu Shengtong Sun Peiyi Wu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyCenter for Advanced Low-dimension MaterialsDonghua UniversityShanghai201620China State Key Laboratory of Macromolecular Engineering of Polymers Department of Macromolecular ScienceFudan University2205 Songhu RoadShanghai200433China Jülich Centre for Neutron Science(JCNS)at Heinz Maier-Leibnitz Zentrum(MLZ)Forschungszentrum Jülich Lichtenbergstr.185748GarchingGermany

Two-dimensional nanosheet membranes with responsive nanochannels are appealing for controlled mass transfer/separation,but limited by everchanging thicknesses arising from unstable ***,an interfacially stable,thermo-responsive nanosheet membrane is assembled from twin-chain stabilized metal-organic framework(MOF)nanosheets,which function via two cyclic amide-bearing polymers,thermo-responsive poly(N-vinyl caprolactam)(PVCL)for adjusting channel size,and non-responsive polyvinylpyrrolidone for supporting constant interlayer *** to the microporosity of MOF nanosheets and controllable interface wettability,the hybrid membrane demonstrates both superior separation performance and stable *** and correlation spectroscopic analyses further corroborate the respective roles of the two polymers and reveal the microenvironment changes of nanochannels are motivated by the dehydration of PVCL chains.

关键词： metal-organic framework(MOF)nanosheet membrane thermo-responsiveness molecular separation infrared(IR)spectroscopy

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Monodomain Liquid Crystals of Two-Dimensional Sheets by Boundary-Free Sheargraphy

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Nano-Micro Letters 2022年第12期14卷 14-26页

作者： Min Cao Senping Liu Qingli Zhu Ya Wang Jingyu Ma Zeshen Li Dan Chang Enhui Zhu Xin Ming Yingjun Liu Yanqiu Jiang Zhen Xu Chao Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang ProvinceZhejiang University38 Zheda RoadHangzhou 310027People’s Republic of China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering TaiyuanPeople’s Republic of China State Key Lab of Chemical Engineering College of Chemical and Biological EngineeringZhejiang University38 Zheda RoadHangzhou 310027People’s Republic of China

Eliminating topological defects to achieve monodomain liquid crystals is highly significant for the fundamental studies of soft matter and building long-range ordered ***,liquid crystals are metastable and sensitive to external stimuli,such as flow,confinement,and electromagnetic fields,which cause their intrinsic polycrystallinity and topological ***,we achieve the monodomain liquid crystals of graphene oxide over 30 cm through boundary-free *** obtained monodomain liquid crystals exhibit large-area uniform alignment of sheets,which has the same optical polarized angle and *** monodomain liquid crystals provide bidirectionally ordered skeletons,which can be applied as lightweight thermal management materials with bidirectionally high thermal and electrical ***,we extend the controllable topology of two-dimensional colloids by introducing singularities and disclinations in monodomain liquid *** structures with defect strength from−2 to+2 were *** work provides a facile methodology to study the structural order of soft matter at a macroscopic level,facilitating the fabrication of metamaterials with tunable and highly anisotropic architectures.

关键词： Monodomain Liquid crystals Graphene oxide Boundary-free sheargraphy Topological structure

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The crystal structure of YBa2Cu306, thee = 1 phase of the superconductor YBa2Cu307 _ x

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Journal of Materials Research 1987年第4期2卷 424-426页

作者： Swinnea, J.S. Steinfink, H. Materials Science and Engineering Program Department of Chemical Engineering The University of Texas at Austin Austin Texas 78712 United States

Black crystals, displaying a micaceous habit, result from heating the 90 K superconducting phase YBa2Cu307_;above 1050 °C. The crystals are tetragonal, PA/mmm, a = 3.863 (2) A, c — 11.830 (4) A, Z= 1, yOcai — 6.115 g/cm3. The 184 independent single-crystal reflections were used to refine the structure by least squares to R — 0.0374, wR — 0.0347. The structure contains Cu+in twofold coordination and corrugated layers of Cu2+— O. The Ba2+is in eightfold coordination between the Cu+and Cu2+layers and Y is in eightfold coordination between the Cu2+layers. © 1987, Materials Research Society. All rights reserved.

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Porphyrin-Grafted Poly(ethylene terephthalate) as a Reusable and Highly Selective Colorimetric Probe for Mercuric Ion Contaminants in Aqueous Samples

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ACS Applied Materials and Interfaces 2024年第30期16卷 39195-39205页

作者： Atayde, Eduardo C. Takenaka, Yasumasa Abe, Hideki Wu, Ming-Rou Wu, Kevin C.-W. Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Department of Chemistry National Tsing Hua University Department of Chemical Engineering National Taiwan University Bioplastic Research Team RIKEN Center for Sustainable Resource Science Department of Chemical Engineering and Materials Science Yuan Ze University Department of Chemical Engineering Chung Yuan Christian University

Heavy metals are the most hazardous water pollutants, with severe health and environmental consequences. Among these, mercuric (Hg2+) ions are known to cause detrimental health issues in both humans and aquatic life. ... 详细信息

Heavy metals are the most hazardous water pollutants, with severe health and environmental consequences. Among these, mercuric (Hg²⁺) ions are known to cause detrimental health issues in both humans and aquatic life. Due to this, several analytical techniques have been devised to detect and quantify the amount of this ion. However, most of these require advanced instrumentation, prolonged analysis time, and sample preparation. In this study, a low-cost and highly reusable colorimetric probe was developed by grafting porphyrin to poly(ethylene terephthalate) sheets using an oxazoline polymer as covalent adhesive. Upon exposure to trace amounts of Hg²⁺ in solution, the fabricated material visually transitioned from faint brownish pink to green by the complexation mechanism. Additionally, the transparency of this probe allowed the quantitative spectrophotometric determination of the Hg²⁺ concentration in aqueous samples. It was also shown that the material is highly stable, which can be reused for more than 50 times without significant decline in its performance, hence, making it suitable for the onsite monitoring of mercuric ion contamination in different bodies of water. © 2024 The Authors. Published by American chemical Society.

关键词： colorimetric probe mercuric ion oxazoline PET porphyrin

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High-Yield Assembly of Plasmon-Coupled Nanodiamonds via DNA Origami for Tailored Emission

arXiv

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arXiv 2025年

作者： Čopák, Jakub Hansen, Niklas Kindermann, Marek Roesel, David Scollo, Federica Bald, Ilko Cigler, Petr Petráková, Vladimíra J. Heyrovský Institute of Physical Chemistry Czech Academy of Sciences Dolejškova 3 Prague182 23 Czech Republic Institute of Chemistry and Biochemistry Czech Academy of Sciences Flemingovo naměstí 542/2 Prague160 00 Czech Republic Department of Physical Chemistry Faculty of Chemical Engineering University of Chemistry and Technology Technická 5 Prague 6166 28 Czech Republic Department of Physical and Macromolecular Chemistry Faculty of Science Charles University Hlavova 2030/8 Prague 2128 40 Czech Republic Faculty of Biomedical Engineering Czech Technical University Naměstí Sítná 3105 Kladno 227201 Czech Republic Institut für Chemie Universität Potsdam Karl-Liebknecht-Straße 24-25 Potsdam14476 Germany

Controlling the spatial arrangement of optically active elements is crucial for the advancement of engineered photonic systems. Color centers in nanodiamond offer unique advantages for quantum sensing and information processing;however, their integration into complex optical architectures is limited by challenges in precise and reproducible positioning, as well as efficient coupling. DNA origami provides an elegant solution, as demonstrated by recent studies showcasing nanoscale positioning of fluorescent nanodiamonds and plasmonic gold nanoparticles. Here, we present a scalable and robust method for covalently functionalizing nanodiamonds with DNA, enabling high-yield, spatially controlled assembly of diamond and gold nanoparticles onto DNA origami. By precisely controlling the interparticle spacing, we reveal distance-dependent modulation of NV center photoluminescence with a 10-fold increase in the fastest decay pathway at short interparticle distances. Our findings indicate selective plasmon-driven effects and interplay between radiative and non-radiative processes. This work overcomes key limitations in current nanodiamond assembly strategies and provides insights into engineering NV photoluminescence by plasmonic coupling that advance toward quantum photonic and sensing applications. © 2025, CC BY.

关键词： Nanodiamonds

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Influence of Water on Zinc Metal-Organic Framework Formation Kinetics

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Crystal Growth and Design 2025年

作者： Wright, Keenan R. Donovan, Julia C. Peterson, Evelyn C. Matzger, Adam J. Department of Chemistry University of Michigan 930 North University Avenue Ann Arbor 48109-1055 MI United States Macromolecular Science and Engineering Program University of Michigan 930 North University Avenue Ann Arbor 48109-1055 MI United States

The role of water concentration, arising primarily from the metal salt and solvent, on the induction time for the solid appearance is investigated for three zinc-based metal-organic frameworks (MOFs). Precursor solutions containing higher levels of water lead to faster induction times. This is observed regardless of the particular phase formed, pointing to a common mechanism for driving supersaturation: solvent hydrolysis. The ultimate phase that arises depends on both water content and counterion employed. © 2025 American chemical Society.

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Self-assembled Conformations of a Core-shell Comb-like Chain with Adjustable Architectural Parameters

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Chinese Journal of Polymer science 2023年第9期41卷 1439-1446,I0008页

作者： Huan-Li Qi Heng-Wei Zhou Chao Duan Wei-Hua Li Ming-Ming Ding Xinjiang Laboratory of Phase Transitions and Microstructures in Condensed Matter Physics College of Physical Science and TechnologyYili Normal UniversityYining835000China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou510006China

Combining Brownian dynamics simulations and self-consistent field theory,we demonstrate that the architectural parameters of coreshell comb-like chains have a decisive influence on their final self-assembled *** the ratio of hydrophilic and hydrophobic segments is N_(g,g)∶N_(g,r)=3∶1,no core-shell structure is observed,and unsegregated chains or clusters are *** N_(g,g)∶N_(g,r)=3∶2or 3∶3,the core-shell comb-like chains can be assembled into single micelles or structures where several small micelles are strung together by the backbone,which is similar to the pearl-necklace structure formed by the polyelectrolytes in poor *** the increase of backbone length or grafting density,the probability of forming single micelles becomes lower,but the structures of two,three or more small micelles strung together are more *** results indicate how to obtain the desired self-assembled structures of core-shell comb-like chains by regulating the architectural parameters,which could provide insights for the optimization of molecular design in various applications.

关键词： Comb-like polymer Self-assembled conformations Brownian dynamics simulations

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Tuning desolvation kinetics of in-situ weakly solvating polyacetal electrolytes for dendrite-free lithium metal batteries

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Journal of Energy Chemistry 2023年第4期79卷 340-347页

作者： Peng Wen Yimin Liu Jinyan Mao Xiaotong Liu Weiping Li Yang Ren Yang Zhou Fei Shao Mao Chen Jun Lin Xinrong Lin Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education and Yunnan ProvinceSchool of Chemical Science and TechnologyYunnan UniversityKunming 650091YunnanChina State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China

The host structure of polymers significantly influences ion transport and interfacial stability of electrolytes,dictating battery cycle life and safety for solid-state lithium metal *** promising properties of ethylene oxide-based electrolytes,their typical clamp-like coordination geometry leads to crowd solvation sheath and overly strong interactions between Li^(+)and electrolytes,rendering difficult dissociation of Li+and unfavorable solid electrolyte interface(SEI).Herein,we explore weakly solvating characteristics of polyacetal electrolytes owing to their alternately changing intervals between–O–coordinating sites in the main *** structural asymmetry leads to unique distorted helical solvation sheath,and can effectively reduce Li^(+)-electrolyte binding and tune Li^(+)desolvation kinetics in the insitu formed polymer electrolytes,yielding anion-derived SEI and dendrite-free Li *** with photoinitiated cationic ring-opening polymerization,polyacetal electrolytes can be instantly formed within 5 min at the surface of electrode,with high segmental chain motion and well adapted *** in-situ polyacetal electrolytes enabled more than 1300-h of stable lithium electrodeposition and prolonged cyclability over 200 cycles in solid-state batteries at ambient temperatures,demonstrating the vital role of molecular structure in changing solvating behavior and Li deposition stability for high-performance electrolytes.

关键词： Polymer electrolyte In-situ photoinitiated polymerization Weakly solvating effect Polyacetal Lithium electrodeposition

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Operando surface science methodology reveals surface effect in charge storage electrodes

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National science Review 2021年第3期8卷 70-77页

作者： Chao Wang Yanxiao Ning Haibo Huang Shiwen Li Chuanhai Xiao Qi Chen Li Peng Shuainan Guo Yifan Li Conghui Liu Zhong-Shuai Wu Xianfeng Li Liwei Chen Chao Gao Chuan Wu Qiang Fu State Key Laboratory of Catalysis iChEMDalian Institute of Chemical PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science &Engineering Beijing Institute of Technology

Surface and interface play critical roles in energy storage devices,calling for operando characterization techniques to probe the electrified surfaces/*** this work,surface science methodology,including electron spectroscopy and scanning probe microscopy,has been successfully applied to visualize electrochemical processes at operating electrode surfaces in an Al/graphite model *** of anions together with cations is directly observed in the surface region of a graphite electrode with tens of nanometers thickness,the concentration of which is one order higher than that in *** intercalation pseudocapacitance mechanism and a double specific capacity in the electrode surface region are expected based on the super-dense intercalants and anion/cation co-intercalation,which are in sharp contrast to the battery-like mechanism in the electrode *** distinct electrochemical mechanism at the electrode surface is verified by performance tests of real battery devices,showing that a surface-dominant,nanometer-thick graphite cathode outperforms a bulk-dominant,micrometer-thick graphite *** findings highlight the important surface effect of working electrodes in charge storage systems.

关键词： surface science methodology aluminum ion battery operando characterization surface effect

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