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Regression models for the prediction of the influence of magnesium ions on primary endothelial cell (HUVEC) proliferation and migration

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Computational and Structural Biotechnology Journal 2025年

作者： Heike Helmholz Redon Resuli Marius Tacke Jalil Nourisa Sven Tomforde Roland Aydin Regine Willumeit-Römer Berit Zeller-Plumhoff Institute of Metallic Biomaterials Helmholz-Zentrum Hereon Geesthacht Institute for Continuum and Material Mechanics Hamburg University of Technology Hamburg Institute of Material Systems Modeling Helmholz-Zentrum Hereon Geesthacht Department of Computer Science Faculty of Engineering Kiel University Kiel Kiel Nano Surface and Interface Science - KiNSIS Kiel University Germany Data-driven Analysis and Design of Materials Faculty of Mechanical Engineering and Marine Technologies University of Rostock Germany Department Life Light & Matter Interdisciplinary Faculty University of Rostock Germany

Angiogenesis is one of the first stages in fracture healing and bone repair. Therefore, numerous studies evaluating the effect of Mg as a promising degradable, metallic biomaterial on the proliferation and function of endothelial cells have been performed. However, these studies lack methodological homogeneity and therefore differ in fundamental conclusions. Here, Mg-concentration-, donor- and cell age- dependent relations to primary human umbilical cord vein endothelial cells (HUVEC) proliferation and migration were investigated systematically. The generated data were utilized to develop regression models in order to assess and predict the cell response on Mg exposition in a concentration range of 2-20 mM Mg in cell culture medium extract. A concentration of >2 mM already induced a detrimental effect in the sensitive primary HUVECs. Molecular data quantifying angiogenesis markers supported this finding. An increased migration capacity has been observed at a concentration of 10 mM Mg. We compared linear regression, random forests, support vector machines, neural networks and large language models for the prediction of HUVEC proliferation for a number of scenarios. Using these machine learning methods, we were able to predict the proliferation of HUVECs for missing Mg concentrations and for missing passages with mean absolute errors below 10% and as low as 8.5%, respectively. Due to strong differences between the cell behaviour of different donors, information for missing donors can be predicted with mean absolute errors of 15.7% only. Support vector machines with linear kernel performed best on the tested data, but large language models also showed promising results.

关键词： Regression models HUVEC cell proliferation Large Language Model

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Electric Power Quality in the Single-Phase Power Supply Networks of Electronic Means

Electric Power Quality in the Single-Phase Power Supply Netw...

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International Multi-Conference on Industrial Engineering and Modern Technologies (FarEastCon)

作者： Z. Gizatullin M. Shkinderov E. Konstantinov Department of Computer Aided Design Systems Kazan National Research Technical University named after A.N. Tupolev-KAI Kazan Russian Federation

The problems of power quality gain relevance, as they are among the most important conditions for the reliable, economical and long-term operation of modern electronic means. The results of the analysis of the quality of electricity in single-phase power supply network in the Republic of Tatarstan of the Russian Federation are presented. The causes and types of violations of power quality parameters are considered. Recommendations for improving the quality of electricity are suggested.

关键词： Voltage measurement Power quality Power measurement Frequency measurement Voltage control Time measurement

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Research of Noise Immunity of Computing Equipment under Exposure of Electrostatic Discharge

Research of Noise Immunity of Computing Equipment under Expo...

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International Russian Automation Conference (RusAutoCon)

作者： Zinnur Gizatullin Maksim Shkinderov Department of Computer Aided Design Systems Kazan National Research Technical University named after A.N Tupolev-KAI Kazan Russian Federation

Automated object management systems are built on the basis of computing equipment, which must meet the requirements for noise immunity. Electrostatic discharge is a common natural source of electromagnetic interference. Mathematical models for analyzing the current of an electrostatic discharge are given. The electromagnetic interference in communication lines under the influence of an electrostatic discharge on a computer case are simulated. The simulation results are compared with experimental data. The methods of protection against of electrostatic discharge are considered. However, they are not always effective. A technical solution aimed at improving the efficiency of shielding the cases of computing equipment at electrostatic discharge by reducing resonance effects are provided.

关键词： Electrostatic discharges Electromagnetic interference Discharges (electric) Immune system Electrostatic measurements Fault diagnosis

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Research of Noise Immunity of computer Equipment of Control systems Under Action of Pulsed Magnetic Field

Research of Noise Immunity of Computer Equipment of Control ...

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International Russian Automation Conference (RusAutoCon)

作者： Zinnur Gizatullin Rifnur Gizatullin Valeriy Drozdikov Department of Computer Aided Design Systems Kazan National Research Technical University named after A.N. Tupolev-KAI Kazan Russian Federation

Computing equipment is an integral part of the automatic control systems. Often powerful pulsed magnetic fields arise around computing equipment. Therefore, it must have the necessary noise immunity and, accordingly, the reliability of operation when exposed to pulsed magnetic fields. The main powerful sources of a pulsed magnetic field are lightning discharges or switching processes of powerful consumers of electricity. The experimental data of the noise immunity of a computer under the influence of a pulsed magnetic field are presented. An analysis of electromagnetic interference in the communication lines of computer equipment under the action of a pulsed magnetic field is presented. A mathematical model for predicting electromagnetic interference was constructed. The modeling and experimental results are compared.

关键词： Magnetic fields Electromagnetic interference Lightning Discharges (electric) Transmission line measurements Conductors Computational modeling

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Development of technological processes for production of items from composite materials based on criterion system

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Journal of Physics: Conference Series 2021年第1期2144卷

作者： V I Galkin A R Paltievich E V Galkin Department of Technologies and Systems for Computer-Aided Design of Metallurgical Processes in Federal State Budgetary Educational Institution of Higher Education 'Moscow Aviation Institute' (National Research University) Volokolamskoe highway 4 Moscow 125993 Russia

The method of development of technological processes of production of items from composite materials is developed, based on application of the criterion system providing formation of strong connection of components an...

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Development of automated identification technology objects during their movement along not typed routes using multi-code labeling

Development of automated identification technology objects d...

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2018 International Russian Automation Conference, RusAutoCon 2018

作者： Astafiev, A.V. Privezentsev, D.G. Department of Physics and Applied Mathematics Vladimir State University Vladimir Russia Department of Computer-Aided Design Systems Vladimir State University Vladimir Russia

ISBN: (纸本)9781538649381

The article proposes an approach of multi-code labeling of industrial products to increase the reliability of automatic identification systems when transporting them during stochastic movement. A practical problem is described, the solution of which is directed at the technology being developed. The problem of product identification during stochastic displacement is considered on the example of OJSC 'Vyksa Steel Works'. The definition of multi-code labeling is given. The classical methods of data integrity control are considered and the possibilities of their use for generation of multi-code labels are considered. The analysis of the method of checksums for the creation of multi-code labels was carried out and an algorithm for their generation was developed. The program implementation of the developed algorithm is carried out. The results of the work are implemented in the warehouse of packaging materials of the 'Group of Companies Global33' company of the Vladimir region for the organization of automatic traceability of the rolls of air-bubble film along the conveyor line. © 2018 IEEE.

关键词： Stochastic systems

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The Analysis of the Noise Immunity of an Electronic Device under the Action of Electrostatic Discharge 14

The Analysis of the Noise Immunity of an Electronic Device u...

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14th International Scientific-Technical Conference on Actual Problems of Electronic Instrument Engineering, APEIE 2018

作者： Gizatullin, Rifnur M. Gizatullin, Zinnur M. Shkinderov, Maksim S. Khuziyakhmetova, Elvina A. Kazan National Research Technical University Named after A.N. Tupolev-KAI Department of Computer Aided Design Systems Kazan Russia

ISBN: (纸本)9781538670545

The paper presents the results of experimental studies of the noise immunity of a personal computer under the action of electrostatic discharge. The analysis of electromagnetic interference in communication lines of electronic devices during of pulsed electrostatic discharge on the metal parts of the case are presented. A mathematical model for predicting interference is constructed. A comparison of the experimental results and modeling is carried out. © 2018 IEEE.

关键词： Signal interference

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Physical modeling of Electromagnetic Interferences in the Electronic Devices at Direct Impact of Lightning on Protection System of Building 14

Physical Modeling of Electromagnetic Interferences in the El...

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14th International Scientific-Technical Conference on Actual Problems of Electronic Instrument Engineering, APEIE 2018

作者： Nuriev, Marat G. Gizatullin, Rifnur M. Gizatullin, Zinnur M. Kazan National Research Technical University Named after A.N. Tupolev-KAI Department of Computer Aided Design Systems Kazan Russia

ISBN: (纸本)9781538670545

The technique has been developed for analysis the noise immunity of electronic devices in the case of lightning strike impact on the lightning protection system on the basis of physical modeling. The mathematical models, the scheme of experimental stand and examples of parameters calculation for physical modeling of electromagnetic interference in communication line under the influence of magnetic fields of lightning discharge are offered. The example of physical modeling of electromagnetic interference in communication lines of electronic devices is presented. © 2018 IEEE.

关键词： Electromagnetic pulse

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Nanoengineering of Anisotropic Materials for Creating the Active Optical Cells with Increased Energy Efficiency

arXiv

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arXiv 2019年

作者： Andrushchak, Nazariy Goering, Petra Andrushchak, Anatoliy Department of Computer-Aided Design Systems Lviv Polytechnic National University Lviv Ukraine Department of Research and Development SmartMembranes GmbH Department of Telecommunication Lviv Polytechnic National University Lviv Ukraine

In this paper the state-of-the-art for exploiting the unique physical and chemical properties of crystalline materials and their possible applications for development of crystalline nanocomposites with the tailored anisotropy were discussed. Using a method of growing crystals from a solution the KDP and TGS nanocrystalites were grown in the mezopores of the Al2O3 matrix. To investigate the developed nanocrystalline samples the X-ray analysis was used. A form of the obtained diffractograms and our calculations show the predominant crystallization of the KDP and TGS in the direction [100], which coincides with the direction of the cylindrical pores. Thus, diffractograms contain only reflexes of crystallographic planes (200) and (400). The achieved result indicates the possibility of growing of nanocrystals in mesopores of such Al2O3 structures developed by us and provides the prospect of creating optical cells with increased energy efficiency. Copyright © 2019, The Authors. All rights reserved.

关键词： Aluminum oxide

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design and Analysis of Lab-Chip Module for Rainwater Chemical Hazards Monitoring System

Design and Analysis of Lab-Chip Module for Rainwater Chemica...

引用

International Conference on CAD systems in Microelectronics (CADSM)

作者： Oleh Matviykiv Tamara Klymkovych Nataliia Bokla Ihor Farmaha Krzysztof Pytel Department of Computer-Aided Design Lviv Polytechnic National University Lviv Ukraine Department of Power Systems and Environmental Protection Facilities AGH University of Science and Technology Krakόw Poland

The paper proposes the construction of a system for monitoring the parameters of the environment (water, air, precipitation) using wireless technologies. The greatest attention is devoted to design and analysis of Lab-chip module for rainwater chemical hazards monitoring system. The decisive point is the exact heating of the Lab-chip reaction chambers, the selection of the required pressure to provide the necessary temperature regime for chemical reactions that will determine the number of harmful substances.

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