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2008 International Conference on Audio，Language and Image Processing(2008国际声音、语言、图像过程大会)

作者： Kuoan Hwang Chiahao Yang Department of Computer Science and Information Engineering & Graduate Institute of Networking and Co Graduate Institute of Informatics Doctoral program Chaoyang University of Technology

Distance learning is a learning style that can overcome the limitation of time and space. Because of the distance, teachers can not handle the student's learning situation, and they do not know whether the student is attentive, drowsy or absent. If teachers can know the student's affective state, they can overcome the difficult. The research applies the image recognition technologies to capture the face images of students when they are learning and analyzes their face features to evaluate the student's affective state by Fuzzy Integral. Finally, teachers can monitor the student's behavior by the detection results on the system interface.

关键词： Distance learning Skin computers Distance measurement Face Image color analysis Education

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Ranking docked models of protein-protein complexes using predicted partner-specific protein-protein interfaces: A preliminary study 11

Ranking docked models of protein-protein complexes using pre...

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2011 ACM Conference on Bioinformatics, Computational Biology and Biomedicine, ACM-BCB 2011

作者： Xue, Li C. Jordan, Rafael A. El-Manzalawy, Yasser Dobbs, Drena Honavar, Vasant Bioinformatics and Computational Biology Program Iowa State University Ames IA 50011 United States Department of Genetics Development and Cell Biology Iowa State University Ames 50011 United States Department of Computer Science Iowa State University Ames IA 50011 United States Department of Computer Science Pontificia Universidad Javeriana Cali Colombia Department of Systems and Computer Engineering AI-Azhar University Cairo Egypt

ISBN: (纸本)9781450307963

Computational protein-protein docking is a valuable tool for determining the conformation of complexes formed by interacting proteins. Selecting near-native conformations from the large number of possible models generated by docking software presents a significant challenge in practice. We introduce a novel method for ranking docked conformations based on the degree of overlap between the interface residues of a docked conformation formed by a pair of proteins with the set of predicted interface residues between them. Our approach relies on a method, called PS-HomPPI, for reliably predicting proteinprotein interface residues by taking into account information derived from both interacting proteins. PS-HomPPI infers the residues of a query protein that are likely to interact with a partner protein based on known interface residues of the homo-interologs of the query-partner protein pair, i.e., pairs of interacting proteins that are homologous to the query protein and partner protein. Our results on Docking Benchmark 3.0 show that the quality of the ranking of docked conformations using our method is consistently superior to that produced using ClusPro cluster-size-based and energy-based criteria for 61 out of the 64 docking complexes for which PS-HomPPI produces interface predictions. An implementation of our method for ranking docked models is freely available at: http://***/DockRank/. Copyright © 2011 ACM.

关键词： Proteins

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The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2

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Cell 2025年

作者： Pekar, Jonathan E. Lytras, Spyros Ghafari, Mahan Magee, Andrew F. Parker, Edyth Wang, Yu Ji, Xiang Havens, Jennifer L. Katzourakis, Aris Vasylyeva, Tetyana I. Suchard, Marc A. Hughes, Alice C. Hughes, Joseph Rambaut, Andrew Robertson, David L. Dellicour, Simon Worobey, Michael Wertheim, Joel O. Lemey, Philippe Institute of Ecology and Evolution University of Edinburgh Edinburgh United Kingdom Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla 92093 CA United States Department of Biomedical Informatics University of California San Diego La Jolla 92093 CA United States Department of Medicine University of California San Diego La Jolla 92093 CA United States Division of Systems Virology Department of Microbiology and Immunology The Institute of Medical Science The University of Tokyo Tokyo Japan Medical Research Council University of Glasgow Centre for Virus Research Glasgow United Kingdom Department of Biology University of Oxford Oxford United Kingdom Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles 90095 CA United States Department of Immunology and Microbiology The Scripps Research Institute La Jolla 92037 CA United States Institute of Genomics and Global Health Redeemer's University Osun State Ede Nigeria Department of Computer Science and Engineering University of California San Diego La Jolla 92093 CA United States Department of Mathematics School of Science and Engineering Tulane University New Orleans LA United States Department of Population Health and Disease Prevention University of California Irvine Irvine 92617 CA United States Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles 90095 CA United States Department of Computational Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles 90095 CA United States School of Biological Sciences University of Hong Kong Hong Kong Hong Kong China Biodiversity Green Development Foundation Beijing China Spatial Epidemiology Lab (SpELL) Université Libre de Bruxelles CP160/12 50 av. FD Roosevelt Bruxelles 1050 Belgium Department of Microbiology Immunology and Transplantation Rega Institute

The emergence of SARS-CoV in 2002 and SARS-CoV-2 in 2019 led to increased sampling of sarbecoviruses circulating in horseshoe bats. Employing phylogenetic inference while accounting for recombination of bat sarbecoviruses, we find that the closest-inferred bat virus ancestors of SARS-CoV and SARS-CoV-2 existed less than a decade prior to their emergence in humans. Phylogeographic analyses show bat sarbecoviruses traveled at rates approximating their horseshoe bat hosts and circulated in Asia for millennia. We find that the direct ancestors of SARS-CoV and SARS-CoV-2 are unlikely to have reached their respective sites of emergence via dispersal in the bat reservoir alone, supporting interactions with intermediate hosts through wildlife trade playing a role in zoonotic spillover. These results can guide future sampling efforts and demonstrate that viral genomic regions extremely closely related to SARS-CoV and SARS-CoV-2 were circulating in horseshoe bats, confirming their importance as the reservoir species for SARS viruses. © 2025 The Authors

关键词： molecular epidemiology phylogeography sarbecoviruses virus evolution

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An integrative systems-biology approach defines mechanisms of Alzheimer’s disease neurodegeneration

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Nature Communications 2025年第1期16卷 1-21页

作者： Leventhal, Matthew J. Zanella, Camila A. Kang, Byunguk Peng, Jiajie Gritsch, David Liao, Zhixiang Bukhari, Hassan Wang, Tao Pao, Ping-Chieh Danquah, Serwah Benetatos, Joseph Nehme, Ralda Farhi, Samouil Tsai, Li-Huei Dong, Xianjun Scherzer, Clemens R. Feany, Mel B. Fraenkel, Ernest MIT Ph.D. Program in Computational and Systems Biology Cambridge MA United States Department of Biological Engineering Massachusetts Institute of Technology Cambridge MA United States Broad Institute of Harvard and MIT Cambridge MA United States Department of Pathology Brigham and Women’s Hospital and Harvard Medical School Boston MA United States Spatial Technology Platform Broad Institute of Harvard and MIT Cambridge MA United States Precision Neurology Program Brigham and Women’s Hospital and Harvard Medical school Boston MA United States APDA Center for Advanced Parkinson’s Disease Research Brigham and Women’s Hospital and Harvard Medical School Boston MA United States Picower Institute for Learning and Memory Massachusetts Institute of Technology Cambridge MA United States Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA United States Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge MA United States School of Computer Science Northwestern Polytechnical University Xi’an China Stephen and Denise Adams Center of Yale School of Medicine New Haven CT United States

Despite years of intense investigation, the mechanisms underlying neuronal death in Alzheimer’s disease, remain incompletely understood. To define relevant pathways, we conducted an unbiased, genome-scale forward genetic screen for age-associated neurodegeneration in Drosophila. We also measured proteomics, phosphoproteomics, and metabolomics in Drosophila models of Alzheimer’s disease and identified Alzheimer’s genetic variants that modify gene expression in disease-vulnerable neurons in humans. We then used a network model to integrate these data with previously published Alzheimer’s disease proteomics, lipidomics and genomics. Here, we computationally predict and experimentally confirm how HNRNPA2B1 and MEPCE enhance toxicity of the tau protein, a pathological feature of Alzheimer’s disease. Furthermore, we demonstrated that the screen hits CSNK2A1 and NOTCH1 regulate DNA damage in Drosophila and human stem cell-derived neural progenitor cells. Our study identifies candidate pathways that could be targeted to ameliorate neurodegeneration in Alzheimer’s disease. © The Author(s) 2025.

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Haptic display for virtual reality: progress and challenges

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Virtual Reality & Intelligent Hardware 2019年第2期1卷 136-162页

作者： Dangxiao WANG Yuan GUO Shiyi LIU Yuru ZHANG Weiliang XU Jing XIAO State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100083China Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 100083China Peng Cheng Laboratory Shenzhen 518055China Department of Mechanical Engineering University of AucklandAuckland 1142New Zealand School of Computer Science and the Robotics Engineering Program Worcester Polytechnic InstituteWorcesterMA 01609-2280USA

Immersion, interaction, and imagination are three features of virtual reality (VR). Existing VR systems possess fairly realistic visual and auditory feedbacks, and however, are poor with haptic feedback, by means of which human can perceive the physical world via abundant haptic properties. Haptic display is an interface aiming to enable bilateral signal communications between human and computer, and thus to greatly enhance the immersion and interaction of VR systems. This paper surveys the paradigm shift of haptic display occurred in the past 30 years, which is classified into three stages, including desktop haptics, surface haptics, and wearable haptics. The driving forces, key technologies and typical applications in each stage are critically reviewed. Toward the future high-fidelity VR interaction, research challenges are highlighted concerning handheld haptic device, multimodal haptic device, and high fidelity haptic rendering. In the end, the importance of understanding human haptic perception for designing effective haptic devices is addressed.

关键词： Haptic display Virtual reality Desktop haptics Surface haptics Wearable haptics Multimodal haptics

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Real-time recognition of traffic signs using opponent color filters

Real-time recognition of traffic signs using opponent color ...

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14th World Congress on Intelligent Transport systems, ITS 2007

作者： Baba, Kyoko Hirai, Yuzo Master's Program in Graduate School of Systems and Information Engineering University of Tsukuba 1-1-1 Ten-nodai Tsukuba Ibaraki 305-8573 Japan Department of Computer Science Graduate School of Systems and Information Engineering University of Tsukuba 1-1-1 Ten-nodai Tsukuba Ibaraki 305-8573 Japan

ISBN: (纸本)9781617387777

In order to assist driver's vision, a real-time recognition system for traffic signs is proposed. After detecting sign candidates, biologically inspired opponent-color filters are used to extract symbol parts of signs. After normalizing the size of symbol, structural features are calculated to identify the sign. 5572 segmented images are used to design the algorithm. In a real-time system, the same sign in a sequence of frames is tracked, and a majority vote is used to integrate the recognition results. For test data, 93.8% recall rate and 99.3% precision rate could be attained. In-vehicle experiment also showed high recall and precision rates.

关键词： Traffic signs

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A Systematic Review of Cross- vs. Within-Company Cost Estimation Studies 10

A Systematic Review of Cross- vs. Within-Company Cost Estima...

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10th International Conference on Evaluation and Assessment in Software engineering, EASE 2006

作者： Kitchenham, Barbara Mendes, Emilia Travassos, Guilherme H. Department of Computer Science Keele University StaffordshireST5 5GB United Kingdom National ICT Australia Locked Bag 9013 AlexandriaNSW1435 Australia Computer Science Department The University of Auckland Private Bag 92019 Auckland New Zealand UFRJ/COPPE Systems Engineering and Computer Science Program Caixa Postal 68511 RJ Rio de Janeiro21941-972 Brazil

OBJECTIVE – The objective of this paper is to determine under what circumstances individual organisations would be able to rely on cross-company based estimation models. METHOD – We performed a systematic review of studies that compared predictions from cross-company models with predictions from within-company models based on analysis of project data. RESULTS – Ten papers compared cross-company and within-company estimation models, however, only seven of the papers presented independent results. Of those seven, three found that cross-company models were as good as within-company models, four found cross-company models were significantly worse than within-company models. Experimental procedures used by the studies differed making it impossible to undertake formal meta-analysis of the results. The main trend distinguishing study results was that studies with small single company data sets (i.e. © EASE *** rights reserved.

关键词： Cost estimating

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Hardware Particle Swarm Optimization with passive congregation for embedded applications

Hardware Particle Swarm Optimization with passive congregati...

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Southern Conference on programmable Logic

作者： Muñoz, Daniel M. Llanos, Carlos H. Coelho, Leandro Dos S. Ayala-Rincón, Mauricio Department of Mechanical Engineering Automation and Control Group/GRACO University of Brasilia Brasilia D.F. Brazil Industrial and Systems Engineering Graduate Program Pontifical Catholic University of Parana Curitiba Parana Brazil Department of Computer Science and Mathematics University of Brasilia Brasilia D.F. Brazil

ISBN: (纸本)9781424488483

Achieving high performance optimization algorithms for embedded applications can be very challenging, particularly when several requirements such as high accuracy computations, short elapsed time, area cost, low power consumption and portability must be accomplished. This paper proposes a hardware implementation of the Particle Swarm Optimization algorithm with passive congregation (HPPSOpc), which was developed using several floating-point arithmetic libraries. The passive congregation is a biological behavior which allows the swarm to preserve its integrity, balancing between global and local search. The HPPSOpc architecture was implemented on a Virtex5 FPGA device and validated using two multimodal benchmark problems. Synthesis, simulation and execution time results demonstrates that the passive congregation approach is a low cost solution for solving embedded optimization problems with a high performance. © 2011 IEEE.

关键词： Digital arithmetic

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Accelerating the Shuffled Frog Leaping algorithm by parallel implementations in FPGAs

Accelerating the Shuffled Frog Leaping algorithm by parallel...

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2010 IEEE 5th International Conference on Bio-Inspired Computing: Theories and Applications, BIC-TA 2010

作者： Muñoz, Daniel M. Llanos, Carlos H. Dos S. Coelho, Leandro Ayala-Rincón, Mauricio Department of Mechanical Engineering Automation and Control Group/GRACG University of Brasilia Brasilia D.F. Brazil Industrial and Systems Engineering Graduate Program Pontifical Catholic University of Parana Curitiba Parana Brazil Department of Computer Science and Mathematics University of Brasilia Brasilia D.F. Brazil

ISBN: (纸本)9781424464388

Meta-heuristics are efficient techniques for solving large scale optimization problems in which traditional mathematical techniques are impractical or provide sub-optimal solutions. The Shuffled Frog Leaping algorithm (SFLA) is a stochastic iterative method, bio-inspired on the memetic evolution of a group of frogs when seeking for food, which combines the social behavior-based of the particle swarm optimization technique (PSO) and the global information exchange of memetic algorithms. However, the SFLA algorithm suffers on large execution times, being this problem clearly evident when solving complex optimization problems for embedded applications. This drawback can be overcome by exploiting the parallel capabilities of the SFLA. This paper proposes a hardware parallel implementation of the SFLA algorithm (HPSFLA) using FPGAs (Field programmable gate Arrays) and the efficient floating-point arithmetic. The proposed architecture allows the SFLA to improve the functionality of the algorithm as well as to decrease the execution times by implementing parallel frogs and parallel memeplexes. Three well-known benchmark problems have been used to validate the implemented algorithm and simulation results demonstrate that the HPSFLA speeds-up by factors of 362, 727 and 211 a C-code implementation using an embedded microprocessor for the Sphere, Rastrigin and Rosenbrock benchmarks problems, respectively. Synthesis, simulation and execution time results demonstrate the effectiveness of the proposed HPSFLA architecture for embedded optimization systems. © 2010 IEEE.

关键词： Global optimization

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A PARALLEL VARIATIONAL MESH QUALITY IMPROVEMENT METHOD FOR TETRAHEDRAL MESHES 28

A PARALLEL VARIATIONAL MESH QUALITY IMPROVEMENT METHOD FOR T...

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28th International Meshing Roundtable, IMR 2019

作者： Shontz, Suzanne M. Varilla, M.A.L. Huang, Weizhang Department of Electrical Engineering and Computer Science Bioengineering Program Information and Telecommunication Technology Center University of Kansas LawrenceKS United States Husky Injection Molding Systems Ltd. Luxembourg Luxembourg Department of Mathematics University of Kansas LawrenceKS United States

ISBN: (纸本)9781733489003

There are numerous large-scale applications requiring mesh adaptivity, e.g., computational uid dynamics and weather prediction. Parallel processing is needed for simulations involving large-scale adaptive meshes. In this paper, we propose a parallel variational mesh quality improvement algorithm for use with distributed memory machines. Our method parallelizes the serial variational mesh quality improvement method by Huang and Kamenski. Their approach is based on the use of the Moving Mesh PDE method to adapt the mesh based on the minimization of an energy functional for mesh equidistribution and alignment. This leads to a system of ordinary differential equations (ODEs) to be solved which determine where to move the interior mesh nodes. An efficient solution is obtained by solving the ODEs on subregions of the mesh with overlapped communication and computation. Strong and weak scaling experiments on up to 128 cores for meshes with up to 160M elements demonstrate excellent results. © 2019 Proceedings of the 28th International Meshing Roundtable, IMR 2019. All rights reserved.

关键词： Ordinary differential equations

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