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A Brief Review of Explainable Artificial Intelligence in Healthcare

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arXiv 2023年

作者： Sadeghi, Zahra Alizadehsani, Roohallah Cifci, Mehmet Akif Kausar, Samina Rehman, Rizwan Mahanta, Priyakshi Bora, Pranjal Kumar Almasri, Ammar Alkhawaldeh, Rami S. Hussain, Sadiq Alatas, Bilal Shoeibi, Afshin Moosaei, Hossein Hladík, Milan Nahavandi, Saeid Pardalos, Panos M. Institute for Big Data Analytics Faculty of Computer Science Dalhousie University Canada Deakin University Geelong Australia The Institute of Computer Technology Tu Wien University Vienna1040 Austria University of Kotli Azad Jammu and Kashmir Azad Kashmir Kotli Pakistan Centre for Computer Science and Applications Dibrugarh University Assam India Department of Management Information Sys Al-Balqa Applied University Salt19117 Jordan Department of Computer Information Systems The University of Jordan Aqaba77110 Jordan Examination Branch Dibrugarh University Assam Dibrugarh India Department of Software Eng. Firat University Elazig23100 Turkey Data Science and Computational Intelligence Institute University of Granada Spain Department of Informatics Faculty of Science Jan Evangelista Purkyně University in Ústí nad Labem Czech Republic Department of Applied Mathematics School of Computer Science Faculty of Mathematics and Physics Charles University Prague Czech Republic Harvard Paulson School of Engineering and Applied Sciences Harvard University AllstonMA02134 United States Center for Applied Optimization Department of Industrial and Systems Engineering University of Florida Gainesville32611 United States

XAI refers to the techniques and methods for building AI applications which assist end users to interpret output and predictions of AI models. Black box AI applications in high-stakes decision-making situations, such as medical domain have increased the demand for transparency and explainability since wrong predictions may have severe consequences. Model explainability and interpretability are vital successful deployment of AI models in healthcare practices. AI applications' underlying reasoning needs to be transparent to clinicians in order to gain their trust. This paper presents a systematic review of XAI aspects and challenges in the healthcare domain. The primary goals of this study are to review various XAI methods, their challenges, and related machine learning models in healthcare. The methods are discussed under six categories: Features-oriented methods, global methods, concept models, surrogate models, local pixel-based methods, and human-centric methods. Most importantly, the paper explores XAI role in healthcare problems to clarify its necessity in safety-critical applications. The paper intends to establish a comprehensive understanding of XAI-related applications in the healthcare field by reviewing the related experimental results. To facilitate future research for filling research gaps, the importance of XAI models from different viewpoints and their limitations are investigated. © 2023, CC BY-NC-ND.

关键词： Decision making

Meta Mask Correction for Nuclei Segmentation in Histopathological Image

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Meta Mask Correction for Nuclei Segmentation in Histopatholo...

2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021

作者： Shi, Jiangbo Jia, Chang Gao, Zeyu Gong, Tieliang Wang, Chunbao Li, Chen Xi'An Jiao Tong University National Engineering Lab for Big Data Analytics Shaanxi Xi'an710049 China School of Computer Science and Technology Xi'An Jiao Tong University Shaanxi Xi'an710049 China Shaanxi Province Key Laboratory of Satellite and Terrestrial Network Tech.RandD Xi'An Jiao Tong University Shaanxi Xi'an710049 China Department of Pathology The First Affiliated Hospital of xi'An Jiaotong University Shaanxi Xi'an710061 China

ISBN: (纸本)9781665401265

Nuclei segmentation is a fundamental task in digital pathology analysis and can be automated by deep learning-based methods. However, the development of such an automated method requires a large amount of data with precisely annotated masks which is hard to obtain. Training with weakly labeled data is a popular solution for reducing the workload of annotation. In this paper, we propose a novel meta-learning-based nuclei segmentation method which follows the label correction paradigm to leverage data with noisy masks. Specifically, we design a fully conventional meta-model that can correct noisy masks using a small amount of clean meta-data. Then the corrected masks can be used to supervise the training of the segmentation model. Meanwhile, a bi-level optimization method is adopted to alternately update the parameters of the main segmentation model and the meta-model in an end-to-end way. Extensive experimental results on two nuclear segmentation datasets show that our method achieves the state-of-the-art result. It even achieves comparable performance with the model training on supervised data in some noisy settings. © 2021 IEEE.

关键词： Deep learning

A Brief Review of Explainable Artificial Intelligence in Healthcare

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SSRN

SSRN 2023年

作者： Sadeghi, Zahra Alizadehsani, Roohallah Cifci, Mehmet Akif Kausar, Samina Rehman, Rizwan Mahanta, Priyakshi Bora, Pranjal Kumar Almasri, Ammar Alkhawaldeh, Rami S. Hussain, Sadiq Alatas, Bilal Shoeibi, Afshin Moosaei, Hossein Hladík, Milan Nahavandi, Saeid Pardalo, Panos M. Institute for Big Data Analytics Faculty of Computer Science Dalhousie University Canada Deakin University Geelong Australia The Institute of Computer Technology Tu Wien University Vienna1040 Austria University of Kotli Azad Jammu and Kashmir Azad Kashmir Kotli Pakistan Centre for Computer Science and Applications Dibrugarh University Assam India Department of Management Information Sys Al-Balqa Applied University Salt19117 Jordan Department of Computer Information Systems The University of Jordan Aqaba77110 Jordan Examination Branch Dibrugarh University Assam Dibrugarh India Department of Software Eng. Firat University Elazig23100 Turkey Data Science and Computational Intelligence Institute University of Granada Spain Department of Informatics Faculty of Science Jan Evangelista Purkyně University in Ústí nad Labem Czech Republic Department of Applied Mathematics School of Computer Science Faculty of Mathematics and Physics Charles University Prague Czech Republic Harvard Paulson School of Engineering and Applied Sciences Harvard University AllstonMA02134 United States Swinburne University of Technology HawthornVIC3122 Australia Center for Applied Optimization Department of Industrial and Systems Engineering University of Florida Gainesville32611 United States

关键词： Decision making

Design of a Hybrid Brain-computer Interface and Virtual Reality System for Post-Stroke Rehabilitation

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IFAC-PapersOnLine 2020年第2期53卷 16010-16015页

作者： Mengjie Huang Yuting Zheng Jingjing Zhang Bin’ao Guo Chenyu Song Rui Yang Department of Computer Science and Software Engineering Xi’an Jiaotong-Liverpool University Suzhou 215123 China Research Institute of Big Data Analytics Xi’an Jiaotong-Liverpool University Suzhou 215123 China

As one of common diseases among elderly, stroke often leads to motor impairment and even serious disability. Post-stroke rehabilitation is of great importance to restore the motor function and improve the life quality of stroke survivors. This study therefore sets out to propose a hybrid system based on brain-computer interface and virtual reality, which can provide various training programs including action observation, motor imagery and physical therapy for post-stroke patients with different motor control levels and training demands. The present work offers new insights into the way in which the conventional rehabilitation programs can be turned into innovative and interactive training experiences with advanced technologies to make optimal rehabilitation outcomes for stroke survivors.

关键词： Rehabilitation engineering Stroke Virtual reality Brain-computer interface Motor imagery

MoCA: Incorporating multi-stage domain pretraining and cross-guided multimodal attention for Textbook Question Answering

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arXiv 2021年

作者： Xu, Fangzhi Lin, Qika Liu, Jun Zhang, Lingling Zhao, Tianzhe Chai, Qi Pan, Yudai Department of Computer Science and Technology Xi'an Jiaotong University China National Engineering Lab for Big Data Analytics Xi'an Jiaotong University China Shaanxi Province Key Laboratory of Satellite and Terrestrial Network Tech. R&D Xi'an Jiaotong University China

Textbook Question Answering (TQA) is a complex multimodal task to infer answers given large context descriptions and abundant diagrams. Compared with Visual Question Answering(VQA), TQA contains a large number of uncommon terminologies and various diagram inputs. It brings new challenges to the representation capability of language model for domain-specific spans. And it also pushes the multimodal fusion to a more complex level. To tackle the above issues, we propose a novel model named MoCA, which incorporates multi-stage domain pretraining and multimodal cross attention for the TQA task. Firstly, we introduce a multi-stage domain pretraining module to conduct unsupervised post-pretraining with the span mask strategy and supervised pre-finetune. Especially for domain post-pretraining, we propose a heuristic generation algorithm to employ the terminology corpus. Secondly, to fully consider the rich inputs of context and diagrams, we propose cross-guided multimodal attention to update the features of text, question diagram and instructional diagram based on a progressive strategy. Further, a dual gating mechanism is adopted to improve the model ensemble. The experimental results show the superiority of our model, which outperforms the state-of-the-art methods by 2.21% and 2.43% for validation and test split respectively. Copyright © 2021, The Authors. All rights reserved.

关键词： Textbooks

Lecture Notes in Electrical Engineering

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Preface

Lecture Notes in Electrical engineering 2023年 1027 LNEE卷 xi-xii页

作者： Dubey, Ashwani Kumar Chong, Peter Han Joo Sugumaran, Vijayan Department of Electronics and Communication Engineering Amity School of Engineering and Technology Amity University Uttar Pradesh Noida India School of Engineering Computer and Mathematical Sciences Auckland University of Technology Auckland New Zealand Department of Decision and Information Sciences Center for Data Science and Big Data Analytics Oakland University RochesterMI United States

A precision diagnostic framework of renal cell carcinoma on whole-slide images using deep learning

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arXiv 2021年

作者： Wu, Jialun Zhang, Haichuan Gao, Zeyu Bao, Xinrui Gong, Tieliang Wang, Chunbao Li, Chen School of Computer Science and Technology Xi’an Jiaotong University Xi’an China National Engineering Lab for Big Data Analytics Xi’an Jiaotong University Xi’an China School of Electrical Engineering and Computer Science Pennsylvania State University University Park PA United States School of Automation Science and Engineering Xi’an Jiaotong University Xi’an China Department of Pathology The First Affiliated Hospital of Xi’an Jiaotong University Xi’an China

Diagnostic pathology, which is the basis and gold standard of cancer diagnosis, provides essential information on the prognosis of the disease and vital evidence for clinical treatment. Tumor region detection, subtype and grade classification are the fundamental diagnostic indicators for renal cell carcinoma (RCC) in whole-slide images (WSIs). However, pathological diagnosis is subjective, differences in observation and diagnosis between pathologists is common in hospitals with inadequate diagnostic capacity. The main challenge for developing deep learning based RCC diagnostic system is the lack of large-scale datasets with precise annotations. In this work, we proposed a deep learning-based framework for analyzing histopathological images of patients with renal cell carcinoma, which has the potential to achieve pathologist-level accuracy in diagnosis. A deep convolutional neural network (InceptionV3) was trained on the high-quality annotated dataset of The Cancer Genome Atlas (TCGA) whole-slide histopathological image for accurate tumor area detection, classification of RCC subtypes, and ISUP grades classification of clear cell carcinoma subtypes. These results suggest that our framework can help pathologists in the detection of cancer region and classification of subtypes and grades, which could be applied to any cancer type, providing auxiliary diagnosis and promoting clinical consensus. © 2021, CC BY.

关键词： Classification (of information)

PIMIP: An open source platform for pathology information management and integration

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arXiv 2021年

作者： Wu, Jialun Mao, Anyu Bao, Xinrui Zhang, Haichuan Gao, Zeyu Wang, Chunbao Gong, Tieliang Li, Chen School of Computer Science and Technology Xi’an Jiaotong University Xi’an China National Engineering Lab for Big Data Analytics Xi’an Jiaotong University Xi’an China School of Automation Science and Engineering Xi’an Jiaotong University Xi’an China School of Electrical Engineering and Computer Science Pennsylvania State University University ParkPA United States Department of Pathology First Affiliated Hospital of Xi’an Jiaotong University Xi’an China

Digital pathology plays a crucial role in the development of artificial intelligence in the medical field. The digital pathology platform can make the pathological resources digital and networked, and realize the permanent storage of visual data and the synchronous browsing processing without the limitation of time and space. It has been widely used in various fields of pathology. However, there is still a lack of an open and universal digital pathology platform to assist doctors in the management and analysis of digital pathological sections, as well as the management and structured description of relevant patient information. Most platforms cannot integrate image viewing, annotation and analysis, and text information management. To solve the above problems, we propose a comprehensive and extensible platform, PIMIP (Pathology Information Management & Integration Platform). Our PIMIP has developed the image annotation functions based on the visualization of digital pathological sections. Our annotation functions support multi-user collaborative annotation and multi-device annotation, and realize the automation of some annotation tasks. In the annotation task, we invited a professional pathologist for guidance. We introduce a machine learning module for image analysis. The data we collected included public data from local hospitals and clinical examples. Our platform is more clinical and suitable for clinical use. In addition to image data, we also structured the management and display of text information. So our platform is comprehensive. The platform framework is built in a modular way to support users to add machine learning modules independently, which makes our platform extensible. © 2021, CC BY.

关键词： Information management

An integrated GIS-based multivariate adaptive regression splines-cat swarm optimization for improving the accuracy of wildfire susceptibility mapping

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Geocarto International 2023年第1期38卷

作者： Hai, Tao Theruvil Sayed, Biju Majdi, Ali Zhou, Jincheng Sagban, Rafid Band, Shahab S. Mosavi, Amir School of Computer and Information Qiannan Normal University for Nationalities Guizhou Duyun China Key Laboratory of Complex Systems and Intelligent Optimization of Guizhou Guizhou Duyun China Institute for Big Data Analytics and Artificial Intelligence (IBDAAI) Universiti Teknologi MARA Selangor Shah Alam Malaysia Department of Computer Science Dhofar University Salalah Oman Department of Building and Construction Technologies Engineering Al-Mustaqbal University College Hilla Iraq Department of Computer Technology Engineering Technical Engineering College Al-Ayen University Thi-Qar Iraq Future Technology Research Center National Yunlin University of Science and Technology Yunlin Douliou Taiwan John von Neumann Faculty of Informatics Obuda University Budapest Hungary German Research Center for Artificial Intelligence Oldenburg Germany Institute of the Information Society University of Public Service Budapest Hungary

A hybrid machine learning method is proposed for wildfire susceptibility mapping. For modeling a geographical information system (GIS) database including 11 influencing factors and 262 fire locations from 2013 to 2018 is used for developing an integrated multivariate adaptive regression splines (MARS). The cat swarm optimization (CSO) algorithm tunes the parameters of the MARS in order to generate accurate susceptibility maps. From the Pearson correlation results, it is observed that land use, temperature, and slope angle have strong correlation with the fire severity. The results demonstrate that the prediction capability of the MARS-CSO model outperforms model tree, reduced error pruning tree and MARS. The resulting wildfire risk map using MARS-CSO reveals that 20% of the study areas is categorized in the very low wildfire risk class, whereas 40% is under the very high class of fire hazard. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

关键词： artificial intelligence cat swarm optimization geospatial machine learning natural hazard Wildfire susceptibility