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science Bulletin 2025年第6期 934-942页

作者：李灏萱江泽铧管洲榆包玉倩刘月星胡婷婷李佳佳刘茹涵吴量程棣纪宏伟王勇王亚星 Carol Y.Cheung 郑颖丰王继红李震吴卫兵 Cynthia Ciwei Lim Yong Mong Bee Hong Chang Tan Elif I.Ekinci David C.Klonoff Justin B.Echouffo-Tcheugui Nestoras Mathioudakis Leonor Corsino Rafael Simó Charumathi Sabanayagam Gavin Siew Wei Tan 程景煜黄天荫李华婷蔡淳毛丽娟 Lee-Ling Lim 覃宇宗盛斌贾伟平 Shanghai University of Sport School of Clinical Medicine Beijing Tsinghua Changgung Hospital Tsinghua Medicine Tsinghua University Beijing Visual Science and Translational Eye Research Institute(BERI) Tsinghua Medicine Tsinghua University Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Computer Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Diabetes Institute Shanghai Clinical Center for Diabetes MoE Key Lab of Artificial Intelligence Artificial Intelligence Institute Shanghai Jiao Tong University Department of Cardiology the Affiliated Hospital of Qingdao University CEMS NCMIS HCMS MADIS Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematics University of Chinese Academy of Sciences Chinese Academy of Sciences Key Laboratory of Systems Health Science of Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Sciences Key Laboratory Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular Diseases Department of Renal Medicine Singapore General Hospital Sing Health-Duke Academic Medical Centre Department of Endocrinology Singapore General Hospital Department of Endocrinology Austin Health Department of Medicine The University of Melbourne(Austin Health) Australian Centre for Accelerating Diabetes Innovations(ACADI) The Univ

Diabetes poses a considerable global health challenge, with varying levels of diabetes knowledge among healthcare professionals, highlighting the importance of diabetes training. Large Language Models(LLMs)provide new insights into diabetes training, but their performance in diabetes-related queries remains uncertain, especially outside the English language like Chinese. We first evaluated the performance of ten LLMs: Chat GPT-3.5, Chat GPT-4.0, Google Bard, Lla MA-7B, Lla MA2-7B, Baidu ERNIE Bot, Ali Tongyi Qianwen, Med GPT, Huatuo GPT, and Chinese Lla MA2-7B on diabetes-related queries, based on the Chinese National Certificate Examination for Primary Diabetes Care in China(NCE-CPDC) and the English Specialty Certificate Examination in Endocrinology and Diabetes of Membership of the Royal College of Physicians of the United Kingdom. Second, we assessed the training of primary care physicians(PCPs) without and with the assistance of Chat GPT-4.0 in the NCE-CPDC examination to ascertain the reliability of LLMs as medical assistants. We found that Chat GPT-4.0 outperformed other LLMs in the English examination, achieving a passing accuracy of 62.50%, which was significantly higher than that of Google Bard, Lla MA-7B, and Lla MA2-7B. For the NCE-CPFC examination, Chat GPT-4.0, Ali Tongyi Qianwen, Baidu ERNIE Bot, Google Bard, Med GPT, and Chat GPT-3.5 successfully passed, whereas Lla MA2-7B, Huatuo GPT,Chinese LLa MA2-7B, and Lla MA-7B failed. Chat GPT-4.0(84.82%) surpassed all PCPs and assisted most PCPs in the NCE-CPDC examination(improving by 1%–6.13%). In summary, LLMs demonstrated outstanding competence for diabetes-related questions in both the Chinese and English language, and hold great potential to assist future diabetes training for physicians globally.

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Involution symmetry quantification using recurrences

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Physical Review E 2024年第2期110卷 024203-024203页

作者： Gabriel Marghoti Thiago de Lima Prado Sergio Roberto Lopes Yoshito Hirata Physics Department Degree Program in Computer Science Interdisciplinary Center for Science Technology and Innovation CICTI Departament of Physics - Telegraphenberg 14473 Potsdam Germany Institute of Systems and Information Engineering

Symmetries are ubiquitous in science, aiding theoretical comprehension by discerning patterns in mathematical models and natural phenomena. This work introduces a method for assessing the extent of symmetry within a time series. We explore both microscopic and macroscopic features extracted from a recurrence plot. By analyzing the statistics of small recurrence matrices, our approach delves into microscale dynamics, facilitating the identification of symmetric time series segments through diagonal macroscale structures on a recurrence plot. We validate our approach by successfully quantifying involution symmetries for three-dimensional dynamical models, specifically, order-2 rotational symmetry in the Lorenz '63 model, and inversion symmetry in the Chua circuit. Our quantifier also detects symmetry breaking in the modified Lorenz model for El Niño phenomenon. The method can be applied in a versatile manner, not only to three-dimensional trajectories but also to univariate time series. Symmetry quantification in time series is promising for enhancing dynamical system modeling and profiling.

关键词： Chaos Dynamical systems Time series analysis

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Comparison of threshold selection methods for microarray gene co-expression matrices

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BMC Research Notes 2009年第1期2卷 1-6页

作者： Borate, Bhavesh Chesler, Elissa Langston, Michael Saxton, Arnold Voy, Brynn Genome Science and Technology Program University of Tennessee Knoxville TN United States Department of Electrical Engineering and Computer Science University of Tennessee Knoxville TN United States Oak Ridge National Laboratory Systems Genetics Group Biosciences Division Oak Ridge TN United States Department of Animal Science University of Tennessee Knoxville TN United States

Background. Network and clustering analyses of microarray co-expression correlation data often require application of a threshold to discard small correlations, thus reducing computational demands and decreasing the number of uninformative correlations. This study investigated threshold selection in the context of combinatorial network analysis of transcriptome data. Findings. Six conceptually diverse methods - based on number of maximal cliques, correlation of control spots with expressed genes, top 1% of correlations, spectral graph clustering, Bonferroni correction of p-values, and statistical power - were used to estimate a correlation threshold for three time-series microarray datasets. The validity of thresholds was tested by comparison to thresholds derived from Gene Ontology information. Stability and reliability of the best methods were evaluated with block bootstrapping. Two threshold methods, number of maximal cliques and spectral graph, used information in the correlation matrix structure and performed well in terms of stability. Comparison to Gene Ontology found thresholds from number of maximal cliques extracted from a co-expression matrix were the most biologically valid. Approaches to improve both methods were suggested. Conclusion. Threshold selection approaches based on network structure of gene relationships gave thresholds with greater relevance to curated biological relationships than approaches based on statistical pair-wise relationships. © 2009 Saxton et al;licensee BioMed Central Ltd.

关键词： Spectral Cluster Maximal Clique Threshold Estimate Biological Relationship Spectral Graph

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Stunting Classification in Toddlers: Implementation and Evaluation of the Decision Tree Algorithm

Stunting Classification in Toddlers: Implementation and Eval...

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2024 International Conference on Information Technology and Computing, ICITCOM 2024

作者： Alita, Debby Ahmad, Imam Jafar Rumandan, Rhaishudin Erkamim, Moh Widyasmoro Universitas Teknokrat Indonesia Faculty of Engineering and Computer Science Bandarlampung Indonesia Institut Agama Islam Negeri Ambon Islamic Education Management Study Program Ambon Indonesia Universitas Tunas Pembangunan Smart City Information Systems Study Program Surakarta Indonesia Universitas Muhammadiyah Yogyakarta Faculty of Engineering Department of Electrical Engineering Yogyakarta Indonesia

ISBN: (纸本)9798350379839

Stunting in toddlers is a chronic nutritional issue that affects the physical and cognitive development of children, with serious long-term consequences such as reduced cognitive function and an increased risk of chronic diseases in adulthood. Therefore, early identification and prevention efforts for stunting are crucial. Classifying toddlers into categories of at-risk for stunting or not is essential to provide timely and appropriate interventions. This study employs data mining techniques using the decision tree algorithm to expedite the stunting detection process and improve the accuracy of nutritional status classification in children. The results indicate that the constructed decision tree model can classify children's nutritional status with an accuracy of 83.26%. The decision tree achieves high accuracy in classifying stunting in toddlers due to its ability to handle complex data and identify significant patterns within the data. © 2024 IEEE.

关键词： Classification Data Mining Decision Tree Stunting

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IoT for Water Quality Categorization 5

IoT for Water Quality Categorization

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5th International Conference on Cybernetics and Intelligent systems, ICORIS 2023

作者： Sastrohartono, Hermantoro Krisdiarto, Andreas Wahyu Uktoro, Arief Ika Rahutomo, Reza Suparyanto, Teddy Pardamean, Bens Institute of Agriculture Stiper Faculty of Agricultural Technology Agricultural Engineering Department Yogyakarta Indonesia Bina Nusantara University School of Information Systems Information System Department Jakarta11480 Indonesia Bina Nusantara University Bioinformatics & Data Science Research Center Jakarta11480 Indonesia Bina Nusantara University Binus Graduate Program Master of Computer Science Computer Science Department Jakarta11480 Indonesia

ISBN: (纸本)9798350369489

In agricultural water research, the adoption of Internet of Things (IoT) technology has emerged as a pivotal approach for large-scale data collection. Water availability in the context of water quality is very important, both for domestic and industrial purposes. For domestic purposes, drinking water and bathing water are separated. Meanwhile, for the palm oil industry, boiler filler is differentiated from additional process water (dilution water). Water quality parameters can be assessed from turbidity and Total Dissolve Solid (TDS). Measurements using measuring instruments separately and repeatedly require significant energy, time, and costs. This research was conducted with the primary objective of presenting a novel method for categorizing water quality with the approach of IoT sensor technology. The research methodology entailed the utilization of an integrated IoT water sensors system in conjunction with manual water categorization. The methods consist of (1) system design, (2) design and installation of sensor and IoT-based microcontrollers, and (3) accuracy and precision testing compared with laboratory measurements. The precision of the integrated IoT water sensors was assessed through a dedicated sensor precision test, resulting in an accuracy rate of 94.4% for the turbidity sensor and 97.5% for the TDS sensor. Notably, this approach successfully discriminated drinking water with valid categorization, while other water types, including groundwater, water with tea, and water with coffee, yielded null categorization results. © 2023 IEEE.

关键词： Internet of things

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Local Periodicity-Based Beat Tracking for Expressive Classical Piano Music

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IEEE/ACM Transactions on Audio Speech and Language Processing 2023年 31卷 2824-2835页

作者： Chiu, Ching-Yu Muller, Meinard Davies, Matthew E. P. Su, Alvin Wen-Yu Yang, Yi-Hsuan National Cheng Kung University Academia Sinica Graduate Program of Multimedia Systems and Intelligent Computing Tainan701401 Taiwan International Audio Laboratories Erlangen Erlangen91058 Germany University of Coimbra Department of Informatics Engineering Centre for Informatics and Systems Coimbra3004-531 Portugal National Cheng Kung University Department of Computer Science and Information Engineering Tainan701401 Taiwan Taiwan AI Labs Yating Music Team Taipei103622 Taiwan Academia Sinica Research Center for IT Innovation Taipei11529 Taiwan

To model the periodicity of beats, state-of-the-art beat tracking systems use 'post-processing trackers' (PPTs) that rely on several empirically determined global assumptions for tempo transition, which work well for music with a steady tempo. For expressive classical music, however, these assumptions can be too rigid. With two large datasets of Western classical piano music, namely the Aligned Scores and Performances (ASAP) dataset and a dataset of Chopin's Mazurkas (Maz-5), we report on experiments showing the failure of existing PPTs to cope with local tempo changes, thus calling for new methods. In this paper, we propose a new local periodicity-based PPT, called predominant local pulse-based dynamic programming (PLPDP) tracking, that allows for more flexible tempo transitions. Specifically, the new PPT incorporates a method called 'predominant local pulses' (PLP) in combination with a dynamic programming (DP) component to jointly consider the locally detected periodicity and beat activation strength at each time instant. Accordingly, PLPDP accounts for the local periodicity, rather than relying on a global tempo assumption. Compared to existing PPTs, PLPDP particularly enhances the recall values at the cost of a lower precision, resulting in an overall improvement of F1-score for beat tracking in ASAP (from 0.473 to 0.493) and Maz-5 (from 0.595 to 0.838). © 2014 IEEE.

关键词： Hidden Markov models

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CORONA-POLED NONLINEAR POLYMERIC FILMS: IN SITU ELECTRIC FIELD MEASUREMENT, CHARACTERIZATION AND ULTRASHORT-PULSE APPLICATIONS

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Journal of Nonlinear Optical Physics & Materials 1992年第1期1卷 73-102页

作者： A. KNOESEN N.E. MOLAU D.R. YANKELEVICH M.A. MORTAZAVI A. DIENES Department of Electrical Engineering and Computer Science Organized Research Program on Polymeric Ultrathin Film Systems University of California Davis CA 95616 USA

Electric poling at field intensities approaching the dielectric strength of the film is possible with corona poling. Polymeric thin films with large second-order nonlinearities can be created with this poling technique. In this paper, the corona poling of nonlinear polymeric films at elevated temperatures, processing, characterization and possible ultrashort-pulse applications are reviewed. An experimental technique is presented to measure the electric field during poling of the nonlinear polymeric film. The characterization of orientational order in corona-poled nonlinear polymeric films and the effects associated with the large electric field during poling are discussed. Poled polymeric thin films are uniquely suited for second-order nonlinear optical applications of ultrashort pulses (< 50 fsec) since minimal pulse spreading occurs. The sum-frequency ultrashort-pulse application of nonlinear polymeric thin films and limitations of the thin polymeric films are discussed. Experimental results are presented of a side-chain nonlinear polymer that is ideally suited for ultrashort-pulse applications.

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A massively parallel hardware architecture for ray-tracing

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International Journal of High Performance systems Architecture 2009年第1期2卷 26-34页

作者： Nery, A.S. Nedjah, N. França, F.M.G. Computer Architecture and Microelectronics Laboratory Systems Engineering and Computer Science Program COPPE P.O. Box 68511 21941-972 Rio de Janeiro Brazil Department of Electronics Engineering and Telecommunications Faculty of Engineering Universidade do Estado do Rio de Janeiro Rua Sao Francisco Xavier 524 Sala 5145-F Maracana 20.550-900 Rio de Janeiro RJ Brazil Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Department of Electronics Engineering and Telecommunications Faculty of Engineering State University of Rio de Janeiro Brazil Brazil

Real time performance of non-interactive rendering of three-dimensional scenes is usually unachievable. Ray tracing is one of the methods used for rendering such scenes. The performance achieved by a sequential software-based implementation of ray tracing is far from satisfactory. In contrast, many parallel implementations of ray tracing have been enabling real time performance, as the underlying algorithm can be massively parallelised. Thus, it is expected that a custom parallel design in hardware is likely to achieve the acceptable performance standards. In this paper, we propose a hardware architecture, which we call GridRT, capable of dealing with the main desirable features of ray tracing, such as shadows and reflections effects, imposing low requirements in terms of silicon area while achieving acceptable performance in terms of rendering time. This architecture achieves is efficient yet compact as it explores the massive parallelism offered by the intrinsic structure of the algorithm. The design exploits the usage the spatial data structure of regular grids. Copyright © 2009 Inderscience Enterprises Ltd.

关键词： Ray tracing

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A Comparison Diagnosis Algorithm for Conditional Fault Local Diagnosis of Multiprocessor systems 25th

A Comparison Diagnosis Algorithm for Conditional Fault Loca...

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25th International computer Symposium on New Trends in computer Technologies and Applications, ICS 2022

作者： Lv, Yali Lin, Cheng-Kuan Hsu, D. Frank Fan, Jianxi School of Information Technology Henan University of Chinese Medicine Zhengzhou China Department of Computer Science National Yang Ming Chiao Tung University Hsinchu Taiwan Undergraduate Degree Program of Systems Engineering and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan Computer Science and Information Engineering Chung Cheng Institute of Technology NDU Taoyuan City Taiwan Department of Computer and Information Science Fordham University New York United States School of Computer Science and Technology Soochow University Suzhou China

ISBN: (纸本)9789811995811

An efficient diagnosis is very important for a multiprocessor system. In this paper, we present a (α, β) -trees combination S(u, X, α, β) and give some conclusions about the local diagnosis. Based on the (α, β) -trees combination, we give a conditional fault local diagnosis algorithm to identify the fault or fault-free status of each processor correctly under the MM ∗ model when the number of faulty nodes does not exceed α+ 2 β- 3 and every node has at least one fault-free neighboring node. According to our results, a connected network with a (α, β) -trees combination S(u, X, α, β) for a node u is conditionally locally (α+ 2 β- 3 ) -diagnosable at node u and the time complexity of our algorithm to diagnose u is O(α2β+ αβ2). As an application, we show that our algorithm can identify all the faulty nodes of n-dimensional star graph Sn if the faulty node number does not exceed 3 n- 8. Compared with existing algorithms, our algorithm allows more faulty node in a multiprocessor system. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Computational complexity

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Computationally designed proteins mimic antibody immune evasion in viral evolution

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Immunity 2025年

作者： Youssef, Noor Gurev, Sarah Ghantous, Fadi Brock, Kelly P. Jaimes, Javier A. Thadani, Nicole N. Dauphin, Ann Sherman, Amy C. Yurkovetskiy, Leonid Soto, Daria Estanboulieh, Ralph Kotzen, Ben Notin, Pascal Kollasch, Aaron W. Cohen, Alexander A. Dross, Sandra E. Erasmus, Jesse Fuller, Deborah H. Bjorkman, Pamela J. Lemieux, Jacob E. Luban, Jeremy Seaman, Michael S. Marks, Debora S. Department of Systems Biology Harvard Medical School Boston 02115 MA United States Broad Institute of Harvard and MIT Cambridge 02139 MA United States Department of Electrical Engineering and Computer Science MIT Cambridge 02139 MA United States Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Boston 02215 MA United States Program in Molecular Medicine University of Massachusetts Chan Medical School Worcester 01655 MA United States Division of Infectious Diseases Department of Medicine Brigham and Women's Hospital Boston 02115 MA United States Massachusetts General Hospital Boston 02114 MA United States Division of Biology and Biological Engineering California Institute of Technology Pasadena 91125 CA United States Department of Microbiology University of Washington Seattle 98195 WA United States National Primate Research Center Seattle 98109 WA United States HDT Bio Seattle 98109 WA United States Massachusetts Consortium on Pathogen Readiness Boston 02115 MA United States Ragon Institute of MGH MIT and Harvard Cambridge 02139 MA United States

Recurrent waves of viral infection necessitate vaccines and therapeutics that remain effective against emerging viruses. Our ability to evaluate interventions is currently limited to assessments against past or circulating variants, which likely differ in their immune escape potential compared with future variants. To address this, we developed EVE-Vax, a computational method for designing antigens that foreshadow immune escape observed in future viral variants. We designed 83 SARS-CoV-2 spike proteins that transduced ACE2-positive cells and displayed neutralization resistance comparable to variants that emerged up to 12 months later in the COVID-19 pandemic. Designed spikes foretold antibody escape from B.1-BA.4/5 bivalent booster sera seen in later variants. The designed constructs also highlighted the increased neutralization breadth elicited by nanoparticle-based, compared with mRNA-based, boosters in non-human primates. Our approach offers targeted panels of synthetic proteins that map the immune landscape for early vaccine and therapeutic evaluation against future viral strains. © 2025 The Authors

关键词： antibody escape generative protein models immune landscape machine learning protein design vaccine evaluation viral evolution

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