Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and t...
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Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.
All the software products developed will need testing to ensure the quality and accuracy of the product. It makes the life of testers much easier when they can optimize on the effort spent and predict defects for the ...
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The importance of object detection within computer vision, especially in the context of detecting small objects, has notably increased. This thorough survey extensively examines small object detection across various a...
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The extensive utilization of the Internet in everyday life can be attributed to the substantial accessibility of online services and the growing significance of the data transmitted via the ***,this development has ex...
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The extensive utilization of the Internet in everyday life can be attributed to the substantial accessibility of online services and the growing significance of the data transmitted via the ***,this development has expanded the potential targets that hackers might *** adequate safeguards,data transmitted on the internet is significantly more susceptible to unauthorized access,theft,or *** identification of unauthorised access attempts is a critical component of cybersecurity as it aids in the detection and prevention of malicious *** research paper introduces a novel intrusion detection framework that utilizes Recurrent Neural Networks(RNN)integrated with Long Short-Term Memory(LSTM)*** proposed model can identify various types of cyberattacks,including conventional and distinctive *** networks,a specific kind of feedforward neural networks,possess an intrinsic memory *** Neural Networks(RNNs)incorporating Long Short-Term Memory(LSTM)mechanisms have demonstrated greater capabilities in retaining and utilizing data dependencies over extended *** such as data types,training duration,accuracy,number of false positives,and number of false negatives are among the parameters employed to assess the effectiveness of these models in identifying both common and unusual *** are utilised in conjunction with LSTM to support human analysts in identifying possible intrusion events,hence enhancing their decision-making capabilities.A potential solution to address the limitations of Shallow learning is the introduction of the Eccentric Intrusion Detection *** model utilises Recurrent Neural Networks,specifically exploiting LSTM *** proposed model achieves detection accuracy(99.5%),generalisation(99%),and false-positive rate(0.72%),the parameters findings reveal that it is superior to state-of-the-art techniques.
Glaucoma is currently one of the most significant causes of permanent blindness. Fundus imaging is the most popular glaucoma screening method because of the compromises it has to make in terms of portability, size, an...
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Glaucoma is currently one of the most significant causes of permanent blindness. Fundus imaging is the most popular glaucoma screening method because of the compromises it has to make in terms of portability, size, and cost. In recent years, convolution neural networks (CNNs) have revolutionized computer vision. Convolution is a "local" CNN technique that is only applicable to a small region surrounding an image. Vision Transformers (ViT) use self-attention, which is a "global" activity since it collects information from the entire image. As a result, the ViT can successfully gather distant semantic relevance from an image. This study examined several optimizers, including Adamax, SGD, RMSprop, Adadelta, Adafactor, Nadam, and Adagrad. With 1750 Healthy and Glaucoma images in the IEEE fundus image dataset and 4800 healthy and glaucoma images in the LAG fundus image dataset, we trained and tested the ViT model on these datasets. Additionally, the datasets underwent image scaling, auto-rotation, and auto-contrast adjustment via adaptive equalization during preprocessing. The results demonstrated that preparing the provided dataset with various optimizers improved accuracy and other performance metrics. Additionally, according to the results, the Nadam Optimizer improved accuracy in the adaptive equalized preprocessing of the IEEE dataset by up to 97.8% and in the adaptive equalized preprocessing of the LAG dataset by up to 92%, both of which were followed by auto rotation and image resizing processes. In addition to integrating our vision transformer model with the shift tokenization model, we also combined ViT with a hybrid model that consisted of six different models, including SVM, Gaussian NB, Bernoulli NB, Decision Tree, KNN, and Random Forest, based on which optimizer was the most successful for each dataset. Empirical results show that the SVM Model worked well and improved accuracy by up to 93% with precision of up to 94% in the adaptive equalization preprocess
In the realm of agricultural automation, the precise identification of crop stress holds immense significance for enhancing crop productivity. Existing methods primarily focus on controlled environments, which may not...
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As a result of its aggressive nature and late identification at advanced stages, lung cancer is one of the leading causes of cancer-related deaths. Lung cancer early diagnosis is a serious and difficult challenge that...
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The cloud computing technology is utilized for achieving resource utilization of remotebased virtual computer to facilitate the consumers with rapid and accurate massive data *** utilizes on-demand resource provisioni...
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The cloud computing technology is utilized for achieving resource utilization of remotebased virtual computer to facilitate the consumers with rapid and accurate massive data *** utilizes on-demand resource provisioning,but the necessitated constraints of rapid turnaround time,minimal execution cost,high rate of resource utilization and limited makespan transforms the Load Balancing(LB)process-based Task Scheduling(TS)problem into an NP-hard optimization *** this paper,Hybrid Prairie Dog and Beluga Whale Optimization Algorithm(HPDBWOA)is propounded for precise mapping of tasks to virtual machines with the due objective of addressing the dynamic nature of cloud *** capability of HPDBWOA helps in decreasing the SLA violations and Makespan with optimal resource *** is modelled as a scheduling strategy which utilizes the merits of PDOA and BWOA for attaining reactive decisions making with respect to the process of assigning the tasks to virtual resources by considering their priorities into *** addresses the problem of pre-convergence with wellbalanced exploration and exploitation to attain necessitated Quality of Service(QoS)for minimizing the waiting time incurred during TS *** further balanced exploration and exploitation rates for reducing the makespan during the task allocation with complete awareness of VM *** results of the proposed HPDBWOA confirmed minimized energy utilization of 32.18% and reduced cost of 28.94% better than approaches used for *** statistical investigation of the proposed HPDBWOA conducted using ANOVA confirmed its efficacy over the benchmarked systems in terms of throughput,system,and response time.
Cancer was found to be a leading cause of human mortality in the year 2020, accounting for one in six deaths worldwide, as per data published by the World Health Organization. Early detection and treatment can play a ...
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Cancer was found to be a leading cause of human mortality in the year 2020, accounting for one in six deaths worldwide, as per data published by the World Health Organization. Early detection and treatment can play a major role in averting these deaths. Delayed cancer care often leads to lower chances of survival, greater complications associated with treatment and higher costs. Histopathology image analysis is a technology that plays a vital role in the early detection and diagnosis of cancer. The segmentation of regions of interest (RoIs) from whole slide images (WSIs) provides useful information for differentiating diseased tissues from normal ones. A strong segmentation framework is required in this case due to the rich and irregular mix of visual patterns of the RoIs. In this work, we present an atrous inception-resnet based UNet model with dense skip connections (AIR-UNet++) for the effective segmentation and detection of various RoIs from histopathology images stained with Hematoxylin and Eosin (H &E). To test the performance of the proposed method, experiments are carried out on five different datasets, including nuclei segmentation, TNBC, MoNuSeg, lymphocyte detection and MoNuSAC (Lymphocyte, Neutrophils, Macrophages, Epithelial). Experimental results show that the proposed AIR-UNet++ method outperforms other UNet variants, pre-trained models. Specifically, for the nuclei segmentation dataset, we achieved a Dice coefficient (DC) of 0.74 and a Jaccard Index (JI) of 0.64. For the TNBC dataset, our method achieved a DC of 0.88 and a JI of 0.79, while on the MoNuSeg dataset, we obtained a DC of 0.79 and a JI of 0.67. For the Lymphocyte detection dataset, we achieved an accuracy of 0.98 and an F1 score of 0.88. Notably, in the MoNuSAC-Lymphocyte dataset, our model achieved a DC of 0.85 and a JI of 0.75. Similarly, for the MoNuSAC-Neutrophils dataset, the DC was 0.83 with a JI of 0.72, for MoNuSAC-Macrophages, the DC was 0.82 with a JI of 0.72, and for MoNuSAC-Ep
Lightweight video representation techniques have advanced significantly for simple activity recognition, but they still encounter several issues when applied to complex activity recognition: (i) The presence of numero...
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