Conventional model predictive current control of permanent magnet synchronous machines (PMSMs) relies heavily on a precise mathematical model, which may be challenging to obtain in certain cases. To address this issue...
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This study introduces an innovative contour detection algorithm,PeakCET,designed for rapid and efficient analysis of natural product image fingerprints using comprehensive two-dimensional gas chromatogram(GC×GC)....
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This study introduces an innovative contour detection algorithm,PeakCET,designed for rapid and efficient analysis of natural product image fingerprints using comprehensive two-dimensional gas chromatogram(GC×GC).This method innovatively combines contour edge tracking with affinity propagation(AP)clustering for peak detection in GC×GC fingerprints,the first in this *** edge tracking signif-icantly reduces false positives caused by“burr”signals,while AP clustering enhances detection accuracy in the face of false *** efficacy of this approach is demonstrated using three medicinal products derived from Curcuma *** not only performs contour detection but also employs inter-group peak matching and peak-volume percentage calculations to assess the compositional similarities and differences among various ***,this algorithm compares the GC×GC fingerprints of Radix/Rhizoma Curcumae Wenyujin with those of products from different botanical *** findings reveal that genetic and geographical factors influence the accumulation of secondary metabolites in various plant *** sample exhibits unique characteristic components alongside common ones,and vari-ations in content may influence their therapeutic *** research establishes a foundational data-set for the quality assessment of Curcuma products and paves the way for the application of computer vision techniques in two-dimensional(2D)fingerprint analysis of GC×GC data.
Parkinson’s disease (PD) is a debilitating neurodegenerative disorder affecting millions worldwide. Early detection is vital for effective management, yet remains challenging. In this study, we investigated four dist...
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This paper presents a thorough study of particle impact breakage in selection function with a unified breakage *** impact mode and breakage pattern for particulate materials are classified based on a significant revie...
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This paper presents a thorough study of particle impact breakage in selection function with a unified breakage *** impact mode and breakage pattern for particulate materials are classified based on a significant review of well-established impact *** was found that the lack of a unified breakage criterion to determine the breakage probability disables a direct comparison of particle breakage propensity from different impact loading *** literature breakage models to describe the breakage probability are reviewed where the advantage and drawback of these models are *** sourced literature breakage models are compared with the zeolite breakage datasets in a unified breakage criterion to evaluate the model performance.A novel computational modelling workflow for a milling process is proposed to provide a guidance in implementing the digital twin in milling process *** breakage probability models,*** selection functions are comprehensively assessed in population balance model to examine the model *** model simplicity and fidelity in the model assessment are specifically discussed and the value of digital twin in substantially reducing the experimental trials is highlighted.
Highly hydrophilic materials enable rapid water delivery and salt redissolution in solar-driven seawater desalination. However, the lack of independent floatability inhibits heat localization at the air/water interfac...
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Highly hydrophilic materials enable rapid water delivery and salt redissolution in solar-driven seawater desalination. However, the lack of independent floatability inhibits heat localization at the air/water interface. In nature, seaweeds with internal gas microvesicles can float near the sea surface to ensure photosynthesis. Here, we have developed a seaweed-inspired, independently floatable, but superhydrophilic (SIFS) solar evaporator. It needs no extra floatation support and can simultaneously achieve continuous water pumping and heat concentration. The evaporator resists salt accumulation, oil pollution, microbial corrosion, and protein adsorption. Densely packed hollow glass microbeads promote intrinsic floatability and heat insulation. Superhydrophilic zwitterionic sulfobetaine hydrogel provides a continuous water supply, redissolves the deposited salt, and endows the SIFS evaporator with excellent anti-fouling properties. With its unprecedented anti-contamination ability, this SIFS evaporator is expected to open a new avenue for designing floatable superhydrophilic materials and solving real-world issues of solar steam generation in complex environmental conditions.
Cyber-physical systems(CPSs)have emerged as an essential area of research in the last decade,providing a new paradigm for the integration of computational and physical units in modern control *** state estimation(RSE)...
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Cyber-physical systems(CPSs)have emerged as an essential area of research in the last decade,providing a new paradigm for the integration of computational and physical units in modern control *** state estimation(RSE)is an indispensable functional module of ***,it has been demonstrated that malicious agents can manipulate data packets transmitted through unreliable channels of RSE,leading to severe estimation performance *** paper aims to present an overview of recent advances in cyber-attacks and defensive countermeasures,with a specific focus on integrity attacks against ***,two representative frameworks for the synthesis of optimal deception attacks with various performance metrics and stealthiness constraints are discussed,which provide a deeper insight into the vulnerabilities of ***,a detailed review of typical attack detection and resilient estimation algorithms is included,illustrating the latest defensive measures safeguarding RSE from ***,some prevalent attacks impairing the confidentiality and data availability of RSE are examined from both attackers'and defenders'***,several challenges and open problems are presented to inspire further exploration and future research in this field.
There are lots of biochemical reactions in the biosynthetic pathway without associated *** predicted by retro-biosynthetic tools are not assigned gene ***,non-natural reactions designed with novel functions also lack ...
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There are lots of biochemical reactions in the biosynthetic pathway without associated *** predicted by retro-biosynthetic tools are not assigned gene ***,non-natural reactions designed with novel functions also lack suitable *** these reactions can be categorized as orphan *** absence of protein-encoding genes in these orphan reactions limits their direct experimental *** tools have been developed to find candidate enzymes for these orphan ***,we discuss recent advances in these computational tools,including reaction similarity-based methods for calculating the substructural similarity between orphan reactions and known enzymatic reactions;sequence-based tools combine metabolic knowledge base and phenotypic information with genomic,transcriptomic,and metabolomic data to mine appropriate enzymes for orphan reactions;and approaches based on the creation of enzyme variants for orphan reactions as enzyme engineering modifications and de novo design of *** believe that our review will greatly facilitate the design of microbial cell factories and contribute to the development of the biomanufacturing field.
Pharmacists in conventional pharmacies and hospitals prepare and visually inspect medications before dispensing these medications to patients, thereby posing risks of exposure through skin contact or inhalation, as we...
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Acetoin is an important platform chemical,which has a wide range of applications in many *** bluephagenesis,a chassis for next generation of industrial biotechnology,has advantages of fast growth and high tolerance to...
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Acetoin is an important platform chemical,which has a wide range of applications in many *** bluephagenesis,a chassis for next generation of industrial biotechnology,has advantages of fast growth and high tolerance to organic acid salts and alkaline ***,α-acetolactate synthase andα-acetolactate decarboxylase from Bacillus subtilis 168 were co-expressed in *** to produce acetoin from *** reaction condition optimization and further increase ofα-acetolactate decarboxylase expression,acetoin production and yield were significantly enhanced to 223.4 mmol·L^(-1) and 0.491 mol·mol^(-1) from 125.4 mmol·L^(-1) and 0.333 mol·mol^(-1),***,the highest titer of 974.3 mmol·L^(-1)(85.84 g·L^(-1))of acetoin was accumulated from 2143.4 mmol·L^(-1)(188.6 g·L^(-1))of pyruvic acid within 8 h in fed-batch bioconversion under optimal reaction ***,the reusability of the cell catalysis was also tested,and the result illustrated that the whole-cell catalysis obtained 433.3,440.2,379.0,442.8 and 339.4 mmol·L^(-1)(38.2,38.8,33.4,39.0 and 29.9 g·L^(-1))acetoin in five repeated cycles under the same *** work therefore provided an efficient *** whole-cell catalysis with a broad development prospect in biosynthesis of acetoin.
The Southwest Maluku region in eastern Indonesia is considered a frontier,outermost and underdeveloped *** inhabitants live on isolated islands,including the residents of Mahaleta Village,where only 9.4%of the communi...
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The Southwest Maluku region in eastern Indonesia is considered a frontier,outermost and underdeveloped *** inhabitants live on isolated islands,including the residents of Mahaleta Village,where only 9.4%of the community have limited access to *** study aimed to design an economically feasible hybrid renewable energy(RE)system based on solar and wind energy to integrate with the productive activities of the *** study developed conceptual schemes to meet the demand for electricity from the resi-dential,community,commercial and productive sectors of the *** analysis was performed using a techno-economic *** hybrid system was designed using the HOMER Pro optimization function,and cold-storage and dryer systems were designed to support related productive *** optimized design of the hybrid RE system comprised 271.62 kW of solar photovoltaics,80 kW of wind turbines and a 1-MWh lead-acid *** found that the hybrid RE system would only be economically feasible with a full-grant incentive and an electricity tariff of$0.0808/***,the productive activity schemes were all economically feasible,with a cold-storage cost of$0.035/kg and a drying cost of$0.082/*** the hybrid RE system with productive activities can improve the economic feasibility of the energy system and create more jobs as well as increase income for the local community.
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