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3rd International Conference on Applied sciences Mathematics and Informatics, ICASMI 2020

作者： Susanto, E.R. Syarif, A. Muludi, K. Perdani, R.R.W. Wantoro, A. Doctoral Program of Mathematics and Science Faculty Lampung University Jl. Sumantri Brojonegoro No 1 Bandar Lampung Indonesia Faculty of Engineering and Computer Science Universitas Teknokrat Indonesia Jl. ZA. Pagaralam No.9-11 Bandar Lampung Indonesia Department of Computer Science Faculty of Mathematics and Science University of Lampung Jl. Sumantri Brojonegoro No 1 Bandar Lampung Indonesia Faculty of Medical Science Lampung University Jl. Sumantri Brojonegoro No 1 Bandar Lampung Indonesia

Thalassemia is known as one of the blood disorder diseases that is inherited by parents. There are several types of Thalassemia, namely as Thalassemia major, minor, and intermedia. Among them, Thalassemia major is the most dangerous and needs more attention. Generally, it can be detected since the child is one year old. Late detection of this disease can have adverse consequences and various complications. This study aims to develop a new model for the prediction of thalassemia for children. The model adopts a fuzzy-based rule. The novelty in this article is that our model has 4 outputs, namely thalassemia major, intermedia, minor and not thalassemia. In the previous article it only had 3 outputs. In this study, we intend to implement a model that we developed using a fuzzy-based approach to classify thalassemia diseases based on CBC data. This article describes how to build a model and implement it in software. We compare the test results with the opinion of pediatricians regarding thalassemia. The final results of testing 4 CBC data show that our proposed model has successfully identified the type of thalassemia. © Published under licence by IOP Publishing Ltd.

关键词： Blood

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Synergizing Data Imputation and Electronic Health Records for Advancing Prostate Cancer Research: Challenges, and Practical Applications

arXiv

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arXiv 2023年

作者： Batouche, Abderrahim O. Czeizler, Eugen Koskinen, Miika Mirtti, Tuomas Rannikko, Antti S. Doctoral Programme in Computer Science University of Helsinki Helsinki Finland Research Program in Systems Oncology University of Helsinki Helsinki Finland ICAN-Digital Precision Cancer Medicine Flagship Helsinki Finland HUS Helsinki University Hospital Helsinki Finland Department of Pathology University of Helsinki Helsinki University Hospital Helsinki Finland Department of Urology University of Helsinki Helsinki University Hospital Helsinki Finland

The presence of detailed clinical information in electronic health record (EHR) systems presents promising prospects for enhancing patient care through automated retrieval techniques. Nevertheless, it is widely acknowledged that accessing data within EHRs is hindered by various methodological challenges. Specifically, the clinical notes stored in EHRs are composed in a narrative form, making them prone to ambiguous formulations and highly unstructured data presentations, while structured reports commonly suffer from missing and/or erroneous data entries. This inherent complexity poses significant challenges when attempting automated large-scale medical knowledge extraction tasks, necessitating the application of advanced tools, such as natural language processing (NLP), as well as data audit techniques. This work aims to address these obstacles by creating and validating a novel pipeline designed to extract relevant data pertaining to prostate cancer patients. The objective is to exploit the inherent redundancies available within the integrated structured and unstructured data entries within EHRs in order to generate comprehensive and reliable medical databases, ready to be used in advanced research studies. Additionally, the study explores potential opportunities arising from these data, offering valuable prospects for advancing research in prostate cancer. © 2023, CC BY.

关键词： Data mining

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Artificial intelligence for modelling infectious disease epidemics

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Nature 2025年第8051期638卷 623-635页

作者： Kraemer, Moritz U. G. Tsui, Joseph L.-H. Chang, Serina Y. Lytras, Spyros Khurana, Mark P. Vanderslott, Samantha Bajaj, Sumali Scheidwasser, Neil Curran-Sebastian, Jacob Liam Semenova, Elizaveta Zhang, Mengyan Unwin, H. Juliette T. Watson, Oliver J. Mills, Cathal Dasgupta, Abhishek Ferretti, Luca Scarpino, Samuel V. Koua, Etien Morgan, Oliver Tegally, Houriiyah Paquet, Ulrich Moutsianas, Loukas Fraser, Christophe Ferguson, Neil M. Topol, Eric J. Duchêne, David A. Stadler, Tanja Kingori, Patricia Parker, Michael J. Dominici, Francesca Shadbolt, Nigel Suchard, Marc A. Ratmann, Oliver Flaxman, Seth Holmes, Edward C. Gomez-Rodriguez, Manuel Schölkopf, Bernhard Donnelly, Christl A. Pybus, Oliver G. Cauchemez, Simon Bhatt, Samir Pandemic Sciences Institute University of Oxford Oxford United Kingdom Department of Biology University of Oxford Oxford United Kingdom Department of Electrical Engineering and Computer Science University of California Berkeley Berkeley CA United States UCSF UC Berkeley Joint Program in Computational Precision Health Berkeley CA United States Division of Systems Virology Department of Microbiology and Immunology The Institute of Medical Science The University of Tokyo Tokyo Japan Section of Epidemiology Department of Public Health University of Copenhagen Copenhagen Denmark Oxford Vaccine Group University of Oxford and NIHR Oxford Biomedical Research Centre Oxford United Kingdom Department of Epidemiology and Biostatistics Imperial College London London United Kingdom Department of Computer Science University of Oxford Oxford United Kingdom School of Mathematics University of Bristol Bristol United Kingdom MRC Centre for Global Infectious Disease Analysis School of Public Health Imperial College London London United Kingdom Department of Statistics University of Oxford Oxford United Kingdom Doctoral Training Centre University of Oxford Oxford United Kingdom Institute for Experiential AI Northeastern University MA Boston Thailand Santa Fe Institute Santa Fe NM United States World Health Organization Regional Office for Africa Brazzaville Congo WHO Hub for Pandemic and Epidemic Intelligence Health Emergencies Programme World Health Organization Berlin Germany Centre for Epidemic Response and Innovation (CERI) School for Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa African Institute for Mathematical Sciences (AIMS) South Africa Muizenberg Cape Town South Africa Genomics England London United Kingdom Scripps Research La Jolla CA United States Department of Biosystems Science and Engineering ETH Zürich Basel Switzerland Swiss Institute of Bioinformatics Lausanne Switzerland The Ethox Centre Nuffield

Infectious disease threats to individual and public health are numerous, varied and frequently unexpected. Artificial intelligence (AI) and related technologies, which are already supporting human decision making in economics, medicine and social science, have the potential to transform the scope and power of infectious disease epidemiology. Here we consider the application to infectious disease modelling of AI systems that combine machine learning, computational statistics, information retrieval and data science. We first outline how recent advances in AI can accelerate breakthroughs in answering key epidemiological questions and we discuss specific AI methods that can be applied to routinely collected infectious disease surveillance data. Second, we elaborate on the social context of AI for infectious disease epidemiology, including issues such as explainability, safety, accountability and ethics. Finally, we summarize some limitations of AI applications in this field and provide recommendations for how infectious disease epidemiology can harness most effectively current and future developments in AI. © Springer Nature Limited 2025.

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Pan-cancer analysis of CDC7 in human tumors: Integrative multi-omics insights and discovery of novel marine-based inhibitors through machine learning and computational approaches

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computers in Biology and Medicine 2025年 190卷 110044-110044页

作者： Saif, Ahmed Islam, Md. Tarikul Raihan, Md. Obayed Yousefi, Niloofar Rahman, Md. Ajijur Faridi, Hafeez Hasan, Al Riyad Hossain, Mirza Mahfuj Saleem, Rasha Mohammed Albadrani, Ghadeer M. Al-Ghadi, Muath Q. Ahasan Setu, Md. Ali Kamel, Mohamed Abdel-Daim, Mohamed M. Aktaruzzaman, Md. Department of Pharmacy Faculty of Science University of Rajshahi Rajshahi6205 Bangladesh Department of Genetic Engineering and Biotechnology Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Jashore7408 Bangladesh Department of Pharmaceutical Sciences College of Health Sciences and Pharmacy Chicago State University ChicagoIL United States Department of Industrial Engineering and Management Systems University of Central Florida USA OrlandoFL United States Department of Pharmacy Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Department of Computer Science and Engineering Faculty of Engineering and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Department of Laboratory Medicine Faculty of Applied Medical Sciences Al-Baha University Al-Baha65431 Saudi Arabia Department of Biology College of Science Princess Nourah bint Abdulrahman University 84428 Riyadh11671 Saudi Arabia Department of Zoology College of Science King Saud University P.O. Box 2455 Riyadh11451 Saudi Arabia Department of Microbiology Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Department of Medicine and Infectious Diseases Faculty of Veterinary Medicine Cairo University Giza12211 Egypt Department of Pharmaceutical Sciences Pharmacy Program Batterjee Medical College P.O. Box 6231 Jeddah21442 Saudi Arabia Pharmacology Department Faculty of Veterinary Medicine Suez Canal University Ismailia41522 Egypt

Cancer remains a significant global health challenge, with the Cell Division Cycle 7 (CDC7) protein emerging as a potential therapeutic target due to its critical role in tumor proliferation, survival, and resistance. However, a comprehensive analysis of CDC7 across multiple cancers is lacking, and existing therapeutic options have come with limited clinical success. The aim of this is to integrate a comprehensive pan-cancer analysis of CDC7 with the identification of novel marine-derived inhibitors, bridging the understanding of CDC7's role as a prognostic biomarker and therapeutic target across diverse cancer types. In this study, we conducted a pan-cancer analysis of CDC7 across 33 tumor types using publicly available datasets to evaluate its expression, genetic alterations, immune interactions, survival, and prognostic significance. Additionally, a marine-derived compound library of 31,492 molecules was screened to identify potential CDC7 inhibitors using chemoinformatics and machine learning. The top candidates underwent rigorous evaluations, including molecular docking, pharmacokinetics, toxicity, Density Functional Theory (DFT) calculations, and Molecular Dynamics (MD) simulations. The findings revealed that CDC7 is overexpressed in several cancers and is associated with poor survival outcomes and unfavorable prognosis. Enrichment analysis linked CDC7 to critical DNA replication pathways, while its role in modulating tumor-immune interactions highlighted its potential as a target for immunotherapy. Among all tested compounds, Tetrahydroaltersolanol D (CMNPD21999) exhibited the strongest binding affinity and stability, along with better drug-likeness and zero toxicity. These attributes highlight its potential as a promising drug candidate for CDC7 inhibition and future cancer treatment development. Furthermore, additional in vitro and in vivo studies are required to confirm the effectiveness of this drug candidate against the CDC7 protein. © 2025

关键词： Gene expression

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Accelerating Real-Time Imaging for Radiotherapy: Leveraging Multi-GPU Training with PyTorch 22

Accelerating Real-Time Imaging for Radiotherapy: Leveraging ...

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22nd IEEE International Conference on Machine Learning and Applications, ICMLA 2023

作者： Obe, Ruth Kaufmann, Brandt Baird, Kaelen Kadel, Sam Soltani, Yasmin Cham, Mostafa Gobbert, Matthias K. Barajas, Carlos A. Jiang, Zhuoran Sharma, Vijay R. Ren, Lei Peterson, Stephen W. Poif, Jerimy C. U. of Houston-Clear Lake Dept. of Computer Science and of Software Engineering United States U. of San Francisco Dept. of Mathematics and Statistics United States Skidmore College Dept. of Computer Science and of Mathematics United States Mount Holyoke College Dept. of Computer Science and of Psychology United States U. of Houston Dept. of Biomedical Engineering United States U. of Maryland Dept. of Information Systems Baltimore County United States U. of Maryland Dept. of Mathematics and Statistics Baltimore County United States Medical Physics Graduate Program Duke University United States U. of Maryland School of Medicine Dept. of Radiation Oncology United States U. of Maryland School of Medicine Department of Radiation Oncology United States U. of Cape Town Dept. of Physics South Africa H3D Inc. United States

ISBN: (纸本)9798350345346

Proton beam therapy is an advanced form of cancer radiotherapy that uses high-energy proton beams to deliver precise and targeted radiation to tumors. This helps to mit-igate unnecessary radiation exposure in healthy tissues. Real-time imaging of prompt gamma rays with Compton cameras has been suggested to improve therapy efficacy. However, the camera's non-zero time resolution leads to incorrect interaction classifications and noisy images that are insufficient for accurately assessing proton delivery in patients. To address the challenges posed by the Compton camera's image quality, machine learning techniques are employed to classify and refine the generated data. These machine-learning techniques include recurrent and feedforward neural networks. A PyTorch model was designed to improve the data captured by the Compton camera. This decision was driven by PyTorch's flexibility, powerful capabilities in handling sequential data, and enhanced G PU usage. This accelerates the model's computations on large-scale radiotherapy data. Through hyperparameter tuning, the validation accuracy of our PyTorch model has been improved from an initial 7 % to over 60 %. Moreover, the PyTorch Distributed Data Parallelism strategy was used to train the RNN models on multiple G PU s, which significantly reduced the training time with a minor impact on model accuracy. © 2023 IEEE.

关键词： Clas-sification Compton camera Distributed Data Parallelism Proton beam therapy PyTorch Recurrent neural network

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Research on Data Security and Privacy of Smart Grids

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International Journal of Network Security 2024年第5期26卷 901-910页

作者： Hwang, Min-Shiang Chang, Yung-Ling Lin, Ko-Yu Lin, Iuon-Chang Yang, Cheng-Ying Department of Computer Science & Information Engineering Asia University 500 Lioufeng Rd. Wufeng Taichung Taichung41354 Taiwan Fintech and Blockchain Research Center Asia University 500 Lioufeng Rd. Wufeng Taichung Taichung41354 Taiwan The Ph.D. Program in Artificial Intelligence Asia University Taiwan Department of Management Information Systems National Chung Hsing University 500 Lioufeng Rd. Wufeng Taichung Taichung41354 Taiwan Department of Computer Science University of Taipei Taipei Taiwan

Developing a smart grid is a trend nowadays and an indispensable basic necessity of life. In recent years, the electricity demand has risen rapidly due to economic development and quality of life improvement. The power grid in significant cities is unstable due to old equipment, and power outages occur frequently. The smart grid can adjust the grid’s distribution strategy through the consumer’s real-time electricity demand so that the consumer’s electricity consumption data is always transmitted to the grid. Failure to protect the privacy and security of such information will expose consumers’ habits and even make the grid unnecessarily wasteful. The smart grid’s abnormality detection efficiency determines the overall grid’s stability. Failure to detect anomalies or power theft in the grid promptly will not only lead to the selection of the wrong distribution strategy for the smart grid but also reduce the transmission efficiency of the grid. This research ensures the privacy and security of transmitted data to enhance the efficiency of abnormality detection in the smart grid. The research issues are divided into privacy of transmitted data, data security authentication, and anomaly detection efficiency. © (2024), (International Journal of Network Security). All rights reserved.

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Ecology, Spatial Structure, and Selection Pressure Induce Strong Signatures in Phylogenetic Structure

arXiv

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arXiv 2024年

作者： Moreno, Matthew Andres Rodriguez-Papa, Santiago Dolson, Emily Department of Ecology and Evolutionary Biology University of Michigan Ann Arbor United States Center for the Study of Complex Systems University of Michigan Ann Arbor United States Michigan Institute for Data Science University of Michigan Ann Arbor United States Department of Computer Science and Engineering Michigan State University East Lansing United States Program in Ecology Evolution and Behavior Michigan State University East Lansing United States

Evolutionary dynamics are shaped by a variety of fundamental, generic drivers, including spatial structure, ecology, and selection pressure. These drivers impact the trajectory of evolution, and have been hypothesized to influence phylogenetic structure. For instance, they can help explain natural history, steer behavior of contemporary evolving populations, and influence efficacy of application-oriented evolutionary optimization. Likewise, in inquiry-oriented artificial life systems, these drivers constitute key building blocks for open-ended evolution. Here, we set out to assess (1) if spatial structure, ecology, and selection pressure leave detectable signatures in phylogenetic structure, (2) the extent, in particular, to which ecology can be detected and discerned in the presence of spatial structure, and (3) the extent to which these phylogenetic signatures generalize across evolutionary systems. To this end, we analyze phylogenies generated by manipulating spatial structure, ecology, and selection pressure within three computational models of varied scope and sophistication. We find that selection pressure, spatial structure, and ecology have characteristic effects on phylogenetic metrics, although these effects are complex and not always intuitive. Signatures have some consistency across systems when using equivalent taxonomic unit definitions (e.g., individual, genotype, species). Further, we find that sufficiently strong ecology can be detected in the presence of spatial structure. We also find that, while low-resolution phylogenetic reconstructions can bias some phylogenetic metrics, high-resolution reconstructions recapitulate them faithfully. Although our results suggest potential for evolutionary inference of spatial structure, ecology, and selection pressure through phylogenetic analysis, further methods development is needed to distinguish these drivers' phylometric signatures from each other and to appropriately normalize phylogenetic metrics. With s

关键词： Abiotic

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Local Periodicity-Based Beat Tracking for Expressive Classical Piano Music

arXiv

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arXiv 2023年

作者： Chiu, Ching-Yu Müller, Meinard Davies, Matthew E.P. Su, Alvin Wen-Yu Yang, Yi-Hsuan The Graduate Program of Multimedia Systems and Intelligent Computing National Cheng Kung University Academia Sinica Taiwan The International Audio Laboratories Erlangen Germany The Department of Informatics Engineering Centre for Informatics and Systems of the University of Coimbra University of Coimbra Portugal The Department of Computer Science and Information Engineering National Cheng Kung University Taiwan Yating Music Team Taiwan AI Labs Taiwan Research Center for IT Innovation Academia Sinica Taiwan

To model the periodicity of beats, state-of-the-art beat tracking systems use "post-processing trackers" (PPTs) that rely on several empirically determined global assumptions for tempo transition, which work well for music with a steady tempo. For expressive classical music, however, these assumptions can be too rigid. With two large datasets of Western classical piano music, namely the Aligned Scores and Performances (ASAP) dataset and a dataset of Chopin's Mazurkas (Maz-5), we report on experiments showing the failure of existing PPTs to cope with local tempo changes, thus calling for new methods. In this paper, we propose a new local periodicity-based PPT, called predominant local pulse-based dynamic programming (PLPDP) tracking, that allows for more flexible tempo transitions. Specifically, the new PPT incorporates a method called "predominant local pulses" (PLP) in combination with a dynamic programming (DP) component to jointly consider the locally detected periodicity and beat activation strength at each time instant. Accordingly, PLPDP accounts for the local periodicity, rather than relying on a global tempo assumption. Compared to existing PPTs, PLPDP particularly enhances the recall values at the cost of a lower precision, resulting in an overall improvement of F1-score for beat tracking in ASAP (from 0.473 to 0.493) and Maz-5 (from 0.595 to 0.838). © 2023, CC BY.

关键词： Dynamic programming

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Intrusion Detection using Deep Neural Network Algorithm on the Internet of Things

Intrusion Detection using Deep Neural Network Algorithm on t...

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IEEE International Conference on Communication, Networks and Satellite (ComNetSat)

作者： Syariful Ikhwan Adi Wibowo Budi Warsito Doctoral Program of Information System School of Postgraduate Studies Diponegoro University Semarang Indonesia D3 Telecommunication Engineering Institut Teknologi Telkom Purwokerto Banyumas Indonesia Computer Science Informatics Department of Science and Mathematics Faculty Diponegoro University Semarang Indonesia Statistics Department of Science and Mathematics Faculty Diponegoro University Semarang Indonesia

ISBN: (数字)9781665460309

ISBN: (纸本)9781665460316

The increasing use of IoT devices on future networks is very helpful for humans in their lives. However, the increase in devices connected to IoT networks also increases the potential for attacks against those networks. Vulnerabilities in Internet of Things (IoT) networks can be exposed at any time. Artificial intelligence can be used to protect the IoT network by being able to detect attacks on the network so that they can be prevented. In this study, network detection was carried out using the Deep Neural Network (DNN) algorithm. The test was carried out using the UNSW Bot-IoT dataset with a comparison of training data of 75% of the overall data. The results obtained show the ability of the algorithm to detect attacks on average with 99.999% accuracy. The validation loss and training loss look very small. In this study, there is a validation loss that still occurs in overfitting, but the difference is very small.

关键词： Deep learning Training Satellites Neural networks Intrusion detection Training data Feature extraction

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Towards a Prosodic Model for Synthesized Speech of Mathematical Expressions in MathML 9

Towards a Prosodic Model for Synthesized Speech of Mathemati...

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9th International Conference on Software Development and Technologies for Enhancing Accessibility and Fighting Info-Exclusion, DSAI 2020

作者： Souza, Adriana Freitas, Diamantino Bahia Federal Institute of Education Science and Technology Porto Seguro Brazil Doctoral Program in Digital Media Faculty of Engineering University of Porto Porto Portugal Department of Electrical and Computer Engineering Faculty of Engineering University of PortoPorto Portugal

ISBN: (纸本)9781450389372

The use of the MathML language made possible to improve the accessibility of mathematics for blind or low-vision persons in digital media. Synthetic speech technologies have advanced significantly using MathML, however, the speech synthesizers' standard reading style is still not suitable for mathematics. Making mathematical reading of the speech synthesizers more natural and expressive is still a challenge. The creation of models to produce the appropriate prosody in the synthesized speech of math content is therefore necessary, as shown in previous research. This article presents a proposal for a model to improve prosody in the synthesized speech of mathematical expressions based on MathML. A corpus of mathematical expressions spoken by Mathematics teachers was created to support the model's development. The Fujisaki intonation model was adopted for intonation control, accent and phrase commands have been extracted from the corpus, and some adjustments have been made to manipulate prosodic parameters in the speech of mathematical expression in correlation with the MathML tree;additionally, a pattern of pauses control is being created. © 2020 ACM.

关键词： Digital storage

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