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UAV-Aided data Acquisition Using Gaining-Sharing Knowledge Optimization Algorithm

computers, Materials & Continua 2022年第9期72卷 5999-6013页

作者： Rania M Tawfik Hazem A.A.Nomer M.Saeed Darweesh Ali Wagdy Mohamed Hassan Mostafa Wireless Intelligent Networks Center(WINC) School of Engineering and Applied SciencesNile UniversityGiza12677Egypt School of Information Technology and Computer Science(ITCS) Nile UniversityGiza12677Egypt Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Department of Mathematics and Actuarial Science School of Science and EngineeringThe American University in CairoEgypt Electronics and Communications Engineering Department Cairo UniversityEgypt University of Science and Technology Nanotechnology and Nanoelectronics ProgramZewal City of Science and TechnologyOctober Gardens6th of OctoberGiza12578Egypt

Unmanned Aerial Vehicles(UAVs)provide a reliable and energyefficient solution for data collection from the Narrowband Internet of Things(NB-IoT)***,the UAV’s deployment optimization,including locations of the UAV’s stop points,is a necessity to minimize the energy consumption of the UAV and the NB-IoT devices and also to conduct the data collection *** this regard,this paper proposes GainingSharing Knowledge(GSK)algorithm for optimizing the UAV’s *** GSK,the number of UAV’s stop points in the three-dimensional space is encapsulated into a single individual with a fixed length representing an entire *** superiority of using GSK in the tackled problem is verified by simulation in seven *** provides significant results in all seven scenarios compared with other four optimization algorithms used before with the same ***,the NB-IoT is proposed as the wireless communication technology between the UAV and IoT devices.

关键词： NB-IoT UAV GSK stop points optimization

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Performance of multimodal prediction models for intracerebral hemorrhage outcomes using real-world data

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International Journal of Medical Informatics 2025年 202卷 105989-105989页

作者： Matsumoto, Koutarou Suzuki, Masahiro Ishihara, Kazuaki Tokunaga, Koki Matsuda, Katsuhiko Chen, Jenhui Yamashiro, Shigeo Soejima, Hidehisa Nakashima, Naoki Kamouchi, Masahiro Department of Health Care Administration and Management of Medical Sciences Kyushu University Fukuoka Japan Graduate Degree Program of Applied Data Sciences Sophia University Tokyo Japan Department of Computer Science and Information Engineering Chang Gung University Taoyuan Taiwan Department of Pharmacy Saiseikai Kumamoto Hospital Kumamoto Japan Department of Radiology Saiseikai Kumamoto Hospital Kumamoto Japan Division of Neurosurgery Saiseikai Kumamoto Hospital Kumamoto Japan Institute for Medical Information Research and Analysis Saiseikai Kumamoto Hospital Kumamoto Japan Medical Information Center Kyushu University Hospital Fukuoka Japan Department of Medical Informatics of Medical Sciences Kyushu University Fukuoka Japan Center for Cohort Studies of Medical Sciences Kyushu University Fukuoka Japan

Background: We aimed to develop and validate multimodal models integrating computed tomography (CT) images, text and tabular clinical data to predict poor functional outcomes and in-hospital mortality in patients with intracerebral hemorrhage (ICH). These models were designed to assist non-specialists in emergency settings with limited access to stroke specialists. Methods: A retrospective analysis of 527 patients with ICH admitted to a Japanese tertiary hospital between April 2019 and February 2022 was conducted. Deep learning techniques were used to extract features from three-dimensional CT images and unstructured data, which were then combined with tabular data to develop an L1-regularized logistic regression model to predict poor functional outcomes (modified Rankin scale score 3–6) and in-hospital mortality. The model's performance was evaluated by assessing discrimination metrics, calibration plots, and decision curve analysis (DCA) using temporal validation data. Results: The multimodal model utilizing both imaging and text data, such as medical interviews, exhibited the highest performance in predicting poor functional outcomes. In contrast, the model that combined imaging with tabular data, including physiological and laboratory results, demonstrated the best predictive performance for in-hospital mortality. These models exhibited high discriminative performance, with areas under the receiver operating curve (AUROCs) of 0.86 (95% CI: 0.79–0.92) and 0.91 (95% CI: 0.84–0.96) for poor functional outcomes and in-hospital mortality, respectively. Calibration was satisfactory for predicting poor functional outcomes, but requires refinement for mortality prediction. The models performed similar to or better than conventional risk scores, and DCA curves supported their clinical utility. Conclusion: Multimodal prediction models have the potential to aid non-specialists in making informed decisions regarding ICH cases in emergency departments as part of clinical dec

关键词： Logistic regression

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Comparative Analysis of Machine Learning Models for Customer Churn Prediction in the U.S. Banking and Financial Services: Economic Impact and Industry-Specific Insights

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Journal of data Analysis and Information Processing 2024年第3期12卷 388-418页

作者： Omoshola S. Owolabi Prince C. Uche Nathaniel T. Adeniken Oghenekome Efijemue Samuel Attakorah Oluwabukola G. Emi-Johnson Emmanuel Hinneh Department of Data Science Carolina University Winston-Salem NC USA Department of Computer Science Austin Peay State University Clarkesville TN USA Department of Statistical Sciences Wake Forest University Winston-Salem NC USA

Customer churn poses a significant challenge for the banking and finance industry in the United States, directly affecting profitability and market share. This study conducts a comprehensive comparative analysis of machine learning models for customer churn prediction, focusing on the U.S. context. The research evaluates the performance of logistic regression, random forest, and neural networks using industry-specific datasets, considering the economic impact and practical implications of the findings. The exploratory data analysis reveals unique patterns and trends in the U.S. banking and finance industry, such as the age distribution of customers and the prevalence of dormant accounts. The study incorporates macroeconomic factors to capture the potential influence of external conditions on customer churn behavior. The findings highlight the importance of leveraging advanced machine learning techniques and comprehensive customer data to develop effective churn prevention strategies in the U.S. context. By accurately predicting customer churn, financial institutions can proactively identify at-risk customers, implement targeted retention strategies, and optimize resource allocation. The study discusses the limitations and potential future improvements, serving as a roadmap for researchers and practitioners to further advance the field of customer churn prediction in the evolving landscape of the U.S. banking and finance industry.

关键词： Churn Prediction Machine Learning Economic Impact Industry-Specific Insights Logistic Regression Random Forest Neural Networks

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Decision fusion of circulating markers for breast cancer detection in premenopausal women

Decision fusion of circulating markers for breast cancer det...

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7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE

作者： Jesneck, Jonathan L. Mukherjee, Sayan Nolte, Loren W. Lokshin, Anna E. Marks, Jeffrey R. Lo, Joseph Department of Biomedical Engineering Department of Statistical Science Computational Biology and Bioinformatics Program Duke Advanced Imaging Labs. Institute for Genome Sciences and Policy Department of Computer Science Duke University Department of Electrical and Computer Engineering Division of Hematology/Oncology University of Pittsburgh School of Medicine University of Pittsburgh Cancer Institute Pittsburgh PA 15213 United States Department of Experimental Surgery Duke University Medical Center Medical Physics Graduate Program Duke University Durham NC 27708 United States

ISBN: (纸本)1424415098

Current mammographic screeningfor breast cancer is less effective for younger women. To complement mammography for premenopausal women, we investigated the feasibility screening test using 98 blood serum proteins. Because the data set was very noisy and contained only weak features, we used a classifier designed for noisy data: decision fusion. Decision fusion outperformed both a support vector machine (SVM) and linear regression with forward stepwise feature selection on all three two-class classification tasks: normal tissue vs. cancer, normal tissue vs. benign lesions, and benign lesions vs. cancer. Decision fusion detected cancer moderately well (AUC=0.84 on normal vs. cancer), demonstrating promise as a screening tool. Decision fusion also detected benign lesions similarly well (AUC=0.83 on normal vs. benign lesions) and was the only classifier to achieve any success in separating benign from malignant lesions (AUC=0.64 on benign vs. cancer). The classification results suggest that the assayed proteins are more indicative of a secondary effect, such as immune response, rather than specific for breast cancer. In conclusion, the decision fusion classifier demonstrated some promise in detecting breast lesions and outperformed other classifiers, especially for the very noisy classification problem of distinguishing benign from malignant lesions. ©2007 IEEE.

关键词： Tissue

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Tractably modelling dependence in networks beyond exchangeability

arXiv

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arXiv 2020年

作者： Wu, Weichi Olhede, Sofia Wolfe, Patrick Center for Statistical Sciences Department of Industrial Engineering Tsinghua University China Institute of Mathematics Chair of Statistical Data Science EPFL Swaziland Departments of Statistics and Computer Science Purdue University United States

We propose a general framework for modelling network data that is designed to describe aspects of non-exchangeable networks. Conditional on latent (unobserved) variables, the edges of the network are generated by their finite growth history (with latent orders) while the marginal probabilities of the adjacency matrix are modeled by a generalization of a graph limit function (or a graphon). In particular, we study the estimation, clustering and degree behavior of the network in our setting. We determine (i) the minimax estimator of a composite graphon with respect to squared error loss;(ii) that spectral clustering is able to consistently detect the latent membership when the block-wise constant composite graphon is considered under additional conditions;and (iii) we are able to construct models with heavy-tailed empirical degrees under specific scenarios and parameter choices. This explores why and under which general conditions non-exchangeable network data can be described by a stochastic block model. The new modelling framework is able to capture empirically important characteristics of network data such as sparsity combined with heavy tailed degree distribution, and add understanding as to what generative mechanisms will make them *** Codes 62G05, 62R07, 62E20, 62G20, secondary 53C20 Copyright © 2020, The Authors. All rights reserved.

关键词： Clustering algorithms

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Advising big data transfer over dedicated connections based on profiling optimization

Advising big data transfer over dedicated connections based ...

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作者： Yun, Daqing Wu, Chase Q. Rao, Nageswara S. V. Kettimuthu, Rajkumar Computer and Information Sciences Program Harrisburg University HarrisburgPA17101 United States Department of Computer Science New Jersey Institute of Technology NewarkNJ07102 United States Computer Science and Mathematics Division Oak Ridge National Laboratory Oak RidgeTN37831 United States Data Science and Learning Division Argonne National Laboratory ArgonneIL60439 United States

Big data transfer in next-generation scientific applications is now commonly carried out over dedicated channels in high-performance networks (HPNs), where transport protocols play a critical role in maximizing application-level throughput. Optimizing the performance of these protocols is challenging: i) transport protocols perform differently in various network environments, and the protocol choice is not straightforward;ii) even for a given protocol in a given environment, different parameter settings of the protocol may lead to significantly different performance and oftentimes the default setting does not yield the best performance. However, it is prohibitively time-consuming to conduct exhaustive transport profiling due to the large parameter space. In this paper, we propose a PRofiling Optimization Based data Transfer Advisor (Probdata) to help end users determine the most effective transport method with the most appropriate parameter settings to achieve satisfactory performance for big data transfer over dedicated connections in HPNs. Probdata employs a fast profiling scheme based on the Simultaneous Perturbation Stochastic Approximation algorithm, namely, FastProf, to accelerate the exploration of the optimal operational zones of various transport methods to improve profiling efficiency. We first present a theoretical background of the optimized profiling approach in Probdata and then detail its design and implementation. The advising procedure and performance benefits of FastProf and Probdata are illustrated and evaluated by both extensive emulations based on real-life performance measurements and experiments over various physical connections in existing production HPNs. © 1993-2012 IEEE.

关键词： data transfer

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HOW MANY DIRECTIONS DETERMINE A SHAPE AND OTHER SUFFICIENCY RESULTS FOR TWO TOPOLOGICAL TRANSFORMS

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Transactions of the American Mathematical Society Series B 2022年第32期9卷 1006-1043页

作者： Curry, Justin Mukherjee, Sayan Turner, Katharine Department of Mathematics and Statistics University at Albany SUNY Albany 12222 NY United States Departments of Statistical Science Mathematics Computer Science Biostatistics & Bioinformatics Duke University Durham 27708 NC United States Center for Scalable Data Analytics and Artificial Intelligence Universität Leipzig Germany Max Planck Institute for Mathematics in the Natural Sciences Leipzig Germany Mathematical Sciences Institute Australian National University Canberra Australia

In this paper we consider two topological transforms that are pop-ular in applied topology: the Persistent Homology Transform and the Euler Characteristic Transform. Both of these transforms are of interest for their mathematical properties as well as their applications to science and engineer-ing, because they provide a way of summarizing shapes in a topological, yet quantitative, way. Both transforms take a shape, viewed as a tame subset M of R^d, and associates to each direction v ∈ S^d−1 a shape summary obtained by scanning M in the direction v. These shape summaries are either persistence diagrams or piecewise constant integer-valued functions called Euler curves. By using an inversion theorem of Schapira, we show that both transforms are injective on the space of shapes, i.e. each shape has a unique transform. Moreover, we prove that these transforms determine continuous maps from the sphere to the space of persistence diagrams, equipped with any Wasserstein p-distance, or the space of Euler curves, equipped with certain L^p norms. By making use of a stratified space structure on the sphere, induced by hyperplane divisions, we prove additional uniqueness results in terms of distributions on the space of Euler curves. Finally, our main result proves that any shape in a certain uncountable space of PL embedded shapes with plausible geometric bounds can be uniquely determined using only finitely many directions. © 2022 by the author(s) under Creative Commons Attribution 3.0 License (CC BY 3.0).

关键词： Euler calculus persistent homology statistical shape analysis

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From mechanism to medicine: The progress and potential of epigenetics in osteoarthritis

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Osteoarthritis and Cartilage Open 2025年第3期7卷 100621-100621页

作者： Roberts, Jack B. Rockel, Jason S. Mulders, Rick Capellini, Terence D. Appleton, C. Thomas Phanstiel, Douglas H. Lories, Rik Geurts, Jeroen Ali, Shabana Amanda Bhutani, Nidhi Stone, Laura Cruz-Almeida, Yenisel Jurisica, Igor Boer, Cindy G. Ramos, Yolande F.M. Rice, Sarah J. Kapoor, Mohit Biosciences Institute Newcastle University Newcastle upon Tyne United Kingdom Division of Orthopedics Osteoarthritis Research Program Schroeder Arthritis Institute University Health Network and Krembil Research Institute University Health Network Toronto ON Canada Department of Medical Biophysics and Computer Science University of Toronto Toronto ON Canada Department of Biomedical Data Sciences Section Molecular Epidemiology Leiden University Medical Center Leiden Netherlands Department of Human Evolutionary Biology Harvard University Cambridge MA United States Bone and Joint Institute and Department of Medicine Schulich School of Medicine and Dentistry Western University London Canada Curriculum in Bioinformatics and Computational Biology University of North Carolina Chapel Hill NC United States Laboratory of Tissue Homeostasis and Disease Skeletal Biology and Engineering Research Centre Department of Development and Regeneration KU Leuven Leuven Belgium Division of Rheumatology University Hospitals Leuven Leuven Belgium Rheumatology Department of Musculoskeletal Medicine Lausanne University Hospital and University of Lausanne (CHUV-UNIL) Lausanne Switzerland Bone and Joint Center Henry Ford Health + Michigan State University Health Sciences Detroit MI United States Department of Orthopaedic Surgery Stanford School of Medicine Stanford CA United States Department of Anesthesiology School of Medicine University of Minnesota Minneapolis MN United States Pain Research and Intervention Center of Excellence (PRICE) at the University of Florida Gainesville FL United States Department of Internal Medicine Genomics Medicine Center Erasmus MC University Medical Center Rotterdam Netherlands Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada Department of Surgery University of Toronto Toronto ON Canada

Objective: Osteoarthritis (OA) is a chronic, degenerative disease of the articular joints. The disease presents an enormous clinical and economic burden globally, due in part to the lack of disease modifying therapies. For over a decade, OA researchers have been working to determine epigenetic mechanisms underlying the disease to better understand pathology, identify biomarkers of progression, and pinpoint novel targets for therapeutic intervention. Design: This article presents a summary of the 3rd International Workshop on the Epigenetics of Osteoarthritis held in Toronto, Ontario, Canada, in September 2024. The purpose of this meeting was to gather the international community to discuss the status of OA epigenetic research and share expertise on innovative techniques for future. Results: Since the two previous meetings, there has been increasing adoption of advanced single-cell and spatial sequencing technologies and bioinfomatic analyses. Furthermore, investigations of multiple joint tissues has highlighted the shifting paradigm from OA as a cartilage centric disease to the consideration of all joint tissues. Conclusions: The workshop provided a unique opportunity for early-career researchers to expand their network, and for all participants to discuss new or improved approaches to advance the field, including international consortia and data sharing. The highlights and outcomes from this OA epigenetics workshop are described in this report. © 2025 The Authors

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Cholesterol allosteric modulation of the oxytocin receptor

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Biophysical Journal 2025年

作者： Marlow, Brennica Vogel, Alexander Kuenze, Georg Pankonin, Maik Reinhardt, Franziska Stadler, Peter F. Hildebrand, Peter W. Meiler, Jens Center for Structural Biology Vanderbilt University Nashville TN United States Institute for Drug Discovery Medical Faculty Leipzig University Leipzig Germany Center for Scalable Data Analytics and Artificial Intelligence ScaDS.AI Leipzig University Leipzig Germany Interdisciplinary Center for Bioinformatics Leipzig University Leipzig Germany Chemical and Physical Biology Program Vanderbilt University Nashville TN United States Department of Chemistry Vanderbilt University Nashville TN United States Institute of Medical Physics and Biophysics Medical Faculty Leipzig University Leipzig Germany Bioinformatics Group Institute of Computer Science Interdisciplinary Center of Bioinformatics Leipzig University Leipzig Germany Max-Planck-Institute for Mathematics in the Sciences Leipzig Germany Institute of Theoretical Chemistry University of Vienna Wien Austria Facultad de Ciencias Universidad National de Colombia Sede Bogota Colombia Santa Fe Institute New Mexico Santa Fe Mexico

G-protein coupled receptors are critical components in cellular signaling, mediating various physiological responses to external stimuli. Here, we investigate the intricate relationship between cholesterol and the oxytocin receptor (OXTR), focusing on the binding mechanisms and the allosteric cross talk of bound cholesterol to the orthosteric ligand binding pocket. Utilizing molecular docking and molecular dynamics simulations, we identify cholesterol binding sites both on the agonist-bound and antagonist-bound state, which show differing distributions and residence times of the cholesterol molecules. Importantly, both methods converge on several key sites, demonstrating strong predictive overlap. Notably, one such site, and several sites detected by our molecular dynamics approach, also coincide with electron density observed in an experimental cryo-EM map, providing orthogonal validation for computational predictions. Allosteric network analysis uncovers the distinct pathways through which cholesterol may affect ligand-mediated receptor signaling, highlighting the significance of one site on the extracellular leaflet between TM4 and TM5, and two sites on the intracellular leaflet between TM2, TM3, and TM4 and between TM4 and TM5 in transmitting allosteric signals to the orthosteric pocket. These findings provide insights into the impact of cholesterol on OXTR function, emphasizing specific binding sites and signaling paths for further experimental exploration. © 2025 Biophysical Society

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Uniform Consistency of Generalized Fréchet Means

arXiv

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arXiv 2024年

作者： Aveni, Andrea Mukherjee, Sayan Department of Statistical Science Duke University United States Center for Scalable Data Analytics and Artificial Intelligence Department of Computer Science Universität Liepzig Germany Max Planck Institute for Mathematics in the Natural Sciences Duke University Departments of Statistical Science Mathematics Computer Science and Biostatistics & Bioinformatics United States

We study a generalization of the Fréchet mean on metric spaces, which we call φ-means. Our generalization is indexed by a convex function φ. We find necessary and sufficient conditions for φ-means to be finite and provide a tight bound for the diameter of the intrinsic mean set. We also provide sufficient conditions under which all the φ-means coincide in a single point. Then, we prove the consistency of the sample φ-mean to its population analogue. We also find conditions under which classes of φ-means converge uniformly, providing a Glivenko-Cantelli result. Finally, we illustrate applications of our results and provide algorithms for the computation of φ-*** Codes 0F05, 60F15, 60D05, 62E20, 62F10, 58K05 © 2024, CC BY.

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