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Nature 2025年第8059期640卷 613-622页

作者： Lanza, Mario Pazos, Sebastian Aguirre, Fernando Sebastian, Abu Le Gallo, Manuel Alam, Syed M. Ikegawa, Sumio Yang, J. Joshua Vianello, Elisa Chang, Meng-Fan Molas, Gabriel Naveh, Ishai Ielmini, Daniele Liu, Ming Roldan, Juan B. Department of Materials Science and Engineering National University of Singapore Singapore Singapore Institute for Functional Intelligent Materials National University of Singapore Singapore Singapore Centre for Advanced 2D Materials (CA2DM) National University of Singapore Singapore Singapore Materials Science and Engineering Program Physical Science and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal Saudi Arabia Intrinsic Semiconductor Technologies London United Kingdom IBM Research – Zurich Rüschlikon Switzerland Everspin Technologies Chandler AZ United States Department of Electrical and Computer Engineering University of Southern California Los Angeles CA United States CEA-Leti Université Grenoble Alpes Grenoble France Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan Weebit Nano Hod Hasharon Israel Dipartimento di Elettronica Informazione e Bioingegneria (DEIB) Politecnico di Milano and *** Milano Italy Key Laboratory of Microelectronic Devices and Integrated Technology Institute of Microelectronics Chinese Academy of Sciences Beijing China Departamento de Electrónica y Tecnología de Computadores Universidad de Granada Facultad de Ciencias Granada Spain

The semiconductor industry is experiencing an accelerated transformation to overcome the scaling limits of the transistor and to adapt to new requirements in terms of data storage and computation, especially driven by artificial intelligence applications and the Internet of Things. In this process, new materials, devices, integration strategies and system architectures are being developed and optimized. Among them, memristive devices and circuits—memristors are two-terminal memory devices that can also mimic some basic bioelectronic functions—offer a potential approach to create more compact, energy-efficient or better-performing systems. The memristor industry is growing quickly, raising abundant capital investment, creating new jobs and placing advanced products in the market. Here we analyse the status and prospects of the memristor industry, focusing on memristor-based products that are already commercially available, prototypes with a high technological readiness level that might affect the market in the near future, and discuss obstacles and pathways to their implementation. © Springer Nature Limited 2025.

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Spectral Extremal Connectivity of Two-State Seizure Brain Waves

arXiv

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arXiv 2025年

作者： Talento, Mara Sherlin D. Richards, Jordan Pinto-Orellana, Marco Huser, Raphael Ombao, Hernando C. Statistics Program Computer Electrical and Mathematical Science & Engineering Division King Abdullah University of Science and Technology 23955 - 6900 Saudi Arabia Neuro-AI Laboratory Computer Electrical and Mathematical Science & Engineering Division King Abdullah University of Science and Technology 23955 - 6900 Saudi Arabia School of Mathematics Maxwell Institute for Mathematical Sciences University of Edinburgh EdinburghEH9 3FD United Kingdom Department of Biomedical Engineering University of California Irvine92697 United States

Coherence analysis plays a vital role in the study of functional brain connectivity. However, coherence captures only linear spectral associations, and thus can produce misleading findings when ignoring variations of connectivity in the tails of the distribution. This limitation becomes important when investigating extreme neural events that are characterized by large signal amplitudes. The focus of this paper is to examine connectivity in the tails of the distribution, as this reveals salient information that may be overlooked by standard methods. We develop a novel notion of spectral tail association of periodograms to study connectivity in the network of electroencephalogram (EEG) signals of seizure-prone neonates. We further develop a novel non-stationary extremal dependence model for multivariate time series that captures differences in extremal dependence during different brain phases, namely burst-suppression and non-burst-suppression. One advantage of our proposed approach is its ability to identify tail connectivity at key frequency bands that could be associated with outbursts of energy which may lead to seizures. We discuss these novel scientific findings alongside a comparison of the extremal behavior of brain signals for epileptic and non-epileptic patients. © 2025, CC BY.

关键词： Electroencephalography

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Multi-department engineering and engineering technology Scholars program

Multi-department Engineering and Engineering Technology Scho...

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2005 ASEE Annual Conference and Exposition: The Changing Landscape of engineering and technology Education in a Global World

作者： Richardson, Carol A. Gupta, Surendra K. Valentine, Maureen L. Merrill, Robert A. Amuso, Vincent J. Rochester Institute of Technology United States RIT Department of Electrical Computer and Telecommunications Engineering Technology United States Department of Mechanical Engineering and Materials Scinece and Engineering Department of Civil Engineering Technology Environmental Management and Safety Mechanical Engineering Technology Program RIT United States Department of Electrical Engineering

This paper describes the objectives, strategies, assessment and evaluation, and special program features of the Rochester Institute of technology's (RIT) Multi-department engineering and engineering technology (MEET) Scholars program. This program began in December, 2004 and is designed to recruit, retain and graduate additional transfer students in our selected engineering and engineering technology degree programs. The MEET Scholars program represents a collaborative effort of five academic departments across two colleges, and the Enrollment Management and Career Services Division at RIT. All of the programs in the five participating departments are ABET-accredited, and require students to obtain one year of industry co-op experience before graduation. The MEET Scholars program builds upon our excellent infrastructure for mentoring students, and involves our mandatory cooperative education program - both of which help students address their financial needs and facilitate placement in the high technology workforce. RIT has an exceptional record in engineering student placement in industry after graduation and an excellent record for both retaining and graduating upper-division transfer students.

关键词： engineering education

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Supply Chain Sustainability in Disruption: SC Intelligence, Customer Knowledge Transfer, and the Mediating Role of IS/IT

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IEEE engineering Management Review 2025年

作者： Ratna, Silvia Saide, Saide Rater, Salya Svyazhanovna, Baizakova Saule Herzavina, Herzavina Faculty of Information Technology Department of Informatics Engineering and Department of Information Systems Banjarmasin Indonesia State Islamic University of Sultan Syarif Kasim Riau Universitas Islam Negeri Sultan Syarif Kasim Riau-UIN SUSKA Riau Department of Information Systems Faculty of Science and Technology Indonesia PRO Knowledge Indonesia Pekanbaru Indonesia Universitas Pahlawan Tuanku Tambusai Indonesia Lembaga Enreach UIN Suska Riau Indonesia Politeknik Aceh Selatan Department of Informatics Engineering Aceh Indonesia Information Communication Technologies Robotics in Arkalyk Pedagogical Institute Master of Natural Sciences Educational Program for the Informatics Computer Science Kazakhstan Universitas Pahlawan Tuanku Tambusai Department of Informatics Engineering Indonesia National Taiwan University of Science and Technology Taiwan

Knowledge resource and information system/technology (IS/IT) capability have been considered to improve firm performance, however there is still a gap regarding the sustainability of supply chain to face and recover from disruption (e.g., COVID-19). Questionnaire-based surveys was adopted and received feedback from sixty (160) Indonesian companies or about 28.07% of response rate. © 1973-2011 IEEE.

关键词： customer knowledge transfer disruption information system/technology (IS/IT) responding knowledge management resource-based view (RBV) Supply chain (SC) sustainability supply chain knowledge transfer

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Gumbel-Softmax Flow Matching with Straight-Through Guidance for Controllable Biological Sequence Generation

arXiv

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arXiv 2025年

作者： Tang, Sophia Zhang, Yinuo Tong, Alexander Chatterjee, Pranam Department of Biomedical Engineering Duke University United States Management and Technology Program University of Pennsylvania United States Center of Computational Biology Duke-NUS Medical School Singapore Mila Quebec AI Institute Canada Université de Montréal Canada Department of Computer Science Duke University United States Department of Biostatistics and Bioinformatics Duke University United States

Flow matching in the continuous simplex has emerged as a promising strategy for DNA sequence design, but struggles to scale to higher simplex dimensions required for peptide and protein generation. We introduce Gumbel-Softmax Flow and Score Matching, a generative framework on the simplex based on a novel Gumbel-Softmax interpolant with a time-dependent temperature. Using this interpolant, we introduce Gumbel-Softmax Flow Matching by deriving a parameterized velocity field that transports from smooth categorical distributions to distributions concentrated at a single vertex of the simplex. We alternatively present Gumbel-Softmax Score Matching which learns to regress the gradient of the probability density. Our framework enables high-quality, diverse generation and scales efficiently to higher-dimensional simplices. To enable training-free guidance, we propose Straight-Through Guided Flows (STGFlow), a classifier-based guidance method that leverages straight-through estimators to steer the unconditional velocity field toward optimal vertices of the simplex. STGFlow enables efficient inference-time guidance using classifiers pre-trained on clean sequences, and can be used with any discrete flow method. Together, these components form a robust framework for controllable de novo sequence generation. We demonstrate state-of-the-art performance in conditional DNA promoter design, sequence-only protein generation, and target-binding peptide design for rare disease treatment. © 2025, CC BY-NC-ND.

关键词： Velocity distribution

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A Conceptual Exploration of Generative AI-Induced Cognitive Dissonance and its Emergence in University-Level Academic Writing

arXiv

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arXiv 2025年

作者： Seran, Carl Errol Tan, Myles Joshua Toledo Karim, Hezerul Abdul AlDahoul, Nouar Biology Program College of Arts and Sciences University of St. La Salle Bacolod Philippines Department of Natural Sciences College of Arts and Sciences University of St. La Salle Bacolod Philippines Faculty of Education University of the Philippines Open University Los Baños Philippines Department of Electrical and Computer Engineering Herbert Wertheim College of Engineering University of Florida GainesvilleFL United States Department of Epidemiology College of Public Health and Health Professions College of Medicine University of Florida GainesvilleFL United States Department of Chemical Engineering College of Engineering and Technology University of St. La Salle Bacolod Philippines Department of Electronics Engineering College of Engineering and Technology University of St. La Salle Bacolod Philippines Yo-Vivo Corporation Bacolod Philippines Faculty of Engineering Multimedia University Persiaran Multimedia Cyberjaya Malaysia Department of Computer Science Division of Science New York University Abu Dhabi Abu Dhabi United Arab Emirates

The integration of Generative Artificial Intelligence (GenAI) intouniversity-level academic writing presents both opportunities and challenges,particularly in relation to cognitive dissonance (CD). This work explores howGenAI serves as both a trigger and amplifier of CD, as students navigateethical concerns, academic integrity, and self-efficacy in their writingpractices. By synthesizing empirical evidence and theoretical insights, weintroduce a hypothetical construct of GenAI-induced CD, illustrating thepsychological tension between AI-driven efficiency and the principles oforiginality, effort, and intellectual ownership. We further discuss strategiesto mitigate this dissonance, including reflective pedagogy, AI literacyprograms, transparency in GenAI use, and discipline-specific task *** approaches reinforce critical engagement with AI, fostering a balancedperspective that integrates technological advancements while safeguarding humancreativity and learning. Our findings contribute to ongoing discussions on AIin education, self-regulated learning, and ethical AI use, offering aconceptual framework for institutions to develop guidelines that align AIadoption with academic values. © 2025, CC BY.

关键词： Generative adversarial networks

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Three-dimensional computation of light scattering from cells

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IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS 1996年第4期2卷 898-905页

作者： Dunn, A RichardsKortum, R Biomedical Engineering Program Department of Electrical and Computer Engineering University of Technology Austin TX USA

Using the finite-difference time-domain method, three-dimensional scattering patterns are computed for cells containing multiple organelles. The scattering cross section and average cosine of the scattering angle are computed for cells as a function of volume fraction of melanin granules and mitochondria, Results show that small organelles play a significant role in light scattering from cells, and the volume fraction of organelles affects both the total amount of scattered light and the angular distribution of scattered light.

关键词： Light scattering Optical scattering Mie scattering Electromagnetic scattering Cells (biology) Optical refraction Finite difference methods Time domain analysis Biomedical optical imaging High-resolution imaging

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Enhancing Diagnostic Accuracy for Knee Osteoarthritis Using a Deep Learning Approach

Enhancing Diagnostic Accuracy for Knee Osteoarthritis Using ...

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International Symposium on Applied Science 2024, ISAS 2024

作者： Raza, Aquib Ching, Congo Tak Shing Liu, Peng-Ta Phan, Thien-Luan Tran, Ngoc-Luan Nguyen, Ha Anh T. Rameez, Mohammad Li, Hung-Chung Linh, Dao Nguyen Phuong Van Hieu, Nguyen Tran, Trung Nghia National Taiwan University Taipei City10673 Taiwan Research Center for Information Technology Academia Sinica Taipei City11529 Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung402 Taiwan Department of Electrical Engineering National Chi Nan University Nantou County Taiwan Advanced Plant and Food Crop Biotechnology Center National Chung Hsing University Taichung402 Taiwan International Doctoral Program in Agriculture National Chung Hsing University Taichung402 Taiwan Fall Prevention Center Department of Physical Medicine & Rehabilitation Changhua Christian Hospital Changhua500 Taiwan Department of Physics and Electronic Engineering University of Science Vietnam National University - Ho Chi Minh City Ho Chi Minh City70000 Viet Nam Department of Computer Science University of York York HeslingtonYO10 5DD United Kingdom Undergraduate Program of Intellectual Creativity Engineering National Chung Hsing University Taichung402 Taiwan Ho Chi Minh City72409 Viet Nam HCMUT Vietnam National University Ho Chi Minh City Thu Duc Ho Chi Minh City71308 Viet Nam

This research introduces a deep learning framework that combines convolutional neural networks with autoencoders to improve the diagnostic accuracy of knee osteoarthritis. The study utilized a publicly available dataset from the Mendeley Data repository, where knee joint images were preprocessed using Contrast Limited Adaptive Histogram Equalization to enhance contrast and ensure consistent image sizing. Initially, an autoencoder was employed in an unsupervised manner to learn compressed representations of the data. These representations were then used to train a CNN to classify knee images into 'healthy' and 'osteoarthritic' categories. The model was trained using an 80:20 split for training and testing data, incorporating early stopping and data augmentation techniques to prevent overfitting and enhance generalization. Performance metrics such as accuracy, precision, recall, and the area under the Receiver Operating Characteristic curve (ROCAUC) were used to evaluate the model, resulting in a high test accuracy of 98.95%. The high precision and recall rates further confirmed the model's robustness in diagnosing KOA. To enhance interpretability, Gradient-weighted Class Activation Mapping (Grad-CAM) was applied to identify critical regions in the images that influenced the model's decisions. Additionally, t-Distributed Stochastic Neighbor Embedding (t-SNE) was used to visualize the high-dimensional encoded features in a two-dimensional space, providing deeper insights into how the model differentiates between classes. The promising results of this deep learning approach suggest its potential for broader applications in medical imaging diagnostics. By providing healthcare professionals with a tool that enhances diagnostic accuracy and operational efficiency, this framework lays the foundation for developing scalable, AI-driven diagnostic systems for various complex medical conditions. © 2025 Institute of Physics Publishing. All rights reserved.

关键词： Joints (anatomy)

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Crack Catcher AI — Enabling Smart Fracture Mechanics Approach for Damage Control in Thin Silicon Wafers for 3D Semiconductor Integrated Devices/Packages

Crack Catcher AI — Enabling Smart Fracture Mechanics Approa...

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Annual International Symposium on Reliability Physics

作者： Gabriel Preston Greer Gonzolez Andrea S. Karnyoto Fitya S. Mozar Matthew M. Henry Mahmud Isnan Kuncahyo S. Nugroho Henry Candra Muhamad Doris Dianing N. N. Putri Tyas K Sari Bens Pardamean Endang Djuana Derrric Speaks Arief S. Budiman Oregon Renewable Energy Center (OREC) Oregon Institute of Technology (Oregon Tech) Klamath Falls OR USA Dept. of Manufacturing & Mechanical Eng. & Tech. (MMET) Oregon Institute of Technology Klamath Falls OR USA Bioinformatics & Data Science Research Center (BDSRC) Bina Nusantara University Jakarta Indonesia Computer Sci. Dept. BINUS Grad. Program - Master of Computer Sci. Bina Nusantara University Jakarta Indonesia Computer Science Department School of Computer Science Bina Nusantara University Jakarta Indonesia Center for Artificial Intelligence and Advanced Technology (CAPTIVATE) Universitas TRISAKTI Jakarta Indonesia Department of Electrical Engineering Faculty of Industrial Technology Universitas TRISAKTI Jakarta Indonesia Industrial Eng. Dept. BINUS Grad. Program – Master of Industrial Eng. Bina Nusantara University Jakarta Indonesia

ISBN: (数字)9798331504779

ISBN: (纸本)9798331504786

The importance of silicon cannot be undermined - in photovoltaics (PV) as well as in semiconductor industries. However, silicon is very brittle. Silicon cells/wafers crack easily during manufacturing assembly and/or during device operations. Crack Catcher AI uses novel smart fracture mechanics approach with Artificial Intelligence (AI) methodologies to predict and control crack/damage evolution in thin silicon cells/wafers. This is critical as semiconductor 3D integration technology calls for wafer-to-wafer bonding with utmost alignment accuracy and yield/reliability.

关键词： Semiconductor device measurement Three-dimensional displays Accuracy Semiconductor device reliability Silicon Artificial intelligence Bonding Stress Three-dimensional integrated circuits Stress measurement

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Pan-cancer analysis of CDC7 in human tumors: Integrative multi-omics insights and discovery of novel marine-based inhibitors through machine learning and computational approaches

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computers in Biology and Medicine 2025年 190卷 110044-110044页

作者： Saif, Ahmed Islam, Md. Tarikul Raihan, Md. Obayed Yousefi, Niloofar Rahman, Md. Ajijur Faridi, Hafeez Hasan, Al Riyad Hossain, Mirza Mahfuj Saleem, Rasha Mohammed Albadrani, Ghadeer M. Al-Ghadi, Muath Q. Ahasan Setu, Md. Ali Kamel, Mohamed Abdel-Daim, Mohamed M. Aktaruzzaman, Md. Department of Pharmacy Faculty of Science University of Rajshahi Rajshahi6205 Bangladesh Department of Genetic Engineering and Biotechnology Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Jashore7408 Bangladesh Department of Pharmaceutical Sciences College of Health Sciences and Pharmacy Chicago State University ChicagoIL United States Department of Industrial Engineering and Management Systems University of Central Florida USA OrlandoFL United States Department of Pharmacy Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Department of Computer Science and Engineering Faculty of Engineering and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Department of Laboratory Medicine Faculty of Applied Medical Sciences Al-Baha University Al-Baha65431 Saudi Arabia Department of Biology College of Science Princess Nourah bint Abdulrahman University 84428 Riyadh11671 Saudi Arabia Department of Zoology College of Science King Saud University P.O. Box 2455 Riyadh11451 Saudi Arabia Department of Microbiology Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Department of Medicine and Infectious Diseases Faculty of Veterinary Medicine Cairo University Giza12211 Egypt Department of Pharmaceutical Sciences Pharmacy Program Batterjee Medical College P.O. Box 6231 Jeddah21442 Saudi Arabia Pharmacology Department Faculty of Veterinary Medicine Suez Canal University Ismailia41522 Egypt

Cancer remains a significant global health challenge, with the Cell Division Cycle 7 (CDC7) protein emerging as a potential therapeutic target due to its critical role in tumor proliferation, survival, and resistance. However, a comprehensive analysis of CDC7 across multiple cancers is lacking, and existing therapeutic options have come with limited clinical success. The aim of this is to integrate a comprehensive pan-cancer analysis of CDC7 with the identification of novel marine-derived inhibitors, bridging the understanding of CDC7's role as a prognostic biomarker and therapeutic target across diverse cancer types. In this study, we conducted a pan-cancer analysis of CDC7 across 33 tumor types using publicly available datasets to evaluate its expression, genetic alterations, immune interactions, survival, and prognostic significance. Additionally, a marine-derived compound library of 31,492 molecules was screened to identify potential CDC7 inhibitors using chemoinformatics and machine learning. The top candidates underwent rigorous evaluations, including molecular docking, pharmacokinetics, toxicity, Density Functional Theory (DFT) calculations, and Molecular Dynamics (MD) simulations. The findings revealed that CDC7 is overexpressed in several cancers and is associated with poor survival outcomes and unfavorable prognosis. Enrichment analysis linked CDC7 to critical DNA replication pathways, while its role in modulating tumor-immune interactions highlighted its potential as a target for immunotherapy. Among all tested compounds, Tetrahydroaltersolanol D (CMNPD21999) exhibited the strongest binding affinity and stability, along with better drug-likeness and zero toxicity. These attributes highlight its potential as a promising drug candidate for CDC7 inhibition and future cancer treatment development. Furthermore, additional in vitro and in vivo studies are required to confirm the effectiveness of this drug candidate against the CDC7 protein. © 2025

关键词： Gene expression

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