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Metallo-supramolecular complexes enantioselectively target monkeypox virus RNA G-quadruplex and bolster immune responses against MPXV

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National Science Review 2025年第1期12卷 167-176页

作者： Jie Yang Geng Qin Baoying Huang Hualong Song Jiewei Sun Miles Postings Peter Scott Chuanqi Zhao Chunyu Wang Wenjie Tan Jinsong Ren Xiaogang Qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) Department of Chemistry University of Warwick School of Pharmacy Xinxiang Medical University State Key Laboratory of Supramolecular Structure and Materials Jilin University

The Mpox virus(MPXV) has emerged as a formidable orthopoxvirus, posing an immense challenge to global public health. An understanding of the regulatory mechanisms of MPXV infection, replication and immune evasion will benefit the development of novel antiviral strategies. Despite the involvement of G-quadruplexes(G4s) in modulating the infection and replication processes of multiple viruses, their roles in the MPXV life cycle remain largely unknown. Here, we found a highly conservative and stable G4 in MPXV that acts as a positive regulatory element for viral immunodominant protein ***, by screening 42 optically pure chiral metal complexes, we identified the Λ enantiomer of a pair of chiral helical compounds that can selectively target m RNA G4 and enhance expression of the 39-k Da core protein encoded by the MPXV A5L gene. Mechanistically, RNA G4-specific helicase DHX36 inhibits A5L protein expression by unwinding G4s. In contrast, MH3 Λ enhanced m RNA stability by specifically targeting G4 structures and subsequently increased protein expression. Furthermore, given the pivotal role of the 39-k Da core protein in activating immune responses and facilitating virion maturation, modulation of MPXV G4 folding by MH3 Λ exhibited inhibitory effects on MPXV replication through enhancing the immune response. Our findings underscore the critical involvement of G4 in the MPXV life cycle and offer potential avenues for developing antiviral drugs that target G4.

关键词： G-quadruplex ligand binding Mpox virus chirality supramolecular chemistry

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Degradation kinetics and disinfection by-products formation of benzophenone-4 during UV/persulfate process

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Environmental Technology (United Kingdom) 2024年第26期45卷 5618-5629页

作者： Hu, Chen-Yan Xiong, Cun Lin, Yi-Li Zhang, Tian-Yang College of Environmental and Chemical Engineering Shanghai Engineering Research Center of Energy-Saving in Heat Exchange Systems Shanghai University of Electric Power Shanghai China Shanghai Institute of Pollution Control and Ecological Security Shanghai China Department of Safety Health and Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan State Key Laboratory of Pollution Control and Resources Reuse Key Laboratory of Yangtze Water Environment Ministry of Education College of Environmental Science and Engineering Tongji University Shanghai China

The degradation kinetics, reaction pathways, and disinfection by-products formation of an organic UV filter, benzophenone-4 (BP4) during UV/persulfate oxidation were investigated. BP4 can hardly be degraded by UV alone, but can be effectively decomposed by UV/persulfate following pseudo-first order kinetics. BP4 degradation rate was enhanced with increasing persulfate dosage and decreasing pH from 8 to 5. However, the degradation rate of BP4 at pH 9 was higher than that at pH 8 because of the presence of phenolic group in BP4 structure. and (Formula presented.) were confirmed as the major contributors to BP4 decomposition in radical scavenging experiments, and the second-order rate constants between (Formula presented.) and BP4 as well as those between (Formula presented.) and BP4 were estimated by establishing and solving a kinetic model. The presence of (Formula presented.) and humic acid inhibited the decomposition of BP4, while (Formula presented.) promoted it. The mineralisation of BP4 was only 9.1% at the persulfate concentration of 50 μM. Six degradation intermediates were identified for the promulgation of the reaction pathways of BP4 during UV/persulfate oxidation were proposed as a result. In addition, the formation of DBP in the sequential chlorination was evaluated at different persulfate dosages, pH values, and water matrix. The results of this study can provide essential knowledge for the effective control of DBP formation with reducing potential hazard to provide safe drinking water to the public. © 2023 Informa UK Limited, trading as Taylor & Francis Group.

关键词： Rate constants

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Metal–Organic Gel Leading to Customized Magnetic‑Coupling engineering in Carbon Aerogels for Excellent Radar Stealth and Thermal Insulation Performances

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Nano-Micro Letters 2024年第3期16卷 36-52页

作者： Xin Li Ruizhe Hu Zhiqiang Xiong Dan Wang Zhixia Zhang Chongbo Liu Xiaojun Zeng Dezhi Chen Renchao Che Xuliang Nie Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Environmental and Chemical Engineering Nanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Department of Materials Science and Collaborative Innovation Center of Chemistry for Energy Materials and Collaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200438People’s Republic of China School of Materials Science and Engineering Jingdezhen Ceramic UniversityJingdezhen 333403People’s Republic of China College of Chemistry and Materials Jiangxi Agricultural UniversityNanchang 330045People’s Republic of China

Metal–organic gel(MOG)derived composites are promising multi-functional materials due to their alterable composition,identifiable chemical homogeneity,tunable shape,and porous ***,stable metal–organic hydrogels are prepared by regulating the complexation effect,solution polarity and curing ***,collagen peptide is used to facilitate the fabrication of a porous aerogel with excellent physical properties as well as the homogeneous dispersion of magnetic particles during ***,two kinds of heterometallic magnetic coupling systems are obtained through the application of Kirkendall ***/nitrogen-doped carbon(NC)aerogel demonstrates an ultra-strong microwave absorption of−85 dB at an ultra-low loading of 5%.After reducing the time taken by atom shifting,a FeCo/Fe3O4/NC aerogel containing virus-shaped particles is obtained,which achieves an ultra-broad absorption of 7.44 GHz at an ultra-thin thickness of 1.59 mm due to the coupling effect offered by dual-soft-magnetic ***,both aerogels show excellent thermal insulation property,and their outstanding radar stealth performances in J-20 aircraft are confirmed by computer simulation *** formation mechanism of MOG is also discussed along with the thermal insulation and electromagnetic wave absorption mechanism of the aerogels,which will enable the development and application of novel and lightweight stealth coatings.

关键词： Metal-organic gels Heterometallic magnetic coupling Radar stealth Thermal insulation Computer simulation technology

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Progresses on two-phase modeling of proton exchange membrane water electrolyzer

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Energy Reviews 2024年第3期3卷 30-57页

作者： Boshi Xu Tao Ouyang Yang Wang Yang Yang Jun Li Liangliang Jiang Chaozhong Qin Dingding Ye Rong Chen Xun Zhu Qiang Liao Key Laboratory of Low-grade Energy Utilization Technologies and Systems Ministry of EducationChongqing UniversityChongqing400030China Institute of Engineering Thermophysics School of Energy and Powering EngineeringChongqing UniversityChongqing400030China Department of Chemical and Petroleum Engineering The University of CalgaryCalgaryAlbertaCanada State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400044China

The Proton Exchange Membrane(PEM)water electrolyzer is considered one of the promising energy storing means for harnessing variable renewable energy sources to produce *** the internal fluid dynamics,which are often challenging to directly observe experimentally,has prompted the use of numerical models to investigate two-phase flow within PEM water *** this study,we provide a comprehensive review of prior research focusing on two-phase modeling of PEM electrolyzers,encompassing both components at mesoscopic scales and the full electrolyzer at the macroscopic *** delve into the specifics of various modeling approaches for two-phase flow at different scales and summarize and discuss the current state of the art in the ***,two-phase models for the full electrolyzer predominantly employ a macroscopic homogeneous ***,mesoscopic and microscopic models capable of tracking phase interfaces are limited to *** persist in integrating various modeling scales into a comprehensive electrolyzer model,particularly in coupling two-phase flow between the channels and porous *** efforts should focus on developing multi-scale models and simulating two-phase flow under fluctuating input ***,given the structural similarities between PEM water electrolyzers and PEM fuel cells,we compare and discuss differences in two-phase modeling between the two *** work offers the insights for researchers in the field of modeling of PEM water electrolyzers and even fuel cells.

关键词： Proton exchange membrane(PEM)water electrolyzer Two-phase model Multiscale modeling Water management Numerical simulation

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The Journey/DAO/TAO of Embodied Intelligence: From Large Models to Foundation Intelligence and Parallel Intelligence

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1313-1316页

作者： Tianyu Shen Jinlin Sun Shihan Kong Yutong Wang Juanjuan Li Xuan Li Fei-Yue Wang College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China School of Electrical and Information Engineering Jiangsu UniversityZhenjiang 212013China State Key Laboratory for Turbulence and Complex Systems Department of Advanced Manufacturing and RoboticsCollege of EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China Peng Cheng Laboratory Shenzhen 518000China State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China IEEE

THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real *** this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].

关键词： Intelligence DAO TAO

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Magnetic Microrobots Fabricated by Photopolymerization and Assembly

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Cyborg and Bionic systems 2023年第1期4卷 41-46页

作者： Xiyue Liang Yue Zhao Dan Liu Yan Deng Tatsuo Arai Masaru Kojima Xiaoming Liu Key Laboratory of Biomimetic Robots and Systems Ministry of EducationState Key Laboratory of Intelligent Control and Decision of Complex SystemBeijing Advanced Innovation Center for Intelligent Robots and Systemsand School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China Center for Neuroscience and Biomedical Engineering The University of Electro-CommunicationsTokyo 182-8585Japan Department of Materials Engineering Science Osaka UniversityOsaka 560-8531Japan

Magnetic soft microrobots have great potential to access narrow spaces and conduct multiple tasks in the biomedical *** now,drug delivery,microsurgery,disease diagnosis,and dredging the blocked blood vessel have been realized by magnetic soft microrobots in vivo or in ***,as the tasks become more and more complex,more functional units have been embedded in the body of the developed magnetic *** magnetic soft microrobots with complex designed geometries,mechanisms,and magnetic orientation are now greatly challenging the fabrication of the magnetic *** this paper,we propose a new method combining photopolymerization and assembly for the fabrication of magnetic soft *** the micro-hand assembly system,magnetic modules with different shapes and materials are firstly arrayed with precise position and orientation ***,the developed photopolymerization system is employed to fix and link these modules with soft *** on the proposed fabrication method,3 kinds of soft magnetic microrobots were fabricated,and the fundamental locomotion was *** believe that the presented fabrication strategy could help accelerate the clinical application of magnetic microrobots.

关键词： Magnetic system precise

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Surfing the nano-wave:Emerging trends in cancer diagnostics and therapy

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Nano Research 2025年第1期18卷 520-544页

作者： Genping Fu Yuting Weng Yunfan Li Carl Ho Yiyu Fu Wenxuan Wang Songbin Fu Wenjing Sun Jie Lin Xiaoyu Fan Binbin Jia Mengdi Cai Linlin Li Laboratory of Medical Genetics Harbin Medical UniversityHarbin 150081China Key Laboratory of Preservation of Human Genetics Resources and Disease Control in China(Harbin Medical University) Ministry of EducationHarbin 150081China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Washington University School of Medicine in St.Louis St.LouisMO 63110USA Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Aix-Marseille College Wuhan University of TechnologyWuhan 430070China

Facing the growing global challenge posed by cancer,the quest for more accurate and potent cancer diagnostic and therapeutic strategies continues to require a multidisciplinary integration *** review firstly summarizes various types of nanoparticles in cancer ***,it offers a comprehensive overview of signalenhancing techniques for visualizing in situ tumors,along with multimodal diagnostic methods for detecting *** for tumor therapy,cutting-edge drug delivery methods that can cross biological barriers and the pinpoint targeting of tumor lesions for precise medical intervention are *** the domain of therapeutic diagnostics,we elucidate the theoretical underpinnings and structural paradigms that underlie a spectrum of advanced diagnostic and therapeutic ***,we present a compendium of publications delineating the clinical applications of each nano-based theragnostic integration ***,this comprehensive review discusses the safety concerns pertaining to the clinical application of nanoparticles and proposes some strategic recommendations to enhance the precision and safety of theragnostic-guided,nanotechnology-based clinical practices.A deeper understanding of nanomaterials,together with intimate interdisciplinary collaborations,nano-wave will most probably guide human beings to win the battle against cancers.

关键词： nanoparticles drug delivery gastric cancer glioma glioblastoma

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Wood-derived freestanding integrated electrode with robust interface-coupling effect boosted bifunctionality for rechargeable zinc-air batteries

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Green Energy & Environment 2024年第12期9卷 1835-1846页

作者： Benji Zhou Nengneng Xu Liangcai Wu Dongqing Cai Eileen HYu Jinli Qiao State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Environmental Science and EngineeringDonghua University2999 Ren'min North RoadShanghai201620China College of Science Donghua University2999 Ren'min North RoadShanghai201620China Shanghai Institute of Pollution Control and Ecological Security 1515 North Zhongshan RoadShanghai200092China Department of Chemical Engineering Loughborough UniversityLoughboroughLE113TUUK

Fabricating non-noble metal-based carbon air electrodes with highly efficient bifunctionality is big challenge owing to the sluggish kinetics of oxygen reduction/evolution reaction(ORR/OER).The efficient cathode catalyst is urgently needed to further improve the performance of rechargeable zinc-air ***,an activation-doping assisted interface modification strategy is demonstrated based on freestanding integrated carbon composite(CoNiLDH@NPC)composed of wood-based N and P doped active carbon(NPC)and CoNi layer double hydroxides(CoNiLDH).In the light of its large specific surface area and unique defective structure,CoNiLDH@NPC with strong interfacecoupling effect in 2D-3D micro-nanostructure exhibits outstanding *** carbon composites show half-wave potential of 0.85 V for ORR,overpotential of 320 mV with current density of 10 mA cm^(-2) for OER,and ultra-low gap of 0.70 ***,highly-ordered open channels of wood provide enormous space to form abundant triple-phase boundary for accelerating the catalytic ***,zinc-air batteries using CoNiLDH@NPC show high power density(aqueous:263 mW cm^(-2),quasi-solid-state:65.8 mW cm^(-2))and long-term stability(aqueous:500 h,quasi-solid-state:120 h).This integrated protocol opens a new avenue for the rational design of efficient freestanding air electrode from biomass resources.

关键词： Wood biomass Bifunctional air electrode Freestanding carbon composite Interface-coupling effect Zinc-air battery

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Advantageous properties of halide perovskite quantum dots towards energy-efficient sustainable applications

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Green Energy & Environment 2024年第6期9卷 949-965页

作者： Qian Zhao Shuo Wang Young-Hoon Kim Shekhar Mondal Qingqing Miao Simiao Li Danya Liu Miao Wang Yaxin Zhai Jianbo Gao Abhijit Hazarika Guo-Ran Li School of Materials Science and Engineering Nankai UniversityTianjin300350China Department of Energy Engineering Hanyang UniversitySeoul04763Republic of Korea Polymers and Functional Materials Division CSIR-Indian Institute of Chemical TechnologyUppal RoadTarnakHyderabad500007India Institute of Process Engineering Chinese Academy of SciencesBeijing100190China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangshHunan410081China Department of Chemistry Brock University1812 Sir Isaac WaySt CatharinesOntarioCanada

As lead halide perovskite(LHP)semiconductors have shown tremendous promise in many application fields,and particularly made strong impact in the solar photovoltaic area,low dimensional quantum dot forms of these perovskites are showing the potential to make distinct marks in the fields of electronics,optoelectronics and *** so-called perovskite quantum dots(PQDs)not only possess the most important features of LHP materials,i.e.,the unusual high defect tolerance,but also demonstrate clear quantum size effects,along with exhibiting desirable optoelectronic properties such as near perfect photoluminescent quantum yield,multiple exciton generation and slow hot-carrier ***,we review the advantageous properties of these nanoscale perovskites and survey the prospects for diverse applications which include lightemitting devices,solar cells,photocatalysts,lasers,detectors and memristors,emphasizing the distinct superiorities as well as the challenges.

关键词： Perovskite quantum dot Light-emitting Detector Laser Solar cell

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Magnetic exchange interaction between unpaired π-and d-electrons in nanographene-metal coordination complexes

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National Science Review 2025年第4期12卷 260-267页

作者： Deng-Yuan Li Yuqiang Zheng Ricardo Ortiz Bing-Xin Wang Yashi Jiang Bingkai Yuan Xin-Yu Zhang Can Li Liang Liu Xiaoxue Liu Dandan Guan Yaoyi Li Hao Zheng Canhua Liu Jinfeng Jia Thomas Frederiksen Pei-Nian Liu Shiyong Wang Key Laboratory of Natural Medicines Department of Medicinal ChemistryChina Pharmaceutical University Key Laboratory of Artificial Structures and Quantum Control (Ministry of Education) TD Lee Institute Shenyang National Laboratory for Materials ScienceSchool of Physics and Astronomy Shanghai Jiao Tong University Donostia International Physics Center (DIPC) Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Frontiers Science Center for Materiobiology and Dynamic ChemistryState Key Laboratory of Chemical Engineering School of Chemistry and Molecular Engineering East China University of Science & Technology Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences (CAS) Hefei National Laboratory Ikerbasque Basque Foundation for Science

The combination of open-shell nanographenes(NGs) and magnetic transition metals holds great promise for generating various new quantum phases applicable in spintronics and quantum information ***,a crucial aspect in accomplishing this is to comprehend the magnetic exchange interactions between unpaired π-and d-electrons,a topic that has been seldom *** this study,we focus on magnetic π-d exchange interactions between open-shell NGs and a magnetic coordination center of Fe or Co by employing scanning tunneling microscopy and *** synthesize two sets of NG-metal coordination complexes on a Au(111) substrate,secured by coordination bonds of carboxyl acid-Fe(Co).Through analysis of the excitation spectra,we observe a characteristic exchange coupling of 9 meV(5 meV) between the unpaired π-electron and the Fe(Co) d-shell *** experimental findings are qualitatively in agreement with multiconfigurational quantum chemistry *** work provides evidence that a substantial magnetic exchange coupling can be achieved and engineered in metal-organic coordination systems,paving the way for designing and customizing extended radical metal-organic frameworks with precisely tailored magnetic properties.

关键词： open-shell nanographene magnetic exchange interaction metal-organic coordination complexes on-surface synthesis scanning probe microscopy

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