Let's Plays (or LPs) are recordings of video gameplay with commentary from the player, that are then shared online for others to view. The creation and sharing of Let's Play content has grown significantly ove...
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With the gradual realization of manned spaceflight goals, the physical and mental health of astronauts has become a core concern. Numerous studies in recent years have indicated that the aerospace special environment ...
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ISBN:
(数字)9798350371499
ISBN:
(纸本)9798350371505
With the gradual realization of manned spaceflight goals, the physical and mental health of astronauts has become a core concern. Numerous studies in recent years have indicated that the aerospace special environment (ASE) can lead to alterations in astronaut cognitive function. However, the adaptive changes in neuronal activity underlying these alterations remain unclear. This study utilized animal models and two-photon imaging technology to investigate the adaptive changes in the activity characteristics and synchronicity of pyramidal neurons in the CA1 region of the mice hippocampus under simulated spaceflight composite environment (SSCE). The results indicate that, with prolonged modeling time, the number of active pyramidal neurons in the CA1 region gradually decreases. Significant reductions in both the frequency and amplitude of neuronal calcium transients occur, stabilizing at lower levels. The calcium transient decay constant extends, and significant decorrelation in neuronal calcium activity is observed. Thus, we posit that these changes may constitute crucial factors leading to the alterations in individual cognitive function induced by the aerospace special environment.
Training Large Language Models (LLMs) from scratch requires immense computational resources, making it prohibitively expensive. Model scaling-up offers a promising solution by leveraging the parameters of smaller mode...
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While interest in blending sound with culinary experiences has grown in human-Food interaction (HFI), the significance of food's material properties in shaping sound-related interactions has largely been overlooke...
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Across all fields of academic study, well-respected experts cite their sources when sharing information. While large language models (LLMs) excel at synthesizing information, they do not provide reliable citation to s...
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Across all fields of academic study, well-respected experts cite their sources when sharing information. While large language models (LLMs) excel at synthesizing information, they do not provide reliable citation to sources, making it difficult to trace and verify the origins of the information they present. In contrast, search engines make sources readily accessible to users and place the burden of synthesizing information on the user. Through a survey, we find that users prefer search engines over LLMs for high-stakes queries, where concerns regarding information provenance outweigh the perceived utility of LLM responses. To rigorously examine the interplay between the verifiability and utility of information-sharing tools, we introduce the extractive-abstractive spectrum, in which search engines and LLMs are extreme endpoints encapsulating multiple unexplored intermediate operating points. Search engines are extractive because they respond to queries with snippets of sources with links (citations) to the original webpages. LLMs are abstractive because they address queries with answers that synthesize and logically transform relevant information from training and in-context sources without reliable citation. We define five operating points that span the extractive-abstractive spectrum and conduct human evaluations on seven systems across four diverse query distributions that reflect real-world QA settings: web search, language simplification, multi-step reasoning, and medical advice. As outputs become more abstractive, we find that perceived utility improves by as much as 200%, while the proportion of properly cited sentences decreases by as much as 50% and users take up to 3 times as long to verify cited information. Our findings recommend distinct operating points for different domain-specific LLM systems. Additionally, our failure analysis informs strategies for citation identification following generation, information retrieval tasks specific to citations, and
Hip fractures is the most common hip clinical trauma. The majority of elderly patients experience a decrease in bone density due to osteoporosis, making them highly prone to various types of hip fractures. In this con...
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In this paper, we proposed MAGNET, a novel modality-agnostic network for 3D medical image segmentation. Different from existing learning methods, MAGNET is specifically designed to handle real medical situations where...
In this paper, we proposed MAGNET, a novel modality-agnostic network for 3D medical image segmentation. Different from existing learning methods, MAGNET is specifically designed to handle real medical situations where multiple modalities/sequences are available during model training, but fewer ones are available or used at time of clinical practice. Our results on multiple datasets show that MAGNET trained on multi-modality data has the unique ability to perform predictions using any subset of training imaging modalities. It outperforms individually trained uni-modality models while can further boost performance when more modalities are available at testing.
During recent years multiple studies focused on how to mediate the intimacy of couples over distance by researching various intimacy aspects, such as physical contact and disclosure. At the same time, mediating intima...
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ISBN:
(纸本)9781450395984
During recent years multiple studies focused on how to mediate the intimacy of couples over distance by researching various intimacy aspects, such as physical contact and disclosure. At the same time, mediating intimacy for co-located couples remains relatively unexplored. Our paper focuses on this and presents an empirical field study involving 13 co-located couples that interacted with a technology probe titled ‘Shaping Romance’. In short, our qualitative findings show that technology can mediate intimacy by allowing partners to look inwards and reflect on their own desires, look outwards and reflect on the desires of their partner, and look at the whole by remembering, acting and validating. Our contributions to HCI are the technological intervention itself, our findings which highlight limitations and opportunities technology has for mediating the intimacy of co-located couples, and a design space full of dilemmas that we present for future researchers and designers.
Exploring new effective treatments for depression holds important social significance and clinical value. Low-intensity focused ultrasound stimulation (LIFUS) has been proven to have significant neuroprotective effect...
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ISBN:
(数字)9798350371499
ISBN:
(纸本)9798350371505
Exploring new effective treatments for depression holds important social significance and clinical value. Low-intensity focused ultrasound stimulation (LIFUS) has been proven to have significant neuroprotective effects on depression. However, the specific genes regulated by LIFUS in depressive mice remain unclear. We established a depression mice model using chronic restraint stress (CRS) and applied LIFUS to the medial prefrontal cortex (mPFC) following CRS. We explored the impact of modeling and treatment on gene expression changes through transcriptomics, revealing that the therapeutic effect of LIFUS may be associated with the improvement of the activity of calcium signaling pathway and synaptic plasticity. The study provides preclinical evidence and a theoretical basis for applying LIFUS for depression treatment.
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