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Communications biology 2021年第1期4卷 533页

作者： Yuanhui Song Hitoshi Uchida Azmeer Sharipol Lindsay Piraino Jared A Mereness Matthew H Ingalls Jonathan Rebhahn Shawn D Newlands Lisa A DeLouise Catherine E Ovitt Danielle S W Benoit Department of Biomedical Engineering University of Rochester Rochester NY USA. Center for Oral Biology University of Rochester Medical Center Rochester NY USA. Department of Biomedical Genetics University of Rochester Medical Center Rochester NY USA. Department of Dermatology University of Rochester Medical Center Rochester NY USA. Department of Environmental Medicine University of Rochester Medical Center Rochester NY USA. David H. Smith Center for Vaccine Biology and Immunology University of Rochester Medical Center Rochester NY USA. Department of Otolaryngology University of Rochester Medical Center Rochester NY USA. Wilmot Cancer Institute University of Rochester Medical Center Rochester NY USA. Department of Neuroscience University of Rochester Medical Center Rochester NY USA. Materials Science Program University of Rochester Rochester NY USA. Department of Biomedical Engineering University of Rochester Rochester NY USA. benoit@bme.rochester.edu. Center for Oral Biology University of Rochester Medical Center Rochester NY USA. benoit@bme.rochester.edu. Department of Biomedical Genetics University of Rochester Medical Center Rochester NY USA. benoit@bme.rochester.edu. Department of Environmental Medicine University of Rochester Medical Center Rochester NY USA. benoit@bme.rochester.edu. Wilmot Cancer Institute University of Rochester Medical Center Rochester NY USA. benoit@bme.rochester.edu. Materials Science Program University of Rochester Rochester NY USA. benoit@bme.rochester.edu. Department of Chemical Engineering University of Rochester Rochester NY USA. benoit@bme.rochester.edu. Center for Musculoskeletal Research University of Rochester Medical Center Rochester NY USA. benoit@bme.rochester.edu.

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Synergistic Catalysis by Brønsted Acid/Carbodicarbene Mimicking Frustrated Lewis Pair-Like Reactivity

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Angewandte Chemie 2021年第36期133卷

作者： Yi-Chen Chan Yuna Bai Dr. Wen-Ching Chen Prof. Hsing-Yin Chen Chen-Yu Li Dr. Ying-Yann Wu Dr. Mei-Chun Tseng Glenn P. A. Yap Prof. Lili Zhao Prof. Hsuan-Ying Chen Prof. Tiow-Gan Ong Institute of Chemistry Academia Sinica Taipei Taiwan R.O.C. Department of Applied Chemistry National Yang Ming Chiao Tung University Hsinchu Taiwan R.O.C. Taiwan International Graduate Program (TIGP) Sustainable Chemical Science and Technology (SCST) Academia Sinica Taipei Taiwan R.O.C. Institute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University Nanjing China Department of Medicinal and Applied Chemistry Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung 80708 Taiwan R.O.C. The Department of Chemistry and Biochemistry University of Delaware Newark DE USA Department of Medicinal Research Kaohsiung Medical University Hospital Kaohsiung 80708 Taiwan R.O.C. Department of Chemistry National (Taiwan) University Taipei Taiwan R.O.C.

Carbodicarbene (CDC), unique carbenic entities bearing two lone pairs of electrons are well-known for their strong Lewis basicity. We demonstrate herein, upon introducing a weak Brønsted acid benzyl alcohol (BnOH) as a co-modulator, CDC is remolded into a Frustrated Lewis Pair (FLP)-like reactivity. DFT calculation and experimental evidence show BnOH loosely interacting with the binding pocket of CDC via H-bonding and π-π stacking. Four distinct reactions in nature were deployed to demonstrate the viability of proof-of-concept as synergistic FLP/Modulator (CDC/BnOH), demonstrating enhanced catalytic reactivity in cyclotrimerization of isocyanate, polymerization process for L -lactide (LA), methyl methacrylate (MMA) and dehydrosilylation of alcohols. Importantly, the catalytic reactivity of carbodicarbene is uniquely distinct from conventional NHC which relies on only single chemical feature of nucleophilicity. This finding also provides a new spin in diversifying FLP reactivity with co-modulator or co-catalyst.

关键词： benzyl alcohol BnOH carbodicarbene frustrated Lewis pair

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Cellulose microcrystalline: A promising ecofriendly approach to control Culex quinquefasciatus larvae

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The science of the total environment 2023年 901卷 165952页

作者： Sindoval Silva de Souza Alex Rodrigues Gomes Abraão Tiago Batista Guimarães Aline Sueli de Lima Rodrigues Letícia Paiva de Matos Juliana Dos Santos Mendonça Thiarlen Marinho da Luz Stênio Gonçalves da Silva Matos M Safiur Rahman Chinnasamy Ragavendran Sengottayan Senthil-Nathan Ajay Guru Md Refat Jahan Rakib Nabisab Mujawar Mubarak Md Mostafizur Rahman Thiago Lopes Rocha Abu Reza Md Towfiqul Islam Guilherme Malafaia Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil Laboratory of Toxicology Applied to the Environment Goiano Federal Institute - Urutaí Campus. Rodovia Geraldo Silva Nascimento 25 km Zona Rural Urutaí GO Brazil. Laboratory of Toxicology Applied to the Environment Goiano Federal Institute - Urutaí Campus. Rodovia Geraldo Silva Nascimento 25 km Zona Rural Urutaí GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil. Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil. Department of Environmental Science and Disaster Management Noakhali Science and Technology University Noakhali 3814 Bangladesh. Saveetha Dental College and Hospitals (SIMATS) Saveetha University Chennai Tamil Nadu India. Division of Biopesticides and Environmental Toxicology Sri Paramakalyani Centre for Excellence in Environmental Sciences Manonmaniam Sundaranar University Alwarkurichi Tirunelveli Tamil Nadu 627 412 India. Department of Cariology Saveetha Dental College and Hospitals SIMATS Chennai 600 077 Tamil Nadu India. Noakhali Science and Technology University Noakhali Bangladesh. Petroleum and Chemical Engineering Faculty of Engineering Universiti Teknologi Brunei Bandar Seri Begawan BE1410 Brunei Darussalam Department of Biosciences Saveetha School of Engineering Saveetha institute of Medical and Technical Sciences Chennai India. Jahangirnagar University Dhaka-1342 Bangladesh. Laboratory of Environmental Biotechnology and Ecotoxicology Institute of Tropical Pathology and Public Health Federal University of Goiás Goiânia Goiás Brazil. Department of Disaster Management Begum Rokeya University Rangpur 5400 Bangladesh. Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Conservation of Cerrado Natural

The growing use of synthetic chemical compounds/substances in vector control of mosquitoes, associated with their adverse effects on the environment and non-target organisms, has demanded the development of eco-friendly alternatives. In this context, this study aimed to evaluate the larvicidal action of different cellulose microcrystalline (CMs) concentrations and investigate their toxicity mechanisms in Culex quinquefasciatus fourth instar larvae as a model species. Probit analysis revealed that the median lethal concentrations (LC) for 24 h and 36 h exposure were 100 and 58.29 mg/L, respectively. We also showed that such concentrations induced a redox imbalance in the larvae, marked by an increase in the production of reactive oxygen species (ROS) and thiobarbituric acid reactive substances (TBARS), as well as a reduction in the activity of superoxide dismutase (SOD) and catalase (CAT). Furthermore, different alterations in the external morphology of the larvae were associated with the ingestion of CMs. On the other hand, exposure of adult zebrafish (Danio rerio) to LC24h and LC36h for seven days did not induce any behavioral changes or alterations mutagenic, genotoxic, biochemical, or in the production of cytokines IFN-γ and IL-10. Thus, taken together, our study demonstrates for the first time that the use of CMs can constitute a promising strategy in the control of C. quinquefasciatus larvae, combining insecticidal efficiency with an "eco-friendly" approach in the fight against an important mosquito vector of several human diseases.

关键词： Eco-friendly particles Ecotoxicity Larvicide assay Mosquitoes Vector control Zebrafish

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LST-1 observations of an enormous flare of BL Lacertae in 2021

arXiv

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arXiv 2023年

作者： Nozaki, Seiya Asano, Katsuaki Escudero, Juan Emery, Gabriel Priyadarshi, Chaitanya Abe, K. Abe, S. Aguasca-Cabot, A. Agudo, I. Crespo, N. Alvarez Antonelli, L.A. Aramo, C. Arbet-Engels, A. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baktash, A. Bamba, A. Larriva, A. Baquero Baroncelli, L. de Almeida, U. Barres Barrio, J.A. Batkovic, I. Baxter, J. González, J. Becerra Bernardini, E. Bernardos, M.I. Medrano, J. Bernete Berti, A. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Carrasco, M.S. Cassol, F. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. Dazzi, F. De Angelis, A. de Lavergne, M. de Bony De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delgado, C. Mengual, J. Delgado della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Ramazani, V. Fallah Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Coromina, L. Freixas Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. López, R. Garcia Gasbarra, C. Gasparrini, D. Geyer, D. Paiva, J. Giesbrecht Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Llorente, J. Herrera Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Ioka, K. Iori, M. Ishio, K. Martinez, I. Jimenez Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lainez, M. Lamanna, G. Lamastra, A. Le Flour, T. Linhoff, M. Longo, F. López-Coto, R. Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Chiba Kashiwa277-8582 Japan Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Aix Marseille Univ CNRS IN2P3 CPPM Marseille France The Barcelona Institute of Science and Technology Campus UAB Bellaterra Barcelona08193 Spain Department of Physics Tokai University Japan Institute for Cosmic Ray Research University of Tokyo Japan Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy Max-Planck-Institut für Physik Germany INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Spain LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain CIEMAT Spain Department of Physics TU Dortmund University Germany INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy INFN Sezione di Trieste Università degli Studi di Udine Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari Università di Bari Italy INFN Sezione di Torino Italy Palacky University Olomouc Faculty of Science Czech Republic University of Alcalá UAH Spain P

The first prototype of LST (LST-1) for the Cherenkov Telescope Array has been in commissioning phase since 2018 and already started scientific observations with the low energy threshold around a few tens of GeV. In 2021, LST-1 observed BL Lac following the alerts based on multi-wavelength observations and detected prominent gamma-ray flares. In addition to the daily flux variability, LST-1 also detected sub-hour-scale intra-night variability reaching 3–4 times higher than the gamma-ray flux from the Crab Nebula above 100 GeV. In this proceeding, we will report the analysis results of LST-1 observations of BL Lac in 2021, especially focusing on flux variability. © 2023, CC BY.

关键词： Gamma rays

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Water-Vapor Responsive Metallo-Peptide Nanofibers

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Angewandte Chemie 2024年第47期136卷

作者： Avishek Dey Elma Naranjo Ranajit Saha Sheng Zhang Maya Narayanan Nair Tai-De Li Xi Chen Rein V. Ulijn Nanoscience Initiative at Advanced Science Research Center of the Graduate Center of the City University of New York New York New York 10031 USA Department of Chemical Engineering The City College of New York 275 Convent Ave New York NY 10031 USA Department of Chemistry Cooch Behar Panchanan Barma University Cooch Behar West Bengal 736101 India Department of Physics City College of New York of City University of New York New York NY 10031 USA Ph.D. Program in Physics The Graduate Center of the City University of New York 365 5th Ave New York NY 10016 USA Ph.D. Program in Chemistry The Graduate Center of the City University of New York 365 5th Ave New York NY 10016 USA Department of Chemistry Hunter College City University of New York New York New York 10065 USA Ph.D. Program in Biochemistry The Graduate Center of the City University of New York 365 5th Ave New York NY 10016 USA

Short peptides are versatile molecules for the construction of supramolecular materials. Most reported peptide materials are hydrophobic, stiff, and show limited response to environmental conditions in the solid-state. Herein, we describe a design strategy for minimalistic supramolecular metallo-peptide nanofibers that, depending on their sequence, change stiffness, or reversibly assemble in the solid-state, in response to changes in relative humidity (RH). We tested a series of histidine (H) containing dipeptides with varying hydrophobicity, XH, where X is G, A, L, Y (glycine, alanine, leucine, and tyrosine). The one-dimensional fiber formation is supported by metal coordination and dynamic H-bonds. Solvent conditions were identified where GH/Zn and AH/Zn formed gels that upon air-drying gave rise to nanofibers. Upon exposure of the nanofiber networks to increasing RH, a reduction in stiffness was observed with GH/Zn fibers reversibly (dis-)assembled at 60–70 % RH driven by a rebalancing of hydrogen bonding interactions between peptides and water. When these metallo-peptide nanofibers were deposited on the surface of polyimide films and exposed to varying RH, peptide/water-vapor interactions in the solid-state mechanically transferred to the polymer film, leading to the rapid and reversible folding-unfolding of the films, thus demonstrating RH-responsive actuation.

关键词： Metallopeptide Actuation Humidity Responsive Assembly-disassembly Water Vapor Responsive

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Retraction notice to "Toxicity assessment of SARS-CoV-2-derived peptides in combination with a mix of pollutants on zebrafish adults: A perspective study of behavioral, biometric, mutagenic, and biochemical toxicity" [Sci. Total Environ. 858 Part 2 (2023) 159838]

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The science of the total environment 2024年 957卷 177710页

作者： Ítalo Nascimento Freitas Amanda Vieira Dourado Amanda Pereira da Costa Araújo Sindoval Silva de Souza Thiarlen Marinho da Luz Abraão Tiago Batista Guimarães Alex Rodrigues Gomes Abu Reza Md Towfiqul Islam Md Mostafizur Rahman Andrés Hugo Arias Davoodbasha Mubarak Ali Chinnasamy Ragavendran Chinnaperumal Kamaraj Guilherme Malafaia Laboratory of Toxicology Applied to the Environment Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil. Laboratory of Toxicology Applied to the Environment Goiano Federal Institute Urutaí GO Brazil. Post-Graduation Program in Environmental Sciences Federal University of Goiás Goiânia GO Brazil. Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil. Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil. Begum Rokeya University Department of Disaster Management Rangpur 5404 Bangladesh. Laboratory of Environmental Health and Ecotoxicology Department of Environmental Sciences Jahangirnagar University Dhaka 1342 Bangladesh. Instituto Argentino de Oceanografía (IADO) Universidad Nacional del Sur (UNS)-CONICET Florida 8000 Complejo CCT CONICET Bahía Blanca Edificio E1 B8000BFW Bahía Blanca Argentina. Petroleum and Chemical Engineering Faculty of Engineering Universiti Teknologi Brunei Bandar Seri Begawan BE1410 Brunei Darussalam. Department of Conservative Dentistry and Endodontics Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai India. Interdisciplinary Institute of Indian System of Medicine (IIISM) Directorate of Research and Virtual Education SRM Institute of Science and Technology (SRMIST) Kattankulathur 603203 Tamil Nadu India. Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil

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Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

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Nature communications 2018年第1期9卷 1112页

作者： Michael H Berry Amy Holt Joshua Levitz Johannes Broichhagen Benjamin M Gaub Meike Visel Cherise Stanley Krishan Aghi Yang Joon Kim Kevin Cao Richard H Kramer Dirk Trauner John Flannery Ehud Y Isacoff Department of Molecular and Cell Biology University of California Berkeley CA 94720 USA. Department of Medicine Oregon Health and Science University Portland OR 97239 USA. Department of Biochemistry Weill Cornell Medical College New York City New York 10024 USA. Department of Chemistry Ludwig-Maximilians-Universität München and Munich Center for Integrated Protein Science Butenandtstrasse 5-13 81377 München Germany. Laboratory of Protein Engineering Institut des Sciences et Ingénierie Chimiques Sciences de Base École Polytechnique Fédérale Lausanne 1015 Lausanne Switzerland. Department of Chemical Biology Max-Planck Institute for Medical Research Jahnstr. 29 69120 Heidelberg Germany. Department of Biosystems Science Engineering ETH Zürich Mattenstrasse 26 4058 Basel Switzerland. Helen Wills Neuroscience Institute University of California Berkeley CA 94720 USA. Biophysics Graduate Program University of California Berkeley CA 94720 USA. Department of Chemistry New York University New York City New York 10003 USA. School of Optometry University of California Berkeley CA 94720 USA. Department of Molecular and Cell Biology University of California Berkeley CA 94720 USA. ehud@berkeley.edu. Helen Wills Neuroscience Institute University of California Berkeley CA 94720 USA. ehud@berkeley.edu. Biophysics Graduate Program University of California Berkeley CA 94720 USA. ehud@berkeley.edu. Bioscience Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA. ehud@berkeley.edu.

Kevin J. Cao and Richard H. Kramer, who developed extended release with beta cyclodextrin, were inadvertently omitted from the author list and author contributions section of this Article. These errors have now been c...

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Macromol. Biosci. 2/2011

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macromolecular Bioscience 2011年第2期11卷

作者： Tomohiro Hiraishi Eriko Masuda Daisuke Miyamoto Naoki Kanayama Hideki Abe Mizuo Maeda Bioengineering Laboratory RIKEN Advanced Science Institute 2‐1 Hirosawa Wako‐shi Saitama 351‐0198 Japan Department of Innovative and Engineered Materials Tokyo Institute of Technology 4259 Nagatsuta Midori‐ku Yokohama Kanagawa 226‐8502 Japan Present address: Asahi Kasei Medical Co. Ltd. 6‐2700 Asahi‐cho Nobeoka‐shi Miyazaki 882‐0847 Japan Present address: Graduate School of Pure and Applied Science University of Tsukuba 1‐1‐1 Ten‐noudai Tsukuba‐shi Ibaraki 305‐8573 Japan Chemical Analysis Team RIKEN Advanced Science Institute 2‐1 Hirosawa Wako‐shi Saitama 351‐0198 Japan Present address: Bioplastic Research Team Biomass Utilization Research Group RIKEN Biomass Engineering Program 2‐1 Hirosawa Wako‐shi Saitama 351‐0198 Japan

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Toxicity assessment of SARS-CoV-2-derived peptides in combination with a mix of pollutants on zebrafish adults: A perspective study of behavioral, biometric, mutagenic, and biochemical toxicity

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The science of the total environment 2023年第PT 2期858卷 159838页

The dispersion of SARS-CoV-2 in aquatic environments via the discharge of domestic and hospital sewage has been confirmed in different locations. Thus, we aimed to evaluate the possible impacts of zebrafish (Danio rerio) exposure to SARS-CoV-2 peptide fragments (PSPD-2001, 2002, and 2003) alone and combined with a mix of emerging pollutants. Our data did not reveal the induction of behavioral, biometric, or mutagenic changes. But we noticed an organ-dependent biochemical response. While nitric oxide and malondialdehyde production in the brain, gills, and muscle did not differ between groups, superoxide dismutase activity was reduced in the "PSPD", "Mix", and "Mix+PSPD" groups. An increase in catalase activity and a reduction in DPPH radical scavenging activity were observed in the brains of animals exposed to the treatments. However, the "Mix+PSPD" group had a higher IBRv2 value, with NO levels (brain), the reduction of acetylcholinesterase activity (muscles), and the DPPH radical scavenging activity (brain and muscles), the most discriminant factors for this group. The principal component analysis (PCA) and hierarchical clustering analysis indicated a clear separation of the "Mix+PSPD" group from the others. Thus, we conclude that exposure to viral fragments, associated with the mix of pollutants, induced more significant toxicity in zebrafish adults than in others.

关键词： Biomarkers COVID-19 Danio rerio Freshwater ecosystems Non-target organisms Novel coronavirus

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Large-scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop

Journal of Extracellular Biology

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Journal of Extracellular Biology 2022年第10期1卷 e63页

作者： Paolini, Lucia Monguió-Tortajada, Marta Costa, Marta Antenucci, Fabio Barilani, Mario Clos-Sansalvador, Marta Andrade, André Cronemberger Driedonks, Tom A. P. Giancaterino, Sara Kronstadt, Stephanie M. Mizenko, Rachel R. Nawaz, Muhammad Osteikoetxea, Xabier Pereira, Carla Shrivastava, Surya Boysen, Anders Toftegaard van de Wakker, Simonides Immanuel van Herwijnen, Martijn J. C. Wang, Xiaoqin Watson, Dionysios C. Gimona, Mario Kaparakis-Liaskos, Maria Konstantinov, Konstantin Lim, Sai Kiang Meisner-Kober, Nicole Stork, Michiel Nejsum, Peter Radeghieri, Annalisa Rohde, Eva Touzet, Nicolas Wauben, Marca H. M. Witwer, Kenneth W. Bongiovanni, Antonella Bergese, Paolo Department of Molecular and Translational Medicine University of Brescia Brescia Italy Center for Colloid and Surface Science (CSGI) Department of Chemistry University of Florence Sesto Fiorentino (FI) Italy Department of Medical and Surgical Specialties Radiological Sciences and Public Health University of Brescia Brescia Italy CREC Research Program Health Science Research Institute Germans Trias i Pujol (IGTP) Badalona Spain Heart Institute (iCor) Cardiology Department Germans Trias i Pujol University Hospital Badalona Spain iBET Instituto de Biologia Experimental e Tecnológica Oeiras Portugal Instituto de Tecnologia Química e Biológica António Xavier Universidade Nova de Lisboa Oeiras Portugal Department of Veterinary and Animal Sciences University of Copenhagen Copenhagen Denmark Laboratory of Regenerative Medicine ‒ Cell Factory Department of Transfusion Medicine and Hematology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy REMAR-IGTP Group Germans Trias i Pujol Research Institute (IGTP) & Nephrology Department University Hospital Germans Trias i Pujol (HUGTiP) Catalonia Badalona (Barcelona) Spain Department of Cell Biology Physiology and Immunology Universitat Autònoma de Barcelona (UAB) Bellaterra Spain Experimental and Clinical Cell Therapy Institute (ExCT) Spinal Cord Injury and Tissue Regeneration Center Paracelsus Medical University Salzburg Austria CDL Research University Medical Center Utrecht Utrecht University Utrecht Netherlands Department of Molecular and Comparative Pathology Johns Hopkins School of Medicine Baltimore MD United States Department of Civil Chemical Environmental and Materials Engineering Alma Mater Studiorum University of Bologna Bologna Italy Fischell Department of Bioengineering University of Maryland College Park MD United States Department of Biomedical Engineering University of California Davis CA United States Department of Rheumatology and Inflammation Research Institute of Medicine

Extracellular vesicles (EVs) large-scale production is a crucial point for the translation of EVs from discovery to application of EV-based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET-OPEN projects, “The Extracellular Vesicle Foundry” (evFOUNDRY) and “Extracellular vesicles from a natural source for tailor-made nanomaterials” (VES4US), organized a workshop entitled “massivEVs” to discuss the potential challenges for translation of EV-based products. This report gives an overview of the topics discussed during “massivEVs”, the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field. © 2022 The Authors. Journal of Extracellular Biology published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.

关键词： EV-based products extracellular vesicles ISEV workshop large-scale production manufacturing processing regulatory issues

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