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IEEE Conference on Decision and control

作者： S.A.N. Nouwens B. de Jager M.M. Paulides W.P.M.H. Heemels Department of Mechanical Engineering Control Systems Technology Eindhoven University of Technology Eindhoven The Netherlands Department of Electrical Engineering Electromagnetics for Care & Cure Eindhoven University of Technology Eindhoven The Netherlands Department of Radiotherapy Erasmus University Medical Center Cancer Institute Rotterdam The Netherlands

ISBN: (数字)9781665467612

ISBN: (纸本)9781665467629

Accurate state estimates are required for increasingly complex systems, to enable, for example, feedback control. However, available state estimation schemes are not necessarily real-time feasible for certain large-scale systems. Therefore, we develop in this paper, a real-time feasible state-estimation scheme for a class of large-scale systems that approximates the steady state Kalman filter. In particular, we focus on systems where the state-vector is the result of discretizing the spatial domain, as typically seen in Partial Differential Equations. In such cases, the correlation between states in the state-vector often have an intuitive interpretation on the spatial domain, which can be exploited to obtain a significant reduction in computational complexity, while still providing accurate state estimates. We illustrate these strengths of our method through a hyperthermia cancer treatment case study. The results of the case study show significant improvements in the computation time, while simultaneously obtaining good state estimates, when compared to Ensemble Kalman filters and Kalman filters using reduced-order models.

关键词： Filtering Partial differential equations Cancer treatment Real-time systems Reduced order systems Large-scale systems Steady-state

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Serum Albumin-Embedding Copper Nanoclusters Inhibit Alzheimer's Β-Amyloid Fibrillogenesis and Neuroinflammation

SSRN

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SSRN 2024年

作者： Liu, Luqi Liu, Wei Sun, Yan Dong, Xiaoyan Department of Biochemical Engineering School of Chemical Engineering and Technology Key Laboratory of Systems Bioengineering Frontiers Science Center for Synthetic Biology Ministry of Education Tianjin University Tianjin300350 China Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Institute of Radiation Medicine Chinese Academy of Medical Sciences Peking Union Medical College Tianjin300192 China

Increasing evidence suggests that the accumulations of reactive oxygen species (ROS), β-amyloid (Aβ), and neuroinflammation are crucial pathological hallmarks for the onset of Alzheimer’s disease (AD), yet there are few effective treatment strategies. Therefore, design of nanomaterials capable of simultaneously elimination of ROS and inhibition of Aβ and neuroinflammation is urgently needed for AD treatment. Herein, we designed human serum albumin (HSA)-embedded ultrasmall copper nanoclusters (CuNCs@HSA) via an HSA-mediated fabrication strategy. The as-prepared CuNCs@HSA exhibited outstanding multiple enzyme-like properties, including superoxide dismutase (>5000 U/mg), catalase, and glutathione peroxidase activities as well as hydroxyl radicals scavenging ability. Besides, CuNCs@HSA prominently inhibited Aβ fibrillization, and its inhibitory potency was 2.5-fold higher than native HSA. Moreover, CuNCs@HSA could significantly increase the viability of Aβ-treated cells from 60% to over 96% at 40 μg/mL and mitigate Aβ-induced oxidative stresses. The secretion of neuroinflammatory cytokines by lipopolysaccharide-induced BV-2 cells, including tumor necrosis factor-α and interleukin-6, was alleviated by CuNCs@HSA. In vivo studies manifested that CuNCs@HSA effectively suppressed the formation of plaques in transgenic C. elegans, reduced ROS levels, and extended C. elegans lifespan by 5 d. This work, using HSA as a template to mediate the fabrication of copper nanoclusters with robust ROS scavenging capability, exhibited promising potentials in inhibiting Aβ aggregation and neuroinflammation for AD treatment. © 2024, The Authors. All rights reserved.

关键词： Glycoproteins

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Rational Basis Functions in Iterative Learning control for Multivariable systems

Rational Basis Functions in Iterative Learning Control for M...

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IEEE Conference on Decision and control

作者： Maurice Poot Jim Portegies Dragan Kostić Tom Oomen Department of Mechanical Engineering Eindhoven University of Technology Eindhoven The Netherlands Department of Mathematics and Computer Science Eindhoven University of Technology Eindhoven The Netherlands ASMPT Center of Competency Beuningen The Netherlands Delft Center for Systems and Control Delft University of Technology Delft The Netherlands

Feedforward control with task flexibility for MIMO systems is essential to meet ever-increasing demands on throughput and accuracy. The aim of this paper is to develop a framework for data-driven tuning of rational feedforward controllers in iterative learning control (ILC) for noncommutative MIMO systems. A convex optimization problem in ILC is achieved by rewriting the nonlinear terms in the control scheme as a function of the previous feedforward parameters. A simulation study on an multivariable industrial printer shows that the developed framework converges and achieves significant better performance than direct application of the RBF algorithm using SK-iterations for SISO systems.

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Autoignition characteristics of bio-based fuels, farnesane and TPGME, in comparison with fuels of similar cetane rating 38th

Autoignition characteristics of bio-based fuels, farnesane a...

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38th International Symposium on Combustion, 2021

作者： Wu, Shiliang Kang, Dongil Xiao, Rui Boehman, Andre L. Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and Environment Southeast University Nanjing 210096 China Department of Chemical Engineering University of Michigan Ann Arbor MI 48109 United States Department of Mechanical Engineering University of Michigan Ann Arbor MI 48109-2133 United States

The development of new combustion concepts in internal combustion engines requires a better understanding of autoignition characteristics of the bio-based alternative fuels. This study investigates two cases of alternative fuels, namely, a kerosene-type fuel farnesane and an oxygenated fuel, TPGME, and compares those fuels with full-boiling range of fuels with similar cetane number. The homogeneous autoignition and spray ignition characteristics of the selected fuels are studied using a modified Cooperative Fuels Research octane rating engine and a cetane rating instrument, respectively. Farnesane and its full-boiling range counterpart (HRJ8) have similar cetane ratings resulting in comparable combustion heat release, but the overall ignition reactivity of farnesane is stronger than HRJ8 during the pre-ignition process. Results from a constant volume spray combustion chamber showed that the spray process of farnesane and HRJ8 strongly influences the overall ignition delay of each fuel. Despite the similar cetane ratings of TPGME and n-heptane, TPGME shows greater apparent low-temperature oxidation reactivity at low compression ratios in the range from CR 4.0-5.5 than n-heptane. A simplified model focused on the key reaction pathways of low-temperature oxidation of TPGME was used to account for the stronger low-temperature reactivity of TPGME, supported by density functional theory (DFT) calculations. Regardless of the similar cetane ratings of the fuels, n-heptane and JP-8/SPK lead to similar total ignition delay times, while TPGME shows the shortest overall ignition delay times in the constant volume combustion chamber.

关键词： Alternative fuels

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A Real-time Hand Gesture Recognition System for Human-Computer and Human-Robot Interaction

A Real-time Hand Gesture Recognition System for Human-Comput...

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2022 International Conference of Yearly Reports on Informatics, Mathematics, and engineering, ICYRIME 2022

作者： Ponzi, Valerio Iacobelli, Emanuele Napoli, Christian Starczewski, Janusz Department of Computer Control and Management Engineering Sapienza University of Rome Via Ariosto 25 Roma00185 Italy Institute for Systems Analysis and Computer Science Italian National Research Council Via dei Taurini 19 Roma00185 Italy Department of Computational Intelligence Czestochowa University of Technology al. Armii Krajowej 36 Czestochowa42-200 Poland

The proposed hand gesture recognition (HGR) system is designed to enhance human-computer interaction (HCI) and human-robot interaction (HRI), which are crucial areas of research aimed at improving the way humans interact with computer or robot systems. With the growing need for intelligent computers and robots in a range of applications, including healthcare, manufacturing, and education, both HCI and HRI have gained significant importance. In this context, the HGR system plays a vital role by enabling natural and intuitive communication between humans and technology through hand gestures. The presented system uses a single camera and efficient image processing techniques that enable real-time gesture detection. Unlike other methods, our approach employs a basic video camera, which is widely available on most computers, eliminating the need for expensive and specialized hardware. © 2022 Copyright for this paper by its authors.

关键词： Human robot interaction

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Fast optimal entrainment of limit-cycle oscillators by strong periodic inputs via phase-amplitude reduction and Floquet theory

arXiv

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arXiv 2021年

作者： Takata, Shohei Kato, Yuzuru Nakao, Hiroya Department of Systems and Control Engineering Tokyo Institute of Technology Tokyo152-8552 Japan

Optimal entrainment of limit-cycle oscillators by strong periodic inputs is studied on the basis of the phase-amplitude reduction and Floquet theory. Two methods for deriving the input waveforms that keep the system state close to the original limit cycle are proposed, which enable the use of strong inputs for entrainment. The first amplitude-feedback method uses feedback control to suppress deviations of the system state from the limit cycle, while the second amplitude-penalty method seeks an input waveform that does not excite large deviations from the limit cycle in the feedforward framework. Optimal entrainment of the van der Pol and Willamowski-Rössler oscillators with real or complex Floquet exponents are analyzed as examples. It is demonstrated that the proposed methods can achieve considerably faster entrainment and provide wider entrainment ranges than the conventional method that relies only on phase reduction. Copyright © 2021, The Authors. All rights reserved.

关键词： Constrained optimization

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Phase and amplitude description of complex oscillatory patterns in reaction-diffusion systems

arXiv

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arXiv 2021年

作者： Nakao, Hiroya Department of Systems and Control Engineering Tokyo Institute of Technology Tokyo152-8552 Japan

Spontaneous rhythmic oscillations are widely observed in various real-world systems. In particular, biological rhythms, which typically arise via synchronization of many self-oscillatory cells, often play important functional roles in living systems. One of the standard theoretical methods for analyzing synchronization dynamics of oscillatory systems is the phase reduction for weakly perturbed limit-cycle oscillators, which allows us to simplify nonlinear dynamical models exhibiting stable limit-cycle oscillations to a simple one-dimensional phase equation. Recently, the classical phase reduction method has been generalized to infinite-dimensional oscillatory systems such as spatially extended systems and time-delayed systems, and also to include amplitude degrees of freedom representing deviations of the system state from the unperturbed limit cycle. In this chapter, we discuss the method of phase-amplitude reduction for spatially extended reaction-diffusion systems exhibiting stable oscillatory patterns. As an application, we analyze entrainment of a reaction-diffusion system exhibiting limit-cycle oscillations by an optimized periodic forcing and additional feedback stabilization. Copyright © 2021, The Authors. All rights reserved.

关键词： Dynamic models

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A Feasible Sequential Linear Programming Algorithm with Application to Time-Optimal Path Planning Problems

A Feasible Sequential Linear Programming Algorithm with Appl...

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IEEE Conference on Decision and control

作者： David Kiessling Andrea Zanelli Armin Nurkanović Joris Gillis Moritz Diehl Melanie Zeilinger Goele Pipeleers Jan Swevers Department of Mechanical Engineering KU Leuven DMMS Lab Flanders Make Leuven Belgium Institute for Dynamic Systems and Control ETH Zurich Switzerland Department of Microsystems Engineering (IMTEK) University of Freiburg Freiburg Germany Department of Mathematics University of Freiburg Freiburg Germany

ISBN: (数字)9781665467612

ISBN: (纸本)9781665467629

In this paper, we propose a Feasible Sequential Linear Programming (FSLP) algorithm applied to time-optimal control problems (TOCP) obtained through direct multiple shooting discretization. This method is motivated by TOCP with nonlinear constraints which arise in motion planning of mechatronic systems. The algorithm applies a trust-region globalization strategy ensuring global convergence. For fully determined problems our algorithm provides locally quadratic convergence. Moreover, the algorithm keeps all iterates feasible enabling early termination at suboptimal, feasible solutions. This additional feasibility is achieved by an efficient iterative strategy using evaluations of constraints, i.e., zero-order information. Convergence of the feasibility iterations can be enforced by reduction of the trust-region radius. These feasibility iterations maintain feasibility for general Nonlinear Programs (NLP). Therefore, the algorithm is applicable to general NLPs. We demonstrate our algorithm’s efficiency and the feasibility update strategy on a TOCP of an overhead crane motion planning simulation case.

关键词： Cranes Mechatronics Globalization Linear programming Path planning Planning Iterative methods

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The future of scientific societies

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Science 2023年第6640期380卷 30-33页

作者： Virgüez, Edgar Eker, Sibel Zdenek, Christina N. Bergh, Cathrine Gerarduzzi, Casimiro Ge, Yan Klinger, Madeline Allareddy, Veerasathpurush Hoots, Elizabeth Henriquez, Tania Waiho, Khor D’Ippoliti, Carlo Al Harraq, Ahmed Xu, Hui Zou, Junyu Xia, Yuanxing Abdul-Ghani, Rashad Chugh, Mayank Biosphere Sciences & Engineering Division Carnegie Institution for Science Stanford CA United States Radboud University Nijmegen Netherlands International Institute for Applied Systems Analysis Laxenburg Austria School of Biological Sciences The University of Queensland Brisbane QLD Australia KTH Royal Institute of Technology Stockholm 11423 Sweden Department of Medicine University of Medicine Montreal QC Canada College of Resources and Environment Northeast Agricultural University Heilongjiang Harbin 150030 China Helen Wills Neuroscience Institute University of California Berkeley Emeryville CA United States Department of Orthodontics University of Illinois Chicago College of Dentistry Chicago IL United States Department of Science Engineering and Built Environment Deakin University Queenscliff VIC Australia Department of Medical Biotechnologies University of Siena Tuscany Siena Italy Higher Institution Centre of Excellence Institute of Tropical Aquaculture and Fisheries Universiti Malaysia Terengganu Terengganu Kuala Nerus Malaysia Department of Statistical Sciences Sapienza University of Rome Rome Italy Cain Department of Chemical Engineering Louisiana State University Baton Rouge LA United States School of Agronomy Anhui Agricultural University Anhui Hefei 230036 China School of Environmental Science and Engineering Southern University of Science and Technology Shenzhen China Department of Electrical Engineering Southeast University Jiangsu Province Nanjing China Faculty of Medicine and Health Sciences Sana’a University Sana’a Yemen Faculty of Medicine and Health Sciences Tropical Disease Research Center University of Science and Technology Sana’a Yemen Department of Systems Biology Harvard Medical School Boston MA United States

AAAS (the publisher of Science) turns 175 years old this year. AAAS’s mission is to advance science, engineering, and innovation throughout the world for the benefit of all. To celebrate this milestone and explore AAAS’s anniversary theme of “igniting progress for the next 175,” we asked young scientists, “How have scientific societies affected your career, and how can societies best support scientists in the future?” Read a selection of the responses here. Follow NextGen Voices on Twitter with hashtag #NextGenSci. —Jennifer Sills

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Elimination of the pharmaceutical sulfadoxine by electro-Fenton: Reaction kinetics, oxidation pathway and stability of the electrode

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Chemosphere 2025年 375卷 144265页

作者： Petsi, Panagiota Plakas, Konstantinos V. Bizirtsakis, Panagiotis Anagnostopoulou, Kyriaki Moschona, Alexandra Lambropoulou, Dimitra Frontistis, Zacharias Department of Chemical Engineering University of Western Macedonia KozaniGR50132 Greece Chemical Process and Energy Resources Institute Centre for Research and Technology-Hellas 6th km of Charilaou-Thermis ThessalonikiGR57001 Greece Department of Chemistry Environmental Pollution Control Laboratory Aristotle University of Thessaloniki ThessalonikiGR54124 Greece Balkan Center 10th km Thessaloniki-Thermi Rd ThessalonikiGR 57001 Greece

In this study, the removal of sulfadoxine (SDX) with the electro-Fenton (EF) process is for the first time investigated, in a commercially available filter press electrochemical cell. A Gas Diffusion Electrode (GDE) was used as the cathode and a Dimensionally Stable Anode (DSA) as the anode. The effects of current density, recirculation flow, and pH on H2O2 generation were examined. The maximum H2O2 concentration was 457 mg/L at 50 mA/cm2, 200 mL/min, and pH 7 after 2 h of operation. Under the same conditions, the effect of Fe2+ on SDX oxidation and mineralization was studied. With 0.5 mM Fe2+, SDX was eliminated within 10 min, with 77.4% total organic carbon (TOC) removal after 2 h. Notably, Fe precipitation was observed at near-neutral pH, indicating that removal via coagulation and adsorption may have contributed to SDX elimination in addition to oxidation. Five transformation products (TPs) were identified via LC/HRMS Orbitrap, with four newly reported. The acute and chronic toxicity of the TPs was assessed in fish, daphnia, and green algae using ECOSAR software. Most TPs showed lower toxicity than SDX, though some exhibited increased toxicity, suggesting longer or more intense treatments may be needed. The stability of the GDE was evaluated over 10 consecutive cycles with 0.1 mM Fe2+. SDX removal remained stable, ranging from 72.2% to 85.4%, though H2O2 electrogeneration decreased steadily from 481.4 mg/L to 200.6 mg/L by the final cycle. These results suggest that while EF effectively removes SDX, improvements in H2O2 generation stability are necessary for long-term use. © 2025

关键词： Diffusion in gases

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