检索结果-内蒙古大学图书馆

46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024

作者： Li, Xin Zhang, Guoying Zheng, Chenguang Tian, Yutao Tianjin University Academy of Medical Engineering and Translational Medicine Medical College Tianjin China Tianjin Key Laboratory of Brain Science and Neuroengineering Tianjin China Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration Tianjin China

ISBN: (纸本)9798350371499

Ultrasound neuromodulation, a burgeoning field aimed at enhancing brain function and behavior, relies on the intricate electrophysiological responses of neurons driven by ion channel dynamics. However, achieving targeted and precise modulation with ultrasound poses a significant challenge. A hypothesis is that mechanosensitive (MS) ion channels may play a pivotal role in achieving the desired specificity in ultrasound effects. Our study involved augmenting MscL-G22S channel expression in specific areas of rats' hippocampus (HP) and primary visual cortex (V1) via AAV virus delivery. We recorded local field potentials (LFPs) to assess the modulation effect and identified distinct evoked-related potentials (ERPs) in regions overexpressing MscL-G22S channels under anesthesia. Notable variations in the amplitude of negative peaks were observed in the ERPs between HP and V1, highlighting a nuanced response to ultrasound stimulation. These results highlight the complexity and promise of MS channel-mediated neuromodulation, offering critical insights into the development of targeted ultrasound interventions to improve brain function. © 2024 IEEE.

关键词： Transient analysis

来源：评论

学校读者我要写书评

暂无评论

Low intensity focused ultrasound stimulation targeted on M1 ameliorates neuroinflammation in hemi-parkinsonian rats 46

Low intensity focused ultrasound stimulation targeted on M1 ...

引用

46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024

作者： Li, Chunchan Sun, Tianyi Liang, Rong Yang, Zihui Yang, Weifan Li, Wanzhe Yin, Yiwei Zhang, Guanglu Wang, Ling Yang, Jiajia He, Feng Ming, Dong Academy of Medical Engineering and Translational Medicine Tianjin University Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin University Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin University Tianjin 300072 China

ISBN: (纸本)9798350371499

Objective: Low intensity focused stimulation (LIFUS) has been proved to improve motor function in Parkinson's disease (PD) animal modules. The aim of this study is to investigate whether LIFUS target on the primary motor cortex (M1) can improve motor deficit in the PD rats. Methods: The PD rat model was induced by injection of 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle (MFB). Two weeks after the injection, LIFUS was used on PD rats for two weeks. Behavioral tests were performed including open field test and rotarod test to examine the motor ability of the rats. The activity of microglia and astrocyte were tested to evaluate the inflammation level in the brain. The tyrosine hydroxylase (TH) staining was done to detect the recovery of dopaminergic (DA) neurons in the substantia nigra (SN) and DA fibers in the striatum (STR). Results: LIFUS treatment decreased the resting time in OFT(p © 2024 IEEE.

关键词： Neurodegenerative diseases

来源：评论

学校读者我要写书评

暂无评论

The Pattern of CA1 c-Fos Expressing Place Cells Correlates with Learning Progression 46

The Pattern of CA1 c-Fos Expressing Place Cells Correlates w...

引用

46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024

作者： Wang, Ning Zhang, Anqi Yang, Jiajia Wang, Ling Zheng, Chenguang Tianjin University Academy of Medical Engineering and Translational Medicine Medical College Tianjin China Tianjin Key Laboratory of Brain Science and Neuroengineering Tianjin China Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration Tianjin China

ISBN: (纸本)9798350371499

Spatial memory supported by the hippocampus is a critical cognitive function in daily life. It helps us to navigate to salient goal locations. Hippocampal place cells stably represent the spatial location, while c-Fos-expressing cells (engram cells) contain rich information about the environment, contributing to the encoding and retrieving of memories. However, the role of cFos as a gateway to a more profound comprehension of the mechanisms underlying the process of goal-oriented spatial memory remained poorly understood. In this study, we labeled rats' c-Fos+ neurons by Channelrhodopsin-2 during memory encoding of a specific goal location. A subset of place cells whether they expressed c-Fos was identified optogenetically. As the rats learned the new goal locations, the spatial correlation between task periods remained stable for the c-Fos- place cell, while increased for the c-Fos+ place cell. This finding shed light on the processing of goal-oriented spatial memories by the hippocampal network involved in c-Fos. C-Fos- place cells consistently maintained a stable representation of the locations, while c-Fos+ place cells exhibited significant flexibility of the goal. © 2024 IEEE.

关键词： Signal encoding

来源：评论

学校读者我要写书评

暂无评论

Firing Pattern of Cells in the Hippocampus and Basolateral Amygdala during Novelty Recognition 46

Firing Pattern of Cells in the Hippocampus and Basolateral A...

引用

46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024

作者： Ren, Xiaoxin Wang, Yimeng Wang, Ling Yang, Jiajia Zheng, Chenguang Tianjin University Academy of Medical Engineering and Translational Medicine Medical College Tianjin China Tianjin Key Laboratory of Brain Science and Neuroengineering Tianjin China Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration Tianjin China

ISBN: (纸本)9798350371499

Novelty recognition is essential for exploring and collecting unknown but interesting information, in which multiple brain regions related to cognitive memory are involved. Dorsal hippocampus (dHPC) is revealed to be closely associated with spatial memory and basolateral amygdala (BLA) is reported recently to be related to state-dependent encoding of exploratory behavior. However, how the firing pattern of cells in these two brain regions responds to novelty dynamically remains unclear. In this study, we observed that the representations of cells in BLA exhibited shift towards novelty, whereas dHPC cells maintained strong stability after the introduction of novelty, which are both engaged in the execution of novel recognition. Our study may provide new evidence for underlying the internal mechanisms of perception of novelty in the brain. © 2024 IEEE.

关键词： Brain

来源：评论

学校读者我要写书评

暂无评论

Astrocytic TRPA1 as a target in reversing social avoidance by low-intensity focused ultrasound stimulation in mice 46

Astrocytic TRPA1 as a target in reversing social avoidance b...

引用

46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024

作者： Wei, Ganjiang Wang, Ling Zhu, Jingnan Wang, Xiao Zang, Yuran Yang, Jiajia Zheng, Chenguang Tianjin University Academy of Medical Engineering and Translational Medicine Medical College Tianjin China Tianjin Key Laboratory of Brain Science and Neuroengineering Tianjin China Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration Tianjin China

ISBN: (纸本)9798350371499

Social avoidance is a prominent clinical feature of multiple neuropsychiatric disorders. Increasing evidence showed that the medial prefrontal cortex (mPFC) regulates social avoidance with suppression of excitatory neurons. Our previous study found that the low-intensity focused ultrasound (LIFUS), as a novel noninvasive neuromodulation technique, could alleviate the social avoidance of social defeat stress (SDS) model mice by increasing the mPFC excitation. However, the underlying target of LIFUS on mPFC neurons in social defeated mice remains unclear. Here we injected AAV-shRNA to knock down astrocytic TRPA1 in the mPFC, and investigated whether astrocytic TRPA1 played a crucial role in LIFUS modulation. We found that the social avoidance of SDS mice with TRPA1 knocked down was not affected by LIFUS. Furthermore, LIFUS didn't induce enhanced expression of membrane NMDAR2A and NMDAR2B in SDS mice with TRPA1 knocked down, compared with that in mice infected with the control virus. It is believed that LIFUS can act on astrocytic TRPA1 to improve social avoidance and hence synaptic function. © 2024 IEEE.

关键词： Ultrasonics

来源：评论

学校读者我要写书评

暂无评论

Exploring Digital Misinformation as a Sociotechnical Phenomenon: Insights from a Small-scale Study 23

Exploring Digital Misinformation as a Sociotechnical Phenome...

引用

Proceedings of the XXII Brazilian Symposium on human Factors in Computing Systems

作者： Alisson Andery Puska Roberto Pereira Human-Computer Interaction Laboratory Universidade Federal do Paraná Brasil Department of Computer Science Universidade Federal do Paraná Brasil

ISBN: (纸本)9798400717154

This article addresses the challenge of comprehending digital misinformation as a sociotechnical phenomenon within the field of human-computer interaction, particularly in the context of COVID-19-related misinformation in Brazil. The study employed an exploratory approach to analyze misinformation cases using various artifacts and conducted a focus group with eight experts in the field. The findings revealed 137 sociotechnical aspects and 29 stakeholders, shedding light on the complex interplay of factors influencing digital misinformation’s creation, dissemination, and consumption. The study emphasizes the necessity of adopting a sociotechnical approach and highlights the challenges in comprehensively analyzing stakeholders, communication channels, and the stages of the misinformation lifecycle. Overall, the research contributes to a deeper understanding of digital misinformation in sociotechnical contexts and its implications for human-computer interaction.

关键词： misinformation misinformation life cycle organizational semiotics sociotechnical analysis

来源：评论

学校读者我要写书评

暂无评论

Study on the Temporal Patterns of CA1 Pyramidal Neuron Activity in Mice Hippocampus under Simulated Spaceflight Composite Environment 46

Study on the Temporal Patterns of CA1 Pyramidal Neuron Activ...

引用

46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024

作者： Sun, Shufan Ren, Jing Zhao, Meiling Wang, Ling Zheng, Chenguang Yang, Jiajia Ming, Dong Academy of Medical Engineering and Translational Medicine Tianjin University Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin University Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin University Tianjin 300072 China

ISBN: (纸本)9798350371499

With the gradual realization of manned spaceflight goals, the physical and mental health of astronauts has become a core concern. Numerous studies in recent years have indicated that the aerospace special environment (ASE) can lead to alterations in astronaut cognitive function. However, the adaptive changes in neuronal activity underlying these alterations remain unclear. This study utilized animal models and two-photon imaging technology to investigate the adaptive changes in the activity characteristics and synchronicity of pyramidal neurons in the CA1 region of the mice hippocampus under simulated spaceflight composite environment (SSCE). The results indicate that, with prolonged modeling time, the number of active pyramidal neurons in the CA1 region gradually decreases. Significant reductions in both the frequency and amplitude of neuronal calcium transients occur, stabilizing at lower levels. The calcium transient decay constant extends, and significant decorrelation in neuronal calcium activity is observed. Thus, we posit that these changes may constitute crucial factors leading to the alterations in individual cognitive function induced by the aerospace special environment. © 2024 IEEE.

关键词： Mammals

来源：评论

学校读者我要写书评

暂无评论

Investigating the Role of Metaphors in human-AI Conversation and Engagement 24

Investigating the Role of Metaphors in Human-AI Conversation...

引用

24th IEEE International Conference on Data Mining Workshops, ICDMW 2024

作者： Maheshwary, Pragati Liu, Qiawen Mao, Rui Carnegie Mellon University Human-Computer Interaction Institute United States University of Wisconsin-Madison Department of Psychology United States Nanyang Technological University College of Computing and Data Science Singapore

ISBN: (纸本)9798331530631

Metaphorical expressions are widely used in daily communication between humans to improve the understanding of both complex and abstract concepts. However, it is unclear whether the usage of metaphorical language is helpful for enhancing the conversational engagement between humans and AI. In this work, we leverage a state-of-the-art computational metaphor processing tool to gain insights from human and ChatGPT conversations. Our quantitative analysis finds that although metaphors may enhance the quality of human-AI interactions, they do not directly lead to higher levels of conversational engagement, which is measured by the duration of the conversation. However, regression analysis shows a notable relationship between user and ChatGPT metaphor usage, suggesting that ChatGPT is adept at reflecting the linguistic style of users, especially in terms of metaphorical language. Additional topic modeling and concept mapping analyses further explored the patterns of metaphorical language across various engagement levels and topics in user and ChatGPT messages. © 2024 IEEE.

关键词： Modeling languages

来源：评论

学校读者我要写书评

暂无评论

Towards Context-Aware Adaptation in Extended Reality: A Design Space for XR Interfaces and an Adaptive Placement Strategy

arXiv

引用

arXiv 2024年

作者： Davari, Shakiba Bowman, Doug A. Center for Human-Computer Interaction Department of Computer Science Virginia Tech BlacksburgVA United States

By converting the entire 3D space around the user into a screen, Extended Reality (XR) can ameliorate traditional displays’ space limitations and facilitate the consumption of multiple pieces of information at a time. However, if designed inappropriately, these XR interfaces can overwhelm the user and complicate information access. In this work, we explored the design dimensions that can be adapted to enable suitable presentation and interaction within an XR interface. To investigate a specific use case of context-aware adaptations within our proposed design space, we concentrated on the spatial layout of the XR content and investigated non-adaptive and adaptive placement strategies. In this paper, we (1) present a comprehensive design space for XR interfaces, (2) propose Environment-referenced, an adaptive placement strategy that uses a relevant intermediary from the environment within a Hybrid Frame of Reference (FoR) for each XR object, and (3) evaluate the effectiveness of this adaptive placement strategy and a non-adaptive Body-Fixed placement strategy in four contextual scenarios varying in terms of social setting and user mobility in the environment. The performance of these placement strategies from our within-subjects user study emphasized the importance of intermediaries’ relevance to the user’s focus. These findings underscore the importance of context-aware interfaces, indicating that the appropriate use of an adaptive content placement strategy in a context can significantly improve task efficiency, accuracy, and usability. © 2024, CC BY-NC-ND.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Exploring Multiscale Navigation of Homogeneous and Dense Objects with Progressive Refinement in Virtual Reality

Exploring Multiscale Navigation of Homogeneous and Dense Obj...

引用

IEEE Annual International Symposium Virtual Reality

作者： Leonardo Pavanatto Alexander Giovannelli Brian Giera Timo Bremer Haichao Miao Doug A. Bowman Department of Computer Science Center for Human-Computer Interaction Virginia Tech USA Center for Applied Scientific Computing Lawrence Livermore National Laboratory USA

ISBN: (数字)9798331536459

ISBN: (纸本)9798331536466

Locating small features in a large, dense object in virtual reality (VR) poses a significant interaction challenge. While existing multiscale techniques support transitions between various levels of scale, they are not focused on handling dense, homogeneous objects with hidden features. We propose a novel approach that applies the concept of progressive refinement to VR navigation, enabling focused inspections. We conducted a user study where we varied two independent variables in our design, navigation style (STRUCTURED vs. UNSTRUCTURED) and display mode (SELECTION vs. EVERYTHING), to better understand their effects on efficiency and awareness during multiscale navigation. Our results showed that unstructured navigation can be faster than structured and that displaying only the selection can be faster than displaying the entire object. However, using an everything display mode can support better location awareness and object understanding.

关键词： human computer interaction Location awareness Three-dimensional displays Navigation Virtual reality Inspection

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：