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Fast and Effective Clustering Method for Ancestry Estimation

Procedia computer science 2019年 157卷 306-312页

作者： Arif Budiarto Bharuno Mahesworo James Baurley Teddy Suparyanto Bens Pardamean Computer Science Department School of Computer Science Bina Nusantara University Jakarta Indonesia 11480 Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480 BioRealm LLC USA Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta 11480 Indonesia

Ancestry estimation which provides family history information is one of the most popular services in direct-to-consumer genomic testing. It is also an important task which aimed to reduce the confounding by ancestry on the relationship of genotypes and disease risk in assocation studies. Several methods have been developed to generate the best ancestry estimated scores even though some of them are still facing inefficient computation time. In this paper, a combination method between KMeans clustering and PCA is proposed estimate ancestry estimation from SNP genotyping data. This method was compared with baseline model, called fastSTRUCTURE, in term of the quality of clustering and computation time. Public data from 1000 Genome project is used to train and evaluate the proposed model and the baseline model. The proposed model can successfully generate clusters with better accuracy than fastSTRUCTURE (91.02% over 90.39%). More importantly, it can boost the computation time until 100 times faster than fastSTRUCTURE (from 490 seconds to 4.86 seconds).

关键词： Ancestry Estimation Population Stratification Clustering bioinformatics Genomics

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Time-series Analysis of Correlation between Climatic Parameters and Dengue Fever in Indonesia

Time-series Analysis of Correlation between Climatic Paramet...

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International Conference on Informatics, Multimedia, Cyber and Information System (ICIMCIS)

作者： Rudi Nirwantono Joko Pebrianto Trinugroho Digdo Sudigyo Alam Ahmad Hidayat Bens Pardamean Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia Computer Science Department BINUS Graduate Program Master of Computer Science Program Bina Nusantara University Jakarta Indonesia

ISBN: (纸本)9781665473286

Dengue fever is mainly caused by female mosquitoes from the genus Aedes. It predominantly occurs in equatorial to sub-tropical regions. The weather factors play a significant role in the mosquito life cycle, so a study on the impact of climate parameters on dengue incidence is required. This study aimed to understand the statistical association between the annual fluctuation of dengue cases with climate factors in Indonesia. Climatic data, annual rainfall, and annual mean ambient temperature of Indonesia were obtained from *** from 2010 to 2020, while the data on the annual incidence of dengue fever in Indonesia were collected from the Indonesian Health Profile by the Ministry of Health of Indonesia from 2010 to 2020. The association between climatic factors with dengue cases was calculated with Spearman statistical test after the data was indicated as not normally distributed. In addition, we performed Poisson regression analysis to examine how the changes in climatic parameters affect the dengue cases. The rain precipitation was insignificantly correlated with the dengue incidence in Indonesia during the study time. In contrast, the ambient temperature statistically showed a strong association with the dengue cases. The association between climatic factors and the number of dengue cases suggests that the model would likely be prospectively applied to the dengue early warning system as a nationwide intervention to reduce the epidemic impact in Indonesia.

关键词： Epidemics Temperature distribution Rain Meteorological factors Multimedia systems Time series analysis Weather forecasting

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A Flow Artist for High-Dimensional Cellular Data 33

A Flow Artist for High-Dimensional Cellular Data

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33rd IEEE International Workshop on Machine Learning for Signal Processing, MLSP 2023

作者： MacDonald, Kincaid Bhaskar, Dhananjay Thampakkul, Guy Nguyen, Nhi Zhang, Joia Perlmutter, Michael Adelstein, Ian Krishnaswamy, Smita Yale University Department of Mathematics United States Pomona College Department of Mathematics United States University of Washington Department of Statistics United States Boise State University Department of Mathematics United States Yale University Department of Computer Science United States Yale University Applied Mathematics Program United States Yale University Computational Biology and Bioinformatics Program United States

ISBN: (纸本)9798350324112

We consider the problem of embedding point cloud data sampled from an underlying manifold with an associated flow or velocity. Such data arises in many contexts where static snapshots of dynamic entities are measured, including in high-throughput biology such as single-cell transcriptomics. Existing embedding techniques either do not utilize velocity information or embed the coordinates and velocities independently, i.e., they either impose velocities on top of an existing point embedding or embed points within a prescribed vector field. Here we present FlowArtist, a neural network that embeds points while jointly learning a vector field around the points. The combination allows FlowArtist to better separate and visualize velocity-informed structures. Our results, on toy datasets and single-cell RNA velocity data, illustrate the value of utilizing coordinate and velocity information in tandem for embedding and visualizing high-dimensional data. © 2023 IEEE.

关键词： RNA

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Enhancing Interoperability of Digital Twin in the Maintenance phase of Lifecycle

Enhancing Interoperability of Digital Twin in the Maintenanc...

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International Conference on Information Technology, Information Systems and Electrical Engineering (ICITISEE)

作者： Dedy Ariansyah Bens Pardamean Bioinformatics and Data Science Research Centre Bina Nusantara University Jakarta Indonesia Computer Science Department BINUS Graduate Program Master of Computer Science Program Bina Nusantara University Jakarta Indonesia

In today's digitalization era, asset management has evolved following the rapid adoption of information systems and digital technologies. In the maintenance phase of the asset, Digital Twin (DT) emerges as an effective approach to improve failure recognition and structural damage prediction through DT-driven Prognostic and Health Monitoring (PHM). As a result, DT allows asset manager to proactively plan maintenance strategy to improve the availability of the assets. However, to reduce asset downtime in a cost-effective and time efficient manner, DT for maintenance phase needs to be integrated with other software systems that manage the provision of maintenance service and spare part such as computerized maintenance management system (CMMS) or Enterprise Resource Planning (ERP). Nevertheless, many of the developed DT in PHM were not equipped with semantic data model and hence, lacks interoperability with other systems (e.g., other DT or non-DT system) and limits the effective use of the DT. To qualify as an effective DT, it needs a semantical-enabled interface to connect with data and models from various domain to enable DT-driven decision-making. This paper leverages a rule-based ontology reasoning model to enhance DT interoperability with other maintenance software systems. The results depicts that the developed model paves a way for an effective use of DT-driven system in asset maintenance management.

关键词： Ontologies Software systems Data models Enterprise resource planning Digital twins Prognostics and health management Interoperability

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Decision fusion of circulating markers for breast cancer detection in premenopausal women

Decision fusion of circulating markers for breast cancer det...

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7th IEEE International Conference on bioinformatics and Bioengineering, BIBE

作者： Jesneck, Jonathan L. Mukherjee, Sayan Nolte, Loren W. Lokshin, Anna E. Marks, Jeffrey R. Lo, Joseph Department of Biomedical Engineering Department of Statistical Science Computational Biology and Bioinformatics Program Duke Advanced Imaging Labs. Institute for Genome Sciences and Policy Department of Computer Science Duke University Department of Electrical and Computer Engineering Division of Hematology/Oncology University of Pittsburgh School of Medicine University of Pittsburgh Cancer Institute Pittsburgh PA 15213 United States Department of Experimental Surgery Duke University Medical Center Medical Physics Graduate Program Duke University Durham NC 27708 United States

ISBN: (纸本)1424415098

Current mammographic screeningfor breast cancer is less effective for younger women. To complement mammography for premenopausal women, we investigated the feasibility screening test using 98 blood serum proteins. Because the data set was very noisy and contained only weak features, we used a classifier designed for noisy data: decision fusion. Decision fusion outperformed both a support vector machine (SVM) and linear regression with forward stepwise feature selection on all three two-class classification tasks: normal tissue vs. cancer, normal tissue vs. benign lesions, and benign lesions vs. cancer. Decision fusion detected cancer moderately well (AUC=0.84 on normal vs. cancer), demonstrating promise as a screening tool. Decision fusion also detected benign lesions similarly well (AUC=0.83 on normal vs. benign lesions) and was the only classifier to achieve any success in separating benign from malignant lesions (AUC=0.64 on benign vs. cancer). The classification results suggest that the assayed proteins are more indicative of a secondary effect, such as immune response, rather than specific for breast cancer. In conclusion, the decision fusion classifier demonstrated some promise in detecting breast lesions and outperformed other classifiers, especially for the very noisy classification problem of distinguishing benign from malignant lesions. ©2007 IEEE.

关键词： Tissue

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Digitizing Farmers' Land Data Collection Systems in Indonesia with the Use of Tani Millenial Apps 4

Digitizing Farmers' Land Data Collection Systems in Indonesi...

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4th International Conference on Cybernetics and Intelligent System, ICORIS 2022

作者： Bimantio, Mohammad Prasanto Putra, Dian Pratama Suparyanto, Teddy Ferhat, Amallia Nugraha, Nanda Satya Hidayat, Alam Ahmad Pardamean, Bens Institute of Agriculture STIPER Department of Food and Agricultural Technology Yogyakarta Indonesia Institute of Agriculture STIPER Department of Agrotechnology Yogyakarta Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Institute of Agriculture STIPER Department of Agricultural Socio-Economics Yogyakarta Indonesia Institute of Agriculture STIPER Department of Forestry Yogyakarta Indonesia Bina Nusantara University BINUS Graduate Program - Master of Computer Science Computer Science Department Jakarta11480 Indonesia

ISBN: (纸本)9781665453950

In this era of digital world information, farmers face challenges about information management of huge data and the complexity of processes in precision farming. The data collection carried out so far can cause several difficulties, especially if the data is needed by the government or academics to support decision-making. Agricultural data collection applications only cover 12% of the market share of Android-based agriculture-based applications. In this study, Tani Milenial application is present as an alternative to support agricultural data collection activities in Indonesia. This application encourages farmers to be active and contribute independently to their role as subjects of agricultural development and is accustomed to digitally recording their agricultural activities. In this developed application system, the community, especially farmers and farmer groups, will find it easier to get information about agricultural potential data around where they carry out agricultural activities and can access this information online. Tani Milenial works as a guide to help farmers and transform agriculture but still have some gaps which should be checked and removed. The data collected can be used by various parties for research and decision-making. The app can be further improved to develop new features related to education, market information, and goods. © 2022 IEEE.

关键词： Decision making

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An Improved Version of Texture-based Foreground Segmentation: Block-based Adaptive Segmenter

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Procedia computer science 2018年 135卷 579-586页

作者： Kahlil Muchtar Faris Rahman Tjeng Wawan Cenggoro Arif Budiarto Bens Pardamean Nodeflux Inc. Jakarta Indonesia Syiah Kuala University Aceh Indonesia Computer Science Department School of Computer Science Bina Nusantara University Jakarta Indonesia 11480 Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480 Computer Science Department BINUS Graduate Program - Master of Computer Science Program Bina Nusantara University Jakarta Indonesia 11480

Foreground segmentation is one of moving object detection techniques of computer vision applications. To date, modern moving object detection methods require complex background modeling and thresholds tuning to confront illumination changes. This paper proposes an adaptive approach based on non-overlapping block texture representation. It aims to design a computationally light and efficient solution to improve the robustness of detection. We evaluate our proposed method on internal and public sequences and provide the quantitative and qualitative measurements. Experimental results show that the proposed method can improve the results of previous method and suitable for real-time challenges.

关键词： change detection foreground segmentation texture features

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bioinformatics exploration into potential mechanisms of Calamus draco for colorectal cancer treatment

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Procedia computer science 2024年 245卷 127-136页

作者： Christian Kenneth Rudi Nirwantono Bens Pardamean Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480 Biotechnology Department Faculty of Engineering Bina Nusantara University Jakarta Indonesia 11480 Computer Science Department BINUS Graduate Program – Master of Computer Science Program Bina Nusantara University Jakarta Indonesia 11480

As one of the cancer types with the highest incidence rates, colorectal cancer (CRC) would benefit from treatments with fewer side effects and reduced treatment-resistant potential. One of the options is to harness the anti-CRC potential of natural products. Previous studies have shown that Calamus draco exudate, dragon's blood, has anticancer activity in liver cancer and acute myeloid leukemia, but its bioactivity has not been studied in CRC. Here we conduct a bioinformatics study based on network pharmacology to explore the anti-CRC potential and mechanism of C. draco -derived compounds. The bioinformatics pipeline is composed of compound and target collection, biological network evaluation, and enrichment analysis. We found that there are 43 bioactive compounds from C. draco targeting 91 CRC-related targets, of which most compounds target MEN1, PTGS2, and IDH1. Further analyses show that the targets of C. draco are involved in the cellular response to hypoxia. By inhibiting those targets, C. draco bioactive compounds can potentially hinder angiogenesis and increase treatment response efficacy.

关键词： bioinformatics network pharmacology Calamus draco colorectal cancer drug discovery

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A Diversity Inventory Monitoring System of Riparian Vegetation 4

A Diversity Inventory Monitoring System of Riparian Vegetati...

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4th International Conference on Cybernetics and Intelligent System, ICORIS 2022

作者： Putra, Dian Pratama Nugraha, Nanda Satya Suparyanto, Teddy Hidayat, Alam Ahmad Sudigyo, Digdo Pardamean, Bens STIPER Agricultural Institute Faculty of Agricultural Technology Yogyakarta55282 Indonesia STIPER Agricultural Institute Yogyakarta Faculty of Agricultural Technology Faculty of Forestry Yogyakarta55282 Indonesia Bina Nusantara University Bioinformatics and Data Science Research Center Jakarta11480 Indonesia Bina Nusantara University BINUS Graduate Program - Master of Computer Science Computer Science Department Jakarta11480 Indonesia

ISBN: (纸本)9781665453950

To strengthen conservation efforts for preserving biodiversity in a conservation area, forest inventory is important to understand the natural succession process in the area and to establish a monitoring strategy. Further, tree inventory aims to monitor the output yielded in the area. More specifically, the tree inventory in the watershed area plays a key role to achieve Sustainable Development Goals (SDG), especially in riparian zones which are also vital parts of green zones in forests. However, the traditional inventory approach is time-consuming and laborious therefore the development of an expert system to assist in inventory monitoring is required. In this study, we develop a monitoring system via a mobile application to collect, analyze and visualize tree inventory data. The application includes algorithms required to compute tree biodiversity, distribution, and richness for the given input of the data of all tree species in a conservation area. For the model validation stage, we compare the traditional inventory approach with our proposed application-based approach to compute diversity inventory in two riparian locations: Klaten Conservation Park and Wonosobo Conservation Park. After the three-day data collection in the areas, we obtain that the accuracy of reading data of our proposed system can achieve more than 90% in comparison with the manual approach. This demonstrates that the system can assist forestry workers to perform more efficient tree inventories in different locations. © 2022 IEEE.

关键词： Biodiversity

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Multiple alignment of continuous time series

Multiple alignment of continuous time series

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18th Annual Conference on Neural Information Processing Systems, NIPS 2004

作者： Listgarten, Jennifer Neal, Radford M. Roweis, Sam T. Emili, Andrew Department of Computer Science University of Toronto Toronto ON M5S 3G4 Canada Banting and Best Department of Medical Research Program in Proteomics and Bioinformatics University of Toronto Toronto ON M5S 3G4 Canada

ISBN: (纸本)0262195348

Multiple realizations of continuous-valued time series from a stochastic process often contain systematic variations in rate and amplitude. To leverage the information contained in such noisy replicate sets, we need to align them in an appropriate way (for example, to allow the data to be properly combined by adaptive averaging). We present the Continuous Profile Model (CPM), a generative model in which each observed time series is a non-uniformly subsampled version of a single latent trace, to which local rescaling and additive noise are applied. After unsupervised training, the learned trace represents a canonical, high resolution fusion of all the replicates. As well, an alignment in time and scale of each observation to this trace can be found by inference in the model. We apply CPM to successfully align speech signals from multiple speakers and sets of Liquid Chromatography-Mass Spectrometry proteomic data.

关键词： Time series

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