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Soil and Environmental Health 2023年第2期1卷

作者： Ma, Xingmao Wang, Xiaoxuan Xu, Lei Shi, Honglan Yang, Hu Landrock, Kerstin K. Sharma, Virender K. Chapkin, Robert S. Zachry Department of Civil and Environmental Engineering Texas A&M University College Station 77843 TX United States Linda and Bipin Doshi Department of Chemical and Biochemical Engineering Missouri University of Science and Technology Rolla 65409 MO United States Department of Chemistry and Center for Research in Energy and Environment Missouri University of Science and Technology Rolla 65409 MO United States Department of Nutrition Texas A&M University College Station 77843 TX United States Program in Integrative Nutrition & Complex Diseases Texas A&M University College Station 77843 TX United States Department of Environmental and Occupational Health Texas A&M University College Station 77843 TX United States

The use of nanoparticles in agrichemical formula and food products as additives has increased their chances of accumulation in humans via oral intake. Due to their potential toxicity, it is critical to understand their fate and distribution following oral intake. Cerium oxide nanoparticle (CeO₂NP) is commonly used in agriculture and is highly stable in the environment. As such, it has been used as a model chemical to investigate nanoparticle's distribution and clearance. Based on their estimated human exposure levels, 0.15–0.75 mg/kg body weight/day of CeO₂NPs with different sizes and surface charges (30–50 nm with negative charge and <25 nm with positive charge) were gavaged into C57BL/6 female mice daily. After 10-d, 50% of mice in each treatment were terminated, with the remaining being gavaged with 0.2 mL of deionized water daily for 7-d. Mouse organ tissues, blood, feces, and urine were collected at termination. At the tested levels, CeO₂NPs displayed minimal overt toxicity to the mice, with their accumulation in various organs being negligible. Fecal discharge as the predominant clearance pathway took less than 7-d regardless of charges. Single particle inductively coupled plasma mass spectrometry analysis demonstrated minimal aggregation of CeO₂NPs in the gastrointestinal tract. These findings suggest that nanoparticle additives >25 nm are unlikely to accumulate in mouse organ after oral intake, indicating limited impacts on human health. © 2023 The Author(s)

关键词： Cerium oxide nanoparticles Different charge Different size Environmental impacts Oral intake SP-ICP-MS

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programmable polyketide biosynthesis platform for production of aromatic compounds in yeast

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Synthetic and Systems Biotechnology 2020年第1期5卷 11-18页

作者： Tadas Jakočiūnas Andreas K.Klitgaard Eftychia Eva Kontou Julie Bang Nielsen Emil Thomsen David Romero-Suarez Kai Blin Christopher J.Petzold Jennifer W.Gin Yaojun Tong Charlotte Held Gotfredsen Pep Charusanti Rasmus J.N.Frandsen Tilmann Weber Sang Yup Lee Michael K.Jensen Jay D.Keasling The Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKgs.LyngbyDenmark Joint BioEnergy Institute EmeryvilleCAUSA Biological Systems&Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCAUSA Department of Chemical and Biomolecular Engineering&Department of Bioengineering University of California BerkeleyCAUSA Center for Synthetic Biochemistry Institute for Synthetic BiologyShenzhen Institutes for Advanced TechnologiesShenzhenChina Department of Chemistry Technical University of DenmarkKgs.LyngbyDenmark Department of Biotechnology and Biomedicine Technical University of DenmarkKgs.LyngbyDenmark Department of Chemical and Biomolecular Engineering(BK21 Plus Program) Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon34141Republic of Korea

To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms,development of new,versatile,bio-based production platforms is *** we present a novel yeast-based platform for biosynthesis of bacterial aromatic *** platform is based on a synthetic polyketide synthase system enabling a first demonstration of bacterial aromatic polyketide biosynthesis in a eukaryotic host.

关键词： Natural products Synthetic biology Aromatic polyketides CRISPR/Cas9 Polyketide Production platform in eukaryotes Metabolic engineering Biotechnology

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Helix-Sense-Selective Memory Polymerization of Biphenylylacetylenes Bearing Carboxy and Amino Groups in Water

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Angewandte Chemie 2024年第45期136卷

作者： Dr. Shogo Okuda Dr. Tomoyuki Ikai Hinako Okutsu Mitsuka Ando Masaki Hattori Dr. Ryoma Ishidate Prof. Eiji Yashima Department of Molecular and Macromolecular Chemistry Graduate School of Engineering Nagoya University Chikusa-ku Nagoya 464-8603 Japan Precursory Research for Embryonic Science and Technology (PRESTO) Japan Science and Technology Agency (JST) Kawaguchi Saitama 332-0012 Japan Department of Molecular Design and Engineering Graduate School of Engineering Nagoya University Chikusa-ku Nagoya 464-8603 Japan Present address: Department of Chemical Engineering National Tsing Hua University 101 Sec. 2 Kuang-Fu Road Hsinchu 30013 Taiwan R.O.C.

We report the helix-sense-selective memory polymerization (HSMP) of achiral biphenylylacetylenes bearing carboxy and amino pendant groups in the presence of basic and acidic chiral guests in water, respectively. The HSMP proceeds in a highly helix-sense-selective manner driven by noncovalent chiral ionic interactions between the monomers and guests under kinetic control, producing the one-handed helical polymers with a static memory of helicity in one-pot during the polymerization in a very short time, accompanied by amplification of asymmetry. The carboxy-bound helicity-memorized polymer self-assembles into a cholesteric liquid crystal in concentrated water, in which a variety of basic achiral fluorophores further co-assembles to form supramolecular helical aggregates that exhibit an induced circularly polarized luminescence in a color tunable manner.

关键词： helical polymers helix-sense-selective polymerization helicity memory polyacetylenes circularly polarized luminescence

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Geometric transformation and three-dimensional hopping of Hopf solitons

arXiv

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arXiv 2021年

作者： Tai, Jung-Shen B. Wu, Jin-Sheng Smalyukh, Ivan I. Department of Physics and Chemical Physics Program University of Colorado BoulderCO80309 United States Department of Electrical Computer and Energy Engineering Materials Science and Engineering Program Soft Materials Research Center University of Colorado BoulderCO80309 United States Renewable and Sustainable Energy Institute National Renewable Energy Laboratory University of Colorado BoulderCO80309 United States

Three-dimensional (3D) topological solitons are marvels of mathematical physics that arise in theoretical models in elementary particle and nuclear physics, condensed matter, and cosmology. A particularly interesting type of them is described by the mathematical Hopf map from a hypersphere to an ordinary sphere, which in the physical 3D space exhibits inter-linked circle-like or knotted localized regions of constant order parameter values. Despite their prevalence in models, such solitons remained experimentally elusive until recently, when hopfions were discovered in colloids and chiral liquid crystals, whereas the so-called "heliknotons" were found both individually and within triclinic 3D lattices while smoothly embedded in a helical background of chiral liquid crystals. Constrained by mathematical theorems, stability of these fragile 3D excitations is thought to rely on a delicate interplay of competing free energy contributions, requiring applied fields or confinement and impeding their practical utility. Here we describe such 3D solitons in a material system where no applied fields or confinement are required for stability. Nevertheless, electric fields allow for inter-transforming heliknotons and hopfions to each other, as well as for 3D hopping-like dynamics arising from nonreciprocal evolution of the molecular alignment field in response to electric pulses. Stability of these solitons both in and out of equilibrium can be enhanced by tuning anisotropy of parameters that describe energetic costs of gradient components in the field, which is implemented through varying chemical composition of liquid crystal mixtures. Numerical modelling reproduces fine details of both the equilibrium structure and Hof-index-preserving out-of-equilibrium evolution of the molecular alignment field during switching and motions. Our findings may enable myriads of solitonic condensed matter phases and active matter systems, as well as their technological applications. © 2021, CC B

关键词： Solitons

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Isolation of 24-homoscalarane sesterterpenoids from a sponge of the genus Lendenfeldia

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Phytochemistry Letters 2024年 61卷 177-181页

作者： Zheng, Li-Guo Chen, You-Yan Liaw, Chia-Ching Lin, Yu-Chi Chien, Su-Ying Lo, Yi-Hao Tsai, Yu-Chi Hu, Hao-Chun Chen, You-Ying Hwang, Tsong-Long Ou, Tzu-Ming Sung, Ping-Jyun Doctoral Degree Program in Marine Biotechnology National Sun Yat-sen University Kaohsiung 804201 Taiwan National Museum of Marine Biology and Aquarium Pingtung 944401 Taiwan School of Traditional Chinese Medicine College of Medicine Chang Gung University Taoyuan 333323 Taiwan Division of Chinese Materia Medica Development National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei 112304 Taiwan Department of Biochemical Science and Technology National Chiayi University Chiayi 600355 Taiwan Instrumentation Center National Taiwan University Taipei 106319 Taiwan Department of Family Medicine Zuoying Armed Forces General Hospital Kaohsiung 813204 Taiwan Shu-Zen Junior College of Medicine and Management Kaohsiung 821004 Taiwan Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung 804201 Taiwan School of Chinese Medicine College of Chinese Medicine China Medical University Taichung 404333 Taiwan Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan 333323 Taiwan Research Center for Chinese Herbal Medicine College of Human Ecology Chang Gung University of Science and Technology Taoyuan 333324 Taiwan Graduate Institute of Health Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan 333324 Taiwan Department of Anesthesiology Chang Gung Memorial Hospital Taoyuan 333423 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City 243303 Taiwan Division of Gastroenterology Department of Internal Medicine Kaohsiung Armed Forces General Hospital Kaohsiung 802301 Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 804201 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung 404394 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung 807378 Taiwan Program in Ph

The chemical screening of an algae-containing marine sponge identified as Lendenfeldia species has isolated two 24-homoscalarane sesterterpenoids, including a known compound, felixin A (1) and a new analogue, lendenfeldarane V (2). The structure of 1, obtained in a previous study, was cited for the first time in this study via single-crystal X-ray diffraction analysis. The structure of 2 was ascertained via 2D NMR experiments and a literature review. The absolute configurations of 1 and 2 were delineated with DP4+ computation and specific optical rotation. Homoscalarane 1 exhibited cytotoxicity towards MG63 human osteosarcoma cells. © 2024 Phytochemical Society of Europe

关键词： Felixin Homoscalarane Lendenfeldarane Lendenfeldia MG63

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Molecular engineering of Azobenzene-Based Anolytes Towards High-Capacity Aqueous Redox Flow Batteries

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Advanced Materials 2020年第49期132卷 22347-22354页

作者： Zu, Xihong Zhang, Leyuan Qian, Yumin Zhang, Changkun Yu, Guihua Materials Science and Engineering Program and Department of Mechanical Engineering The University of Texas at Austin AustinTX78712 United States School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Guangzhou510006 China

Aqueous redox flow batteries (RFBs) are promising alternatives for large-scale energy storage. However, new organic redox-active molecules with good chemical stability and high solubility are still desired for high-performance aqueous RFBs due to their low crossover capability and high abundance. We report azobenzene-based molecules with hydrophilic groups as new active materials for aqueous RFBs by utilizing the reversible redox activity of azo groups. By rationally tailoring the molecular structure of azobenzene, the solubility is favorably improved from near zero to 2 M due to the highly charged asymmetric structure formed in alkaline environment. DFT simulations suggest that the concentrated solution stability can be enhanced by adding hydrotropic agent to form intermolecular hydrogen bonds. The demonstrated RFB exhibits long cycling stability with a capacity retention of 99.95% per cycle over 500 cycles. It presents a viable chemical design route towards advanced aqueous RFBs. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

关键词： Hydrogen bonds

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engineering Tunable Ratiometric Dual Emission in Single Emitter-based Amorphous Systems

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Angewandte Chemie 2024年第10期136卷

作者： Dr. Hao Sun Dr. Menglu He Dr. Glib V. Baryshnikov Dr. Bin Wu Dr. Rashid R. Valiev Dr. Shen Shen Dr. Man Zhang Dr. Xiaoyan Xu Dr. Zhongyu Li Prof. Guofeng Liu Prof. Hans Ågren Prof. Liangliang Zhu State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University Shanghai 200438 China Department of Chemistry Advanced Research Institute School of Chemical Science and Engineering Tongji University Shanghai 200092 China Laboratory of Organic Electronics Department of Science and Technology Linköping University 60174 Norrköping Sweden Tomsk State University 36 Lenin Avenue 634050 Tomsk Russia Department of Physics and Astronomy Uppsala University Box 516 SE-75120 Uppsala Sweden

Molecular emitters with multi-emissive properties are in high demand in numerous fields, while these properties basically depend on specific molecular conformation and packing. For amorphous systems, special molecular arrangement is unnecessary, but it remains challenging to achieve such luminescent behaviors. Herein, we present a general strategy that takes advantage of molecular rigidity and S 1 -T 1 energy gap balance for emitter design, which enables fluorescence–phosphorescence dual-emission properties in various solid forms, whether crystalline or amorphous. Subsequently, the amorphism of the emitters based polymethyl methacrylate films endowed an in situ regulation of the dual-emissive characteristics. With the ratiometric regulation of phosphorescence by external stimuli and stable fluorescence as internal reference, highly controllable luminescent color tuning (yellow to blue including white emission) was achieved. There properties together with a persistent luminous behavior is of benefit for an irreplaceable set of optical information combination, featuring an ultrahigh-security anti-counterfeiting ability. Our research introduces a concept of eliminating the crystal-form and molecular-conformational dependence of complex luminescent properties through emitter molecular design. This has profound implications for the development of functional materials.

关键词： Amorphous Materials Color Conversion Luminescence Multi-Emission Stimuli-Response

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Corrigendum to "Extracellular vesicles from human adipose-derived stem cell spheroids: Characterization and therapeutic implications in diabetic wound healing" [Mater. Today Bio Volume 29, December 2024, 101333](S2590006424003946)(10.1016/***.2024.101333)

Materials Today Bio

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Materials Today Bio 2025年 32卷

作者： Quiñones, Edgar Daniel Wang, Mu-Hui Liu, Kuan-Ting Lu, Ting-Yu Lan, Guan-Yu Lin, Yu-Ting Chen, Yu-Liang Shen, Tang-Long Wu, Pei-Hsun Hsiao, Yu-Sheng Chuang, Er-Yuan Yu, Jiashing Cheng, Nai-Chen Taiwan International Graduate Program Sustainable Chemical Science & Technology Academia Sinica Institute of Chemistry Taipei115 Taiwan Department of Surgery National Taiwan University Hospital and College of Medicine Taipei100 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Program in Materials Science and Engineering University of California San Diego CA92093 United States Department of Plant Pathology & Microbiology National Taiwan University Taiwan Johns Hopkins Institute for NanoBioTechnology John Hopkins University Baltimore MD21218 United States Department of Materials Science and Engineering National Taiwan University of Science and Technology Taipei106 Taiwan School of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center for Developmental Biology and Regenerative Medicine National Taiwan University Taipei Taiwan

The authors regret that the selected Figure 2A, depicting cell sheets and spheroids, was previously published in Stem Cell Research & Therapy (2022;13:276. https://***/10.1186/s13287-022-02948-3). This duplication was an unintentional oversight, as the image was included solely for illustrative purposes and does not contribute to any quantitative analysis. We sincerely apologize for this mistake and propose the following corrections: 1. Replacing Figure 2A with a new image as below that does not overlap with our previously published work.2. Including a correction statement clarifying that the image serves only an illustrative function and does not affect the study's quantitative ***, we have identified an error in Section 3.3 of the text, where "SEM" should be corrected to "TEM." We appreciate your consideration of these revisions and apologize for any confusion caused. The authors would like to apologize for any inconvenience caused. Your sincerely, Jiashing Yu and Nai-Chen Cheng Fixed Figure 2A[Figure presented] © 2025 The Author(s)

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Single cell analysis reveals the instructive role of 2d and 3d engineered microenvironments on driving stem cell behavior 42

Single cell analysis reveals the instructive role of 2d and ...

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42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence

作者： Muñiz, Ayse J. Brooks, Michael Neale, Dylan Topal, Tuğba Sze, Angela Wicha, Max Lahann, Joerg Macromolecular Science and Engineering The University of Michigan United States Department of Internal Medicine The University of Michigan United States Department of Chemical Engineering The University of Michigan United States Biointerfaces Institute The University of Michigan United States

ISBN: (纸本)9781510883901

Statement of Purpose: Mammalian cell behavior is guided by a microenvironment that provides chemical, physical, and biological cues through interactions between the extracellular matrix (ECM), other cells, and soluble factors. Demystifying this relationship between cell behavior and the environments they occupy remains an important goal across biomedical disciplines. A major challenge lies in recapitulating the complexity of the microenvironment in a systematic way to understand and direct cell fate. Here, we leverage recent advances in developing 3D engineered extracellular matrices (eECMs) to systematically profile the effects of ECM composition in driving cell behavior using high-resolution single-cell transcriptomics profiling and compare these behaviors to responses observed on 2D and other 3D substrates. We specifically target the influence of these environments in driving embryonic stem cell behavior and altering breast cancer stem cell populations. © 2019 Omnipress - All rights reserved.

关键词： Stem cells

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In Situ Alloying Enabled by Active Liquid Metal Filler for Self-Healing Composite Polymer Electrolytes

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Angewandte Chemie 2024年第47期136卷

作者： Dr. Kai Wu Dr. Zhengyu Ju Dr. Bowen Zhang Prof. Amy C. Marschilok Prof. Esther S. Takeuchi Prof. Kenneth J. Takeuchi Prof. Guihua Yu Materials Science and Engineering Program and Walker Department of Mechanical Engineering The University of Texas at Austin 78712 Austin TX USA Institute of Energy Sustainability Environment and Equity Stony Brook University 11794 Stony Brook NY USA Department of Chemistry Stony Brook University 11794 Stony Brook NY USA Interdisciplinary Science Department Brookhaven National Laboratory 11973 Upton NY USA Department of Materials Science and Chemical Engineering Stony Brook University 11794 Stony Brook NY USA

Solid inorganics, known for kinetically inhibiting polymer crystallization and enhancing ionic conductivity, have attracted significant attention in solid polymer electrolytes. However, current composite polymer electrolytes (CPEs) are still facing challenges in Li metal batteries, falling short of inhibiting severe dendritic growth and resulting in very limited cycling life. This study introduces Ga 62.5 In 21.5 Sn 16 (Galinstan) liquid metal (LM) as an active liquid alternative to conventional passive solid fillers, aiming at realizing self-healing protection against dendrite problems. Compared to solid inorganics, for example silica, LM droplets could more significantly reduce polymer crystallinity and enhance Li-ion conductivity due to their liquid nature, especially at temperatures below the polymer melting point. More importantly, LMs are unraveled as dynamic chemical traps, which are capable of blocking and consuming lithium dendrites upon contact via in situ alloying during battery operation and further inhibiting dendritic growth due to the lower deposition energy barrier of the formed Li-LM alloy. As a proof of concept, by strategically designing an asymmetric CPE with the active LM filling, a solid-state Li/LiFePO 4 battery achieves promising full-cell functionality with notable rate performance and stable cycle life. This active filler-mediated self-healing approach could bring new insights into the battery design in versatile solid-state systems.

关键词： Solid-state battery Composite polymer electrolyte Liquid metal Lithium-metal battery Li dendrite

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