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检索条件"机构=Department of Computer Science The Bioinformatics Program"
585 条 记 录,以下是271-280 订阅
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KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
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science (New York, N.Y.) 2025年 第6735期387卷 eadn2337页
作者: Fagerberg, Eric Attanasio, John Dien, Christine Singh, Jaiveer Kessler, Emily A. Abdullah, Leena Shen, Jian Hunt, Brian G. Connolly, Kelli A. De Brouwer, Edward He, Jiaming Iyer, Nivedita R. Buck, Jessica Borr, Emily R. Damo, Martina Foster, Gena G. Giles, Josephine R. Huang, Yina H. Tsang, John S. Krishnaswamy, Smita Cui, Weiguo Joshi, Nikhil S. Department of Immunobiology Yale University School of Medicine New Haven CT United States Program in Computational Biology & Bioinformatics Yale University New Haven CT United States Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth NH United States Department of Pathology Feinberg School of Medicine at Northwestern University Chicago IL United States Department of Genetics and Computer Science Yale University School of Medicine New Haven CT United States Department of Medicine University of Chicago Chicago IL United States Section of Hematology Department of Internal Medicine Yale University School of Medicine New Haven CT United States Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Philadelphia PA United States Institute for Immunology Perelman School of Medicine University of Pennsylvania Philadelphia PA United States Parker Institute for Cancer Immunotherapy Perelman School of Medicine University of Pennsylvania Philadelphia PA United States Yale Center for Systems and Engineering Immunology Yale University School of Medicine New Haven CT United States New Haven CT United States Department of Biomedical Engineering Yale University New Haven CT United States Computational Biology and Bioinformatics Program Yale University CT USA New Haven United States Applied Math Program Yale University New Haven CT United States
Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress differentiati...
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Cholesterol allosteric modulation of the oxytocin receptor
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Biophysical Journal 2025年
作者: Marlow, Brennica Vogel, Alexander Kuenze, Georg Pankonin, Maik Reinhardt, Franziska Stadler, Peter F. Hildebrand, Peter W. Meiler, Jens Center for Structural Biology Vanderbilt University Nashville TN United States Institute for Drug Discovery Medical Faculty Leipzig University Leipzig Germany Center for Scalable Data Analytics and Artificial Intelligence ScaDS.AI Leipzig University Leipzig Germany Interdisciplinary Center for Bioinformatics Leipzig University Leipzig Germany Chemical and Physical Biology Program Vanderbilt University Nashville TN United States Department of Chemistry Vanderbilt University Nashville TN United States Institute of Medical Physics and Biophysics Medical Faculty Leipzig University Leipzig Germany Bioinformatics Group Institute of Computer Science Interdisciplinary Center of Bioinformatics Leipzig University Leipzig Germany Max-Planck-Institute for Mathematics in the Sciences Leipzig Germany Institute of Theoretical Chemistry University of Vienna Wien Austria Facultad de Ciencias Universidad National de Colombia Sede Bogota Colombia Santa Fe Institute New Mexico Santa Fe Mexico
G-protein coupled receptors are critical components in cellular signaling, mediating various physiological responses to external stimuli. Here, we investigate the intricate relationship between cholesterol and the oxy...
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A Drug-Induced Liver Injury Prediction Model using Transcriptional Response Data with Graph Neural Network
A Drug-Induced Liver Injury Prediction Model using Transcrip...
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International Conference on Big Data and Smart Computing (BIGCOMP)
作者: Doyeong Hwang Minji Jeon Jaewoo Kang Department of Computer Science and Engineering Korea University Seoul Republic of Korea Interdisciplinary Graduate Program in Bioinformatics Korea University Seoul Republic of Korea
Drug-Induced Liver Injury (DILI) is a major cause of failed drug candidates in clinical trials and withdrawal of approved drugs from the market. Therefore, machine learning-based DILI prediction can be key in increasi... 详细信息
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Development of Machine Learning Models for Predicting Radiation Dermatitis in Breast Cancer Patients Using Clinical Risk Factors, Patient-Reported Outcomes, and Serum Cytokine Biomarkers
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Clinical Breast Cancer 2025年
作者: Lin, Neil Abbas-Aghababazadeh, Farnoosh Su, Jie Wu, Alison J. Lin, Cherie Shi, Wei Xu, Wei Haibe-Kains, Benjamin Liu, Fei-Fei Kwan, Jennifer Y.Y. Institute of Medical Science Temerty Faculty of Medicine University of Toronto Toronto Canada Temerty Faculty of Medicine University of Toronto Toronto Canada Princess Margaret Bioinformatics and Computational Genomics Laboratory University Health Network Toronto Canada Biostatistics Division Princess Margaret Cancer Centre Toronto Canada Research Institute Princess Margaret Cancer Centre Toronto Canada Department of Computer Science University of Toronto Toronto Canada Ontario Institute for Cancer Research Toronto Canada Vector Institute for Artificial Intelligence Toronto Canada Department of Radiation Oncology Temerty Faculty of Medicine University of Toronto Toronto Canada Department of Medical Biophysics Temerty Faculty of Medicine University of Toronto Toronto Canada Radiation Medicine Program Princess Margaret Cancer Centre Toronto Canada
Background: Radiation dermatitis (RD) is a significant side effect of radiotherapy experienced by breast cancer patients. Severe symptoms include desquamation or ulceration of irradiated skin, which impacts quality of... 详细信息
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Spectral Top-Down Recovery of Latent Tree Models
arXiv
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arXiv 2021年
作者: Aizenbud, Yariv Jaffe, Ariel Wang, Meng Hu, Amber Amsel, Noah Nadler, Boaz Chang, Joseph T. Kluger, Yuval Program in Applied Mathematics Yale University New HavenCT06511 United States Department of Computer Science Weizmann Institute of Science Rehovot76100 Israel Department of Statistics Yale University New HavenCT06520 United States Interdepartmental Program in Computational Biology and Bioinformatics Yale University New HavenCT06511 United States Department of Pathology Yale University New HavenCT06511 United States
Modeling the distribution of high dimensional data by a latent tree graphical model is a prevalent approach in multiple scientific domains. A common task is to infer the underlying tree structure, given only observati... 详细信息
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TargetNet: Functional microRNA target prediction with deep neural networks
arXiv
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arXiv 2021年
作者: Min, Seonwoo Lee, Byunghan Yoon, Sungroh Department of Electrical and Computer Engineering Seoul National University Seoul08826 Korea Republic of LG AI Research Seoul07796 Korea Republic of Department of Electronic and IT Media Engineering Seoul National University of Science and Technology Seoul01811 Korea Republic of Interdisciplinary Program in Artificial Intelligence and Interdisciplinary Program in Bioinformatics Seoul National University Seoul08826 Korea Republic of
Motivation: MicroRNAs (miRNAs) play pivotal roles in gene expression regulation by binding to target sites of messenger RNAs (mRNAs). While identifying functional targets of miRNAs is of utmost importance, their predi... 详细信息
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Predicting Protein Interaction Network Perturbation by Alternative Splicing with Semi-Supervised Learning
SSRN
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SSRN 2020年
作者: Narykov, Oleksandr Johnson, Nathan Korkin, Dmitry Department of Computer Science Bioinformatics and Computational Biology Program Worcester Polytechnic Institute WorcesterMA United States Harvard Program in Therapeutic Sciences Harvard Medical School Breast Tumor Immunology Laboratory Dana-Farber Cancer Institute BostonMA United States Department of Computer Science Bioinformatics and Computational Biology Program Worcester Polytechnic Institute WorcesterMA United States
Alternative splicing introduces a new layer of protein diversity and complexity in regulating cellular functions that can be specific to the tissue and cell type, physiological state of a cell, or disease phenotype. I... 详细信息
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Gene knockout inference with variational graph autoencoder learning single-cell gene regulatory networks
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Nucleic acids research 2023年 第13期51卷 6578-6592页
作者: Yongjian Yang Guanxun Li Yan Zhong Qian Xu Bo-Jia Chen Yu-Te Lin Robert S Chapkin James J Cai Department of Electrical and Computer Engineering Texas A&M University College Station TX 77843 USA. Department of Statistics Texas A&M University College Station TX 77843 USA. Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of Statistics East China Normal University 3663 North Zhongshan Road Shanghai 200062 China. Department of Veterinary Integrative Biosciences Texas A&M University College Station TX 77843 USA. Graduate Institute of Microbiology and Public Health College of Veterinary Medicine National Chung Hsing University Taichung 402 Taiwan. Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan. Program in Integrative & Complex Diseases Department of Nutrition Texas A&M University College Station TX 77843 USA. Interdisciplinary Program of Genetics Texas A&M University College Station TX 77843 USA.
In this paper, we introduce Gene Knockout Inference (GenKI), a virtual knockout (KO) tool for gene function prediction using single-cell RNA sequencing (scRNA-seq) data in the absence of KO samples when only wild-type...
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Implications of self-identified race, ethnicity, and genetic ancestry on genetic association studies in biobanks within health systems
arXiv
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arXiv 2024年
作者: Johnson, Ruth Pasaniuc, Bogdan Department of Biomedical Informatics Harvard Medical School BostonMA02115 United States Department of Computer Science University of California Los Angeles Los AngelesCA90095 United States Bioinformatics Interdepartmental Program University of California Los Angeles Los AngelesCA90095 United States Department of Pathology Laboratory Medicine David Geffen School of Medicine University of California Los Angeles Los AngelesCA90095 United States Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los AngelesCA90095 United States Department of Computational Medicine David Geffen School of Medicine University of California Los Angeles Los AngelesCA90095 United States Institute of Precision Health University of California Los Angeles Los AngelesCA90095 United States
Precision medicine aims to create biomedical solutions tailored to specific factors that affect disease risk and treatment responses within the population. The success of the genomics era and recent widespread availab... 详细信息
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Detecting Hemileia vastatrix using Vision AI as Supporting to Food Security for Smallholder Coffee Commodities
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IOP Conference Series: Earth and Environmental science 2022年 第1期998卷
作者: Teddy Suparyanto Erick Firmansyah Tjeng Wawan Cenggoro Digdo Sudigyo Bens Pardamean Faculty of Agricultural Technology Institute of Agriculture STIPER Yogyakarta Indonesia 55282 Bioinformatics & Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480 Computer Science Department School of Computer Science Bina Nusantara University Jakarta Indonesia 11480 Computer Science Department BINUS Graduate Program - Master of Computer Science Program Bina Nusantara University Jakarta Indonesia 11480
The loss of food crops during the COVID-19 pandemic threatens food security in Indonesia as one of the world's top coffee producers. This affects the insecurity of coffee commodities which is influenced by several...
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