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Local and global sensitivity analyses on the overflow probability of Abadia de Goiás radioactive near surface repository

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Nuclear engineering and Design 2025年 439卷

作者： Teixeira, D.G. Frutuoso e Melo, P.F. Alvim, L.G.M. Alvim, A.C.M. Alves, A.S.M. Graduate Program of Nuclear Engineering COPPE Federal University of Rio de Janeiro RJ Rio de Janeiro Brazil Department of Computer Science Multidisciplinary Institute Federal Rural University of Rio de Janeiro UFRRJ RJ Nova Iguaçu Brazil Eletronuclear S. A. RJ Rio de Janeiro Brazil

This work presents a sensitivity analysis of the overflow probability of the near- surface radioactive repository built after the Abadia de Goiás accident, where radioactive 137Cs was released. The purpose of the analysis is to help the repository owner and the regulatory body make decisions on design parameters that affect the overflow probability. The following parameters have been considered: degradation function of the repository ceiling, internal porosity of the repository, internal area of the repository base, repository base and wall thicknesses, repository height, height of the liquid column inside the repository, average rainfall rate, evapotranspiration rate, surface runoff and hydraulic conductivity of the repository concrete. The choice for the range of each parameter is discussed. An investigation of the role of the mentioned parameters is detailed based on results obtained in a previous paper, and the dependencies among the rate parameters on the average rainfall rate is emphasized and modeled. To give a deeper perspective, local and global sensitivity analyses have been performed. In the case of global analysis, two approaches have been followed: in the first, the concept of Normalized Mutual Information and the other one leverages Shapley values derived from Light Gradient Boosting Machine and Shapley values have been used for investigating non-linearities. For some parameters the lowest values are to be considered, e.g., the repository base thickness and the average rainfall rate, while for others the highest value is desirable, like the evapotranspiration rate and the surface runoff in order to obtain lower overflow probabilities. These results should be looked with care because nonlinearities have been identified by the Shapley value analysis. Overall, the degradation function and the evapotranspiration rate emerge as the most influential parameters. The legacy of this work lies in the robust methodological framework it provides, paving the way fo

关键词： Nuclear reactor accidents

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GAITGen: Disentangled Motion-Pathology Impaired Gait Generative Model – Bringing Motion Generation to the Clinical Domain

arXiv

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arXiv 2025年

作者： Adeli, Vida Mehraban, Soroush Mirmehdi, Majid Whone, Alan Filtjens, Benjamin Dadashzadeh, Amirhossein Fasano, Alfonso Iaboni, Andrea Taati, Babak University of Toronto Computer Science Department Canada Vector Institute Canada KITE Research Institute UHN Canada University of Toronto Institute of Biomedical Engineering Canada University of Bristol School of Computer Science United Kingdom University of Bristol Translational Health Science United Kingdom University of Toronto Data Sciences Institute Canada University of Toronto Department of Medicine Division of Neurology Canada Krembil Research Institute UHN Canada Edmond J. Safra Program in Parkinson’s Disease UHN Canada University of Toronto Department of Psychiatry Canada Centre for Mental Health UHN Canada

Gait analysis is crucial for the diagnosis and monitoring of movement disorders like Parkinson’s Disease. While computer vision models have shown potential for objectively evaluating parkinsonian gait, their effectiveness is limited by scarce clinical datasets and the challenge of collecting large and well-labelled data, impacting model accuracy and risk of bias. To address these gaps, we propose GAITGen, a novel framework that generates realistic gait sequences conditioned on specified pathology severity levels. GAITGen employs a Conditional Residual Vector Quantized Variational Autoencoder to learn disentangled representations of motion dynamics and pathology-specific factors, coupled with Mask and Residual Transformers for conditioned sequence generation. GAITGen generates realistic, diverse gait sequences across severity levels, enriching datasets and enabling large-scale model training in parkinsonian gait analysis. Experiments on our new PD-GaM (real) dataset demonstrate that GAITGen outperforms adapted state-of-the-art models in both reconstruction fidelity and generation quality, accurately capturing critical pathology-specific gait features. A clinical user study confirms the realism and clinical relevance of our generated sequences. Moreover, incorporating GAITGen-generated data into downstream tasks improves parkinsonian gait severity estimation, highlighting its potential for advancing clinical gait analysis. © 2025, CC BY-NC-SA.

关键词： Pathology

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A Deep Learning Approach for Nerve Injury Classification in Brachial Plexopathies Using Magnetic Resonance Neurography with Modified Hiking Optimization Algorithm

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Academic Radiology 2025年

作者： Dahou, Abdelghani Elaziz, Mohamed Abd Khattap, Mohamed G. Hassan, Hend Galal Eldeen Mohamed Ali School of Computer Science and Technology Zhejiang Normal University Jinhua 321004 China Mathematics and Computer Science department University of Ahmed DRAIA Adrar 01000 Algeria Department of Mathematics Faculty of Science Zagazig University Zagazig 44519 Egypt Faculty of Computer Science and Engineering Galala University Suez 435611 Egypt Artificial Intelligence Research Center (AIRC) Ajman University Ajman 346 United Arab Emirates Department of Diagnostic Interventional Radiology and Molecular Imaging Faculty of Medicine Ain Shams University Cairo 11591 Egypt Technology of Radiology and Medical Imaging Program Faculty of Applied Health Sciences Technology Galala University Suez 435611 Egypt

Rationale and Objectives: Brachial plexopathies (BPs) encompass a complex spectrum of nerve injuries affecting motor and sensory function in the upper extremities. Diagnosis is challenging due to the intricate anatomy and symptom overlap with other neuropathies. Magnetic Resonance Neurography (MRN) provides advanced imaging but requires specialized interpretation. This study proposes an AI-based framework that combines deep learning (DL) with the modified Hiking Optimization Algorithm (MHOA) enhanced by a Comprehensive Learning (CL) technique to improve the classification of nerve injuries (neuropraxia, axonotmesis, neurotmesis) using MRN data. Materials and Methods: The framework utilizes MobileNetV4 for feature extraction and MHOA for optimized feature selection across different MRI sequences (STIR, T2, T1, and DWI). A dataset of 39 patients diagnosed with BP was used. The framework classifies injuries based on Seddon's criteria, distinguishing between normal and abnormal conditions as well as injury severity. Results: The model achieved excellent performance, with 1.0000 accuracy in distinguishing normal from abnormal conditions using STIR and T2 sequences. For injury severity classification, accuracy was 0.9820 in STIR, outperforming the original HOA and other metaheuristic algorithms. Additionally, high classification accuracy (0.9667) was observed in DWI. The proposed framework outperformed traditional methods and demonstrated high sensitivity and specificity. Conclusion: The proposed AI-based framework significantly improves the diagnosis of BP by accurately classifying nerve injury types. By integrating DL and optimization techniques, it reduces diagnostic variability, making it a valuable tool for clinical settings with limited specialized neuroimaging expertise. This framework has the potential to enhance clinical decision-making and optimize patient outcomes through precise and timely diagnoses. © 2025 The Association of University Radiologists

关键词： Brachial Plexopathy (BP) Comprehensive Learning (CL) Deep Learning (DL) Feature Selection (FS) Hiking Optimization Algorithm (HOA) Magnetic Resonance Neurography (MRN) MobileNetV4

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MV-CLAM: Multi-View Molecular Interpretation with Cross-Modal Projection via Language Model

arXiv

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arXiv 2025年

作者： Ha, Sumin Kim, Jun Hyeong Piao, Yinhua Kim, Sun Interdisciplinary Program in Artificial Intelligence Seoul National University Korea Republic of Bio-MAX/N-Bio Seoul National University Korea Republic of Department of Computer Science and Engineering Seoul National University Korea Republic of Interdisciplinary Program in Bioinformatics Seoul National University Korea Republic of AIGENDRUG Co. Ltd. Korea Republic of

Human expertise in chemistry and biomedicine relies on contextual molecular understanding, a capability that large language models (LLMs) can extend through fine-grained alignment between molecular structures and text. Recent multimodal learning advances focus on cross-modal alignment, but existing molecule-text models ignore complementary information in different molecular views and rely on single-view representations, limiting molecular understanding. Moreover, naïve multi-view alignment strategies face two challenges: (1) separate aligned spaces with inconsistent mappings between molecule and text embeddings, and that (2) existing loss objectives fail to preserve complementary information for fine-grained alignment. This can limit the LLM’s ability to fully understand the molecular properties. To address these issues, we propose MV-CLAM, a novel framework that aligns multi-view molecular representations into a unified textual space using a multi-query transformer (MQ-Former). Our approach ensures cross-view consistency while a token-level contrastive loss preserves diverse molecular features across textual queries. MV-CLAM enhances molecular reasoning, improving retrieval and captioning accuracy. The source code of MV-CLAM is available in https://***/sumin124/***. © 2025, CC BY-NC-SA.

关键词： Molecular docking

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Enhancing Diagnostic Accuracy for Knee Osteoarthritis Using a Deep Learning Approach

Enhancing Diagnostic Accuracy for Knee Osteoarthritis Using ...

引用

International Symposium on Applied science 2024, ISAS 2024

作者： Raza, Aquib Ching, Congo Tak Shing Liu, Peng-Ta Phan, Thien-Luan Tran, Ngoc-Luan Nguyen, Ha Anh T. Rameez, Mohammad Li, Hung-Chung Linh, Dao Nguyen Phuong Van Hieu, Nguyen Tran, Trung Nghia National Taiwan University Taipei City10673 Taiwan Research Center for Information Technology Academia Sinica Taipei City11529 Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung402 Taiwan Department of Electrical Engineering National Chi Nan University Nantou County Taiwan Advanced Plant and Food Crop Biotechnology Center National Chung Hsing University Taichung402 Taiwan International Doctoral Program in Agriculture National Chung Hsing University Taichung402 Taiwan Fall Prevention Center Department of Physical Medicine & Rehabilitation Changhua Christian Hospital Changhua500 Taiwan Department of Physics and Electronic Engineering University of Science Vietnam National University - Ho Chi Minh City Ho Chi Minh City70000 Viet Nam Department of Computer Science University of York York HeslingtonYO10 5DD United Kingdom Undergraduate Program of Intellectual Creativity Engineering National Chung Hsing University Taichung402 Taiwan Ho Chi Minh City72409 Viet Nam HCMUT Vietnam National University Ho Chi Minh City Thu Duc Ho Chi Minh City71308 Viet Nam

This research introduces a deep learning framework that combines convolutional neural networks with autoencoders to improve the diagnostic accuracy of knee osteoarthritis. The study utilized a publicly available dataset from the Mendeley Data repository, where knee joint images were preprocessed using Contrast Limited Adaptive Histogram Equalization to enhance contrast and ensure consistent image sizing. Initially, an autoencoder was employed in an unsupervised manner to learn compressed representations of the data. These representations were then used to train a CNN to classify knee images into 'healthy' and 'osteoarthritic' categories. The model was trained using an 80:20 split for training and testing data, incorporating early stopping and data augmentation techniques to prevent overfitting and enhance generalization. Performance metrics such as accuracy, precision, recall, and the area under the Receiver Operating Characteristic curve (ROCAUC) were used to evaluate the model, resulting in a high test accuracy of 98.95%. The high precision and recall rates further confirmed the model's robustness in diagnosing KOA. To enhance interpretability, Gradient-weighted Class Activation Mapping (Grad-CAM) was applied to identify critical regions in the images that influenced the model's decisions. Additionally, t-Distributed Stochastic Neighbor Embedding (t-SNE) was used to visualize the high-dimensional encoded features in a two-dimensional space, providing deeper insights into how the model differentiates between classes. The promising results of this deep learning approach suggest its potential for broader applications in medical imaging diagnostics. By providing healthcare professionals with a tool that enhances diagnostic accuracy and operational efficiency, this framework lays the foundation for developing scalable, AI-driven diagnostic systems for various complex medical conditions. © 2025 Institute of Physics Publishing. All rights reserved.

关键词： Joints (anatomy)

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OPRLM: A Web Tool and a Database for Positioning and Simulations of Proteins in Realistic Lipid Membranes

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Journal of Molecular Biology 2025年 168966页

作者： Park, Sang-Jun Schnitzer, Kyle A. Kovalenko, Alexey Cherepanov, Stanislav Patro, L. Ponoop Prasad Song, Zigang Pogozheva, Irina D. Lomize, Andrei L. Im, Wonpil Department of Computer Science and Engineering Lehigh University 111 Research Drive Bethlehem 18015 PA United States Department of Electrical Engineering and Computer Science College of Engineering University of Michigan 1221 Beal Ave Ann Arbor 48109-2102 MI United States Department of Computer Science College of Literature Science and the Arts University of Michigan 2260 Hayward Street Ann Arbor 48109-2121 MI United States Biophysics Program University of Michigan 930 N. University Avenue Ann Arbor 48109-1065 MI United States Department of Biological Sciences Lehigh University 111 Research Drive Bethlehem 18015 PA United States Department of Medicinal Chemistry College of Pharmacy University of Michigan 428 Church St. Ann Arbor 48109-1065 MI United States

Molecular dynamics (MD) simulations in explicit lipid bilayers enable modeling of protein-lipid interactions essential for membrane protein functions and regulation. The newly developed computational web tool, OPRLM (Orientations of Proteins in Realistic Lipid Membranes), automates the assembly of membrane protein structures with explicit lipids corresponding to 18 biological membrane types with symmetric or asymmetric lipid distributions, as well as 5 types of two-component lipid bilayers with varying cholesterol content. Built upon the CHARMM-GUI toolset and the PPM method, OPRLM simplifies the setup of complex simulation system involving integral and/or peripheral membrane proteins with explicit lipid mixtures and generates all necessary files for subsequent all-atom MD simulations. OPRLM has successfully generated protein-membrane systems for 286 tested protein structures in various biomembranes, including 138 structures containing ligands. The OPRLM database, an advanced successor of the OPM database, includes explicit protein-lipid systems for tested proteins in their native biomembranes. It provides coordinates of integral and peripheral membrane proteins from the Protein Data Bank embedded in planar or curved implicit lipid bilayers. Additionally, it includes the classification of proteins into types, superfamilies, and families, along with the information on intracellular localizations and membrane topology and visualization options. The OPRLM web tool and the database are publicly accessible at https://***. © 2025 The Authors

关键词： biomembrane explicit lipid lipid bilayer peripheral membrane protein transmembrane

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AgriField3D: A Curated 3D Point Cloud and Procedural Model Dataset of Field-Grown Maize from a Diversity Panel

arXiv

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arXiv 2025年

作者： Kimara, Elvis Hadadi, Mozhgan Godbersen, Jackson Balu, Aditya Jubery, Talukder Li, Yawei Krishnamurthy, Adarsh Schnable, Patrick S. Ganapathysubramanian, Baskar Department of Computer Science Iowa State University Ames United States Translational AI Research and Education Center Ames United States Department of Mechanical Engineering Iowa State University Ames United States Plant Science Institute Iowa State University Ames United States Interdepartmental Genetics and Genomics Graduate Program Iowa State University Ames United States Department of Agronomy Iowa State University Ames United States

The application of artificial intelligence (AI) in three-dimensional (3D) agricultural research, particularly for maize, has been limited by the scarcity of large-scale, diverse datasets. While 2D image datasets are abundant, they fail to capture essential structural details such as leaf architecture, plant volume, and spatial arrangements that 3D data provide. To address this limitation, we present AgriField3D (website), a curated dataset of 3D point clouds of field-grown maize plants from a diverse genetic panel, designed to be AI-ready for advancing agricultural research. Our dataset comprises over 1,000 high-quality point clouds collected using a Terrestrial Laser Scanner, complemented by procedural models that provide structured, parametric representations of maize plants. These procedural models, generated using Non-Uniform Rational B-Splines (NURBS) and optimized via a two-step process combining Particle Swarm Optimization (PSO) and differentiable programming, enable precise, scalable reconstructions of leaf surfaces and plant architectures. To enhance usability, we performed graph-based segmentation to isolate individual leaves and stalks, ensuring consistent labeling across all samples. We also conducted rigorous manual quality control on all datasets, correcting errors in segmentation, ensuring accurate leaf ordering, and validating metadata annotations. The dataset further includes metadata detailing plant morphology and quality, alongside multi-resolution subsampled versions (100k, 50k, 10k points) optimized for various computational needs. By integrating point cloud data of field grown plants with high-fidelity procedural models and ensuring meticulous manual validation, AgriField3D provides a comprehensive foundation for AI-driven phenotyping, plant structural analysis, and 3D applications in agricultural research. © 2025, CC BY-NC-SA.

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engineering Andreev Bound States for Thermal Sensing in Proximity Josephson Junctions

arXiv

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arXiv 2025年

作者： Jung, Woochan Arnault, Ethan G. Huang, Bevin Park, Jinho Jang, Seong Watanabe, Kenji Taniguchi, Takashi Englund, Dirk Fong, Kin Chung Lee, Gil-Ho Physics Department Pohang University of Science and Technology Pohang37673 Korea Republic of Research Laboratory of Electronics Massachusetts Institute of Technology CambridgeMA02139 United States Intelligence Community Postdoctoral Research Fellowship Program Massachusetts Institute of Technology CambridgeMA02139 United States Department of Mechanical Engineering Columbia University New YorkNY10027 United States Research Center for Functional Materials National Institute for Materials Science Tsukuba Japan International Center for Materials Nanoarchitectonics National Institute for Materials Science Tsukuba Japan Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology CambridgeMA02139 United States Department of Electrical and Computer Engineering Northeastern University BostonMA02115 United States Department of Physics Northeastern University BostonMA02115 United States Quantum Materials and Sensing Institute BurlingtonMA01803 United States

The thermal response of proximity Josephson junctions (JJs) is governed by the temperature (T)- dependent occupation of Andreev bound states (ABS), making them promising candidates for sensitive thermal detection. In this study, we systematically engineer ABS to enhance the thermal sensitivity of critical current (lc) of proximity JJs, quantified as |dlc/dT/| for threshold readout scheme and |dlc/***−1| for inductive readout scheme. Using a gate-tunable graphene-based JJ platform, we explore the impact of key parameters—including channel length, transparency, carrier density, and superconducting material—on the thermal response. Our results reveal that the proximity-induced superconducting gap plays a crucial role in optimizing thermal sensitivity. Notably, we see a maximum |dlc/***−1| value of 0.6 K−1 at low temperatures with titanium-based graphene JJs. By demonstrating a systematic approach to engineering ABS in proximity JJs, this work establishes a versatile framework for optimizing thermal sensors and advancing the study of ABS-mediated transport. © 2025, CC BY.

关键词： Superconducting materials

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Mixotrophic Chlorella pyrenoidosa biofilm with enhanced biomass production, microalgal activity, and nutrient removal from nutrient-rich wastewater

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Journal of Environmental sciences (China) 2025年 157卷 366-377页

作者： Wu, Xiongwei Jin, Cong Zhang, Chiqian Li, Ping Huang, Jim Junhui Wu, Jing Wu, Jinhua Hu, Zhiqiang School of Environment and Energy South China University of Technology Guangzhou510006 China Zhongshan Institute of Modern Industrial Technology of South China University of Technology Zhongshan528400 China Civil Engineering Program College of Engineering & Computer Science Arkansas State University JonesboroAR72467 United States Environmental Research Institute National University of Singapore Singapore117411 Singapore Department of Civil and Environmental Engineering University of Missouri-Columbia 65211 United States

Microalgae possess significant advantages in nitrogen and phosphorus removal from nutrient-rich wastewater that are highly efficient and independent of the C/N ratio. However, challenges such as low biomass productivity, high variability in nutrient removal under different trophic types, and difficulty in harvesting biomass limits the large-scale application of microalgae wastewater treatment. This study attempted to employ mixotrophic microalgae biofilm to address these issues. The biomass production, microalgal activity, and nutrient removal of Chlorella pyrenoidosa biofilms with different trophic types were compared for nutrient-rich wastewater treatment. The results showed that the biomass productivity of the mixotrophic microalgal biofilm (0.215 g/(L·d)) was 2.3, 8.6, and 6.0 times higher than that of photoautotrophic microalgal biofilm, heterotrophic microalgal biofilm, and photoautotrophic suspended microalga, respectively. Additionally, the dehydrogenase activity (DHA), indicating microalgal activity, of the mixotrophic biofilm was 2.3 and 16.5 times higher than that of photoautotrophic and heterotrophic biofilms, respectively. Meanwhile, the mixotrophic biofilm removed 96.0 % of NH4+-N and 99.2 % of PO43–-P, more efficient than that with other types of biofilms and suspended microalgae. In an open-ended air-lift photobioreactor, the mixotrophic microalgal biofilm produced biomass at 0.12 g/(L·d) and removed 90.0 % of NH4+-N and 97.6 % of PO43–-P. This study suggests that the mixotrophic microalgal biofilm shows promise in treating nutrient-rich wastewater and producing microalgal biomass for value-added products. © 2024

关键词： Microalgae

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Effects of Superabsorbent Polymers on Autogenous Shrinkage and Microstructure in Metakaolin-Based Cementitious Materials

SSRN

引用

SSRN 2025年

作者： Palma e Silva, Arthur Aviz Capuzzo, Valdirene Maria Silva da Silva, Eugência Fonseca Agostinho, Lívia Borba Pereira, André Maués Brabo University of Brasília Postgraduate Program in Structures and Civil Construction DF BrasíliaCEP: 70910-900 Brazil Federal Fluminense University Department of Computer Science RJ Rio de JaneiroCEP: 22290-240 Brazil Federal University Uberlândia Postgraduate Program in Civil Engineering Minas Gerais UberlandiaCEP: 38408-100 Brazil

The use of superabsorbent polymers (SAPs) in combination with supplementary cementitious materials like metakaolin presents an opportunity to enhance concrete performance while addressing environmental concerns in construction, lowering CO2 emissions by clincker substitution. This study investigates the behavior of high-strength microconcrete incorporating SAPs and metakaolin, evaluating their feasibility and sustainability for construction applications. Three microconcrete and paste mixes were analyzed: a reference mix and two mixes containing 0.15% and 0.30% SAP by cement mass. All mixes included a 10% metakaolin substitution by cement mass and maintained the same water/cement ratio, without additional curing water for SAPs. Fresh-state tests assessed consistency and specific mass, while hardened-state tests measured elastic modulus. Autogenous shrinkage was evaluated through linear volumetric variation using dial gauges. Microstructural analysis of the pastes and microconcretes involved thermogravimetry, isothermal conduction calorimetry, and X-ray microtomography. The results highlight the beneficial effects of SAPs with metakaolin, including enhanced hardened state properties and refined pore structure, achieved despite the absence of extra curing water. SAPs contributed to increased pozzolanic activity in metakaolin, likely due to delayed water release from SAP desorption. Furthermore, SAPs effectively mitigated autogenous shrinkage, making their application in concrete mixes promising. These findings emphasize the dual benefit of improving concrete performance and advancing environmental sustainability, showcasing the potential of SAPs and metakaolin in producing high-performance, eco-friendly concrete solutions for the construction industry. © 2025, The Authors. All rights reserved.

关键词： Hardening

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