Predicting RNA binding protein(RBP) binding sites on circular RNAs(circ RNAs) is a fundamental step to understand their interaction mechanism. Numerous computational methods are developed to solve this problem, but th...
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Predicting RNA binding protein(RBP) binding sites on circular RNAs(circ RNAs) is a fundamental step to understand their interaction mechanism. Numerous computational methods are developed to solve this problem, but they cannot fully learn the features. Therefore, we propose circ-CNNED, a convolutional neural network(CNN)-based encoding and decoding framework. We first adopt two encoding methods to obtain two original matrices. We preprocess them using CNN before fusion. To capture the feature dependencies, we utilize temporal convolutional network(TCN) and CNN to construct encoding and decoding blocks, respectively. Then we introduce global expectation pooling to learn latent information and enhance the robustness of circ-CNNED. We perform circ-CNNED across 37 datasets to evaluate its effect. The comparison and ablation experiments demonstrate that our method is superior. In addition, motif enrichment analysis on four datasets helps us to explore the reason for performance improvement of circ-CNNED.
Rice is a major crop and staple food for more than half of the world’s population and plays a vital role in ensuring food security as well as the global economy pests and diseases pose a threat to the production of r...
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Rice is a major crop and staple food for more than half of the world’s population and plays a vital role in ensuring food security as well as the global economy pests and diseases pose a threat to the production of rice and have a substantial impact on the yield and quality of the crop. In recent times, deep learning methods have gained prominence in predicting rice leaf diseases. Despite the increasing use of these methods, there are notable limitations in existing approaches. These include a scarcity of extensive and diverse collections of leaf disease images, lower accuracy rates, higher time complexity, and challenges in real-time leaf disease detection. To address the limitations, we explicitly investigate various data augmentation approaches using different generative adversarial networks (GANs) for rice leaf disease detection. Along with the GAN model, advanced CNN-based classifiers have been applied to classify the images with improving data augmentation. Our approach involves employing various GANs to generate high-quality synthetic images. This strategy aims to tackle the challenges posed by limited and imbalanced datasets in the identification of leaf diseases. The key benefit of incorporating GANs in leaf disease detection lies in their ability to create synthetic images, effectively augmenting the dataset’s size, enhancing diversity, and reducing the risk of overfitting. For dataset augmentation, we used three distinct GAN architectures—namely simple GAN, CycleGAN, and DCGAN. Our experiments demonstrated that models utilizing the GAN-augmented dataset generally outperformed those relying on the non-augmented dataset. Notably, the CycleGAN architecture exhibited the most favorable outcomes, with the MobileNet model achieving an accuracy of 98.54%. These findings underscore the significant potential of GAN models in improving the performance of detection models for rice leaf diseases, suggesting their promising role in the future research within this doma
The Internet of Things(IoT)has taken the interconnected world by *** to their immense applicability,IoT devices are being scaled at exponential proportions ***,very little focus has been given to securing such *** the...
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The Internet of Things(IoT)has taken the interconnected world by *** to their immense applicability,IoT devices are being scaled at exponential proportions ***,very little focus has been given to securing such *** these devices are constrained in numerous aspects,it leaves network designers and administrators with no choice but to deploy them with minimal or no security at *** have seen distributed denial-ofservice attacks being raised using such devices during the infamous Mirai botnet attack in *** we propose a lightweight authentication protocol to provide proper access to such *** have considered several aspects while designing our authentication protocol,such as scalability,movement,user registration,device registration,*** define the architecture we used a three-layered model consisting of cloud,fog,and edge *** have also proposed several pre-existing cipher suites based on post-quantum cryptography for evaluation and *** also provide a fail-safe mechanism for a situation where an authenticating server might fail,and the deployed IoT devices can self-organize to keep providing services with no human *** find that our protocol works the fastest when using ring learning with *** prove the safety of our authentication protocol using the automated validation of Internet security protocols and applications *** conclusion,we propose a safe,hybrid,and fast authentication protocol for authenticating IoT devices in a fog computing environment.
Thyroid nodules,a common disorder in the endocrine system,require accurate segmentation in ultrasound images for effective diagnosis and ***,achieving precise segmentation remains a challenge due to various factors,in...
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Thyroid nodules,a common disorder in the endocrine system,require accurate segmentation in ultrasound images for effective diagnosis and ***,achieving precise segmentation remains a challenge due to various factors,including scattering noise,low contrast,and limited resolution in ultrasound *** existing segmentation models have made progress,they still suffer from several limitations,such as high error rates,low generalizability,overfitting,limited feature learning capability,*** address these challenges,this paper proposes a Multi-level Relation Transformer-based U-Net(MLRT-UNet)to improve thyroid nodule *** MLRTUNet leverages a novel Relation Transformer,which processes images at multiple scales,overcoming the limitations of traditional encoding *** transformer integrates both local and global features effectively through selfattention and cross-attention units,capturing intricate relationships within the *** approach also introduces a Co-operative Transformer Fusion(CTF)module to combine multi-scale features from different encoding layers,enhancing the model’s ability to capture complex patterns in the ***,the Relation Transformer block enhances long-distance dependencies during the decoding process,improving segmentation *** results showthat the MLRT-UNet achieves high segmentation accuracy,reaching 98.2% on the Digital database Thyroid Image(DDT)dataset,97.8% on the Thyroid Nodule 3493(TG3K)dataset,and 98.2% on the Thyroid Nodule3K(TN3K)*** findings demonstrate that the proposed method significantly enhances the accuracy of thyroid nodule segmentation,addressing the limitations of existing models.
Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and t...
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Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.
Evaluation system of small arms firing has an important effect in the context of military domain. A partially automated evaluation system has been conducted and performed at the ground level. Automation of such system...
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Evaluation system of small arms firing has an important effect in the context of military domain. A partially automated evaluation system has been conducted and performed at the ground level. Automation of such system with the inclusion of artificial intelligence is a much required process. This papers puts focus on designing and developing an AI-based small arms firing evaluation systems in the context of military environment. Initially image processing techniques are used to calculate the target firing score. Additionally, firing errors during the shooting have also been detected using a machine learning algorithm. However, consistency in firing requires an abundance of practice and updated analysis of the previous results. Accuracy and precision are the basic requirements of a good shooter. To test the shooting skill of combatants, firing practices are held by the military personnel at frequent intervals that include 'grouping' and 'shoot to hit' scores. Shortage of skilled personnel and lack of personal interest leads to an inefficient evaluation of the firing standard of a firer. This paper introduces a system that will automatically be able to fetch the target data and evaluate the standard based on the fuzzy *** it will be able to predict the shooter performance based on linear regression ***, it compares with recognized patterns to analyze the individual expertise and suggest improvements based on previous values. The paper is developed on a Small Arms Firing Skill Evaluation System, which makes the whole process of firing and target evaluation faster with better accuracy. The experiment has been conducted on real-time scenarios considering the military field and shows a promising result to evaluate the system automatically.
Acute Bilirubin Encephalopathy(ABE)is a significant threat to neonates and it leads to disability and high mortality *** and treating ABE promptly is important to prevent further complications and long-term *** studie...
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Acute Bilirubin Encephalopathy(ABE)is a significant threat to neonates and it leads to disability and high mortality *** and treating ABE promptly is important to prevent further complications and long-term *** studies have explored ABE ***,they often face limitations in classification due to reliance on a single modality of Magnetic Resonance Imaging(MRI).To tackle this problem,the authors propose a Tri-M2MT model for precise ABE detection by using tri-modality MRI *** scans include T1-weighted imaging(T1WI),T2-weighted imaging(T2WI),and apparent diffusion coefficient maps to get indepth ***,the tri-modality MRI scans are collected and preprocessesed by using an Advanced Gaussian Filter for noise reduction and Z-score normalisation for data *** Advanced Capsule Network was utilised to extract relevant features by using Snake Optimization Algorithm to select optimal features based on feature correlation with the aim of minimising complexity and enhancing detection ***,a multi-transformer approach was used for feature fusion and identify feature correlations ***,accurate ABE diagnosis is achieved through the utilisation of a SoftMax *** performance of the proposed Tri-M2MT model is evaluated across various metrics,including accuracy,specificity,sensitivity,F1-score,and ROC curve analysis,and the proposed methodology provides better performance compared to existing methodologies.
To generate dance that temporally and aesthetically matches the music is a challenging problem in three ***,the generated motion should be beats-aligned to the local musical ***,the global aesthetic style should be ma...
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To generate dance that temporally and aesthetically matches the music is a challenging problem in three ***,the generated motion should be beats-aligned to the local musical ***,the global aesthetic style should be matched between motion and *** third,the generated motion should be diverse and *** address these challenges,we propose ReChoreoNet,which re-choreographs high-quality dance motion for a given piece of music.A data-driven learning strategy is proposed to efficiently correlate the temporal connections between music and motion in a progressively learned cross-modality embedding *** beats-aligned content motion will be subsequently used as autoregressive context and control signal to control a normalizing-flow model,which transfers the style of a prototype motion to the final generated *** addition,we present an aesthetically labelled music-dance repertoire(MDR)for both efficient learning of the cross-modality embedding,and understanding of the aesthetic connections between music and *** demonstrate that our repertoire-based framework is robustly extensible in both content and *** quantitative and qualitative experiments have been carried out to validate the efficiency of our proposed model.
Despite the various advances in medical technology, heart disease continues to rank among the leading causes of mortality in the world, killing millions each year. There is hope that the risks involved with heart dise...
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Purpose: The difficulty of diagnosing several lung disorders, including atelectasis, cardiomegaly, lung cancer, and COVID-19, is a challenging problem and needs to be addressed. These conditions exhibit some symptoms ...
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Purpose: The difficulty of diagnosing several lung disorders, including atelectasis, cardiomegaly, lung cancer, and COVID-19, is a challenging problem and needs to be addressed. These conditions exhibit some symptoms and demand advanced medical imaging process, thorough clinical assessments, and innovative procedures for accurate diagnosis. The shortage of qualified radiologists further makes the problem more complex to deal with. COVID-19 in particular has resulted in a remarkable number of fatalities around the world. Children below the age of 5 and individuals over 65 are more likely to be affected by lung disorders. It is very hard to diagnose and manage COVID-19 absolutely, but it can be identified earlier by employing computer-aided diagnosis (CAD) technologies to make timely diagnosis. Currently, radiologists adopt technologies, which are driven by artificial intelligence. By using them, medical imaging data, such as chest X-rays and CT scans, can be investigated to identify patterns to diagnose the severity of the virus. This expedites the diagnostic process and enhances accuracy, facilitating more timely and precise medical interventions. The efficiency of artificial intelligence in processing large datasets can directly help healthcare professionals in making diagnosis quicker and more accurate. The objective of the work in this paper is to design and implement deep learning model classifiers, which will effectively categorize the patterns found in the X-rays and CT scans. Methods: Three techniques for categorization are exploited to propose an entirely new hybrid convolutional neural network (CNN) model in this context. MRI and CT image categorization in the first classification method employ Fully Connected (FC) layers. The weights are calculated and tuned for training the algorithm over multiple periods to deliver the maximum precision for classification. The most accurate MRI and CT image characteristics are studied, and deep learning model classifiers
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