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Science China Life Sciences 2025年第5期68卷 1536-1540页

作者： Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I

The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integrating biological knowledge into models and even accelerating the development of new AI based on biological discoveries, the boundaries of both are constantly expanding, and their connections are becoming closer.

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A Deep Learning Approach for Nerve Injury Classification in Brachial Plexopathies Using Magnetic Resonance Neurography with Modified Hiking Optimization Algorithm

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Academic Radiology 2025年

作者： Dahou, Abdelghani Elaziz, Mohamed Abd Khattap, Mohamed G. Hassan, Hend Galal Eldeen Mohamed Ali School of Computer Science and Technology Zhejiang Normal University Jinhua 321004 China Mathematics and Computer Science department University of Ahmed DRAIA Adrar 01000 Algeria Department of Mathematics Faculty of Science Zagazig University Zagazig 44519 Egypt Faculty of Computer Science and Engineering Galala University Suez 435611 Egypt Artificial Intelligence Research Center (AIRC) Ajman University Ajman 346 United Arab Emirates Department of Diagnostic Interventional Radiology and Molecular Imaging Faculty of Medicine Ain Shams University Cairo 11591 Egypt Technology of Radiology and Medical Imaging Program Faculty of Applied Health Sciences Technology Galala University Suez 435611 Egypt

Rationale and Objectives: Brachial plexopathies (BPs) encompass a complex spectrum of nerve injuries affecting motor and sensory function in the upper extremities. Diagnosis is challenging due to the intricate anatomy and symptom overlap with other neuropathies. Magnetic Resonance Neurography (MRN) provides advanced imaging but requires specialized interpretation. This study proposes an AI-based framework that combines deep learning (DL) with the modified Hiking Optimization Algorithm (MHOA) enhanced by a Comprehensive Learning (CL) technique to improve the classification of nerve injuries (neuropraxia, axonotmesis, neurotmesis) using MRN data. Materials and Methods: The framework utilizes MobileNetV4 for feature extraction and MHOA for optimized feature selection across different MRI sequences (STIR, T2, T1, and DWI). A dataset of 39 patients diagnosed with BP was used. The framework classifies injuries based on Seddon's criteria, distinguishing between normal and abnormal conditions as well as injury severity. Results: The model achieved excellent performance, with 1.0000 accuracy in distinguishing normal from abnormal conditions using STIR and T2 sequences. For injury severity classification, accuracy was 0.9820 in STIR, outperforming the original HOA and other metaheuristic algorithms. Additionally, high classification accuracy (0.9667) was observed in DWI. The proposed framework outperformed traditional methods and demonstrated high sensitivity and specificity. Conclusion: The proposed AI-based framework significantly improves the diagnosis of BP by accurately classifying nerve injury types. By integrating DL and optimization techniques, it reduces diagnostic variability, making it a valuable tool for clinical settings with limited specialized neuroimaging expertise. This framework has the potential to enhance clinical decision-making and optimize patient outcomes through precise and timely diagnoses. © 2025 The Association of University Radiologists

关键词： Brachial Plexopathy (BP) Comprehensive Learning (CL) Deep Learning (DL) Feature Selection (FS) Hiking Optimization Algorithm (HOA) Magnetic Resonance Neurography (MRN) MobileNetV4

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Assessing disruptive potential of retail central bank digital currency and influence of design considerations: An open innovation approach in Thailand

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Journal of Open Innovation: technology, Market, and Complexity 2025年第1期11卷

作者： Wathahong, Thanwa Ratanabanchuen, Roongkiat Israsena Na Ayudhya, Praima Tientanopajai, Kitt Technology Management and Innopreneurship Program Graduate School Chulalongkorn University Phayathai Road Bangkok 10330 Thailand Department of Banking and Finance Chulalongkorn Business School Chulalongkorn University Phayathai Road Bangkok 10330 Thailand Department of Industrial Design Faculty of Architecture Chulalongkorn University Phayathai Road Bangkok 10330 Thailand Department of Computer Engineering Faculty of Engineering Khon Kaen University Mittraphap Road Khon Kaen 40002 Thailand

Monetary authorities globally have studied central bank digital currency (CBDC) for wholesale and retail applications since the 1990s. Besides countering private cryptocurrencies' influence, central banks have also explored other benefits of CBDC, such as improving their financial oversight, enhancing digital payment systems, and reducing transaction fees and friction. For several years, the Bank of Thailand has also invested in research and development of CBDC, including retail use cases. However, an optimized design for an official launch of a retail CBDC in Thailand has yet to be determined, resembling fragmented progress observed among other central banks. This research has leveraged disruptive innovation theory to provide a fresh perspective on retail CBDC as potentially disruptive financial innovations. Additionally, it has proposed an open innovation-based methodology to determine industry preferences concerning twelve design considerations for retail CBDC and their impact on nine indicators of disruptive innovation. Data has been collected and analyzed from 98 respondents outside the Bank of Thailand, all possessing relevant expertise or experience in electronic payments. Crosstab and logistic regression analyses have indicated that retail CBDC in Thailand could embark on a disruptive innovation trajectory by adhering to defined design choices. Significantly, entering a new detached market has been identified as the most promising entry point, accompanied by explicit recommendations on nine out of twelve design considerations. © 2025 The Authors

关键词： CBDC Central bank digital Currency Disruptive innovation Open Innovation Retail

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Nonsaturated large magnetoresistance and transport dynamics in a n-doped cryogenic WSe2 field-effect device

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Physical Review B 2025年第12期111卷 125307-125307页

作者： Wei-Chen Lin Ching-Chen Yeh Jia-Zhu Zou Nhat Anh Nguyen Phan Inayat Uddin Hai Yen Le Thi Kenji Watanabe Takashi Taniguchi Gil-Ho Kim Department of Engineering and System Science National Tsing Hua University Hsinchu 300 Taiwan Taiwan International Graduate Program Academia Sinica Taipei 115 Taiwan Department of Physics National Taiwan University Taipei 106 Taiwan Department of Electrical and Computer Engineering Sungkyunkwan University (SKKU) Suwon 164 Republic of Korea Sungkyunkwan Advanced Institute of Nano Technology (SAINT) Sungkyunkwan University (SKKU) Suwon 16419 Republic of Korea Research Center for Electronic and Optical Materials National Institute for Materials Science 1-1 Namiki Tsukuba 305-0044 Japan Research Center for Materials Nanoarchitectonics National Institute for Materials Science 1-1 Namiki Tsukuba 305-0044 Japan

Interest in the two-dimensional (2D) semiconducting transition metal dichalcogenides (TMDs) continues to intensify, driven by their suitable band gaps to supplant silicon as next-generation semiconductor materials. Among various TMDs, tungsten diselenide (WSe2) is renowned for its superior electrical properties in carrier density and mobility under ambient conditions. Despite its notable attributes, the behavior of monolayer WSe2 in the electron-doped regime under cryogenic conditions remains largely uncharted, particularly concerning its magnetotransport properties. In this study, we reveal the transport mechanisms of monolayer WSe2 from high temperatures down to the cryogenic regime. As evident by Efros–Shklovskii variable-range hopping (E-S VRH) in the cryogenic regime, strong Coulomb interactions arise between electrons. Above 8 K, an uncommon nonsaturated quadratic large magnetoresistance (MR) can be explained by the wave-function shrinkage model, which is consistent with the E-S VRH transport mechanism. Notably, the nonsaturated quadratic large MR shows a magnitude up to 1740% at 13 T. These findings underscore the potential applications for monolayer WSe2 in cryogenic field-effect devices, magnetic sensors, and memory devices and mark a significant advance in magnetotransport research.

关键词： Monolayers

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Medical Image Segmentation by Improved Nested Unet 2nd

Medical Image Segmentation by Improved Nested Unet

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2nd International Conference on Intelligent Systems and Data Science, ISDS 2024

作者： Tran, Song-Toan Le, Minh-Hai Nguyen, Thai-Son Nghi, Vinh-Khanh Nguyen, Thanh-Nguyen School of Engineering and Technology Tra Vinh University Tra Vinh87000 Viet Nam Resource Development Institute Tra Vinh University Tra Vinh87000 Viet Nam PhD program in Computer Science Tra Vinh University Tra Vinh87000 Viet Nam Facilities Management Department Tien Giang University Tien Giang84000 Viet Nam

ISBN: (纸本)9789819796120

Deep learning is revolutionizing the field of medical image segmentation. The U-shaped (Unet) model, with its encoder-decoder architecture and skip connections, has become the dominant architecture for this task. However, variations like Nested-Unet are necessary to address the challenge of adapting network size for datasets of varying scales. This study proposes a novel model based on a multilayer Unet architecture that leverages all output features within nodes of a Nested Unet network. We evaluate the proposed model on four key medical image datasets: electron microscopy (EM), nuclei, polyps (CVC-ClinicDB), and skin lesions. The model achieves impressive Dice scores: 94.08% for EM, 92.68% for nuclei, 87.20% for skin lesions, and 93.02% for the CVC-ClinicDB dataset. These outstanding results demonstrate the superior performance of our proposed model compared to recent advancements in the field. Remarkably, the model achieves this performance while maintaining a size that is half that of a traditional Unet model. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Image segmentation

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Innovative Integration of Machine Learning Predictive Models Within Blockchain Frameworks for Supply Chain Fault Tolerance 1st

Innovative Integration of Machine Learning Predictive Models...

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1st International Conference on Advanced Network Technologies and Computational Intelligence, ICANTCI 2024

作者： Kaur, Jatinder Rusho, Maher Ali Yogi, Kottala Sri Soni, Mukesh Raparthi, Mohan Garg, Yakshit Department of Computer Science and Engineering Lovely Professional University Jalandhar Phagwara India Degree Program University of Colorado Boulder Boulder United States Telangana Hyderabad India Dr. D. Y. Patil Vidyapeeth Pune India Dr. D. Y. Patil School of Science and Technology Tathawade Pune India Alphabet Life Science Texas Dallas75063 India Chitkara University Institute of Engineering and Technology Chitkara University Punjab Rajpura India

ISBN: (纸本)9783031860683

The creative incorporation of machine learning predictive models into blockchain frameworks appears as a game-changing approach for augmenting fault tolerance and increasing operational resilience in the dynamic environment of supply chain management. The potential, results, and implications of the integration are examined in this paper, providing a holistic perspective on its effect on contemporary supply networks. The essay starts by discussing the ever-changing difficulties encountered by supply chain networks operating in the modern global economy. Fault tolerance in the supply chain is becoming a pressing issue, calling for creative solutions to minimize interruptions and maximize efficiency. The importance of using machine learning predictive models into blockchain frameworks is outlined in the introduction, which also provides context for the rest of the paper. Methods used to test the integration's usefulness are described in the research paper. Logical regression, random forests, CNNs, SVMs, and LSTM models are all part of this category of cutting-edge machine learning methods. Machine learning algorithms in blockchain frameworks may protect supply networks from catastrophic breakdowns. The suggested strategy beats conventional models in accuracy (92%), precision (88%), recall (93%), F1-Score (90%), MAE (0.12), and MSE (0.15). The recommended method has a higher MSE than traditional models. The findings suggest that supply chain networks anticipate future occurrences and identify issues *** a result, businesses will be able to prevent and correct problems like shipment delays and stock-outs. The danger of data tampering and fraudulent activities has also been reduced thanks to the use of blockchain technology, which has improved data integrity and trust among supply chain players. This impact is shown by a 30% decrease in data tampering events inside the supply chain. The revolutionary potential of the novel integration of machine learning prediction

关键词： Supply chain management

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Norepinephrine changes behavioral state through astroglial purinergic signaling

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Science (New York, N.Y.) 2025年第6748期388卷 769-775页

作者： Chen, Alex B. Duque, Marc Rymbek, Altyn Dhanasekar, Mahalakshmi Wang, Vickie M. Mi, Xuelong Tocquer, Loeva Narayan, Sujatha Legorreta, Emmanuel Marquez Eddison, Mark Yu, Guoqiang Wyart, Claire Prober, David A. Engert, Florian Ahrens, Misha B. Howard Hughes Medical Institute Janelia Research Campus Ashburn VA United States Department of Molecular and Cellular Biology Harvard University Cambridge MA United States Graduate Program in Neuroscience Harvard Medical School Boston MA United States Tianqiao and Chrissy Chen Institute for Neuroscience Division of Biology and Biological Engineering California Institute of Technology Pasadena CA United States Sorbonne Université Paris Brain Institute (Institut du Cerveau Institut National de la Santé et de la Recherche Médicale U1127 Centre National de la Recherche Scientifique Unité Mixte de Recherche 7225 Assistance Publique-Hôpitaux de Paris Campus Hospitalier Pitié-Salpêtrière Paris France Bradley Department of Electrical and Computer Engineering Virginia Polytechnic Institute and State University Arlington VA United States Present address: Allen Institute for Brain Science Seattle WA United States Department of Automation Tsinghua University Beijing China

Both neurons and glia communicate through diffusible neuromodulators;however, how neuron-glial interactions in such neuromodulatory networks influence circuit computation and behavior is unclear. During futility-induced behavioral transitions in the larval zebrafish, the neuromodulator norepinephrine (NE) drives fast excitation and delayed inhibition of behavior and circuit activity. We found that astroglial purinergic signaling implements the inhibitory arm of this motif. In larval zebrafish, NE triggers astroglial release of adenosine triphosphate (ATP), extracellular conversion of ATP into adenosine, and behavioral suppression through activation of hindbrain neuronal adenosine receptors. Our results suggest a computational and behavioral role for an evolutionarily conserved astroglial purinergic signaling axis in NE-mediated behavioral and brain state transitions and position astroglia as important effectors in neuromodulatory signaling.

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Optimizing solar-powered multi-generation systems for sustainable energy management in university buildings using Neural Networks and Genetic Algorithms

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Journal of Building engineering 2025年 108卷

作者： Assareh, Ehsanolah Izadyar, Nima Jamei, Elmira Monzavian, Mohammad amin Agarwal, Saurabh Agarwal, Neha Strategic Research Institute (SRI) Asia Pacific University of Technology and Innovation (APU) Technology Park Malaysia Kuala Lumpur Built Environment and Engineering Program College of Sport Health and Engineering (CoSHE) Victoria University Melbourne Australia Department of Renewable Energy Technology Materials and Energy Research Center Dezful Branch Islamic Azad University Dezful Iran Institute for Sustainable Industries and Liveable Cities Victoria University Melbourne 3011 VIC Australia School of Computer Science and Engineering Yeungnam University Gyeongsan 38541 South Korea School of Chemical Engineering Yeungnam University Gyeongsan 38541 South Korea

University campuses operate like small cities, with complex energy demands driven by diverse activities, making energy management particularly challenging in extreme climates. Traditional energy systems often rely on fossil fuels, leading to inefficiencies, high costs, and increased carbon footprints. This study optimizes a solar-powered multi-generation system for a university building in the severe hot climate of Dezful, Iran, using a two-step approach. First, the Building Energy Optimization Tool (BEopt) was used to select optimal building materials, leading to a reduction in total energy demand. Then, Artificial Intelligence algorithms (Neural Networks and Genetic Algorithms) were applied to enhance system performance and cost-effectiveness. The engineering Equation Solver (EES) validated the thermodynamic performance of the optimized system. This optimized system generates 49.55 GW-hours (GWh) of electricity annually, along with 19.47 GWh of heating and 13.93 GWh of cooling, producing a surplus of 34.28 GWh (69 % of total generation). Compared to the base case, electricity generation increased by over 224 %, cooling by 120 %, and heating by more than 3500 %, while CO₂ emissions decreased from 37.18 to 35.34 metric tons/year. The optimized system operates with an exergy efficiency of 23.44 % and a cost rate of 14.93 $/h. What sets this study novel is the integration of demand-side improvements with AI-enhanced multi-generation systems and thermodynamic validation, creating a practical model for achieving net-zero energy on university campuses. This methodology is scalable to more complex energy networks, including district energy systems, with future work focusing on real-time weather integration and advanced forecasting to improve adaptability and resilience. © 2025 The Authors

关键词： Artificial intelligence optimization Energy efficiency Renewable energy integration Solar-powered multi-generation systems Sustainable university campuses

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Glaucoma identification with retinal fundus images using deep learning: Systematic review

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Informatics in Medicine Unlocked 2025年 56卷

作者： Meedeniya, Dulani Shyamalee, Thisara Lim, Gilbert Yogarajah, Pratheepan Department of Computer Science and Engineering University of Moratuwa Moratuwa 10400 Sri Lanka First-Year Division Faculty of Computing Sri Lanka Institute of Information Technology Malabe 10115 Sri Lanka SingHealth AI Health Program SingHealth Group Singapore 168582 Singapore School of Computing Engineering and Intelligent System Ulster University Londonderry BT48 7JL United Kingdom

Glaucoma is a leading cause of blindness, affecting millions of people worldwide. It is a chronic eye condition that damages the optic nerve and, if left untreated, can lead to vision loss and a decreased quality of life. Therefore, there is a need to explore practical and reliable mechanisms for glaucoma identification. This study systematically reviews deep-learning approaches for glaucoma identification using retinal fundus images from 2018 to 2024. Compared to existing survey studies, we cover the latest research, including several public retinal fundus image datasets, and focus on segmentation, classification based on convolutional neural networks and vision transformers, and explainability. The findings of this study, including comparisons of existing methods and key insights, will assist researchers and developers in identifying the most suitable techniques for glaucoma detection. © 2025 The Authors

关键词： Artificial intelligence Classification Deep learning Explainability Glaucoma Segmentation Trustworthiness

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Integrated 6G TN and NTN Localization: Challenges, Opportunities, and Advancements

IEEE Communications Standards Magazine

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IEEE Communications Standards Magazine 2025年

作者： Saleh, Sharief Zheng, Pinjun Liu, Xing Chen, Hui Keskin, Musa Furkan Priyanto, Basuki Beale, Martin Ettefagh, Yasaman Seco-Granados, Gonzalo Al-Naffouri, Tareq Y. Wymeersch, Henk Chalmers University of Technology Department of Electrical Engineering Sweden King Abdullah University of Science and Technology (KAUST) Electrical and Computer Engineering Program Division of Computer Electrical and Mathematical Sciences and Engineering (CEMSE) Saudi Arabia Sony Europe BV United Kingdom Universitat Autònoma de Barcelona Department of Telecommunications and Systems Engineering Spain

The rapid evolution of cellular networks has introduced groundbreaking technologies, including large and distributed antenna arrays and reconfigurable intelligent surfaces in terrestrial networks (TNs), as well as aerial and space-based nodes in non-terrestrial networks (NTNs). These advancements enable applications beyond traditional communication, such as high-precision localization and sensing. While integrating TN and NTN enablers will lead to unparalleled opportunities for seamless global localization, such integration attempts are expected to face several challenges. To understand these opportunities and challenges, we first examine the distinctive characteristics of the key 6G enablers, evaluating their roles in localization from both technical and practical perspectives. Next, to identify developments driving TN-NTN localization, we review the latest standardization and industrial innovation progress. Finally, we discuss the opportunities and challenges of TN-NTN integration, illustrating its potential through two numerical case studies. © 2017 IEEE.

关键词： 6G localization low-Earth-orbit (LEO) satellites non-terrestrial network (NTN) reconfigurable intelligent surface (RIS) terrestrial network (TN)

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