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Advances in transcription factor delivery: Target selection, engineering strategies, and delivery platforms

Journal of Controlled Release 2025年 384卷 113885页

作者： Lee, Yeji Yoo, Seongkyeong Cho, Seongeon Kim, Iljin Kim, In-San KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Chemical and Biological Integrative Research Center Biomedical Research Institute Korea Institute Science and Technology Seoul02792 Korea Republic of Department of Pharmacology and Program in Biomedical Science and Engineering Inha University College of Medicine Incheon22212 Korea Republic of Research Center for Controlling Intercellular Communication Inha University College of Medicine Incheon22212 Korea Republic of

Recent advances in delivery systems for transcription factors (TFs) have opened new therapeutic opportunities in regenerative medicine, cancer therapy, and genetic disorders. However, effective TF delivery still faces substantial obstacles, including limited cellular uptake, inefficient nuclear translocation, low cargo stability, and insufficient target specificity. Furthermore, artificial TFs have enabled targeted modulation of gene expression, further expanding their therapeutic potential. This review comprehensively discusses current progress in TF delivery methodologies, including direct TF protein delivery using cell-penetrating peptides, and extracellular vesicles, as well as TF gene delivery approaches utilizing both lipid-based nanoparticles and viral strategies. Notably, engineered nanoparticles have emerged as promising platforms due to their precise control over TF delivery, improved specificity, and minimized off-target effects. Despite these significant advancements, major hurdles in delivery efficiency, cargo stability, and overall safety persist. Overcoming these obstacles will be essential to accelerate the clinical translation of TF-based therapeutics for a broad spectrum of diseases. © 2024

关键词： Transcription factors

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The Role of Applied Potential on Particle Sizing Precision in Single-Entity Blocking Electrochemistry

SSRN

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SSRN 2023年

作者： Liu, Eric Z. Popescu, Sofia Rivalta Eden, Alexander Chung, Julia Roehrich, Brian Sepunaru, Lior Department of Chemistry and Biochemistry University of California at Santa Barbara Santa BarbaraCA93106 United States Department of Chemical Engineering University of California Santa Barbara Santa BarbaraCA93106 United States Department of Mechanical Engineering University of California Santa Barbara Santa BarbaraCA93106 United States Interdepartmental Program in Biomolecular Science and Engineering University of California at Santa Barbara Santa BarbaraCA93106 United States

Blocking electrochemistry, a subfield of single-entity electrochemistry, enables in-situ sizing of redox-inactive particles. This method exploits the adsorptive impact of individual insulating particles on a microelectrode, which decreases the electrochemically active surface area of the electrode. Against the background of an electroactive redox reaction in solution, each individual impacting particle results in a discrete current drop, with the magnitude of the drop corresponding to the size of the blocking particle. One significant limitation of this technique is "edge effects", resulting from the inhomogeneous flux of the redox species’ diffusion due to increased mass transport to the edge of the disk electrode surface. "Edge effects" cause increased errors in size detection, resulting in poor analytical precision. Here, we use computational simulations to demonstrate that inhomogeneous diffusional edge flux of quasi-reversible redox species is mitigated at lowered overpotentials. This phenomenon is further illustrated experimentally by lowering the applied potential such that the system is operating under a kinetically-controlled regime instead of a diffusion-limited regime, which mitigates edge effects and increases particle sizing precision significantly. In addition, we found this method to be generalizable, as the precision enhancement is not limited to geometrically spherical particles but also occurs for cubic particles. This work presents a simple, novel methodology for edge effect mitigation with general applicability across different particle types. © 2023, The Authors. All rights reserved.

关键词： Microelectrodes

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Exploring Environmentally Friendly Corrosion Inhibitors: Insights from Natural and Biomass Residue-Derived Compounds

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SSRN 2024年

作者： Othman, Norinsan Kamil Mohammed, Naba Jasim Yusop, Muhammed Rahimi Al-Gburi, Ahmed Jamal Abdullah Materials Science Program Department of Applied Physics Faculty of Science and Technology University Kebangsaan Malaysia Selangor Bangi43600 Malaysia Faculty of Science and Technology School of Chemical Sciences and Food Technology University Kepangsaan Malaysia Selangor Bangi43600 Malaysia Faculty of Electronics and Computer Engineering Universiti Teknikal Malaysia Melaka Hang Tuah Jaya Melaka Durian Tunggal76100 Malaysia

In this investigation, we explored the corrosive effects of date palm seed extracted from natural sources and biomass residues on mild steel in a solution of 0.5 M hydrochloric acid (HCl), employing a combination of experimental and theoretical approaches. Our objective was to scrutinize the interaction of the inhibitor with the metal surface, analyze experimental data, and elucidate how the structural characteristics of the inhibitors influence the corrosion process. The experimental results indicated that as the immersion time and temperature increased, the inhibitory effectiveness declined. Notably, the highest level of inhibition occurred when the concentration of date palm seed extract (DPSE) reached 1100 ppm, showcasing peak inhibitory effects of 95.8% and 97.8% through potentiodynamic polarization and electrochemical impedance spectroscopy techniques, respectively. Additionally, an analysis using X-ray diffraction (XRD) was conducted to scrutinize the chemical composition of the mild steel's surface. The adsorption data were evaluated using adsorption isotherms, revealing that DPSE adhered to the Langmuir adsorption isotherm on the mild steel surface. The Langmuir model exhibited the highest linear regression coefficient value and a slope close to unity. The Gibbs free energy () values suggested that the protection afforded by DPSE involved physical and spontaneous absorption. Examination of the results pertaining to the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) indicated that the carboxyl (COOH) group and the C=C bond were the principal regions exhibiting elevated electron acceptance activity. These components were found to be crucial in the adsorption process on the surface of iron (Fe). © 2024, The Authors. All rights reserved.

关键词： Electrochemical impedance spectroscopy

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Evaluation of Automatic Microstructural Analysis of Energy Dispersive Spectroscopy (EDS) Maps via a Python-Based Data Processing Framework 240

Evaluation of Automatic Microstructural Analysis of Energy D...

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240th ECS Meeting

作者： Batool, Mariah O. Godoy, Andres Birnbach, Martin Dekel, Dario R Jankovic, Jasna Institute of Materials Science University of Connecticut 97 North Eagleville Road StorrsCT06269-3136 United States Department of Materials Science and Engineering University of Connecticut 97 North Eagleville Road StorrsCT06269-3136 United States Wolfson Department of Chemical Engineering Nancy and Stephen Grand Technion Energy Program Israel Institute of Technology Haifa3200003 Israel

ISBN: (纸本)9781607685395

Computer-aided data acquisition, analysis and interpretation have been employed in various research areas generating useful information. Among these, image processing is most often implemented for post-processing of material characterization data. However, to tackle ambiguity of multi-component materials analysis, spectral data analysis can be used instead. The current study introduces a unique Python-based data processing method for in-depth analysis of energy dispersive spectroscopy (EDS) elemental maps to analyze agglomerate size distribution, average area of each component and their overlap. The framework developed in this study is applied to examine interaction of Cerium (Ce) and Palladium (Pd) particles in membrane electrode assembly (MEA) of Anion-Exchange Membrane Fuel Cell (AEMFC) and investigate if this approach can be utilized to predict the fuel cell's electrochemical behavior. The study concludes that the developed framework is a promising method for automatic data extraction and can be beneficial for use in a variety of clean energy applications. © 2021 ECS - The Electrochemical Society.

关键词： Python

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Effect of Different Manufacturing Methods on Polyamide Reverse-Osmosis Membranes for Desalination: Insights from Molecular Dynamics Simulations

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SSRN 2022年

作者： He, Jinlong McCutcheon, Jeffrey R. Li, Ying Department of Mechanical Engineering University of Connecticut StorrsCT06269 United States Department of Chemical & Biomolecular Engineering Center for Environmental Sciences and Engineering University of Connecticut StorrsCT06269 United States Polymer Program Institute of Materials Science University of Connecticut StorrsCT06269 United States

The industry-leading polyamide (PA) reverse osmosis (RO) membranes can be manufactured via molecular layer-by-layer (mLBL) deposition, interfacial polymerization (IP), and 3D-printing technique. However, the influence of different manufacturing methods on PA membrane’s properties is far from understood. In this study, we present the high-pressure transport behavior of water and salt ions for PA membranes formed with IP, mLBL, and 3D-printing through non-equilibrium molecular dynamics simulations. Studies show that membranes fabricated with 3D-printing have similar performances to those manufactured using mLBL, quantified by water permeability, rejection of salt ions, structural integrity, and porosity features. However, the membranes formed with IP exhibit faster water transport, lower rejection, worse structural integrity, and more inhomogeneous network pores than those constructed using mLBL and 3D-printing. The unconnected water-accessible space governs water transport for PA membranes formed with mLBL and 3D-printing, which offers the impermanent open-closed pores that enable water to jump through PA membranes. In contrast, the permeated water-enterable space plays a prominent role in water movement across the PA membrane formed with IP, providing a continuous transport channel at high pressure. Importantly, we observe the more significant compaction features at high pressure for PA membranes formed with IP than mLBL and 3D-printing. © 2022, The Authors. All rights reserved.

关键词： Polymerization

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Cementing the grain boundary defects in the strain relaxed mixed Sn-Pb perovskite solar cells

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chemical engineering Journal 2025年 516卷

作者： Kumar, Abhishek Ansari, Zeeshan Alam Hanmandlu, Chintam Banerjee, Soumallya Chen, Yu-Te Yang, Po-Yu Musa, Ahmed Fouad You, Yun-Wen Pao, Chun-Wei Wei, Tzu-Chien Shyue, Jing-Jong Lu, Yu-Jung Chu, Chih-Wei Department of Physics National Taiwan University Sec. 4 Roosevelt Road Taipei106 Taiwan Research Center for Applied Sciences Academia Sinica 128 Academia Road Section 2 Taipei Nangang11529 Taiwan Nano-Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei106 Taiwan Department of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Chemical Engineering National Tsing Hua University 101 Section 2 Kuang-Fu Road Hsinchu City300044 Taiwan College of Engineering Center for Green Technology Chang Gung University Taoyuan City333002 Taiwan Department of Photonics National Yang Ming Chiao Tung University Hsinchu City30010 Taiwan Institute of Applied Mechanics National Taiwan University Sec. 4 Roosevelt Road Taipei106 Taiwan

Mixed Tin-lead (Sn-Pb) perovskite solar cells (PSCs) offer a promising avenue for achieving high power conversion efficiencies (PCEs) due to their narrow bandgaps and substantial optical absorption in the visible–near-infrared region. However, the disparated reaction kinetics of PbI2 and SnI2 with organic salts, resulting in an uneven spatial distribution of Sn2+ and Pb2+ within the perovskite lattice, inducing micro-strain in the film and a Sn-rich surface vulnerable to oxidation-Sn2+ to Sn4+, thereby elevating nonradiative recombination. Here, we report the incorporation of 2,5-Dibromo-3,4-pyridinediamine (DBPDA) as an additive in the mixed Sn-Pb perovskite precursor solution, designed to mitigate micro-strain formation, reduce defect density by suppressing Sn4+ formation, and enhance the passivation of undercoordinated Sn/Pb species through synergistic bonding interaction. The best performing PSCs achieved an impressive PCE of 21.24 % with a high open circuit voltage (Voc) of 0.85 V, alongside significantly improved long-term stability, retaining near 80 % of their initial PCE after 1,008 h in a nitrogen-filled glovebox without encapsulation. In contrast, the control devices retained only 18 % of their initial efficiency under identical conditions. Additionally, an enhanced field effect hole mobility, increasing from 0.18 cm2/V-s in the control film to 1.43 cm2/V-s in the target film, was achieved in mixed Sn-Pb perovskite thin film transistors (TFTs) using these films as active layers. These findings present a viable strategy for strain-relieved perovskite films, enabling stable and high-performance mixed Sn-Pb PSCs and TFTs. © 2025 Elsevier B.V.

关键词： Crystallization kinetics

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Tailoring Molecular Interaction in Heteronetwork Polymer Electrolytes for Stretchable, High-Voltage Fiber Supercapacitors

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SSRN 2022年

作者： Handayani, Puji Lestari Kim, Taehoon Song, Yeon Hwa Park, Jae Seo Yang, Seung Jae Choi, U. Hyeok Department of Polymer Science and Engineering and Program in Environmental and Polymer Engineering Inha University Incheon22212 Korea Republic of Changwon51508 Korea Republic of Department of Polymer Engineering Pukyong National University Busan48513 Korea Republic of Department of Chemistry and Chemical Engineering Education and Research Center for Smart Energy and Materials Inha University Incheon22212 Korea Republic of

Mechanically and electrochemically stable all-solid-state supercapacitors are of great interest in the field of wearable and portable electronic devices. However, when conventional liquid or gel electrolytes are used in supercapacitors, their discontinuous functions appear in harsh external environments. Here, we prepare freeze-tolerant heteronetwork nanohybrid polymer electrolytes (NPEs), composed of hydrophilic poly(lithium acrylate) (PLiA) containing mobile lithium countercations and mechanically robust silica nanoparticles (SNs) serving as stress buffers, via sol-gel reaction and radical polymerization. The combination of PLiA and SN provides NPE (PLiA-SN) with high room temperature ionic conductivity, remaining 100% even after 700% elongation, as well as exhibiting high ionic conductivity at low temperatures. The cross-linking of SNs with PLiA also gives the resultant NPE superelasticity and self-healing property. The optimized NPE is assembled with metal-organic framework derived carbon-coated CNTY hybrid electrodes to fabricate high-performance all-solid-state fiber supercapacitors (FSCs). The assembled FSC delivers a high specific capacitance, high power and energy densities, as well as a wide operating voltage window. Moreover, the electrochemical performance of the FSC is maintained under varying stretching strains and degrees of bending, and still retains capacity even at a low temperature, demonstrating excellent mechanical, thermal, and electrochemical stability. © 2022, The Authors. All rights reserved.

关键词： Supercapacitor

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Solid waste management in the paper industry 5

Solid waste management in the paper industry

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5th International Conference on Energy, Environmental and Information System, ICENIS 2020

作者： Devichi Wibowo, Isabella Purwanto, P. Suherman, S. Master Program of Environmental Science Post-Graduate Studies Universitas Diponegoro Semarang Indonesia Department of Chemical Engineering Faculty of Engineering Universitas Diponegoro Semarang Indonesia

The industry developed rapidly since the Industrial Revolution in the 18th century. The side effect of industrial development was a large amount of non-hazardous waste and hazardous waste. All of this waste must be managed properly so that environmental sustainability is maintained and does not cause harm or problems to the community. A review will be conducted from various research journals in various countries and the types of waste also vary, namely plastic, pulp and paper industry waste, and other solid waste. A comparison of solid waste management will be carried on to reduce the generation of waste in the environment. © The Authors, published by EDP sciences, 2020.

关键词： Solid wastes

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Opto-thermoelectric pulling of light-absorbing particles

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Light(science & Applications) 2020年第1期9卷 1686-1696页

作者： Linhan Lin Pavana Siddhartha Kollipara Abhay Kotnala Taizhi Jiang Yaoran Liu Xiaolei Peng Brian A.Korgel Yuebing Zheng Walker Department of Mechanical Engineering The University of Texas at AustinAustinTX 78712USA Materials Science&Engineering Program and Texas Materials Institute The University of Texas at AustinAustinTX 78712USA State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084People’s Republic of China McKetta Department of Chemical Engineering The University of Texas at AustinAustinTX 78712USA Department of Electrical and Computer Engineering The University of Texas at AustinAustinTX 78712USA

Optomechanics arises from the photon momentum and its exchange with low-dimensional *** is well known that optical radiation exerts pressure on objects,pushing them along the light ***,optical pulling of an object against the light path is still a counter-intuitive ***,we present a general concept of optical pulling-opto-thermoelectric pulling(OTEP)—where the optical heating of a light-absorbing particle using a simple plane wave can pull the particle itself against the light *** irradiation orientation-directed pulling force imparts self-restoring behaviour to the particles,and three-dimensional(3D)trapping of single particles is achieved at an extremely low optical intensity of 10^(−2)mWμm^(−2).Moreover,the OTEP force can overcome the short trapping range of conventional optical tweezers and optically drive the particle flow up to a macroscopic *** concept of selfinduced opto-thermomechanical coupling is paving the way towards freeform optofluidic technology and lab-on-achip devices.

关键词： absorbing light trapping

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Changes in fluoride removal ability of chicken bone char with changes in calcination time

International Journal of Ceramic Engineering and Science

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International Journal of Ceramic engineering and science 2020年第2期2卷 83-91页

作者： Kikuchi, Masanori Arioka, Yuki Tafu, Masamoto Irie, Mitsuteru Bioceramics Group National Institute for Materials Science Tsukuba Japan Master's Program in Life Science Innovation University of Tsukuba Tsukuba Japan Department of Applied Chemistry and Chemical Engineering Toyama College National Institute of Technology Toyama Japan Faculty of Engineering University of Miyazaki Miyazaki Japan

Changes in fluoride removal ability of chicken bone char (CBC) were investigated by both remained amounts of carbon including organic substances and crystallite size of hydroxyapatite in the CBC. Carbon contents in CBC were controlled by heating time at 600°C. Although temperature for crystal-grain growth for HAp, 650°C, was higher than 600°C, crystallite size of HAp in CBC increased with heating time. Fluoride ion removal ability positively related to the amount of remaining carbon and negatively related to the square of crystallite size, as an index of surface area, of HAp. These results suggested that fluoride ion removal from water by CBC is not only by ion exchange and/or dissolution-precipitation process, but also by adsorption by carbon and/or temporal capture of fluoride ion by microstructure of carbonate in CBC before immobilize it in apatite structure. © 2019 The Authors. International Journal of Ceramic engineering & science published by Wiley Periodicals, Inc. on behalf of American Ceramic Society.

关键词： Crystallite size

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