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作者： Lu, Shaoying Michailova, Anushka Saucerman, Jeffrey Cheng, Yuhui Yu, Zeyun Kaiser, Timothy Li, Wilfred Bank, Randolph Holst, Michael McCammon, J. Hayashi, Takeharu Hoshijima, Masahiko Arzberger, Peter McCulloch, Andrew Bioengineering Department University of Illinois United States Bioengineering Department UCSD United States Department of Biomedical Engineering University of Virginia United States Department of Mathematics UCSD United States UCSD United States College of Computer Science and Technology Jilin University China Department of Mathematics Center for Computational Mathematics and the Computational Science Mathematics and Engineering Doctoral Program at UCSD Department of Pharmacology UCSD United States Center for Research in Biological Systems UCSD United States Department of Bioengineering UCSD United States Department of Bioengineering PFBH 241 University of California San Diego 9500 Gilman Drive San Diego CA 92093-0412 United States

There is a growing body of experimental evidence suggesting that the Ca2+ signaling in ventricular myocytes is characterized by a high gradient near the cell membrane and a more uniform Ca2+ distribution in the cell interior [1]--[7]. An important reason for this phenomenon might be that in these cells the t-tubular system forms a network of extracellular space, extending deep into the cell interior. This allows the electrical signal, that propagates rapidly along the cell membrane, to reach the vicinity of the sarcoplasmic reticulum (SR), where intracellular Ca2+ required for myofilament activation is stored [1], [8]--[11]. Early studies of cardiac muscle showed that the t-tubules are found at intervals of about 2 lm along the longitudinal cell axis in close proximity to the Z-disks of the sarcomeres [12]. Subsequent studies have demonstrated that the t-tubular system has also longitudinal extensions [9]--[11], [13].

关键词： Cells

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GridRT: A Massively Parallel Architecture for Ray-Tracing Using Uniform Grids

GridRT: A Massively Parallel Architecture for Ray-Tracing Us...

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Euromicro Symposium on Digital System Design

作者： Alexandre Solon Nery Nadia Nedjah Felipe Maia Galvão Franca Systems Engineering and Computer Science Program Universidade Federal do Rio de Janeiro Brazil Department of Electronics Engineering and Telecommunications Universidade do Estado do Rio de Janeiro Brazil

In this paper, we propose an architecture, which we call GridRT, capable of dealing with the main features, such as shadows and reflections effects, of Ray Tracing used for rendering three-dimensional scenes. This architecture achieves an efficient overall performance yet using a simple and compact massively parallel design. The design exploits the usage of Xilinx ® Floating Point Operator IP Core and the spatial data structure of Regular Grids.

关键词： Parallel architectures Ray tracing Layout computer architecture Rendering (computer graphics) Optical reflection Data structures computer graphics Pipelines Pixel

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Time Series Mining Approach for Noninvasive Intracranial Pressure Assessment: An Investigation of Different Regularization Techniques

Time Series Mining Approach for Noninvasive Intracranial Pre...

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computer science and Information engineering, CSIE, WRI World Congress on FLAGGED

作者： Shaozhi Wu Peng Xu Shadnaz Asgari Marvin Bergsneider Xiao Hu Biomedical Engineering Graduate Program Henry Samueli School of Engineering and Applied Science University of California Los Angeles USA Neural Systems and Dynamics Laboratory Department of Neurosurgery the David Geffen School of Medicine University of California Los Angeles USA School of Computer Science and Engineering University of Electronic Science and Technology Chengdu China

A data mining framework has been proposed to estimate intracranial pressure (ICP) non-invasively in our previous work. In the corresponding approach, the feature vector extracted from arterial blood pressure (ABP) and flow velocity (FV) is translated to the estimated errors by the mapping function for each entry in the database. In this paper, three different mapping function solutions, linear least squares (LLS), truncated singular value decomposition (TSVD) and standard Tikhonov regularization (STR) are systemically tested to compare the possible effects of different solutions on the non-invasive ICP estimation. The conducted comparison demonstrated that the selection of mapping function solution actually influences the estimation. Among the tested three solutions for mapping function, TSVD and STR show better ICP estimation performance with smaller ICP errors than LLS.

关键词： Cranial pressure Data mining Biomedical engineering Data engineering Spatial databases computer science Feature extraction Arterial blood pressure Biomedical measurements Laboratories

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Probabilistic structure from sound

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Advanced Robotics 2009年第12-13期23卷 1687-1702页

作者： Wang, Chieh-Chih Lin, Chi-Hao Hu, Jwu-Sheng Department of Computer Science and Information Engineering Graduate Institute of Networking and Multimedia National Taiwan University Taipei 10617 Taiwan Intelligent Robotics Program of Industrial Technology Research Institute Department of Electrical and Control Engineering National Chiao Tung University HsinChu 310 Taiwan

Auditory perception is one of the most important functions for robotics applications. Microphone arrays are widely used for auditory perception in which the spatial structure of microphones is usually known. In practice, microphone array calibration can be tedious and other devices or means are required. The structure from sound (SFS) approach addresses the problem of simultaneously localizing a set of microphones and a set of acoustic events that provides a great flexibility to calibrate different setups of microphone arrays. However, the existing method does not take measurement uncertainty into account and does not provide uncertainty estimates of the SFS results. In this paper, we propose a probabilistic structure from sound (PSFS) approach using the unscented transform in which the uncertainties of the PSFS results are also available. In addition, a probabilistic sound source localization approach using the PSFS results is provided to improve sound source localization accuracy. The ample results of simulation and experiments using low-cost, off-the-shelf microphones demonstrate the feasibility and performance of the proposed PSFS approach. © 2009 VSP.

关键词： Microphone array

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Detection of P, QRS, and T Components of ECG using wavelet transformation

Detection of P, QRS, and T Components of ECG using wavelet t...

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IEEE/ICME International Conference on Complex Medical engineering, CME

作者： Abed Al Raoof Bsoul Soo-Yeon Ji Kevin Ward Kayvan Najarian Department of Computer Science at Virginia Commonwealth University Richmond VA USA Department of Emergency Medicine at Virginia Commonwealth University and Associate Director of Virginia Commonwealth University Reanimation Engineering Shock Richmond VA USA Computer Science at the Virginia Commonwealth University and director of the Biomedical Signal Analysis program at Virginia Commonwealth University Reanimation Engineering Shock (VCURES) Richmond VA USA

Electrocardiogram (ECG) signals are composed of five important waves: P, Q, R, S, and T. Sometimes, a sixth wave (U) may follow T. Q, R, and S are grouped together to form the QRS-complex. Detection of these waves is a vital step in ECG signal analysis to extract hidden patterns. Many prior studies have focused only on detection of the QRS-complex, because P and T waves are sparse and harder to isolate from the signal. In this paper, we develop an algorithm to detect all five waves - P, Q, R, S, and T in ECG signals using wavelet transformation. The accuracy for P wave detection is 99.5%, 99.8% for QRS complex, and 99.2% for T waves.

关键词： Electrocardiography Electric shock computer science Signal analysis Heart rate detection Biomedical engineering Helium Cardiac disease Fibrillation Heart rate

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Hardware Architecture for Particle Swarm Optimization Using Floating-Point Arithmetic

Hardware Architecture for Particle Swarm Optimization Using ...

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International Conference on Intelligent Systems Design and Applications (ISDA)

作者： Daniel M. Muñoz Arboleda Carlos H. Llanos Leandro dos_S. Coelho Mauricio Ayala-Rincón Department of Mechanical Engineering University of Brasilia Brasília Brazil Industrial and Systems Engineering Graduate Program Pontificial Catholic University of Paraná Curitiba Brazil Departments of Computer Science and Mathematics University of Brasilia Brasília Brazil

High computational cost for solving large engineering optimization problems point out the design of parallel optimization algorithms. Population based optimization algorithms provide parallel capabilities that can be explored by their implementations done directly in hardware. This paper presents a hardware implementation of particle swarm optimization algorithms using an efficient floating-point arithmetic which performs the computations with high precision. All the architectures are parameterizable by bit-width, allowing the designer to choose the suitable format according to the requirements of the optimization problem. Synthesis and simulation results demonstrate that the proposed architecture achieves satisfactory results obtaining a better performance in therms of elapsed time than conventional software implementations.

关键词： Hardware Particle swarm optimization Floating-point arithmetic computer architecture Design optimization Computational efficiency Design engineering Algorithm design and analysis High performance computing Computational modeling

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Comparison of Different Approaches to ICP Dominated Pulse Extraction

Comparison of Different Approaches to ICP Dominated Pulse Ex...

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International Conference on Bioinformatics and Biomedical engineering (ICBBE)

作者： Peng Xu Shaozhi Wu Shadnaz Asgari Magdalena Kasprowicz Marvin Bergsneider Xiao Hu Center of Neuroinformatics School of Life Science and Technology University of Electronic Science and Technology Chengdu China Neural Systems and Dynamics Laboratory Department of Neurosurgery the David Geffen School of Medicine University of California Los Angeles USA School of Computer Science and Engineering University of Electronic Science and Technology Chengdu China Biomedical Engineering Graduate Program Henry Samueli School of Engineering and Applied Science University of California Los Angeles USA University of California Los Angeles Los Angeles CA US

Changes of ICP waveform morphology are characterized with different patients' states like hypertension, hydrocephalus and traumatic brain injury etc. Morphological clustering and analysis of ICP pulse (MOCAIP) approach is recently developed to extract ICP morphology feature, in which hierarchical clustering is used to extract the dominated pulse. In this paper, we evaluate the feasibility of using principle component analysis (PCA) and independent component analysis (ICA) to extract dominated pulse. The comparative study among clustering, PCA and ICP based approaches shows that PCA approach may be an alternative of clustering approach to extract dominated pulse in a faster fashion when dataset is of large size.

关键词： Independent component analysis Morphology Principal component analysis Biomedical engineering Feature extraction Electrocardiography Tellurium Hypertension Data mining Laboratories

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A distributed neural system for top-down face processing

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Neuroscience Letters 2009年第1期451卷 6-10页

作者： Li, Jun Liu, Jiangang Liang, Jimin Zhang, Hongchuan Zhao, Jizheng Huber, David E. Rieth, Cory A. Lee, Kang Tian, Jie Shi, Guangming Life Science Research Center School of Electronic Engineering Xidian University Xi'an Shaanxi 710071 China School of Computer and Information Technology Beijing Jiaotong University Beijing 1000441 China Institute of Automation Chinese Academy of Sciences Beijing 100190 China Developmental Cognitive Neuroscience Laboratory Northwestern University IL United States Department of Psychology University of California San Diego La Jolla CA United States Institute of Child Study University of Toronto Toronto Ont. Canada

Evidence suggests that the neural system associated with face processing is a distributed cortical network containing both bottom-up and top-down mechanisms. While bottom-up face processing has been the focus of many studies, the neural areas involved in the top-down face processing have not been extensively investigated due to difficulty in isolating top-down influences from the bottom-up response engendered by presentation of a face. In the present study, we used a novel experimental method to induce illusory face-detection. This method allowed for directly examining the neural systems involved in top-down face processing while minimizing the influence of bottom-up perceptual input. A distributed cortical network of top-down face processing was identified by analyzing the functional connectivity patterns of the right fusiform face area (FFA). This distributed cortical network model for face processing includes both "core" and "extended" face processing areas. It also includes left anterior cingulate cortex (ACC), bilateral orbitofrontal cortex (OFC), left dorsolateral prefrontal cortex (DLPFC), left premotor cortex, and left inferior parietal cortex. These findings suggest that top-down face processing contains not only regions for analyzing the visual appearance of faces, but also those involved in processing low spatial frequency (LSF) information, decision-making, and working memory. © 2008 Elsevier Ireland Ltd.

关键词： Distributed cortical network Face processing fMRI Psychophysiological interaction (PPI) Top-down processing

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Conditional IMS Learning Design Generation Using User Modeling and Planning Techniques

Conditional IMS Learning Design Generation Using User Modeli...

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International Conference on Advanced Learning Technologies (ICALT)

作者： Jorge Hernandez Silvia Baldiris Olga C. Santos Ramón Fabregat Jesus G. Boticario System Engineering Program Corporación Universitaria de la Costa Colombia Institute of Informatics and Aplications (IliA) Universidad de Girona Spain ADeNu Research Group Artificial Intelligence Department Computer Science School UNED (Spanish National University of Distance Education) Spain aDeNu Research Group Computer Science School UNED

Active modeling is required in learning settings to cope with the dynamic evolution of the knowledge, since learners competences evolves over time as they participate in the course activities. Moreover, one of the main issues in a competence based eLearning process is to deliver personalized instructional designs adjusted to both 1) intrinsic characteristics of users (i.e. learning styles) and 2) the desired and achieved competences in the learning process (i.e. specific and generic competences). This delivery includes the adaptation of the content and the activities in a learning scenario based on a dynamic user model that evolves according to user interactions. In this paper, an approach to support Conditional Plans Generation (IMS Learning Designs) in the context of a virtual learning environment is presented. The process is supported by a pervasive usage of standards and specifications (IMS family of specifications) in conjunction with an integral user modeling.

关键词： Learning Artificial intelligence Process planning Monitoring Technology planning Design engineering Knowledge engineering Systems engineering and theory Informatics computer science

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Learning a nonlinear color distance metric for the identification of skin immunohistochemical staining

Learning a nonlinear color distance metric for the identific...

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2009 22nd IEEE International Symposium on computer-Based Medical Systems, CBMS 2009

作者： Sobieranski, Antonio Carlos Neto, Sylvio Luiz Mantelli Coser, Leandro Comunello, Eros Von Wangenheim, Aldo Cargnin-Ferreira, Eduardo Di Giunta, Gabriella LAPIX Laboratory of Image Processing and Computer Graphics UFSC Federal University of Santa Catarina Brazil CPTEC Center for Weather Forecasts and Environment Studies INPE - Brazilian Institute for Space Research Brazil EGC Knowledge Engineering Department UFSC - Federal University of Santa Catarina Brazil MCA Graduate Program in Applied Computer Science UNIVALI - Itajai Valley University Brazil Laboratory of Histological Markers Department of Biology Embriology and Genetics UFSC - Federal University of Santa Catarina Brazil Pathology Service UFSC - Federal University of Santa Catarina Brazil

ISBN: (纸本)9781424448784

This paper presents a semiautomatic method for the identification of immunohistochemical (IHC) staining in digitized samples. The user trains the system by selecting on a sample image some typical positive stained regions that will be used as a reference for the construction of a distance metric. In this learning process, the global optimum is obtained by induction employing higher polynomial terms of the Mahalanobis distance, extracting nonlinear features of the IHC pattern distributions. The results of the proposed method showed a high correlation to a pathologist's manual analysis, which was used as a golden standard, presenting a more robust discrimination between stained and non-stained areas with little bias. © 2009 IEEE.

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