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arXiv 2020年

作者： Köster, Raphael Hadfield-Menell, Dylan Hadfield, Gillian K. Leibo, Joel Z. DeepMind Department of Electrical Engineering and Computer Science University of California Berkeley Center for Human-Compatible AI Schwartz Reisman Institute for Technology and Society University of Toronto Vector Institute Center for Human-Compatible AI OpenAI

How can societies learn to enforce and comply with social norms? Here we investigate the learning dynamics and emergence of compliance and enforcement of social norms in a foraging game, implemented in a multi-agent reinforcement learning setting. In this spatiotemporally extended game, individuals are incentivized to implement complex berry-foraging policies and punish transgressions against social taboos covering specific berry types. We show that agents benefit when eating poisonous berries is taboo, meaning the behavior is punished by other agents, as this helps overcome a credit-assignment problem in discovering delayed health effects. Critically, however, we also show that introducing an additional taboo, which results in punishment for eating a harmless berry, improves the rate and stability with which agents learn to punish taboo violations and comply with taboos. Counterintuitively, our results show that an arbitrary taboo (a "silly rule") can enhance social learning dynamics and achieve better outcomes in the middle stages of learning. We discuss the results in the context of studying normativity as a group-level emergent phenomenon. Copyright © 2020, The Authors. All rights reserved.

关键词： Fruits

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DCFH: A dynamic clustering approach based on fire hawk optimizer in flying ad hoc networks

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Vehicular Communications 2024年 47卷

作者： Hosseinzadeh, Mehdi Ali, Saqib Ahmad, Husham Jawad Alanazi, Faisal Yousefpoor, Mohammad Sadegh Yousefpoor, Efat Darwesh, Aso Rahmani, Amir Masoud Lee, Sang-Woong Institute of Research and Development Duy Tan University Da Nang Viet Nam School of Medicine and Pharmacy Duy Tan University Da Nang Viet Nam Department of Information Systems College of Economics and Political Science Sultan Qaboos University Al Khoudh Muscat Oman Department of Communication and Computer Engineering Cihan University-Erbil Kurdistan Region Iraq Department of Electrical Engineering College of Engineering Prince Sattam bin Abdulaziz University Al-Kharj 11942 Saudi Arabia Center of Research and Strategic Studies Lebanese French University Kurdistan Region Iraq Department of Information Technology University of Human Development Kurdistan Region Sulaymaniyah Iraq Future Technology Research Center National Yunlin University of Science and Technology Yunlin Taiwan Pattern Recognition and Machine Learning Lab Gachon University 1342 Seongnamdaero Sujeonggu Seongnam 13120 South Korea

In flying ad hoc networks (FANETs), unmanned aerial vehicles (UAVs) communicate with each other without any fixed infrastructure. Because of frequent topological changes, instability of wireless communication, three-dimensional movement of UAVs, and limited resources, especially energy, FANETs deal with many challenges, especially the instability of UAV swarms. One solution to address these problems is clustering because it maintains network performance and increases scalability. In this paper, a dynamic clustering scheme based on fire hawk optimizer (DCFH) is proposed for FANETs. In DCFH, each cluster head calculates the period of hello messages in its cluster based on its velocity. Then, a fire hawk optimizer (FHO)-based dynamic clustering operation is carried out to determine the role of each UAV (cluster head (CH) or cluster member (CM)) in the network. To calculate the fitness value of each fire hawk, a fitness function is suggested based on four elements, namely the balance of energy consumption, the number of isolated clusters, the distribution of CHs, and the neighbor degree. To improve cluster stability, each CH manages the movement of its CMs and adjusts it based on its movement in the network. In the last phase, DCFH defines a greedy routing process to determine the next-hop node based on a score, which consists of distance between CHs, energy, and buffer capacity. Finally, DCFH is simulated using the network simulator version 2 (NS2), and its performance is compared with three methods, including the mobility-based weighted cluster routing scheme (MWCRSF), the dynamic clustering mechanism (DCM), and the Grey wolf optimization (GWO)-based clustering protocol. The simulation results show that DCFH well manages the number of clusters in the network. It improves the cluster construction time (about 55.51%), cluster lifetime (approximately 11.13%), energy consumption (about 15.16%), network lifetime (about 2.6%), throughput (approximately 3.9%), packet deliver

关键词： Artificial intelligence (AI) Clustering Flying ad hoc networks (FANETs) Optimization algorithms Unmanned aerial vehicles (UAVs)

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Generating 3D TOF-MRA volumes and segmentation labels using generative adversarial networks

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Medical Image Analysis 2022年 78卷 102396-102396页

作者： Subramaniam, Pooja Kossen, Tabea Ritter, Kerstin Hennemuth, Anja Hildebrand, Kristian Hilbert, Adam Sobesky, Jan Livne, Michelle Galinovic, Ivana Khalil, Ahmed A. Fiebach, Jochen B. Frey, Dietmar Madai, Vince I. CLAIM - Charité Lab for AI in Medicine Charité Universitätsmedizin Berlin Germany Department of Computer Engineering and Microelectronics Computer Vision & Remote Sensing Technical University Berlin Berlin Germany Berlin Germany Bernstein Center for Computational Neuroscience Berlin Germany Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine Charité Universitätsmedizin Berlin Berlin Germany Fraunhofer MEVIS Max-von-Laue-Str. 2 Bremen Germany Department VI Computer Science and Media Beuth University of Applied Sciences Berlin Germany Johanna-Etienne-Hospital Neuss Germany Centre for Stroke Research Berlin Charité Universitätsmedizin Berlin Berlin Germany Department of Neurology Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany Mind Brain Body Institute Berlin School of Mind and Brain Humboldt University Berlin Berlin Germany Berlin Institute of Health Berlin Germany School of Computing and Digital Technology Faculty of Computing Engineering and the Built Environment Birmingham City University Birmingham United Kingdom QUEST-Center for Transforming Biomedical Research Berlin Institute of Health Charité Universitätsmedizin Berlin Charitéplatz 1 Berlin10117 Germany

Deep learning requires large labeled datasets that are difficult to gather in medical imaging due to data privacy issues and time-consuming manual labeling. Generative Adversarial Networks (GANs) can alleviate these challenges enabling synthesis of shareable data. While 2D GANs have been used to generate 2D images with their corresponding labels, they cannot capture the volumetric information of 3D medical imaging. 3D GANs are more suitable for this and have been used to generate 3D volumes but not their corresponding labels. One reason might be that synthesizing 3D volumes is challenging owing to computational limitations. In this work, we present 3D GANs for the generation of 3D medical image volumes with corresponding labels applying mixed precision to alleviate computational constraints. We generated 3D Time-of-Flight Magnetic Resonance Angiography (TOF-MRA) patches with their corresponding brain blood vessel segmentation labels. We used four variants of 3D Wasserstein GAN (WGAN) with: 1) gradient penalty (GP), 2) GP with spectral normalization (SN), 3) SN with mixed precision (SN-MP), and 4) SN-MP with double filters per layer (c-SN-MP). The generated patches were quantitatively evaluated using the Fréchet Inception Distance (FID) and Precision and Recall of Distributions (PRD). Further, 3D U-Nets were trained with patch-label pairs from different WGAN models and their performance was compared to the performance of a benchmark U-Net trained on real data. The segmentation performance of all U-Net models was assessed using Dice Similarity Coefficient (DSC) and balanced Average Hausdorff Distance (bAVD) for a) all vessels, and b) intracranial vessels only. Our results show that patches generated with WGAN models using mixed precision (SN-MP and c-SN-MP) yielded the lowest FID scores and the best PRD curves. Among the 3D U-Nets trained with synthetic patch-label pairs, c-SN-MP pairs achieved the highest DSC (0.841) and lowest bAVD (0.508) compared to the benchmark

关键词： Generative adversarial networks

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CMR×Recon: An open cardiac MRI dataset for the competition of accelerated image reconstruction

arXiv

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arXiv 2023年

作者： Wang, Chengyan Lyu, Jun Wang, Shuo Qin, Chen Guo, Kunyuan Zhang, Xinyu Yu, Xiaotong Li, Yan Wang, Fanwen Jin, Jianhua Shi, Zhang Xu, Ziqiang Tian, Yapeng Hua, Sha Chen, Zhensen Liu, Meng Sun, Mengting Kuang, Xutong Wang, Kang Wang, Haoran Li, Hao Chu, Yinghua Yang, Guang Bai, Wenjia Zhuang, Xiahai Wang, He Qin, Jing Qu, Xiaobo Human Phenome Institute Fudan University Shanghai China School of Nursing The Hong Kong Polytechnic University Hong Kong Digital Medical Research Center School of Basic Medical Sciences Fudan University Shanghai China Department of Electrical and Electronic Engineering & I-X Imperial College London United Kingdom Department of Electronic Science Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance National Institute for Data Science in Health and Medicine Institute of Artificial Intelligence Xiamen University Xiamen China Department of Radiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Bioengineering/˜Imperial-X Imperial College London United Kingdom School of Data Science Fudan University Shanghai China Department of Radiology Zhongshan Hospital Fudan University Shanghai China School of Health Science and Engineering University of Shanghai for Science and Technology Shanghai China Department of Computer Science The University of Texas Dallas United States Department of Cardiovascular Medicine Ruijin Hospital Lu Wan Branch Shanghai Jiao Tong University School of Medicine Shanghai China Institute of Science and Technology for Brain-Inspired Intelligence Fudan University Shanghai200433 China Simens Healthineers Ltd. China Department of Brain Sciences Imperial College London London United Kingdom Department of Computing Imperial College London London United Kingdom

Cardiac magnetic resonance imaging (CMR) has emerged as a valuable diagnostic tool for cardiac diseases. However, a limitation of CMR is its slow imaging speed, which causes patient discomfort and introduces artifacts in the images. There has been growing interest in deep learning-based CMR imaging algorithms that can reconstruct high-quality images from highly under-sampled k-space data. However, the development of deep learning methods requires large training datasets, which have not been publicly available for CMR. To address this gap, we released a dataset that includes multi-contrast, multi-view, multi-slice and multi-coil CMR imaging data from 300 subjects. Imaging studies include cardiac cine and mapping sequences. Manual segmentations of the myocardium and chambers of all the subjects are also provided within the dataset. Scripts of state-of-the-art reconstruction algorithms were also provided as a point of reference. Our aim is to facilitate the advancement of state-of-the-art CMR image reconstruction by introducing standardized evaluation criteria and making the dataset freely accessible to the research community. Researchers can access the dataset at https://***/#!Synapse:syn51471091/wiki/. Copyright © 2023, The Authors. All rights reserved.

关键词： Image reconstruction

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Mining Thousands of Genomes to Classify Somatic and Pathogenic Structural Variants

Research Square

引用

Research Square 2021年

作者： Layer, Ryan M. Sedlazeck, Fritz J. Pedersen, Brent S. Quinlan, Aaron R. Department of Computer Science University of Colorado Boulder United States BioFrontiers Institute University of Colorado Boulder United States Human Genome Sequencing Center Baylor College of Medicine Houston United States Department of Human Genetics University of Utah Salt Lake City United States Department of Biomedical Informatics University of Utah Salt Lake City United States Utah Center for Genetic Discovery University of Utah Salt Lake City United States

Structural variants (SVs) are associated with cancer progression and Mendelian disorders, but challenges with estimating SV frequency remain a barrier to somatic and de novo classification. In particular, variability in filtering and variant calling heuristics limit our ability to use SV catalogs from large cohorts. We present a method to index and search the raw alignments from thousands of samples that overcomes these limitations and supports robust SV analysis. © 2021, CC BY.

关键词： Genome

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Why is the Winner the Best?

Why is the Winner the Best?

引用

Conference on computer Vision and Pattern Recognition (CVPR)

作者： M. Eisenmann A. Reinke V. Weru M. D. Tizabi F. Isensee T. J. Adler S. Ali V. Andrearczyk M. Aubreville U. Baid S. Bakas N. Balu S. Bano J. Bernal S. Bodenstedt A. Casella V. Cheplygina M. Daum M. De Bruijne A. Depeursinge R. Dorent J. Egger D. G. Ellis S. Engelhardt M. Ganz N. Ghatwary G. Girard P. Godau A. Gupta L. Hansen K. Harada M. Heinrich N. Heller A. Hering A. Huaulmé P. Jannin A. E. Kavur O. Kodym M. Kozubek J. Li H. Li J. Ma C. Martín-Isla B. Menze A. Noble V. Oreiller N. Padoy S. Pati K. Payette T. Rädsch J. Rafael-Patiño V. Singh Bawa S. Speidel C. H. Sudre K. Van Wijnen M. Wagner D. Wei A. Yamlahi M. H. Yap C. Yuan M. Zenk A. Zia D. Zimmerer D. Aydogan B. Bhattarai L. Bloch R. Brüngel J. Cho C. Choi Q. Dou I. Ezhov C. M. Friedrich C. Fuller R. R. Gaire A. Galdran Á. García Faura M. Grammatikopoulou S. Hong M. Jahanifar I. Jang A. Kadkhodamohammadi I. Kang F. Kofler S. Kondo H. Kuijf M. Li M. Luu T. Martinčič P. Morais M. A. Naser B. Oliveira D. Owen S. Pang J. Park S. Park S. Płotka E. Puybareau N. Rajpoot K. Ryu N. Saeed A. Shephard P. Shi D. Štepec R. Subedi G. Tochon H. R. Torres H. Urien J. L. Vilaça K. A. Wahid H. Wang J. Wang L. Wang X. Wang B. Wiestler M. Wodzinski F. Xia J. Xie Z. Xiong S. Yang Y. Yang Z. Zhao K. Maier-Hein P. F. Jäger A. Kopp-Schneider L. Maier-Hein Division of Intelligent Medical Systems German Cancer Research Center (DKFZ) Heidelberg Germany Helmholtz Imaging German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Mathematics and Computer Science Heidelberg University Heidelberg Germany Division of Biostatistics German Cancer Research Center (DKFZ) Heidelberg Germany Division of Medical Image Computing German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Engineering and Physical Sciences School of Computing University of Leeds Leeds UK Institute of Informatics School of Management HES-SO Valais-Wallis University of Applied Sciences and Arts Western Switzerland Sierre Switzerland Department of Nuclear Medicine and Molecular Imaging Lausanne University Hospital Lausanne Switzerland Technische Hochschule Ingolstadt Ingolstadt Germany Center for Artificial Intelligence and Data Science for Integrated Diagnostics (AI2D) and Center for Biomedical Image Computing and Analytics (CBICA) University of Pennsylvania Philadelphia PA USA Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Radiology University of Washington Seattle WA USA Department of Computer Science Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS) University College London London UK Universitat Autònoma de Barcelona & Computer Vision Center Barcelona Spain Division of Translational Surgical Oncology National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany Department of Advanced Robotics Istituto Italiano di Tecnologia Italy Department of Electronics Information and Bioengineering Politecnico di Milano Milan Italy IT University of Copenhagen Copenhagen Denmark Department of General Visceral and Transplantation Surgery Heidelberg University Hospital Heidelberg Germany Department of Radiology and Nuc

International benchmarking competitions have become fundamental for the comparative performance assessment of image analysis methods. However, little attention has been given to investigating what can be learnt from these competitions. Do they really generate scientific progress? What are common and successful participation strategies? What makes a solution superior to a competing method? To address this gap in the literature, we performed a multicenter study with all 80 competitions that were conducted in the scope of IEEE ISBI 2021 and MICCAI 2021. Statistical analyses performed based on comprehensive descriptions of the submitted algorithms linked to their rank as well as the underlying participation strategies revealed common characteristics of winning solutions. These typically include the use of multi-task learning (63%) and/or multi-stage pipelines (61%), and a focus on augmentation (100%), image preprocessing (97%), data curation (79%), and post-processing (66%). The “typical” lead of a winning team is a computer scientist with a doctoral degree, five years of experience in biomedical image analysis, and four years of experience in deep learning. Two core general development strategies stood out for highly-ranked teams: the reflection of the metrics in the method design and the focus on analyzing and handling failure cases. According to the organizers, 43% of the winning algorithms exceeded the state of the art but only 11% completely solved the respective domain problem. The insights of our study could help researchers (1) improve algorithm development strategies when approaching new problems, and (2) focus on open research questions revealed by this work.

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Assessment of multiple-biomarker classifiers: Fundamental principles and a proposed strategy

arXiv

引用

arXiv 2019年

作者： Yousef, Waleed A. Computer Science Department Faculty of Computers and Information Helwan University Egypt Human Computer Interaction Laboratory [HCI Lab. Egypt

The multiple-biomarker classifier problem and its assessment are reviewed against the background of some fundamental principles from the field of statistical pattern recognition, machine learning, or the recently so-called "data science". A narrow reading of that literature has led many authors to neglect the contribution to the total uncertainty of performance assessment from the finite training sample. Yet the latter is a fundamental indicator of the stability of a classifier;thus its neglect may be contributing to the problematic status of many studies. A three-level strategy is proposed for moving forward in this field. The lowest level is that of construction, where candidate features are selected and the choice of classifier architecture is made. At that point, the effective dimensionality of the classifier is estimated and used to size the next level of analysis, a pilot study on previously unseen cases. The total (training and testing) uncertainty resulting from the pilot study is, in turn, used to size the highest level of analysis, a pivotal study with a target level of uncertainty. Some resources available in the literature for implementing this approach are reviewed. Although the concepts explained in the present article may be fundamental and straightforward for many researchers in the machine learning community they are subtle for many practitioners, for whom we provided a general advice for the best practice in [1] and elaborate here in the present paper. Copyright © 2019, The Authors. All rights reserved.

关键词： Uncertainty analysis

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Designing Health Care Provider–centered Emergency department Interventions: Participatory Design Study

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JMIR Formative Research 2025年 9卷 e68891页

作者： Seo, Woosuk Li, Jiaqi Zhang, Zhan Zheng, Chuxuan Singh, Hardeep Pasupathy, Kalyan Mahajan, Prashant Park, Sun Young School of Information University of Michigan Ann Arbor MI United States Seidenberg School of Computer Science and Information Systems Pace University New York NY United States Department of Human Centered Design & Engineering University of Washington Seattle WA United States Center for Innovations in Quality Effectiveness and Safety (IQuESt) Michael E. DeBakey Veterans Affairs Medical Center Baylor College of Medicine Houston TX United States Biomedical and Health Information Sciences University of Illinois Chicago Chicago IL United States Department of Emergency Medicine University of Michigan Medical School Ann Arbor MI United States School of Information Stamps School of Art and Design University of Michigan Ann Arbor MI United States

Background: In the emergency department (ED), health care providers face extraordinary pressures in delivering accurate diagnoses and care, often working with fragmented or inaccessible patient histories while managing severe time constraints and constant interruptions. These challenges and pressures may lead to potential errors in the ED diagnostic process and risks to patient safety. With advances in technology, interventions have been developed to support ED providers in such pressured settings. However, these interventions may not align with the current practices of ED providers. To better design ED provider–centered interventions, identifying their needs in the diagnostic process is critical. Objective: This study aimed to identify ED providers’ needs in the diagnostic process through participatory design sessions and to propose design guidelines for provider-centered technological interventions that support decision-making and reduce errors. Methods: We conducted a participatory design study with ED providers to validate their needs and identify considerations for designing ED provider–centered interventions to improve diagnostic safety. We used 9 technological intervention ideas as storyboards to address the study participants’ needs. We had participants discuss the use cases of each intervention idea to assess their needs during the ED care process and facilitated co-design activities with the participants to improve the technological intervention designs. We audio- and video-recorded the design sessions. We then analyzed session transcripts, field notes, and design sketches. In total, we conducted 6 design sessions with 17 ED frontline providers. Results: Through design sessions with ED providers, we identified 4 key needs in the diagnostic process: information integration, patient prioritization, ED provider-patient communication, and care coordination. We interpreted them as insights for designing technological interventions for ED patients. Hence, we dis

关键词： artificial intelligence emergency departments health care providers interventions participatory design technology

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Development of a Method for Compliance Detection in Wearable Sensors

Development of a Method for Compliance Detection in Wearable...

引用

Electrical, computer and Energy Technologies (ICECET), International Conference on

作者： Siavash Esfandiari Fard Tonmoy Ghosh Delwar Hossain Megan A McCrory Graham Thomas Janine Higgins Wenyan Jia Tom Baranowski Matilda Steiner-Asiedu Alex K. Anderson Mingui Sun Gary Frost Benny Lo Edward Sazonov Department of Electrical and Computer Engineering University of Alabama Tuscaloosa AL USA Department of Health Sciences Boston University Boston MA USA Psychiatry and Human Behavior Warren Alpert Medical School of Brown University Providence RI USA Division of Endocrinology Metabolism and Diabetes University of Colorado Anschutz Medical Campus Aurora Colorado USA Department of Neurological Surgery University of Pittsburgh Pittsburgh PA USA Department of Pediatrics USDA/ARS Children's Nutrition Research Center Baylor College of Medicine Houston TX USA Department of Nutrition and Food Science University of Ghana Legon Ghana Department of Nutritional Sciences University of Georgia Athens GA USA Department of Metabolism Section for Nutrition Research Digestion and Reproduction University of Imperial College London London UK Department of Surgery and Cancer Hamlyn Centre Imperial College London London UK

One of the crucial elements in studies relying on wearable sensors for quantification of human activities (like physical activity or food intake) is the assessment of wear time (compliance). In this paper, we propose a novel method based on the Automatic Ingestion Monitor v2 (AIM-2), deployed for measuring nutrient and energy intake. The proposed method was developed using data from a study of 30 participants for two days each (US dataset) and tested with an independent dataset (Ghana dataset) on 10 households (30 Participants, 3 days for each, a total of 90 days). The signals from the accelerometer sensor of the AIM-2 were used to extract features and train the gradient-boosting tree classifier. To reduce the error in the classification of non-compliance in situations where the sensor changes its position with respect to gravity, a two-stage classifier followed by post-processing was introduced. Previously, we developed an offline compliance classifier, and this work aimed to develop a classifier for a cloud-based feedback system. The accuracy and F1-score of the developed two-phase classifier based on K-fold validation for the training and validation dataset were 95.37% and 96.93%, and for the Ghana dataset, were 95.86% and 92.56%, respectively, showing satisfactory performance results. The trained classifier can be deployed to monitor compliance with device wear in realtime applications. Clinical Relevance– Food Intake and physical activity studies can contribute to detecting, controlling, and even improving eating or physical activity-related problems, like obesity, diabetes, and eating planning. To ensure effective monitoring, compliance with the wearing of the device is crucial.

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The Multi-modality Cell Segmentation Challenge: Towards Universal Solutions

arXiv

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arXiv 2023年

作者： Ma, Jun Xie, Ronald Ayyadhury, Shamini Ge, Cheng Gupta, Anubha Gupta, Ritu Gu, Song Zhang, Yao Lee, Gihun Kim, Joonkee Lou, Wei Li, Haofeng Upschulte, Eric Dickscheid, Timo de Almeida, José Guilherme Wang, Yixin Han, Lin Yang, Xin Labagnara, Marco Gligorovski, Vojislav Scheder, Maxime Rahi, Sahand Jamal Kempster, Carly Pollitt, Alice Espinosa, Leon Mignot, Tâm Middeke, Jan Moritz Eckardt, Jan-Niklas Li, Wangkai Li, Zhaoyang Cai, Xiaochen Bai, Bizhe Greenwald, Noah F. Van Valen, David Weisbart, Erin Cimini, Beth A. Cheung, Trevor Brück, Oscar Bader, Gary D. Wang, Bo Peter Munk Cardiac Centre University Health Network TorontoON Canada Department of Laboratory Medicine and Pathobiology University of Toronto TorontoON Canada Vector Institute TorontoON Canada Department of Molecular Genetics University of Toronto TorontoON Canada Donnelly Centre University of Toronto TorontoON Canada Princess Margaret Cancer Centre University Health Network TorontoON Canada School of Medicine and Pharmacy Ocean University of China Qingdao China New Delhi India Laboratory Oncology Dr. BRA-IRCH All India Institute of Medical Sciences New Delhi India Department of Image Reconstruction Nanjing Anke Medical Technology Co. Ltd. Nanjing China Shanghai Artificial Intelligence Laboratory Shanghai China Graduate School of AI KAIST Seoul Korea Republic of Shenzhen Research Institute of Big Data Shenzhen China Shenzhen China Helmholtz AI Research Center Jülich Jülich Germany Faculty of Mathematics and Natural Sciences Institute of Computer Science Heinrich Heine University Düsseldorf Düsseldorf Germany Hinxton United Kingdom Champalimaud Foundation - Centre for the Unknown Lisbon Portugal Department of Bioengineering Stanford University Palo AltoCA United States Tandon School of Engineering New York University New YorkNY United States School of Biomedical Engineering Health Science Center Shenzhen University Shenzhen China Lausanne Switzerland School of Biological Sciences University of Reading Reading United Kingdom Laboratoire de Chimie Bactérienne CNRS Université Aix Marseille UMR Institut de Microbiologie de la Méditerranée Marseille France Department of Internal Medicine I University Hospital Dresden Technical University Dresden Dresden Germany Else Kroener Fresenius Center for Digital Health Technical University Dresden Dresden Germany Department of Automation University of Science and Technology of China Hefei China Institute of Advanced Technology University of Science and Technology of China Hefei Chi

Cell segmentation is a critical step for quantitative single-cell analysis in microscopy images. Existing cell segmentation methods are often tailored to specific modalities or require manual interventions to specify hyper-parameters in different experimental settings. Here, we present a multi-modality cell segmentation benchmark, comprising over 1500 labeled images derived from more than 50 diverse biological experiments. The top participants developed a Transformer-based deep-learning algorithm that not only exceeds existing methods but can also be applied to diverse microscopy images across imaging platforms and tissue types without manual parameter adjustments. This benchmark and the improved algorithm offer promising avenues for more accurate and versatile cell analysis in microscopy imaging. © 2023, CC BY-NC-ND.

关键词： Deep learning

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