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Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis (vol 14, 3750, 2023)

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NATURE COMMUNICATIONS 2023年第1期14卷 1-16页

作者： Takada, Hitomi Sasagawa, Yohei Yoshimura, Mika Tanaka, Kaori Iwayama, Yoshimi Hayashi, Tetsutaro Isomura-Matoba, Ayako Nikaido, Itoshi Kurisaki, Akira Laboratory of Stem Cell Technologies Graduate School of Science and Technology Nara Institute of Science and Technology Takayama-cho Ikoma Nara Japan Laboratory for Bioinformatics Research RIKEN Center for Biosystems Dynamics Research Wako Saitama Japan Department of Functional Genome Informatics Biological Data Science Medical Research Institute Tokyo Medical and Dental University Bunkyo Tokyo Japan Master’s/Doctoral Program in Life Science Innovation (Bioinformatics) Degree Programs in Systems and Information Engineering Graduate School of Science and Technology University of Tsukuba Tsukuba Ibaraki Japan

Defects in gastric progenitor cell differentiation are associated with various gastric disorders, including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the mechanisms underlying the multilineage differentiation of gastric progenitor cells during healthy homeostasis remain poorly understood. Here, using a single-cell RNA sequencing method, Quartz-Seq2, we analyzed the gene expression dynamics of progenitor cell differentiation toward pit cell, neck cell, and parietal cell lineages in healthy adult mouse corpus tissues. Enrichment analysis of pseudotime-dependent genes and a gastric organoid assay revealed that EGFR-ERK signaling promotes pit cell differentiation, whereas NF-κB signaling maintains gastric progenitor cells in an undifferentiated state. In addition, pharmacological inhibition of EGFR in vivo resulted in a decreased number of pit cells. Although activation of EGFR signaling in gastric progenitor cells has been suggested as one of the major inducers of gastric cancers, our findings unexpectedly identified that EGFR signaling exerts a differentiation-promoting function, not a mitogenic function, in normal gastric homeostasis.

关键词： Adult stem cells Stem-cell differentiation Stem-cell niche

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An Adaptive Large Neighborhood Search with Learning Automata for the Unrelated Parallel Machine Scheduling Problem

An Adaptive Large Neighborhood Search with Learning Automata...

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2017 IEEE Congress on Evolutionary Computation, CEC 2017

作者： Cota, Luciano Perdigao Guimaraes, Frederico Gadelha De Oliveira, Fernando B. Souza, Marcone J. Freitas Graduate Program in Electrical Engineering Federal University of Minas Gerais Belo Horizonte Brazil Department of Electrical Engineering Universidade Federal de Minas Gerais Belo Horizonte Brazil Department of Computer and Systems Universidade Federal de Ouro Preto João Monlevade Brazil Department of Computer Science Universidade Federal de Ouro Preto Brazil

ISBN: (纸本)9781509046010

This work deals with the Unrelated Parallel Machine Scheduling Problem with Setup Times, with the objective of minimizing the makespan. It is proposed an Adaptive Large Neighborhood Search (ALNS) metaheuristic using Learning Automata (LA) to adapt the probabilities of using removal and insertion heuristics and methods. A computable function in the LA updates the probability vector for selecting the actions, corresponding to six removal and six insertion methods. We also propose a new insertion method based on Hungarian algorithm, which is applied to solve subproblems optimally. Computational experiments are performed to verify the performance of the proposed method. A set of instances available in the literature with problems up to 150 jobs and 10 machines is employed in the experiments. The proposed LA-ALNS is compared against three other algorithms from the literature. The results suggest that our algorithm has better performance in most of cases (88%) under the defined conditions of experiments. Statistical tests also suggest that LA-ALNS is better than the other algorithms from the literature. The proposed method is able to automatically choose the most suitable heuristics for the instance of the problem, through adaptation and learning in the Learning Automata. © 2017 IEEE.

关键词： Heuristic methods

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Strategic Planning and Knowledge Management Approaches as input to remote area strategic plans: A Case study in Aru Islands Regency Maluku Province 8

Strategic Planning and Knowledge Management Approaches as in...

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8th International Conference on ICT for Smart Society, ICISS 2021

作者： Irena Gutandjala, Ilona Harso Supangkat, Suhono Lumban Gaol, Ford Rianti, Benny Bina Nusantara University BINUS Graduate Program-Computer Science Computer Science Department Jakarta11480 Indonesia Bandung Institute of Technology Smart City and Community Innovation Center School of Electrical and Informatics Engineering Bandung Indonesia Information Systems Department BINUS Online Learning Bina Nusantara University Jakarta11480 Indonesia

ISBN: (纸本)9781665416979

Knowledge is an important asset in an organization. Aru Islands District is one of the districts in Maluku Province. The Government of Aru Islands District Maluku has a vision and mission as outlined in the Regional Strategic Plan or commonly referred to as RENSTRA. This vision and mission are an activity that requires a policy direction that is planned and integrated with the strategic environment of all related aspects. The strategic plan is then realized with the implementation of the government with regional autonomy which is the modern governance in realizing quality public services, fast, easy, fair and unlimited for the welfare and progress of the region. In this research will be used a strategic approach as input from the analysis with knowledge management and assessment of the condition of Aru district. © 2021 IEEE.

关键词： Strategic planning

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The Smart Analysis of Performing Scalable Inference for Big Data Analytics

The Smart Analysis of Performing Scalable Inference for Big ...

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2023 International Conference on Power Energy, Environment and Intelligent Control, PEEIC 2023

作者： Bhandarkar, Vishakha D. Rongali, Aruna Sri Shamout, Mohamed Dawood Pund, Sachin Nama, Gigih Forda Patil, Shrishailappa Yeshwantrao Chavan College of Engineering Applied Mathematics and Humanities India University of the Cumberlands Graduate Doctoral Information Technology Information Technology Emphasis/Information Technology United States College of Business Administration University of Sharjah Department of Management Sharjah United Arab Emirates Shri Ramdeobaba College of Engineering and Management Department of Industrial Engineering Maharashtra Nagpur India Doctoral Program of Environtmental Science University of Lampung Department of Informatics Bandar Lampung Indonesia Vishwakarma Institute of Technology Computer Engineering Pune India

ISBN: (纸本)9798350357769

This paper examines the reproducibility of massive information analytics under particular factors. The paper proposes the 'performing Scalable Inference' technique to cope with scalability troubles and to exploit current big statistics platforms for efficient computing and statistics garage of the statistics. In particular, the paper describes how to perform leak-free, parallelizable visible analytics over massive datasets using present extensive records analytics frameworks such as Apache Flink. This method presents an automated manner to execute analytics that preserves reproducibility and the ability to make adjustments without re-running the entire technique. The paper also demonstrates how these analytics may help several real-world use instances, explore affected person cohorts for studies, and develop stratified patient cohorts for hospital therapy. In the end, the paper observes how the proposed method may be exercised within the real world. Actively scalable inference for massive information analytics is pivotal in optimizing decision-making and allocation of assets. Typically, such inferences are made based on information accumulated from numerous sources, databases, unstructured data, and different digital sources. So one can ensure scalability, a complete cloud-primarily based platform has to be hired. This solution will permit the ***, deploying the essential records series and evaluation algorithms are prime here. It could permit the platform to recognize the styles inside the statistics and discover any ability correlations or traits. Additionally, predictive analytics and system mastering strategies may be incorporated to provide insights into the results of the information. In the long run, by leveraging those techniques, the platform can draw efficient inferences and appropriately compare situations in an agile and green way.. © 2023 IEEE.

关键词： adjustments an a lytics automated preserves statistics

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An efficient parallel architecture for ray-tracing

An efficient parallel architecture for ray-tracing

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作者： Nery, Alexandre S. Nedjah, Nadia França, Felipe M.G. LAM - Computer Architecture and Microeletronics Laboratory Systems Engineering and Computer Science Program COPPE Universidade Federal Do Rio de Janeiro Rio de Janeiro RJ Brazil Department of Electronics Engineering and Telecommunications Faculty of Engineering Universidade Do Estado Do Rio de Janeiro Rio de Janeiro RJ Brazil

Real time rendering of three-dimensional scenes in high photorealistic details is a hard task, such as in the ray tracing rendering algorithm. In general, the performance achieved by a sequential software-based implementation of ray tracing is far from satisfactory. However, parallel implementations of ray tracing have been enabling reasonable real time performance, as the algorithm is embarrassingly parallel. Thus, a custom parallel design in hardware is likely to achieve an even higher performance. In this paper, we propose a hardware parallel architecture capable of dealing with the main desirable features of ray tracing, such as shadows and reflection effects, imposing low area cost and a promising rendering performance. Such architecture, called GridRT, is based on the Uniform Grid acceleration structure and is intended to deliver massive parallelism through parallel ray-triangle intersection tests as well as parallel processing of many rays. A hardware implementation of the proposed architecture is presented, together with some performance results and resources requirements. The rendering is reduced by 80% using a grid configuration of eight processing elements. © Springer science+Business Media, LLC 2011.

关键词： Field programmable gate arrays (FPGA)

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Drone Application Model for Image Acquisition of Plantation Areas and Oil Palm Trees Counting 7

Drone Application Model for Image Acquisition of Plantation ...

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7th International Conference on Information Management and Technology, ICIMTech 2022

作者： Sastrohartono, Hermantoro Suryotomo, Andiko Putro Saifullah, Shoffan Suparyanto, Teddy Perbangsa, Anzaludin Samsinga Pardamean, Bens Instiper Yogyakarta Faculty of Agricultural Technology Department of Agricultural Engineering Yogyakarta55281 Indonesia Universitas Pembangunan Nasional Veteran Yogyakarta Department of Informatics Yogyakarta55283 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia School of Information Systems Bina Nusantara University Information Systems Department Jakarta11480 Indonesia BINUS Graduate Program - Master of Computer Science Bina Nusantara University Computer Science Department Jakarta11480 Indonesia

ISBN: (数字)9781665450904

ISBN: (纸本)9781665450904

The area of oil palm plantations in Indonesia increased by 7% from 14 million ha in 2017 to 15 million ha in 2021. The vast land requires the support of effective and efficient management techniques to maintain sustainable productivity. The high-performance computing technologies, Internet of Things (IoT), Big Data, Artificial Intelligence, spatial modeling, and drones are the answers to these needs. This study aims to design an application that can obtain plantation image data and analyze the calculation of the number of oil palm trees. The image of oil palm plantations is obtained from processing photo data from drones through a mosaic and composite process. This study also employed Scrum and UML as a system model development method. The image of the oil palm plantation area is used to build a tree counting model using the Viola-Jones algorithm. The oil palm tree count information generated by this system can then be used by management for fertilizing, harvesting, and monitoring the condition of oil palm trees. © 2022 IEEE.

关键词： Drones

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Modeling the breakage-fusion-bridge mechanism: Combinatorics and cancer genomics

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16th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2012

作者： Kinsella, Marcus Bafna, Vineet Bioinformatics and Systems Biology Program University of California San Diego San Diego CA 92093 United States Department of Computer Science and Engineering University of California San Diego San Diego CA 92093 United States

ISBN: (纸本)9783642296260

The breakage-fusion-bridge (BFB) mechanism was proposed over seven decades ago and is a source of genomic variability and gene amplification in cancer. Here we formally model and analyze the BFB mechanism, to our knowledge this first time this has been undertaken. We show that BFB can be modeled as successive inverted prefix duplications of a string. Using this model, we show that BFB can achieve a surprisingly broad range of amplification patterns. We find that a sequence of BFB operations can be found that nearly fits most patterns of copy number increases along a chromosome. We conclude that this limits the usefulness of methods like array CGH for detecting BFB and discuss other implications for understanding mechanisms of genomic instability. © 2012 Springer-Verlag Berlin Heidelberg.

关键词： Pattern matching

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Adaptation of current signals with floating-gate circuits

Adaptation of current signals with floating-gate circuits

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作者： Pesavento, Alberto Horiuchi, Timothy Diorio, Chris Koch, Christof Department of Electrical Engineering California Institute of Technology Pasadena CA 91125 United States Department of Electrical and Computer Engineering University of Maryland College Park MD 20742 United States Department of Computer Science and Engineering University of Washington Seattle WA 98195-2350 United States Computation and Neural Systems Program California Institute of Technology Pasadena CA 91125 United States

In this paper we present a new, adaptive spatial-derivative circuit for CMOS image sensors. The circuit removes its offset as a natural part of its operation using a combination of electron tunneling and hot-electron injection to add or remove charge on a floating-gate of an auto-zeroing amplifier. We designed, fabricated and successfully tested a chip with the circuit. Test results show that the circuit reduces the offsets by more than an order of magnitude.

关键词： Image sensors

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Rice Variety Identification Using Edge Feature Extraction and Texture-Based Segmentation

Rice Variety Identification Using Edge Feature Extraction an...

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2023 International Seminar on Application for Technology of Information and Communication, iSemantic 2023

作者： Setiawan, Aji Adi, Kusworo Widodo, Catur Edi Diponegoro University Doctoral Program of Information Systems School of Postgraduate Studies Semarang Indonesia Faculty of Engineering Darma Persada University Department of Information Technology Jakarta Indonesia Diponegoro University School of Postgraduate Studies Semarang Indonesia Diponegoro University Faculty of Science and Mathematics Department of Physics Semarang Indonesia

ISBN: (纸本)9798350339215

This research proposes a methodology for identifying the optimal feature combination using Support Vector Machine (SVM) based on edge and texture features. Canny, Sobel, and Prewitt for edge detection and GLCM, Gabor, and LBP for texture analysis are popular feature extraction techniques widely employed in various cases. The approach combines edge and texture features with SVM to classify rice types into five categories: Ipsala, Jasmine, Karacadag, Arborio, and Basmati. Experimental results demonstrate that SVM using Canny, Sobel, and Prewitt combined Gabor texture features outperforms the comparative methods. A comparative analysis based on accuracy scores using confusion matrices is conducted. Combining all feature edge methods, Canny, Sobel, and Prewitt with Gabor on SVM classification is the best model for rice object classification, achieving an accuracy of 96%. © 2023 IEEE.

关键词： Support vector machines

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Implementation of Mobile game for Religion Learning

Implementation of Mobile game for Religion Learning

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2019 IEEE International Conference on engineering, Technology and Education, TALE 2019

作者： Sulistiyo, Edy Vindy Anwar, Nizirwan Warnars, Diana Teresia Spits Wibawa, Setya Chendra Brotosaputro, Goenawan Kristiadi, Dedy Prasetya Warnars, Harco Leslie Hendric Spits Hashimoto, Kiyota Universitas Negeri Surabaya Electrical Engineering Department Jawa Timur60213 Indonesia School of Computer Science Bina Nusantara University Game Application Technology Program Jakarta11480 Indonesia Esa Unggul University Faculty of Computer Science Jakarta11510 Indonesia Bina Nusantara University Information Systems Department Jakarta11480 Indonesia Universitas Budi Luhur Information System Department Jakarta12260 Indonesia Raharja University Computer Science Department Tangerang15117 Indonesia Binus Graduate Program - Doctor of Computer Science Bina Nusantara University Computer Science Department Jakarta11480 Indonesia Prince Songkla University Faculty of Technology and Environment Phuket Campus Thailand

ISBN: (纸本)9781728126654

Currently, the growth of information and technology is rapid. It makes a lot of things in various fields including education becoming more effective and efficient. In education, one of its implementation which is a game is proven to be a useful tool to support conventional teaching methods and bring a more natural understanding of learning materials. Moreover, as a product of the popular culture in modern society, video game mirrors the general culture practice in real life and reflects it via its own culture inside the game. This makes a video game can give a contribution to the social construction of reality as it affects the player's view towards learning in real life and vice versa. From there, we see that there is an opportunity for learning about religion to be supported by its utilization to provide an interactive and fun learning experience. In this paper, we discuss how a video game is implemented to support religious learning. The game was developed with the scrum method where we surveyed to gather the user requirements before the design step. The game design was made by using the use case diagram and storyboard, and it was built using Unity version 2017.3.0f3. © 2019 IEEE.

关键词： Serious games

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