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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

NAtURE 2023年第7948期614卷 E37-E37页

作者： calabrese, claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, tannistha Pan-Hammarstrom, Qiang Pedamallu, chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong tan, Patrick Waszak, Sebastian M. Yung, christina Zhu, Shida Awadalla, Philip creighton, chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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Measurement of the Sensitivity of two-Particle correlations in pp collisions to the Presence of Hard Scatterings

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Physical Review Letters 2023年第16期131卷 162301-162301页

作者： G. Aad B. Abbott K. Abeling N. J. Abicht S. H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti A. c. Abusleme Hoffman B. S. Acharya c. Adam Bourdarios L. Adamczyk L. Adamek S. V. Addepalli M. J. Addison J. Adelman A. Adiguzel t. Adye A. A. Affolder Y. Afik M. N. Agaras J. Agarwala A. Aggarwal c. Agheorghiesei A. Ahmad F. Ahmadov W. S. Ahmed S. Ahuja X. Ai G. Aielli M. Ait tamlihat B. Aitbenchikh i. Aizenberg M. Akbiyik t. P. A. Åkesson A. V. Akimov D. Akiyama N. N. Akolkar K. Al Khoury G. L. Alberghi J. Albert P. Albicocco G. L. Albouy S. Alderweireldt M. Aleksa i. N. Aleksandrov c. Alexa t. Alexopoulos A. Alfonsi F. Alfonsi M. Algren M. Alhroob B. Ali H. M. J. Ali S. Ali S. W. Alibocus M. Aliev G. Alimonti W. Alkakhi c. Allaire B. M. M. Allbrooke J. F. Allen c. A. Allendes Flores P. P. Allport A. Aloisio F. Alonso c. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. G. Alviggi M. Aly Y. Amaral coutinho A. Ambler c. Amelung M. Amerl c. G. Ames D. Amidei S. P. Amor Dos Santos K. R. Amos V. Ananiev c. Anastopoulos t. Andeen J. K. Anders S. Y. Andrean A. Andreazza S. Angelidakis A. Angerami A. V. Anisenkov A. Annovi c. Antel M. t. Anthony E. Antipov M. Antonelli D. J. A. Antrim F. Anulli M. Aoki t. Aoki J. A. Aparisi Pozo M. A. Aparo L. Aperio Bella c. Appelt A. Apyan N. Aranzabal c. Arcangeletti A. t. H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling A. J. Armbruster O. Arnaez H. Arnold Z. P. Arrubarrena tame G. Artoni H. Asada K. Asai S. Asai N. A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R. J. Atkin M. Atkinson N. B. Atlay H. Atmani P. A. Atmasiddha K. Augsten S. Auricchio A. D. Auriol V. A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A. J. Bailey V. R. Bailey J. t. Baines L. Baines c. Bakalis O. K. Baker E. Bakos D. Bakshi Gupta R. Balasubramanian E. M. Baldin P. Balek E. Ballabene F. Balli L. M. Baltes W. K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E. L. Bar CPPM Aix-Marseille Université CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA II. Physikalisches Institut Georg-August-Universität Göttingen Göttingen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Physics Department Brookhaven National Laboratory Upton New York USA Faculté des sciences Université Mohammed V Rabat Morocco Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion Israel Institute of Technology Haifa Israel Department of Physics New York University New York New York USA Departamento de Física Pontificia Universidad Católica de Chile Santiago Chile INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy LAPP Université Savoie Mont Blanc CNRS/IN2P3 Annecy France AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics University of Toronto Toronto Ontario Canada Department of Physics Brandeis University Waltham Massachusetts USA School of Physics and Astronomy University of Manchester Manchester United Kingdom Department of Physics Northern Illinois University DeKalb Illinois USA Department of Physics Istanbul University Istanbul Türkiye Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA CERN Geneva Switzerland Institut de Física d’Altes Energies (IFAE) Barcelona Institute of Science and Technology Barcelona Spain INFN Sezione di Pavia Pavia Italy Dipartimento di Fisica Università di Pavia Pavia Italy Institut für Physik Universität Mainz Mainz Germany Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Affiliated with an international laboratory covered by a cooperation agreement with CERN Department of

A key open question in the study of multiparticle production in high-energy pp collisions is the relationship between the “ridge”—i.e., the observed azimuthal correlations between particles in the underlying event that extend over all rapidities—and hard or semihard scattering processes. in particular, it is not known whether jets or their soft fragments are correlated with particles in the underlying event. to address this question, two-particle correlations are measured in pp collisions at s=13 teV using data collected by the AtLAS experiment at the LHc, with an integrated luminosity of 15.8 pb−1, in two different configurations. in the first case, charged particles associated with jets are excluded from the correlation analysis, while in the second case, correlations are measured between particles within jets and charged particles from the underlying event. Second-order flow coefficients, v2, are presented as a function of event multiplicity and transverse momentum. these measurements show that excluding particles associated with jets does not affect the measured correlations. Moreover, particles associated with jets do not exhibit any significant azimuthal correlations with the underlying event, ruling out hard processes contributing to the ridge.

关键词： Particle correlations & fluctuations Quark matter Relativistic heavy-ion collisions

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integrated and differential fiducial cross-section measurements for the vector boson fusion production of the Higgs boson in the H→WW*→eνμν decay channel at 13 teV with the AtLAS detector

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Physical Review D 2023年第7期108卷 072003-072003页

作者： G. Aad B. Abbott K. Abeling N. J. Abicht S. H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti A. c. Abusleme Hoffman B. S. Acharya c. Adam Bourdarios L. Adamczyk L. Adamek S. V. Addepalli M. J. Addison J. Adelman A. Adiguzel t. Adye A. A. Affolder Y. Afik M. N. Agaras J. Agarwala A. Aggarwal c. Agheorghiesei A. Ahmad F. Ahmadov W. S. Ahmed S. Ahuja X. Ai G. Aielli M. Ait tamlihat B. Aitbenchikh i. Aizenberg M. Akbiyik t. P. A. Åkesson A. V. Akimov D. Akiyama N. N. Akolkar K. Al Khoury G. L. Alberghi J. Albert P. Albicocco G. L. Albouy S. Alderweireldt M. Aleksa i. N. Aleksandrov c. Alexa t. Alexopoulos A. Alfonsi F. Alfonsi M. Algren M. Alhroob B. Ali H. M. J. Ali S. Ali S. W. Alibocus M. Aliev G. Alimonti W. Alkakhi c. Allaire B. M. M. Allbrooke J. F. Allen c. A. Allendes Flores P. P. Allport A. Aloisio F. Alonso c. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. G. Alviggi M. Aly Y. Amaral coutinho A. Ambler c. Amelung M. Amerl c. G. Ames D. Amidei S. P. Amor Dos Santos K. R. Amos V. Ananiev c. Anastopoulos t. Andeen J. K. Anders S. Y. Andrean A. Andreazza S. Angelidakis A. Angerami A. V. Anisenkov A. Annovi c. Antel M. t. Anthony E. Antipov M. Antonelli D. J. A. Antrim F. Anulli M. Aoki t. Aoki J. A. Aparisi Pozo M. A. Aparo L. Aperio Bella c. Appelt N. Aranzabal c. Arcangeletti A. t. H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling A. J. Armbruster O. Arnaez H. Arnold Z. P. Arrubarrena tame G. Artoni H. Asada K. Asai S. Asai N. A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R. J. Atkin M. Atkinson N. B. Atlay H. Atmani P. A. Atmasiddha K. Augsten S. Auricchio A. D. Auriol V. A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A. J. Bailey V. R. Bailey J. t. Baines L. Baines c. Bakalis O. K. Baker E. Bakos D. Bakshi Gupta R. Balasubramanian E. M. Baldin P. Balek E. Ballabene F. Balli L. M. Baltes W. K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E. L. Barberio D. CPPM Aix-Marseille Université CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA II. Physikalisches Institut Georg-August-Universität Göttingen Göttingen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Physics Department Brookhaven National Laboratory Upton New York USA Faculté des sciences Université Mohammed V Rabat Morocco Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion Israel Institute of Technology Haifa Israel Department of Physics New York University New York New York USA Departamento de Física Pontificia Universidad Católica de Chile Santiago Chile INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy LAPP Université Savoie Mont Blanc CNRS/IN2P3 Annecy France AGH University of Krakow Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics University of Toronto Toronto Ontario Canada Department of Physics Brandeis University Waltham Massachusetts USA School of Physics and Astronomy University of Manchester Manchester United Kingdom Department of Physics Northern Illinois University DeKalb Illinois USA Department of Physics Istanbul University Istanbul Türkiye Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA CERN Geneva Switzerland Institut de Física d’Altes Energies (IFAE) Barcelona Institute of Science and Technology Barcelona Spain INFN Sezione di Pavia Pavia Italy Dipartimento di Fisica Università di Pavia Pavia Italy Institut für Physik Universität Mainz Mainz Germany Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Affiliated with an international laboratory covered by a cooperation agreement with CERN Department of Physics McGill

the vector-boson production cross section for the Higgs boson decay in the H→WW*→eνμν channel is measured as a function of kinematic observables sensitive to the Higgs boson production and decay properties as well as integrated in a fiducial phase space. the analysis is performed using the proton-proton collision data collected by the AtLAS detector in Run 2 of the LHc at s=13 teV center-of-mass energy, corresponding to an integrated luminosity of 139 fb−1. the different flavor final state is studied by selecting an electron and a muon originating from a pair of W bosons and compatible with the Higgs boson decay. the data are corrected for the effects of detector inefficiency and resolution, and the measurements are compared with different state-of-the-art theoretical predictions. the differential cross sections are used to constrain anomalous interactions described by dimension-six operators in an effective field theory.

关键词： Higgs bosons Particle properties

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combined Measurement of the Higgs Boson Mass from the H→γγ and H→ZZ*→4ℓ Decay channels with the AtLAS Detector Using s=7, 8, and 13 teV pp collision Data

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Physical Review Letters 2023年第25期131卷 251802-251802页

作者： G. Aad B. Abbott K. Abeling N. J. Abicht S. H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B. S. Acharya c. Adam Bourdarios L. Adamczyk S. V. Addepalli M. J. Addison J. Adelman A. Adiguzel t. Adye A. A. Affolder Y. Afik M. N. Agaras J. Agarwala A. Aggarwal c. Agheorghiesei A. Ahmad F. Ahmadov W. S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait tamlihat B. Aitbenchikh i. Aizenberg M. Akbiyik t. P. A. Åkesson A. V. Akimov D. Akiyama N. N. Akolkar K. Al Khoury G. L. Alberghi J. Albert P. Albicocco G. L. Albouy S. Alderweireldt M. Aleksa i. N. Aleksandrov c. Alexa t. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H. M. J. Ali S. Ali S. W. Alibocus M. Aliev G. Alimonti W. Alkakhi c. Allaire B. M. M. Allbrooke J. F. Allen c. A. Allendes Flores P. P. Allport A. Aloisio F. Alonso c. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves cardoso M. G. Alviggi M. Aly Y. Amaral coutinho A. Ambler c. Amelung M. Amerl c. G. Ames D. Amidei S. P. Amor Dos Santos K. R. Amos V. Ananiev c. Anastopoulos t. Andeen J. K. Anders S. Y. Andrean A. Andreazza S. Angelidakis A. Angerami A. V. Anisenkov A. Annovi c. Antel M. t. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki t. Aoki J. A. Aparisi Pozo M. A. Aparo L. Aperio Bella c. Appelt A. Apyan N. Aranzabal S. J. Arbiol Val c. Arcangeletti A. t. H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N. A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R. J. Atkin M. Atkinson H. Atmani P. A. Atmasiddha K. Augsten S. Auricchio A. D. Auriol V. A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea t. M. Baer P. Bagnaia M. Bahmani A. J. Bailey V. R. Bailey J. t. Baines L. Baines O. K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E. M. Baldin P. Balek E. Ballabene F. Balli L. M. Baltes W. K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E. L. Barberio D. Barberis M. Barbero M. Z. Barel K. N. Barend CPPM Aix-Marseille Université CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA II. Physikalisches Institut Georg-August-Universität Göttingen Göttingen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Physics Department Brookhaven National Laboratory Upton New York USA Faculté des sciences Université Mohammed V Rabat Morocco Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion Israel Institute of Technology Haifa Israel Department of Physics New York University New York New York USA INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy LAPP Université Savoie Mont Blanc CNRS/IN2P3 Annecy France AGH University of Krakow Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Brandeis University Waltham Massachusetts USA School of Physics and Astronomy University of Manchester Manchester United Kingdom Department of Physics Northern Illinois University DeKalb Illinois USA Department of Physics Istanbul University Istanbul Türkiye Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA CERN Geneva Switzerland Institut de Física d’Altes Energies (IFAE) Barcelona Institute of Science and Technology Barcelona Spain INFN Sezione di Pavia Italy Dipartimento di Fisica Università di Pavia Pavia Italy Institut für Physik Universität Mainz Mainz Germany Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Affiliated with an international laboratory covered by a cooperation agreement with CERN Department of Physics McGill University Montreal Quebec Canada Department of Physics Royal Holloway University of London Egham United Kingdom Department of Modern Physics and State K

A measurement of the mass of the Higgs boson combining the H→ZZ*→4ℓ and H→γγ decay channels is presented. the result is based on 140 fb−1 of proton-proton collision data collected by the AtLAS detector during LHc run 2 at a center-of-mass energy of 13 teV combined with the run 1 AtLAS mass measurement, performed at center-of-mass energies of 7 and 8 teV, yielding a Higgs boson mass of 125.11±0.09(stat)±0.06(syst)=125.11±0.11 GeV. this corresponds to a 0.09% precision achieved on this fundamental parameter of the Standard Model of particle physics.

关键词： Higgs bosons Mass

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Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: analysis for the Global Burden of Disease Study 2017 (vol 395, pg 1779, 2020)

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LANcEt 2020年第10239期395卷 1762-1762页

作者： Reiner, R. c., Jr. Hay, S., i Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Global Health School of Medicine University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States College of Health and Medical Sciences Haramaya University Harar Ethiopia Department of Epidemiology and Biostatistics Haramaya University Harar Ethiopia Department of Medical Laboratory Sciences Haramaya University Harar Ethiopia School of Nursing and Midwifery Haramaya University Harar Ethiopia School of Pharmacy Haramaya University Harar Ethiopia School of Public Health Haramaya University Harar Ethiopia Haramaya University Harar Ethiopia Advanced Diagnostic and Interventional Radiology Research Center Tehran University of Medical Sciences Tehran Iran Cancer Biology Research Center Tehran University of Medical Sciences Tehran Iran Cancer Research Institute Tehran University of Medical Sciences Tehran Iran Department of Economics and Management Sciences for Health Tehran University of Medical Sciences Tehran Iran Department of Environmental Health Engineering Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran Department of Microbiology Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran Hematology-Oncology and Stem Cell Transplantation Research Center Tehran University of Medical Sciences Tehran Iran Iran National Institute of Health Research Tehran University of Medical Sciences Tehran Iran Metabolomics and

Summary Background Across low-income and middle-income countries (LMics), one in ten deaths in children younger than 5 years is attributable to diarrhoea. the substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. identifying subnational regions with the highest burden and mapping associated risk factors can aid in reducing preventable childhood *** We used Bayesian model-based geostatistics and a geolocated dataset comprising 15 072 746 children younger than 5 years from 466 surveys in 94 LMics, in combination with findings of the Global Burden of Diseases, injuries, and Risk Factors Study (GBD) 2017, to estimate posterior distributions of diarrhoea prevalence, incidence, and mortality from 2000 to 2017. From these data, we estimated the burden of diarrhoea at varying subnational levels (termed units) by spatially aggregating draws, and we investigated the drivers of subnational patterns by creating aggregated risk factor *** the greatest declines in diarrhoeal mortality were seen in south and southeast Asia and South America, where 54·0% (95% uncertainty interval [Ui] 38·1-65·8), 17·4% (7·7-28·4), and 59·5% (34·2-86·9) of units, respectively, recorded decreases in deaths from diarrhoea greater than 10%. Although children in much of Africa remain at high risk of death due to diarrhoea, regions with the most deaths were outside Africa, with the highest mortality units located in Pakistan. indonesia showed the greatest within-country geographical inequality; some regions had mortality rates nearly four times the average country rate. Reductions in mortality were correlated to improvements in water, sanitation, and hygiene (WASH) or reductions in child growth failure (cGF). Similarly, most high-risk areas had poor WASH, high cGF, or low oral rehydration therapy *** By co-analysing geospatial trends in d

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Harmonized-Multinational qEEG norms (HarMNqEEG)

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NEUROiMAGE 2022年 256卷 119190-119190页

作者： Li, Min Wang, Ying Lopez-Naranjo, carlos Hu, Shiang Reyes, Ronaldo cesar Garcia Paz-Linares, Deirel Areces-Gonzalez, Ariosky Hamid, Aini ismafairus Abd Evans, Alan c. Savostyanov, Alexander N. calzada-Reyes, Ana Villringer, Arno tobon-Quintero, carlos A. Garcia-Agustin, Daysi Yao, Dezhong Dong, Li Aubert-Vazquez, Eduardo Reza, Faruque Razzaq, Fuleah Abdul Omar, Hazim Abdullah, Jafri Malin Galler, Janina R. Ochoa-Gomez, John F. Prichep, Leslie S. Galan-Garcia, Lidice Morales-chacon, Lilia Valdes-Sosa, Mitchell J. trondle, Marius Zulkifly, Mohd Faizal Mohd Rahman, Muhammad Riddha Bin Abdul Milakhina, Natalya S. Langer, Nicolas Rudych, Pavel Koenig, thomas Virues-Alba, trinidad A. Lei, Xu Bringas-Vega, Maria L. Bosch-Bayard, Jorge F. Valdes-Sosa, Pedro Antonio [a]The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for Neuroinformation School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China [b]Cuban Center for Neurocience La Habana Cuba [c]McGill Centre for Integrative Neuroscience Ludmer Centre for Neuroinformatics and Mental Health Montreal Neurological Institute Canada [d]Department of Neurosciences School of Medical Sciences Universiti Sains Malaysia Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [e]Brain and Behaviour Cluster School of Medical Sciences Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [f]Hospital Universiti Sains Malaysia Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [g]Humanitarian Institute Novosibirsk State University Novosibirsk 630090 Russia [h]Laboratory of Psychophysiology of Individual Differences Federal State Budgetary Scientific Institution Scientific Research Institute of Neurosciences and Medicine Novosibirsk 630117 Russia [i]Laboratory of Psychological Genetics at the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences Novosibirsk 630090 Russia [j]University of Pinar del Río “Hermanos Saiz Montes de Oca” Pinar del Río Cuba [k]Department of Neurology Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany [l]Department of Cognitive Neurology University Hospital Leipzig Leipzig Germany [m]Center for Stroke Research Charité-Universitätsmedizin Berlin Berlin Germany [n]Grupo Neuropsicología y Conducta - GRUNECO Faculty of Medicine Universidad de Antioquia Colombia [o]Research Department Institución Prestadora de Servicios de Salud IPS Universitaria Colombia [p]The Cuban center aging longevity and health Havana Cuba [q]Research Unit of NeuroInformation Chinese Academy of Medical Sciences Chengdu 2019RU035 China [r]School of Electrical Engineering Zhengzhou University Zhengzhou 4500

this paper extends frequency domain quantitative electroencephalography (qEEG) methods pursuing higher sensitivity to detect Brain developmental Disorders. Prior qEEG work lacked integration of cross-spectral information omitting important functional connectivity descriptors. Lack of geographical diversity precluded accounting for site-specific variance, increasing qEEG nuisance variance. We ameliorate these weaknesses. (i) create lifespan Riemannian multinational qEEG norms for cross-spectral tensors. these norms result from the HarMNqEEG project fostered by the Global Brain consortium. We calculate the norms with data from 9 countries, 12 devices, and 14 studies, including 1564 subjects. instead of raw data, only anonymized metadata and EEG cross spectral tensors were shared. After visual and automatic quality control, developmental equations for the mean and standard deviation of qEEG traditional and Riemannian DPs were calculated using additive mixed-effects models. We demonstrate qEEG "batch effects " and provide methods to calculate harmonized z-scores. (ii) We also show that harmonized Riemannian norms produce z-scores with increased diagnostic accuracy predicting brain dysfunction produced by malnutrition in the first year of life and detecting cOViD induced brain dysfunction. (iii) We offer open code and data to calculate different individual z-scores from the HarMNqEEG dataset. these results contribute to developing bias-free, low-cost neuroimaging technologies applicable in various health settings.

关键词： Quantitative EEG EEG cross-spectrum Riemannian geometry Batch effects Z-score Harmonization Malnutrition covid induced brain dysfunction developmental Brain chart

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Search for Dark Photons in Rare Z Boson Decays with the AtLAS Detector

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Physical Review Letters 2023年第25期131卷 251801-251801页

作者： G. Aad B. Abbott K. Abeling N. J. Abicht S. H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti A. c. Abusleme Hoffman B. S. Acharya c. Adam Bourdarios L. Adamczyk L. Adamek S. V. Addepalli M. J. Addison J. Adelman A. Adiguzel t. Adye A. A. Affolder Y. Afik M. N. Agaras J. Agarwala A. Aggarwal c. Agheorghiesei A. Ahmad F. Ahmadov W. S. Ahmed S. Ahuja X. Ai G. Aielli M. Ait tamlihat B. Aitbenchikh i. Aizenberg M. Akbiyik t. P. A. Åkesson A. V. Akimov D. Akiyama N. N. Akolkar K. Al Khoury G. L. Alberghi J. Albert P. Albicocco G. L. Albouy S. Alderweireldt M. Aleksa i. N. Aleksandrov c. Alexa t. Alexopoulos A. Alfonsi F. Alfonsi M. Algren M. Alhroob B. Ali H. M. J. Ali S. Ali S. W. Alibocus M. Aliev G. Alimonti W. Alkakhi c. Allaire B. M. M. Allbrooke J. F. Allen c. A. Allendes Flores P. P. Allport A. Aloisio F. Alonso c. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves cardoso M. G. Alviggi M. Aly Y. Amaral coutinho A. Ambler c. Amelung M. Amerl c. G. Ames D. Amidei S. P. Amor Dos Santos K. R. Amos V. Ananiev c. Anastopoulos t. Andeen J. K. Anders S. Y. Andrean A. Andreazza S. Angelidakis A. Angerami A. V. Anisenkov A. Annovi c. Antel M. t. Anthony E. Antipov M. Antonelli D. J. A. Antrim F. Anulli M. Aoki t. Aoki J. A. Aparisi Pozo M. A. Aparo L. Aperio Bella c. Appelt A. Apyan N. Aranzabal c. Arcangeletti A. t. H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold Z. P. Arrubarrena tame G. Artoni H. Asada K. Asai S. Asai N. A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R. J. Atkin M. Atkinson N. B. Atlay H. Atmani P. A. Atmasiddha K. Augsten S. Auricchio A. D. Auriol V. A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A. J. Bailey V. R. Bailey J. t. Baines L. Baines c. Bakalis O. K. Baker E. Bakos D. Bakshi Gupta R. Balasubramanian E. M. Baldin P. Balek E. Ballabene F. Balli L. M. Baltes W. K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E. L. Bar CPPM Aix-Marseille Université CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA II. Physikalisches Institut Georg-August-Universität Göttingen Göttingen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Physics Department Brookhaven National Laboratory Upton New York USA Faculté des sciences Université Mohammed V Rabat Morocco Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion Israel Institute of Technology Haifa Israel Department of Physics New York University New York New York USA Departamento de Física Pontificia Universidad Católica de Chile Santiago Chile INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy LAPP Université Savoie Mont Blanc CNRS/IN2P3 Annecy France AGH University of Krakow Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics University of Toronto Toronto Ontario Canada Department of Physics Brandeis University Waltham Massachusetts USA School of Physics and Astronomy University of Manchester Manchester United Kingdom Department of Physics Northern Illinois University DeKalb Illinois USA Department of Physics Istanbul University Istanbul Türkiye Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA CERN Geneva Switzerland Institut de Física d’Altes Energies (IFAE) Barcelona Institute of Science and Technology Barcelona Spain INFN Sezione di Pavia Pavia Italy Dipartimento di Fisica Università di Pavia Pavia Italy Institut für Physik Universität Mainz Mainz Germany Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Affiliated with an international laboratory covered by a cooperation agreement with CERN Department of Physics McGill

A search for events with a dark photon produced in association with a dark Higgs boson via rare decays of the standard model Z boson is presented, using 139 fb−1 of s=13 teV proton-proton collision data recorded by the AtLAS detector at the Large Hadron collider. the dark boson decays into a pair of dark photons, and at least two of the three dark photons must each decay into a pair of electrons or muons, resulting in at least two same-flavor opposite-charge lepton pairs in the final state. the data are found to be consistent with the background prediction, and upper limits are set on the dark photon’s coupling to the dark Higgs boson times the kinetic mixing between the standard model photon and the dark photon, αDϵ2, in the dark photon mass range of [5, 40] GeV except for the ϒ mass window [8.8, 11.1] GeV. this search explores new parameter space not previously excluded by other experiments.

关键词： Extensions of gauge sector Hypothetical gauge bosons W & Z bosons Hadron colliders

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Search for the jet-induced diffusion wake in the quark-gluon plasma via measurements of jet-track correlations in photon-jet events in Pb+Pb collisions at sNN=5.02teV with the AtLAS detector

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Physical Review c 2025年第4期111卷 044909-044909页

作者： G. Aad E. Aakvaag B. Abbott S. Abdelhameed K. Abeling N. J. Abicht S. H. Abidi M. Aboelela A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B. S. Acharya A. Ackermann c. Adam Bourdarios L. Adamczyk S. V. Addepalli M. J. Addison J. Adelman A. Adiguzel t. Adye A. A. Affolder Y. Afik M. N. Agaras J. Agarwala A. Aggarwal c. Agheorghiesei F. Ahmadov W. S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait tamlihat B. Aitbenchikh M. Akbiyik t. P. A. Åkesson A. V. Akimov D. Akiyama N. N. Akolkar S. Aktas K. Al Khoury G. L. Alberghi J. Albert P. Albicocco G. L. Albouy S. Alderweireldt Z. L. Alegria M. Aleksa i. N. Aleksandrov c. Alexa t. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H. M. J. Ali S. Ali S. W. Alibocus M. Aliev G. Alimonti W. Alkakhi c. Allaire B. M. M. Allbrooke J. S. Allen J. F. Allen c. A. Allendes Flores P. P. Allport A. Aloisio F. Alonso c. Alpigiani Z. M. K. Alsolami M. Alvarez Estevez A. Alvarez Fernandez M. Alves cardoso M. G. Alviggi M. Aly Y. Amaral coutinho A. Ambler c. Amelung M. Amerl c. G. Ames D. Amidei B. Amini K. J. Amirie S. P. Amor Dos Santos K. R. Amos D. Amperiadou S. An V. Ananiev c. Anastopoulos t. Andeen J. K. Anders A. c. Anderson S. Y. Andrean A. Andreazza S. Angelidakis A. Angerami A. V. Anisenkov A. Annovi c. Antel E. Antipov M. Antonelli F. Anulli M. Aoki t. Aoki M. A. Aparo L. Aperio Bella c. Appelt A. Apyan S. J. Arbiol Val c. Arcangeletti A. t. H. Arce J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N. A. Asbah R. A. Ashby Pickering K. Assamagan R. Astalos K. S. V. Astrand S. Atashi R. J. Atkin M. Atkinson H. Atmani P. A. Atmasiddha K. Augsten S. Auricchio A. D. Auriol V. A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea t. M. Baer P. Bagnaia M. Bahmani D. Bahner K. Bai J. t. Baines L. Baines O. K. Baker E. Bakos D. Bakshi Gupta L. E. Balabram Filho V. Balakrishnan R. Balasubramanian E. M. Baldin P. Balek E. Ballabene F. Balli L. M. Baltes W. K. Balunas J. Balz i. Bamwidhi CPPM Aix-Marseille Université CNRS/IN2P3 Marseille France Department for Physics and Technology University of Bergen Bergen Norway Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA New York University Abu Dhabi Abu Dhabi United Arab Emirates II. Physikalisches Institut Georg-August-Universität Göttingen Göttingen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Physics Department Brookhaven National Laboratory Upton New York USA Physics Department Southern Methodist University Dallas Texas USA Faculté des sciences Université Mohammed V Rabat Morocco Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion Israel Institute of Technology Haifa Israel Department of Physics New York University New York New York USA INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy Also at Department of Physics King's College London London United Kingdom. Kirchhoff-Institut für Physik Ruprecht-Karls-Universität Heidelberg Heidelberg Germany LAPP Université Savoie Mont Blanc CNRS/IN2P3 Annecy France AGH University of Krakow Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Brandeis University Waltham Massachusetts USA School of Physics and Astronomy University of Manchester Manchester United Kingdom Department of Physics Northern Illinois University DeKalb Illinois USA Department of Physics Istanbul University Istanbul Türkiye Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA Enrico Fermi Institute University of Chicago Chicago Illinois USA Institut de Física d'Altes Energies (IFAE) Barcelona Institute of Science and Technology Barcelona Spain INFN Sezione di Pavia Pavia Italy Dipartimento di Fisica Università di Pa

this paper presents a measurement of jet-track correlations in photon-jet events, using 1.72 nb−1 of Pb+Pb data at sNN=5.02teV recorded with the AtLAS detector at the LHc. Events with energetic photon-jet pairs are selected, where the photon and jet are approximately back-to-back in azimuth. the angular correlation between jets and charged-particle tracks with transverse momentum (pt) in the range 0.5–2.0 GeV in the hemisphere opposite to the jet, |Δϕ(jet,track)|>π/2, is measured as a function of their relative pseudorapidity difference, |Δη(jet,track)|. in central Pb+Pb collisions, these correlations are predicted to be sensitive to the diffusion wake in the quark-gluon plasma resulting from the lost energy of high-pt partons traversing the plasma, with a characteristic modification as a function of |Δη(jet,track)|. the correlations are examined with different selections on the jet-to-photon pt ratio to select events with different degrees of energy loss. No diffusion wake signal is observed within the current sensitivity and upper limits at 95% confidence level on the diffusion wake amplitude are reported.

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Global investments in pandemic preparedness and cOViD-19: development assistance and domestic spending on health between 1990 and 2026

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the Lancet Global Health 2023年第3期11卷 e385-e413页

作者： Micah, Angela E. Bhangdia, Kayleigh cogswell, ian E. Lasher, Dylan Lidral-Porter, Brendan Maddison, Emilie R. Nguyen, trang Nhu Ngoc Patel, Nishali Pedroza, Paola Solorio, Juan Stutzman, Hayley tsakalos, Golsum Wang, Yifeng Warriner, Wesley Zhao, Yingxi Zlavog, Bianca S. Abbafati, cristiana Abbas, Jaffar Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abdelmasseh, Michael Abdulah, Deldar Morad Abedi, Aidin Abegaz, Kedir Hussein Abhilash, E.S. Aboagye, Richard Gyan Abolhassani, Hassan Abrigo, Michael R.M. Abubaker Ali, Hiwa Abu-Gharbieh, Eman Adem, Mohammed Hussien Afzal, Muhammad Sohail Ahmadi, Ali Ahmed, Haroon Ahmed Rashid, tarik Aji, Budi Akbarialiabad, Hossein Akelew, Yibeltal Al Hamad, Hanadi Alam, Khurshid Alanezi, Fahad Mashhour Alanzi, turki M. Al-Hanawi, Mohammed Khaled Alhassan, Robert Kaba Aljunid, Syed Mohamed Almustanyir, Sami Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw t. Ameyaw, Edward Kwabena Amini-Rarani, Mostafa Amu, Hubert Ancuceanu, Robert Andrei, tudorel Anwar, Sumadi Lukman Appiah, Francis Aqeel, Muhammad Arabloo, Jalal Arab-Zozani, Morteza Aravkin, Aleksandr Y. Aremu, Olatunde Aruleba, Raphael taiwo Athari, Seyyed Shamsadin Avila-Burgos, Leticia Ayanore, Martin Amogre Azari, Samad Baig, Atif Amin Bantie, Abere tilahun Barrow, Amadou Baskaran, Pritish Basu, Sanjay Batiha, Abdul-Monim Mohammad Baune, Bernhard t. Berezvai, Zombor Bhardwaj, Nikha Bhardwaj, Pankaj Bhaskar, Sonu Boachie, Micheal Kofi Bodolica, Virginia Botelho, João Silva Botelho Braithwaite, Dejana Breitborde, Nicholas J.K. Busse, Reinhard cahuana-Hurtado, Lucero catalá-López, Ferrán chansa, collins charan, Jaykaran chattu, Vijay Kumar chen, Simiao chukwu, isaac Sunday Dadras, Omid Dandona, Lalit Dandona, Rakhi Dargahi, Abdollah Debela, Sisay Abebe Denova-Gutiérrez, Edgar Desye, Belay Dharmaratne, Samath Dhamminda Diao, Nancy Doan, Linh Phuong Dodangeh, Milad dos Santos, Wendel Mombaque Doshmangir, Leila Dube, John Eini, Ebrahim El Sayed Zaki, Maysaa El tantawi, Maha Enyew, Daniel Berhanie Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Applied Mathematics University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Nuffield Department of Medicine University of Oxford Oxford United Kingdom Department of Juridical and Economic Studies La Sapienza University Rome Italy Antai College of Economics Shanghai Jiao Tong University Shanghai China Non-communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Children’s Medical Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Tehran Heart Center Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Tehran University of Medical Sciences Tehran Iran National Institute for Health Research Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Department of Cardiology Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Center Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Department of Neurology Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Epidemiology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Health Economics and Statistics Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurosurgery Shahid Beheshti University of Medical Sciences Tehran Iran Ophthalmic R

Background: the cOViD-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these gaps is the issue of the financing of national health systems, especially in low-income and middle-income countries (LMics), as well as a robust global system for pandemic preparedness. We aimed to provide a comparative assessment of global health spending at the onset of the pandemic;characterise the amount of development assistance for pandemic preparedness and response disbursed in the first 2 years of the cOViD-19 pandemic;and examine expectations for future health spending and put into context the expected need for investment in pandemic preparedness. Methods: in this analysis of global health spending between 1990 and 2021, and prediction from 2021 to 2026, we estimated four sources of health spending: development assistance for health (DAH), government spending, out-of-pocket spending, and prepaid private spending across 204 countries and territories. We used the Organisation for Economic co-operation and development (OEcD)'s creditor Reporting System (cRS) and the WHO Global Health Expenditure Database (GHED) to estimate spending. We estimated development assistance for general health, cOViD-19 response, and pandemic preparedness and response using a keyword search. Health spending estimates were combined with estimates of resources needed for pandemic prevention and preparedness to analyse future health spending patterns, relative to need. Findings: in 2019, at the onset of the cOViD-19 pandemic, US$9·2 trillion (95% uncertainty interval [Ui] 9·1–9·3) was spent on health worldwide. We found great disparities in the amount of resources devoted to health, with high-income countries spending $7·3 trillion (95% Ui 7·2–7·4) in 2019;293·7 times the $24·8 billion (95% Ui 24·3–25·3) spent by low-income countries in 2019. that same year, $43·1 billion in development assistance was provided

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iran in transition (vol 393, pg 1984, 2019)

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LANcEt 2019年第10186期393卷 2124-2124页

作者： Danaei, G. Farzadfar, F. Kelishadi, R. [a]Department of Global Health and Population and Department of Epidemiology Harvard T H Chan School of Public Health Boston MA USA Department of Global Health and Population and Department of Epidemiology Harvard T H Chan School of Public Health Boston MA USA [b]Scientific Association for Public Health in Iran Boston MA USA Scientific Association for Public Health in Iran Boston MA USA [c]Non-Communicable Diseases Research Center Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences Tehran Iran Non-Communicable Diseases Research Center Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences Tehran Iran [d]Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran [e]Diabetes Research Center Tehran University of Medical Sciences Tehran Iran Diabetes Research Center Tehran University of Medical Sciences Tehran Iran [f]Endocrinology and Metabolism Clinical Sciences Institute Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Clinical Sciences Institute Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran [g]Department of Global Health and Public Policy Tehran University of Medical Sciences Tehran Iran Department of Global Health and Public Policy Tehran University of Medical Sciences Tehran Iran [h]Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran [i]School of Public Health Tehran University of Medical Sciences Tehran Iran School of Public Health Tehran University of Medical Sciences Tehran Iran [j]Faculty of Medicine Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Te

Summary Being the second-largest country in the Middle East, iran has a long history of civilisation during which several dynasties have been overthrown and established and health-related structures have been reorganised. iran has had the replacement of traditional practices with modern medical treatments, emergence of multiple pioneer scientists and physicians with great contributions to the advancement of science, environmental and ecological changes in addition to large-scale natural disasters, epidemics of multiple communicable diseases, and the shift towards non-communicable diseases in recent decades. Given the lessons learnt from political instabilities in the past centuries and the approaches undertaken to overcome health challenges at the time, iran has emerged as it is today. iran is now a country with a population exceeding 80 million, mainly inhabiting urban regions, and has an increasing burden of non-communicable diseases, including cardiovascular diseases, hypertension, diabetes, malignancies, mental disorders, substance abuse, and road injuries.

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