检索结果-内蒙古大学图书馆

Estimating the volume of penumbra in rodents using DTI and stack-based ensemble machine learning framework

European Radiology Experimental 2024年第1期8卷 59页

作者： Kuo, Duen-Pang Chen, Yung-Chieh Li, Yi-Tien Cheng, Sho-Jen Hsieh, Kevin Li-Chun Kuo, Po-Chih Ou, Chen-Yin Chen, Cheng-Yu Department of Medical Imaging Taipei Medical University Hospital No.250 Wu Hsing Street Taipei Taiwan Translational Imaging Research Center Taipei Medical University Hospital Taipei Taiwan Research Center for Neuroscience Taipei Medical University Taipei Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Computer Science National Tsing Hua University Hsinchu Taiwan Research Center for Artificial Intelligence in Medicine Taipei Medical University Taipei Taiwan Department of Radiology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Radiology National Defense Medical Center Taipei Taiwan

Background: This study investigates the potential of diffusion tensor imaging (DTI) in identifying penumbral volume (PV) compared to the standard gadolinium-required perfusion–diffusion mismatch (PDM), utilizing a stack-based ensemble machine learning (ML) approach with enhanced explainability. Methods: Sixteen male rats were subjected to middle cerebral artery occlusion. The penumbra was identified using PDM at 30 and 90 min after occlusion. We used 11 DTI-derived metrics and 14 distance-based features to train five voxel-wise ML models. The model predictions were integrated using stack-based ensemble techniques. ML-estimated and PDM-defined PVs were compared to evaluate model performance through volume similarity assessment, the Pearson correlation analysis, and Bland–Altman analysis. Feature importance was determined for explainability. Results: In the test rats, the ML-estimated median PV was 106.4 mL (interquartile range 44.6–157.3 mL), whereas the PDM-defined median PV was 102.0 mL (52.1–144.9 mL). These PVs had a volume similarity of 0.88 (0.79–0.96), a Pearson correlation coefficient of 0.93 (p < 0.001), and a Bland–Altman bias of 2.5 mL (2.4% of the mean PDM-defined PV), with 95% limits of agreement ranging from -44.9 to 49.9 mL. Among the features used for PV prediction, the mean diffusivity was the most important feature. Conclusions: Our study confirmed that PV can be estimated using DTI metrics with a stack-based ensemble ML approach, yielding results comparable to the volume defined by the standard PDM. The model explainability enhanced its clinical relevance. Human studies are warranted to validate our findings. Relevance statement: The proposed DTI-based ML model can estimate PV without the need for contrast agent administration, offering a valuable option for patients with kidney dysfunction. It also can serve as an alternative if perfusion map interpretation fails in the clinical setting. Key points: • Penumbral volume can be estimated by DTI combi

关键词： Animals Diffusion tensor imaging Infarction (middle cerebral artery) Ischemic stroke Machine learning

来源：评论

学校读者我要写书评

暂无评论

Spectral learning of shared dynamics between generalized-linear processes 24

Spectral learning of shared dynamics between generalized-lin...

引用

Proceedings of the 38th International Conference on Neural Information Processing Systems

作者： Lucine L. Oganesian Omid G. Sani Maryam M. Shanechi Ming Hsieh Department of Electrical and Computer Engineering University of Southern California Los Angeles CA Ming Hsieh Department of Electrical and Computer Engineering Thomas Lord Department of Computer Science Alfred E. Mann Department of Biomedical Engineering Neuroscience Graduate Program University of Southern California Los Angeles CA

ISBN: (纸本)9798331314385

Generalized-linear dynamical models (GLDMs) remain a widely-used framework within neuroscience for modeling time-series data, such as neural spiking activity or categorical decision outcomes. Whereas the standard usage of GLDMs is to model a single data source, certain applications require jointly modeling two generalized-linear time-series sources while also dissociating their shared and private dynamics. Most existing GLDM variants and their associated learning algorithms do not support this capability. Here we address this challenge by developing a multi-step analytical subspace identification algorithm for learning a GLDM that explicitly models shared vs. private dynamics within two generalized-linear time-series. In simulations, we demonstrate our algorithm's ability to dissociate and model the dynamics within two time-series sources while being agnostic to their respective observation distributions. In neural data, we consider two specific applications of our algorithm for modeling discrete population spiking activity with respect to a secondary time-series. In both synthetic and real data, GLDMs learned with our algorithm more accurately decoded one time-series from the other using lower-dimensional latent states, as compared to models identified using existing GLDM learning algorithms.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Convergent effects of peptides on the initiation of feeding motor programs in the mollusk Aplysia

引用

Journal of Neurophysiology 2025年第5期133卷 1368-1379页

作者： Evans, Colin G. Barry, Michael A. Reaver, Carrie N. Patel, Paras R. Chestek, Cynthia A. Perkins, Matthew H. Jing, Jian Cropper, Elizabeth C. Department of Neuroscience Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York NY United States Department of Biomedical Engineering Biointerfaces Institute University of Michigan Ann Arbor MI United States Department of Electrical Engineering and Computer Science Neurosciences Program Robotics Program University of Michigan Ann Arbor MI United States State Key Laboratory of Pharmaceutical Biotechnology Institute for Brain Sciences Chemistry and Biomedicine Innovation Center Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology Advanced Institute for Life Sciences School of Life Sciences Nanjing University Nanjing China

Neuropeptides configure the feeding network of Aplysia. For example, egestive activity is promoted by small cardioactive peptide (SCP), and ingestive activity is promoted by a combination of feeding circuit activating peptide (FCAP) and cerebral peptide 2 (CP-2). In addition, SCP and FCAP/CP-2 have a common network effect that does not contribute to motor program specification. They increase the excitability of an interneuron, B63. In this report, we further characterized the effects of peptides on B63. We performed voltage-clamp experiments and used a step protocol to look at steady-state currents. We found that SCP and FCAP/CP-2 both induced an inward current that was virtually absent in low-sodium saline. Previous work has established that B63 is unusual in the feeding circuit in that subthreshold depolarizations are autonomously generated that can trigger motor programs. Here, we show that this autonomous activity is more frequent in the presence of peptides. Previous studies have also shown that activity of the feeding central pattern generator (CPG) can be initiated by neurons that excite B63, e.g., by cerebral buccal interneuron 2 (CBI-2), a projection neuron that triggers biting-like motor programs. Here, we show that the latency of CBI-2-induced activity is decreased by stimulation of the esophageal nerve (EN) (which releases endogenous SCP). These results, taken together with previous results, indicate that peptides that act divergently to configure network activity additionally act convergently to promote motor program induction. We present data that suggest that this arrangement facilitates brief switches between ingestive and egestive motor activity. © 2025 The Authors.

关键词： central pattern generator invertebrate modulation motor program neuropeptide

来源：评论

学校读者我要写书评

暂无评论

Machines Develop Consciousness Through Autonomous programming for General Purposes (APFGP) 1

引用

2nd International Workshop on Human Brain and Artificial Intelligence, HBAI 2020 held in Conjunction with IJCAI-PRICAI 2020

作者： Weng, Juyang Department of Computer Science Cognitive Science Program Neuroscience Program Michigan State University East LansingMI48824 United States GENISAMA LLC OkemosMI48864 United States

ISBN: (数字)9789811612886

ISBN: (纸本)9789811612879

Consider a question, "Can machines be conscious?" The subject "consciousness" is vague and challenging. Although there has been a rich collection of literature on consciousness, computational modeling of consciousness that is both holistic in scope and detailed in simulatable computation is lacking. Based on recent advances on a new capability—Autonomous programming For General Purposes (APFGP)—this work presents APFGP as a clearer, deeper and more practical characterization of consciousness, for natural (biological) and artificial (machine) systems. All animals have APFGP but traditional AI systems do not. This work reports a new kind of AI systems—conscious machines. Instead of arguing what static tasks a conscious machine should be able to do, this work suggests that APFGP is a computationally clearer and necessary criterion for us to dynamically judge whether a system can become maturely conscious through lifelong development, even if it (e.g., a fruit fly) does not have a full array of primate like capabilities such as vision, audition, and natural language understanding. The results here involve a series of new concepts and experimental studies for vision, audition, and natural languages with new developmental capabilities that are not present in many published systems, e.g., IBM Deep Blue, IBM Watson, AlphaGo, AlphaFold and other traditional AI systems and intelligent robots. © 2021, Springer Nature Singapore Pte Ltd.

关键词： Audition

来源：评论

学校读者我要写书评

暂无评论

Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision

引用

Light(science & Applications) 2022年第11期11卷 2817-2831页

作者： Yueming Li Ying Jiang Lu Lan Xiaowei Ge Ran Cheng Yuewei Zhan Guo Chen Linli Shi Runyu Wang Nan Zheng Chen Yang Ji-Xin Cheng Department of Mechanical Engineering Boston UniversityBostonMA 02215USA Graduate Program for Neuroscience Boston UniversityBostonMA 02215USA Department of Electrical and Computer Engineering Boston UniversityBostonMA 02215USA Department of Chemistry Boston UniversitBostonMA 02215USA Department of Biomedical Engineering Boston UniversityBostonMA 02215USA Division of Materials Science and Engineering Boston UniversityBostonMA 02215USA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02142USA

High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological *** non-invasive neuromodulation methods offer limited precision at the milimeter ***,we report opticallygenerated focused ultrasound(OFUS)for non-invasive brain stimulation with ultrahigh *** is generated by a soft optoacoustic pad(SOAP)fabricated through embedding candle soot nanoparticles in a curved polydimethylsiloxane *** generates a transcranial ultrasound focus at 15 MHz with an ultrahigh lateral resolution of 83μm,which is two orders of magnitude smaller than that of conventional transcranial-focused ultrasound(tFUS).Here,we show effective OFUS neurostimulation in vitro with a single ultrasound *** demonstrate submillimeter transcranial stimulation of the mouse motor cortex in *** acoustic energy of 0.6 mJ/cm?,four orders of magnitude less than that of tFUS,is suffcient for successful OFUS *** offers new capabilities for neuroscience studies and disease treatments by delivering a focus with ultrahigh precision noninvasively.

关键词： SOAP stimulation precision

来源：评论

学校读者我要写书评

暂无评论

Learning Linear Embeddings for Non-Linear Network Dynamics with Koopman Message Passing

arXiv

引用

arXiv 2023年

作者： Yeh, King Fai Flood, Paris Redman, William Liò, Pietro Department of Computer Science and Technology University of Cambridge United Kingdom Interdepartmental Graduate Program in Dynamical Neuroscience University of California Santa Barbara United States

Recently, Koopman operator theory has become a powerful tool for developing linear representations of non-linear dynamical systems. However, existing data-driven applications of Koopman operator theory, including both traditional and deep learning approaches, perform poorly on nonlinear network dynamics problems as they do not address the underlying geometric structure. In this paper we present a novel approach based on Koopman operator theory and message passing networks that finds a linear representation for the dynamical system which is globally valid at any time step. The linearisations found by our method produce predictions on a suite of network dynamics problems that are several orders of magnitude better than current state-of-the-art techniques. We also apply our approach to the highly non-linear training dynamics of neural network architectures, and obtain linear representations which can generate network parameters with comparable performance to networks trained by classical optimisers. © 2023, CC BY.

关键词： Network architecture

来源：评论

学校读者我要写书评

暂无评论

The Effect of Major Depressive Disorder on Producing Intelligible Speech

SSRN

引用

SSRN 2024年

作者： Seneviratne, Nadee Li, Leslie Espy-Wilson, Carol Department of Electrical and Computer Engineering University of Maryland College ParkMD20740 United States Program in Neuroscience and Cognitive Science Department of Linguistics University of Maryland College ParkMD20740 United States

Understanding the characteristics of depressed speech can provide insights on aspects to consider when developing biomarkers for automatic depression detection systems. We present the results of a speech intelligibility study that was conducted to assess the intelligibility of the speech of a female and a male subject when they were severely depressed and when they were in remission. Our analysis shows that, in general, the depressed speech is at least as intelligible as in-remission speech. This is further supported by the underlying "simpler" articulatory coordination of depressed speech as derived from the Articulatory Coordination Features. Acoustically, the simpler articulatory coordination means that there is less variability due to coarticulation in the speech signal. © 2024, The Authors. All rights reserved.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Unveiling Population Heterogeneity in Health Risks Posed by Environmental Hazards Using Regression-Guided Neural Network

arXiv

引用

arXiv 2024年

作者： Nam, Jong Woo Choi, Eun Young Ailshire, Jennifer A. Chiang, Yao-Yi Neuroscience Graduate Program University of Southern California United States Leonard Davis School of Gerontology University of Southern California United States Department of Computer Science and Engineering University of Minnesota United States

Environmental hazards place certain individuals at disproportionately higher risks. As these hazards increasingly endanger human health, precise identification of the most vulnerable population subgroups is critical for public health. Moderated multiple regression (MMR) offers a straightforward method for investigating this by adding interaction terms between the exposure to a hazard and other population characteristics to a linear regression model. However, when the vulnerabilities are hidden within a cross-section of many characteristics, MMR is often limited in its capabilities to find any meaningful discoveries. Here, we introduce a hybrid method, named regression-guided neural networks (ReGNN), which utilizes artificial neural networks (ANNs) to non-linearly combine predictors, generating a latent representation that interacts with a focal predictor (i.e. variable measuring exposure to an environmental hazard). We showcase the use of ReGNN for investigating the population heterogeneity in the health effects of exposure to air pollution (PM2.5) on cognitive functioning scores. We demonstrate that population heterogeneity that would otherwise be hidden using traditional MMR can be found using ReGNN by comparing its results to the fit results of the traditional MMR models. In essence, ReGNN is a novel tool that enhances traditional regression models by effectively summarizing and quantifying an individual’s susceptibility to health risks. © 2024, CC BY-NC-SA.

关键词： Multiple linear regression

来源：评论

学校读者我要写书评

暂无评论

Human intracortical responses to varying electrical stimulation conditions are separable in low-dimensional subspaces

Human intracortical responses to varying electrical stimulat...

引用

2022 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2022

作者： Sun, Samantha Levinson, Lila H. Paschall, Courtnie J. Herron, Jeffrey Weaver, Kurt Hauptman, Jason Ko, Andrew Ojemann, Jeffrey Rao, Rajesh P. N. University of Washington Paul G. Allen School of Computer Science & Engineering Department of Bioengineering SeattleWA98195 United States University of Washington Graduate Program in Neuroscience Paul G. Allen School of Computer Science & Engineering SeattleWA98195 United States University of Washington Paul G. Allen School of Computer Science & Engineering Department of Neurological Surgery SeattleWA98195 United States University of Washington Paul G. Allen School of Computer Science & Engineering Department of Radiology SeattleWA98195 United States

ISBN: (数字)9781665452588

ISBN: (纸本)9781665452588

Electrical stimulation is a powerful tool for targeted neurorehabilitation, and recent work in adaptive stimulation where stimulation can be adjusted in real-time has shown promise in improving stimulation outcomes and reducing stimulation-induced side effects. Mapping the relationship between electrical stimulation input and neural activity response can help reveal their interactions and can give us tools to iterate and improve on our stimulation protocols. Here, we introduce methods for identifying low-dimensional subspaces of human intracortical responses to electrical stimulation in invasive electroencephalography. In epilepsy patients (n=4) undergoing clinical monitoring, we applied a stimulation protocol of varying amplitude and frequency in 5-second intervals to capture a range of responses to different stimulation conditions. We characterized these responses using time-frequency spectral power, applied baseline subtraction and outlier removal procedures, and performed principal component analysis across frequencies. We identified that intracortical responses to different stimulation conditions can be represented in a 3-dimensional subspace, accounting for more than 95% of the variance. Using support vector machine classification, we demonstrated separability of intracortical responses in different stimulation conditions across subjects, where this separability was contingent on applying baseline subtraction and outlier removal. Our results represent a first step towards building a predictive model of neural response from stimulation input, an important prerequisite for adaptive closed-loop stimulation for targeted neurorehabilitation. © 2022 IEEE.

关键词： Electroencephalography

来源：评论

学校读者我要写书评

暂无评论

Joint Source Decomposition of Concurrent EEG-FMRI Data in Epilepsy and Control Groups

Joint Source Decomposition of Concurrent EEG-FMRI Data in Ep...

引用

IEEE International Symposium on Biomedical Imaging

作者： J. Mason Harding Haatef Pourmotabbed Yamin Li Kimberly Rogge-Obando Kate Wang Sarah E. Goodale Shiyu Wang Camden Bibro Bergen Allee Caroline Martin Victoria L. Morgan Dario J. Englot Catie Chang Department of Electrical and Computer Engineering Vanderbilt University Department of Biomedical Engineering Vanderbilt University Department of Computer Science Vanderbilt University Neuroscience Graduate Program Vanderbilt University Vanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center Department of Neurological Surgery Vanderbilt University Medical Center Department of Radiology Vanderbilt University Medical Center

ISBN: (数字)9798331520526

ISBN: (纸本)9798331520533

EEG and fMRI are complementary, noninvasive technologies for investigating human brain function. These modalities have been used to uncover large-scale functional networks and their disruptions in clinical populations. Given the high temporal resolution of EEG and high spatial resolution of fMRI, integrating these modalities can provide a more holistic understanding of brain activity. This work explores a multimodal source decomposition technique for extracting shared modes of temporal variation between fMRI BOLD signals and EEG spectral power fluctuations in the resting state. The resulting components are then compared between patients with focal epilepsy and controls, revealing multimodal network differences between groups.

关键词： Neuroimaging Brain Fluctuations Epilepsy Functional magnetic resonance imaging Electroencephalography Pattern recognition Hemodynamics Spatial resolution Signal resolution

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：