Predicting RNA binding protein(RBP) binding sites on circular RNAs(circ RNAs) is a fundamental step to understand their interaction mechanism. Numerous computational methods are developed to solve this problem, but th...
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Predicting RNA binding protein(RBP) binding sites on circular RNAs(circ RNAs) is a fundamental step to understand their interaction mechanism. Numerous computational methods are developed to solve this problem, but they cannot fully learn the features. Therefore, we propose circ-CNNED, a convolutional neural network(CNN)-based encoding and decoding framework. We first adopt two encoding methods to obtain two original matrices. We preprocess them using CNN before fusion. To capture the feature dependencies, we utilize temporal convolutional network(TCN) and CNN to construct encoding and decoding blocks, respectively. Then we introduce global expectation pooling to learn latent information and enhance the robustness of circ-CNNED. We perform circ-CNNED across 37 datasets to evaluate its effect. The comparison and ablation experiments demonstrate that our method is superior. In addition, motif enrichment analysis on four datasets helps us to explore the reason for performance improvement of circ-CNNED.
All the software products developed will need testing to ensure the quality and accuracy of the product. It makes the life of testers much easier when they can optimize on the effort spent and predict defects for the ...
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Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and t...
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Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.
Generative Artificial Intelligence (GenAI) models such as LLMs, GPTs, and Diffusion Models have recently gained widespread attention from both the research and the industrial communities. This survey explores their ap...
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Background: Sugarcane, an essential commodity for the global sugar industry, is very vulnerable to several illnesses that significantly impact its output and quality. Methods: The study uses Spatial Relation Assisted ...
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Task management and energy efficiency have grown increasingly crucial in cloud computing environments. Effective job scheduling is essential to maximizing resource usage and overall efficiency in cloud computing. Howe...
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Children's nutrition is an essential determinant of their development, so there is a need to forecast their food consumption adequately. This work presents a model for assessing children's nutritional intake l...
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This research introduces an advanced model architecture for chronic disease detection, leveraging highly developed artificial intelligence algorithms. The prototype combines the Convolutional Neural Network (CNN) and ...
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The Internet of Things (IoT) transforms connectivity, enabling devices to share data seamlessly via the cloud or wireless networks. However, IoT systems remain vulnerable to sophisticated cyberattacks, and traditional...
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Intrusion Detection Systems (IDS) have grown to be essential to network and computer security. However, it complicates the training phase and makes it time-consuming to detect vulnerabilities in data sharing on the ne...
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