检索结果-内蒙古大学图书馆

Spatiotemporal multi-omics:exploring molecular landscapes in aging and regenerative medicine

Military Medical Research 2025年第4期12卷 528-566页

作者： Liu-Xi Chu Wen-Jia Wang Xin-Pei Gu Ping Wu Chen Gao Quan Zhang Jia Wu Da-Wei Jiang Jun-Qing Huang Xin-Wang Ying Jia-Men Shen Yi Jiang Li-Hua Luo Jun-Peng Xu Yi-Bo Ying Hao-Man Chen Ao Fang Zun-Yong Feng Shu-Hong An Xiao-Kun Li Zhou-Guang Wang Affiliated Cixi Hospital Wenzhou Medical UniversityNingbo 315300ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina National Key Laboratory of Macromolecular Drug Development and Manufacturing School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina State Key Laboratory of Bioelectronics School of Biological Science&Medical EngineeringSoutheast UniversityNanjing 210096China School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug ScreeningSouthern Medical UniversityGuangzhou 510515China Department of Human Anatomy Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271000ShandongChina Integrative Muscle Biology Laboratory Division of Regenerative and Rehabilitative SciencesUniversity of Tennessee Health Science CenterMemphisTN 38163United States Key Laboratory for Laboratory Medicine Ministry of EducationZhejiang Provincial Key Laboratory of Medical GeneticsSchool of Laboratory Medicine and Life ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui Hospital of Zhejiang UniversityLishui 323000ZhejiangChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 324025ZhejiangChina Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Nanomedicine Translational Research Program NUS Center for Nanom

Aging and regeneration represent complex biological phenomena that have long captivated the scientific *** fully comprehend these processes,it is essential to investigate molecular dynamics through a lens that encompasses both spatial and temporal *** omics methodologies,such as genomics and transcriptomics,have been instrumental in identifying critical molecular facets of aging and ***,these methods are somewhat limited,constrained by their spatial resolution and their lack of capacity to dynamically represent tissue *** advent of emerging spatiotemporal multi-omics approaches,encompassing transcriptomics,proteomics,metabolomics,and epigenomics,furnishes comprehensive insights into these intricate molecular *** sophisticated techniques facilitate accurate delineation of molecular patterns across an array of cells,tissues,and organs,thereby offering an in-depth understanding of the fundamental mechanisms at *** review meticulously examines the significance of spatiotemporal multi-omics in the realms of aging and regeneration *** underscores how these methodologies augment our comprehension of molecular dynamics,cellular interactions,and signaling ***,the review delineates the foundational principles underpinning these methods,followed by an evaluation of their recent applications within the *** review ultimately concludes by addressing the prevailing challenges and projecting future advancements in the ***,spatiotemporal multi-omics are instrumental in deciphering the complexities inherent in aging and regeneration,thus charting a course toward potential therapeutic innovations.

关键词： Spatiotemporal multi-omics Aging and regeneration Cellular interactions Innovative therapeutic strategies

来源：评论

学校读者我要写书评

暂无评论

Correction to: Environmental consequences of interacting effects of changes in stratospheric ozone, ultraviolet radiation, and climate: UNEP Environmental Effects Assessment Panel, Update 2024 (Photochemical & Photobiological sciences, (2025), 24, 3, (357-392), 10.1007/s43630-025-00687-x)

引用

Photochemical and Photobiological sciences 2025年第5期24卷 863-865页

作者： Neale, Patrick J. Hylander, Samuel Banaszak, Anastazia T. Häder, Donat-P. Rose, Kevin C. Vione, Davide Wängberg, Sten-Åke Jansen, Marcel A. K. Busquets, Rosa Andersen, Mads P. Sulbæk Madronich, Sasha Hanson, Mark L. Schikowski, Tamara Solomon, Keith R. Sulzberger, Barbara Wallington, Timothy J. Heikkilä, Anu M. Pandey, Krishna K. Andrady, Anthony L. Bruckman, Laura S. White, Christopher C. Zhu, Liping Bernhard, Germar H. Bais, Alkiviadis Aucamp, Pieter J. Chiodo, Gabriel Cordero, Raúl R. Petropavlovskikh, Irina Neale, Rachel E. Olsen, Catherine M. Hales, Simon Lal, Aparna Lingham, Gareth Rhodes, Lesley E. Young, Antony R. Robson, T. Matthew Robinson, Sharon A. Barnes, Paul W. Bornman, Janet F. Harper, Anna B. Lee, Hanna Calderón, Roy Mackenzie Ossola, Rachele Paul, Nigel D. Revell, Laura E. Wang, Qing-Wei Zepp, Richard G. Environmental Research Center Smithsonian Institution EdgewaterMD United States Centre for Ecology and Evolution in Microbial Model Systems Linnaeus University Kalmar Sweden Unidad Académica de Sistemas Arrecifales Universidad Nacional Autónoma de México Puerto Morelos Mexico Erlangen Germany Department of Biological Sciences and Department of Civil and Environmental Engineering Rensselaer Polytechnic Institute TroyNY United States Department of Chemistry University of Turin Turin Italy Department of Marine Sciences University of Gothenburg Gotheburg Sweden School of Biological Earth and Environmental Sciences Environmental Research Institute University College Cork Cork Ireland Chemical and Pharmaceutical Sciences Kingston University London Kingston Upon Thames United Kingdom Civil Environmental & Geomatic Engineering University College London London United Kingdom Department of Chemistry and Biochemistry California State University NorthridgeCA United States Atmospheric Chemistry Observations and Modeling National Center for Atmospheric Research BoulderCO United States USDA UV-B Monitoring and Research Program Colorado State University Fort. CollinsCO United States Department of Environment and Geography University of Manitoba WinnipegMB Canada Working Group Environmental Epidemiology IUF-Leibniz Research Institute for Environmental Medicine Düsseldorf Germany Department of Environment and Health School of Public Health University of Bielefeld Bielefeld Germany School of Environmental Sciences University of Guelph GuelphON Canada Retired From Eawag Swiss Federal Institute of Aquatic Science and Technology Dübendorf Switzerland Center for Sustainable Systems School for Environment and Sustainability University of Michigan Ann ArborMI United States Climate Research Finnish Meteorological Institute Helsinki Finland Indian Academy of Wood Science Bengaluru India Chemical and Biomolecular Engineering North Carolina State University RaleighN

This work is not a product of the U.S. Government or the U.S. Environmental Protection Agency, and the author is not doing this work in any governmental capacity. This research was not performed or funded by EPA and was not subject to EPA’s quality system requirements. The views expressed in this journal article are those of the author(s) and do not necessarily represent the views or the policies of the U.S. Environmental Protection Agency. The original article has been corrected. © The Author(s), under exclusive licence to the European Photochemistry Association, European Society for Photobiology 2025.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer

引用

Cancer Drug Resistance 2021年第2期4卷 264-297页

作者： Aleksandra Benko David Medina-Cruz Ada Vernet-Crua Catherine P.O'Connell MałgorzataŚwiętek Hamed Barabadi Muthupandian Saravanan Thomas J.Webster AGH University of Science and Technology Faculty of Materials Science and CeramicsKrakow 30059Poland Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA Institute of Macromolecular Chemistry Czech Academy of SciencesPrague 16206Czech Republic Department of Pharmaceutical Biotechnology School of PharmacyShahid Beheshti University of Medical SciencesTehran 19919-53381Iran Department of Medical Microbiology and Immunology Division of Biomedical SciencesSchool of MedicineCollege of Health SciencesMekelle UniversityMekelle 231Ethiopia.

Cancer is one of the biggest healthcare concerns in our century,a disease whose treatment has become even more difficult following reports of drug-resistant *** this happens,chemotherapy treatments fail or decrease in efficiency,leading to catastrophic consequences to the *** discovery,along with the fact that drug resistance limits the efficacy of current treatments,has led to a new wave of discovery for new methods of *** use of nanomedicine has been widely studied in current years as a way to effectively fight drug resistance in *** in the area of cancer nanotechnology over the past decades has led to tremendous advancement in the synthesis of tailored nanoparticles with targeting ligands that can successfully attach to chemotherapy-resistant cancer by preferentially accumulating within the tumor region through means of active and passive ***,these approaches can reduce the off-target accumulation of their payload and lead to reduced cytotoxicity and better *** review explores some categories of nanocarriers that have been used in the treatment of drug-resistant cancers,including polymeric,viral,lipid-based,metal-based,carbon-based,and magnetic nanocarriers,opening the door for an exciting field of discovery that holds tremendous promise in the treatment of these tumors.

关键词： Drug-resistance cancer nanotechnology nanocarriers drug delivery

来源：评论

学校读者我要写书评

暂无评论

On the origin of anomalous hysteresis in graphite/boron nitride transistors

arXiv

引用

arXiv 2024年

作者： Waters, Dacen Waleffe, Derek Thompson, Ellis Arreguin-Martinez, Esmeralda Fonseca, Jordan Poirier, Thomas Edgar, James H. Watanabe, Kenji Taniguchi, Takashi Xu, Xiaodong Cobden, David Yankowitz, Matthew Department of Physics University of Washington SeattleWA98195 United States Intelligence Community Postdoctoral Research Fellowship Program University of Washington SeattleWA98195 United States Department of Materials Science and Engineering University of Washington SeattleWA98195 United States Tim Taylor Department of Chemical Engineering Kansas State University Durland Hall ManhattanKS United States Research Center for Electronic and Optical Materials National Institute for Materials Science 1-1 Namiki Tsukuba305-0044 Japan Research Center for Materials Nanoarchitectonics National Institute for Materials Science 1-1 Namiki Tsukuba305-0044 Japan

Field-effect devices constructed by stacking flakes of van der Waals (vdW) materials, with hexagonal boron nitride (hBN) playing the role of gate dielectric, often exhibit virtually no hysteresis in their characteristics. This permits exquisitely detailed studies of diverse gate-voltage-tuned phenomena in vdW devices. Recently, however, a dramatic form of gate hysteresis, sometimes called the "gate doesn't work" (GDW) or "electron ratchet" effect, has been seen in certain individual vdW devices that seem otherwise unexceptional [1-10]. When it occurs, this hysteresis phenomenon is striking and robust, yet it is difficult to reliably reproduce between devices and, largely as a result, its origin remains disputed. Most devices where it has been seen have a bilayer graphene channel and nominal rotational alignment between the graphene and hBN, which has engendered explanations based on properties of bilayer graphene combined with moiré effects [1, 2, 6]. Here, we report our studies of the phenomenon observed in devices that have multilayer graphene channels. We find that the effect can occur in devices with graphite channels that have many more than two graphene layers, in which case it is unambiguously associated with just one surface of the graphite. It can also survive to room temperature, occur in the absence of intentional rotational alignment with hBN, persist when a monolayer of WSe2 is inserted between the graphene and hBN, and exhibit continuous relaxation on timescales of hours or longer. These observations impose strong constraints on the origin of this puzzling phenomenon, which has exciting potential applications if it can be mastered [4, 10, 11]. Copyright © 2024, The Authors. All rights reserved.

关键词： Van der Waals forces

来源：评论

学校读者我要写书评

暂无评论

Molecular-Scale Visualization of Steric Effects of Ligand Binding to Reconstructed Au(111) Surfaces

arXiv

引用

arXiv 2023年

作者： Bi, Liya Jamnuch, Sasawat Chen, Amanda Do, Alexandria Balto, Krista P. Wang, Zhe Zhu, Qingyi Wang, Yufei Zhang, Yanning Tao, Andrea R. Pascal, Tod A. Figueroa, Joshua S. Li, Shaowei Department of Chemistry and Biochemistry University of California La Jolla San DiegoCA92093-0309 United States Program in Materials Science and Engineering University of California La Jolla San DiegoCA92093-0418 United States Department of Nano and Chemical Engineering University of California La Jolla San DiegoCA92093-0448 United States Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Chengdu611731 China

Direct imaging of single molecules at nanostructured interfaces is a grand challenge, with potential to enable new, precise material architectures and technologies. Of particular interest are the structural morphology and spectroscopic signatures of the adsorbed molecule, where modern probes are only now being developed with the necessary spatial and energetic resolution to provide detailed information at molecule-surface interface. Here, we directly visualize the binding of individual m-terphenyl isocyanide ligands to a reconstructed Au(111) surface through scanning tunneling microscopy (STM) and inelastic electron tunneling spectroscopy (IETS). The site-dependent steric pressure of the various surface features alters the vibrational fingerprints of the m-terphenyl isocyanides, which is characterized with single-molecule precision through joint experimental and theoretical approaches. This study for the first time provides molecular-level insights into the steric-pressure-enabled surface binding selectivity, as well as its effect on the chemical properties of individual surface-binding ligands. © 2023, CC BY.

关键词： Scanning tunneling microscopy

来源：评论

学校读者我要写书评

暂无评论

Geophysical investigation for engineering construction assessment in Karst

引用

PHYSICS AND CHEMISTRY OF THE EARTH 2023年 129卷

作者： [Anonymous] [a]Program of Geology Department of Earth Sciences and Environment Faculty of Science and Technology Universiti Kebangsaan Malaysia Bangi Selangor Malaysia [b]School of Chemical and Energy Engineering Faculty of Engineering Teknologi Malaysia 81310 Skudai Johor Malaysia [c]Geo Technology Resources Sdn. Bhd (1174319 - P) 31-1 Jalan Mawar 5B Taman Mawar 43900 Sepang Selangor Malaysia [d]Geophysics Unit School of Physics Universiti Sains Malaysia 11800 Pulau Pinang Malaysia

A geophysical survey involving electrical resistivity imaging was carried out in various parts of Perak state, Malaysia, to assess the risk of establishing engineering structures in a karst system. The area is underlain by the Palaeozoic Kinta limestone bedrock. A total of 9 survey lines were established on the proposed sites. The data collected from the survey areas was processed and subjected to computer iteration to simulates physical models of the most common karstic features in the area. The study results are remarkably vital in evaluating weathered zones and hard limestone bedrock, as well as in locating infiltrated water and cavities beneath them. This study emphasized the significance of geophysical surveys for foundation investigation because they can properly assess the competence of subsurface physical properties.

关键词： Electrical resistivity imaging Induced polarization Karst Perak Peninsular Malaysia

来源：评论

学校读者我要写书评

暂无评论

3D Printed Biomimetic Composite for Treatment of Osteochondral Defects: A Preliminary Study in Porcine

SSRN

引用

SSRN 2025年

作者： Eckstein, Kevin N. Liu, Boyuan Schoonraad, Sarah A. Guastaldi, Fernando Pozzi Semeghini Uzcategui, Camila Muralidharan, Archish McLeod, Robert R. Randolph, Mark A. Bryant, Stephanie J. Ferguson, Viginia L. Paul M. Rady Department of Mechanical Engineering University of Colorado at Boulder BoulderCO80309 United States Materials Science and Engineering Program University of Colorado at Boulder BoulderCO80309 United States Division of Oral and Maxillofacial Surgery Department of Surgery Massachusetts General Hospital Harvard School of Dental Medicine Harvard Medical School BostonMA02114 United States Division of Plastic and Reconstructive Surgery Department of Surgery Massachusetts General Hospital Harvard Medical School BostonMA02114 United States Department of Electrical Computer and Energy Engineering University of Colorado at Boulder BoulderCO80309 United States Department of Chemical and Biological Engineering University of Colorado at Boulder BoulderCO80309 United States BioFrontiers Institute University of Colorado at Boulder BoulderCO80309 United States

Osteochondral defects in diarthrodial joints can occur as a result of trauma. When left untreated, the surrounding tissues experience abnormal mechanical loads that can cause further degeneration. Thus, treatment of osteochondral defects requires the ability to support physiological loads and prevent further degeneration of surrounding tissues. Additive manufacturing techniques, such as bio-ink printing, have been explored to structurally reinforce soft scaffolds;however, these methods struggle to accurately print complex designs with small feature sizes (e.g., on the order of ~100 micrometers). In this study, we present a composite osteochondral scaffold with regional stiffness gradients, optimized to mimic the mechanical properties of articular cartilage and limit high strains in the subchondral bone. This scaffold incorporates a load-bearing structure, with ≥ 180 μm diameter truss elements, that is 3D printed via projection micro-stereolithography with a biomimetic soft hydrogel. We hypothesized that incorporating a reinforcing structure with cartilage and bone regions possessing tissue-specific stiffnesses, compared to a soft gel alone, would reduce degradation of native cartilage tissue adjacent to osteochondral defects and promote multi-tissue integration in porcine knees after six weeks. Histological analysis and microcomputed tomography revealed site-specific changes in the surrounding tissue, notably in the adjacent cartilage. Mechanical evaluation of adjacent native tissue showed that scaffolds with the 3D printed composite structure resulted in 33% less surrounding cartilage degradation compared to gel-only treatments. Within the defect, the soft gel alone limited mineralization, while the composite supported mineralization but only in its stiffer region. These findings suggest that incorporating a 3D printed reinforcing osteochondral mimetic structure protects the adjacent cartilage, enhances tissue integration, and spatially supports mineralization. © 2

关键词： Bone

来源：评论

学校读者我要写书评

暂无评论

A biomimetic micropillar wound dressing with flavone and polyphenol control release in vitro and in vivo

引用

Journal of the Taiwan Institute of chemical Engineers 2024年 160卷

作者： Cheng, Tien-Hsin Lin, Ruei-Hong Cheng, Yu-Shen Shih, Pin-Keng Show, Pau Loke Chen, Hsiao-Yi Nakmee, Pattarawadee Sumthong Chang, Jui-Jen Huang, Dong-Ming Wang, Hui-Min David Department of Chemical and Materials Engineering National Yunlin University of Science and Technology Yunlin Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Xingda Rd. South Dist. Taichung402 China Department of Neurological Institute Taichung Veterans General Hospital Taichung China Doctoral Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung China Department of Surgery China Medical University Hospital Taichung Taiwan School of Medicine China Medical University Taichung Taiwan Department of Chemical Engineering Khalifa University Abu Dhabi United Arab Emirates Faculty of Science at Sriracha Kasetsart University Sriracha Campus 199 Moo 6 Sukhumvit Rd. Chonburi Sriracha20230 Thailand Department of Medical Research China Medical University Hospital China Medical University Taichung China Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County China Regenerative Medicine and Cell Therapy Research Center Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung China

Background: Wound healing is a complex and dynamic process involving the replacement of devitalized and missing cellular structures and tissue layers. Methods: This study involved developing a drug-loaded biomimetic micropillar wound dressing based upon inspiration from witnessing the adhesive ability in a gecko's footpad. The conformal adhesion was set up by applying a soft elastomer thin film on the developed wound dressing surfaces. The results showed that the developed surfaces prepared based on polydimethylsiloxane (PDMS) had low surface free energy, high chemical stability, and good plasticity. Astaxanthin (AST) and curcumin were applied as the patch's bioactive compounds to help accelerate the wound healing process. Results: The results showed that the developed surfaces prepared based on polydimethylsiloxane (PDMS) had low surface free energy, high chemical stability, and good plasticity. Astaxanthin (AST) and curcumin were applied as the patch's bioactive compounds to help accelerate the wound healing process. The results indicate that the developed biomimetic micropillar patches could release the loaded drugs and significantly increase cell viability and collagen content to 20 % ∼ 25 % in vitro and in vivo. Conclusion: In summation, the primary purpose of this study has been to design a novel encapsulated carrier (micropillar patch) for use in adjustable drug release, while combining with the biomimetic microstructure to reach wound healing through percutaneous absorption. © 2024 Taiwan Institute of chemical Engineers

关键词： chemical stability

来源：评论

学校读者我要写书评

暂无评论

Novel Biodegradable Ca–P/Ti–F Composite Conversion Coatings for Improving the Corrosion Resistance of Medical Magnesium Materials

SSRN

引用

SSRN 2024年

作者： Sun, Ying-Sui Chu, Peng-Wei Cheng, An-Yu You, Jhu-Lin Chang, Tsung-Ming Jian, Shun-Yi Chi, Chun-Shang Liu, Yu-Cheng Chang, Chin-Jou School of Dental Technology College of Oral Medicine Taipei Medical University Taipei Taiwan Department of Engineering and System Science National Tsing Hua University Hsinchu300044 Taiwan Department of Chemical & Materials Engineering Chung Cheng Institute of Technology National Defense University Taoyuan335 Taiwan System Engineering and Technology Program National Chiao Tung University Hsinchu300 Taiwan Department of Material Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Center for Plasma and Thin Film Technology Ming Chi University of Technology New Taipei243303 Taiwan Combination Medical Device Technology Division Medical Devices R&D Service Department Metal Industries Research & Development Centre Kaohsiung802 Taiwan

Mg and its alloys are characterized by favorable biocompatibility and nontoxicity, and these properties have stimulated considerable research interest in their application as degradable biomaterials for medical implants. However, the clinical application of these materials is restricted by their rapid degradation. Therefore, this study designed a surface modification method for Mg and Mg alloys to enable them to satisfy clinical requirements. A two-step conversion coating method was applied to pure Mg. Pure Mg samples were first coated with calcium phosphate (Ca–P), following which they were coated with titanium fluoride (Ti–F), resulting in the production of Mg samples coated with a bioactive Ca–P/Ti–F composite. The composition of the coated samples was investigated through energy-dispersive X-ray spectroscopy with transmission electron microscopy, and their morphology was characterized through scanning electron microscopy. Moreover, hydrogen evolution measurements in simulated body fluid (SBF), electrochemical impedance spectroscopy, and polarization curves were employed to evaluate the samples’ corrosion resistance. The prepared composite conversion coatings had an average thickness of approximately 350 nm, and their corroded area was less than 5% of their total area following their immersion in SBF for 72 h. Thus, the prepared Ca–P/Ti–F composite conversion coatings effectively inhibited Mg corrosion in SBF. Moreover, the attachment and differentiation of MG-63 cells on the prepared coatings were observed. © 2024, The Authors. All rights reserved.

关键词： Energy dispersive spectroscopy

来源：评论

学校读者我要写书评

暂无评论

Enhancing forensic investigations: Identifying bloodstains on various substrates through ATR-FTIR spectroscopy combined with machine learning algorithms

引用

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 2024年 308卷 123755页

作者： Wei, Chun-Ta You, Jhu-Lin Weng, Shiuh-Ku Jian, Shun-Yi Lee, Jeff Cheng-Lung Chiang, Tang-Lun School of Defense Science Chung Cheng Institute of Technology National Defense University Taoyuan 335009 Taiwan Department of Chemical and Materials Engineering Chung Cheng Institute of Technology National Defense University Taoyuan 335009 Taiwan System Engineering and Technology Program National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan Department of Electronic Engineering Chien Hsin University of Science and Technology Taoyuan 320678 Taiwan Department of Material Engineering Ming Chi University of Technology New Taipei 243303 Taiwan Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei 243303 Taiwan Department of Criminal Investigation Taiwan Police College Taipei 116078 Taiwan

The forensic analysis of bloodstains on various substrates plays a crucial role in criminal investigations. This study presents a novel approach for analyzing bloodstains using Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR-FTIR) in combination with machine learning. ATR-FTIR offers non-destructive and non-invasive advantages, requiring minimal sample preparation. By detecting specific chemical bonds in blood components, it enables the differentiation of various body fluids. However, the subjective interpretation of the spectra poses challenges in distinguishing different fluids. To address this, we employ machine learning techniques. Machine learning is extensively used in chemometrics to analyze chemical data, build models, and extract useful information. This includes both unsupervised learning and supervised learning methods, which provide objective characterization and differentiation. The focus of this study was to identify human and porcine blood on substrates using ATR-FTIR spectroscopy. The substrates included paper, plastic, cloth, and wood. Data preprocessing was performed using Principal Component Analysis (PCA) to reduce dimensionality and analyze latent variables. Subsequently, six machine learning algorithms were used to build classification models and compare their performance. These algorithms comprise Partial Least Squares Discriminant Analysis (PLS-DA), Decision Trees (DT), Logistic Regression (LR), Naive Bayes Classifier (NBC), Support Vector Machine (SVM), and Neural Network (NN). The results indicate that the PCA-NN model provides the optimal solution on most substrates. Although ATR-FTIR spectroscopy combined with machine learning effectively identifies bloodstains on substrates, the performance of different identification models still varies based on the type of substrate. The integration of these disciplines enables researchers to harness the power of data-driven approaches for solving complex forensic problems. Th

关键词： ATR-FTIR Bloodstains Forensic investigations Machine learning Substrates

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：