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Author Correction: π-HuB: the proteomic navigator of the human body

Nature 2025年第8046期637卷 E22页

作者： Fuchu He Ruedi Aebersold Mark S Baker Xiuwu Bian Xiaochen Bo Daniel W Chan Cheng Chang Luonan Chen Xiangmei Chen Yu-Ju Chen Heping Cheng Ben C Collins Fernando Corrales Jürgen Cox Weinan E Jennifer E Van Eyk Jia Fan Pouya Faridi Daniel Figeys George Fu Gao Wen Gao Zu-Hua Gao Keisuke Goda Wilson Wen Bin Goh Dongfeng Gu Changjiang Guo Tiannan Guo Yuezhong He Albert J R Heck Henning Hermjakob Tony Hunter Narayanan Gopalakrishna Iyer Ying Jiang Connie R Jimenez Lokesh Joshi Neil L Kelleher Ming Li Yang Li Qingsong Lin Cui Hua Liu Fan Liu Guang-Hui Liu Yansheng Liu Zhihua Liu Teck Yew Low Ben Lu Matthias Mann Anming Meng Robert L Moritz Edouard Nice Guang Ning Gilbert S Omenn Christopher M Overall Giuseppe Palmisano Yaojin Peng Charles Pineau Terence Chuen Wai Poon Anthony W Purcell Jie Qiao Roger R Reddel Phillip J Robinson Paola Roncada Chris Sander Jiahao Sha Erwei Song Sanjeeva Srivastava Aihua Sun Siu Kwan Sze Chao Tang Liujun Tang Ruijun Tian Juan Antonio Vizcaíno Chanjuan Wang Chen Wang Xiaowen Wang Xinxing Wang Yan Wang Tobias Weiss Mathias Wilhelm Robert Winkler Bernd Wollscheid Limsoon Wong Linhai Xie Wei Xie Tao Xu Tianhao Xu Liying Yan Jing Yang Xiao Yang John Yates Tao Yun Qiwei Zhai Bing Zhang Hui Zhang Lihua Zhang Lingqiang Zhang Pingwen Zhang Yukui Zhang Yu Zi Zheng Qing Zhong Yunping Zhu State Key Laboratory of Medical Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing China. hefc@***. International Academy of Phronesis Medicine (Guangdong) Guangdong China. hefc@***. Department of Biology Institute of Molecular Systems Biology ETH Zurich Zurich Switzerland. aebersold@imsb.biol.ethz.ch. Macquarie Medical School Macquarie University Sydney New South Wales Australia. Institute of Pathology and Southwest Cancer Center Southwest Hospital Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology Ministry of Education of China Chongqing China. Institute of Health Service and Transfusion Medicine Beijing China. Department of Pathology and The Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University Baltimore MD USA. State Key Laboratory of Medical Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing China. Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai China. Department of Nephrology First Medical Center of Chinese PLA General Hospital Nephrology Institute of the Chinese People's Liberation Army State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Disease Research Beijing China. Institute of Chemistry Academia Sinica Taipei China. National Biomedical Imaging Center State Key Laboratory of Membrane Biology Institute of Molecular Medicine Peking-Tsinghua Center for Life Sciences College of Future Technology Peking University Beijing China. School of Biological Sciences Queen's University of Belfast Belfast UK. Functional Proteomics Laboratory Centro Nacional de Biotecnología-CSIC Madrid Spain. Computational Systems Biochemistry Research Group Ma

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High-Throughput Screening: One-Step Generation of a Drug-Releasing Hydrogel Microarray-On-A-Chip for Large-Scale Sequential Drug Combination Screening (Adv. Sci. 3/2019)

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Advanced science 2019年第3期6卷 1970014-1970014页

作者： Seo Woo Song Su Deok Kim Dong Yoon Oh Yongju Lee Amos Chungwon Lee Yunjin Jeong Hyung Jong Bae Daewon Lee Sumin Lee Jiyun Kim Sunghoon Kwon Department of Electrical and Computer Engineering Seoul National University Seoul 08826 South Korea Institutes of Entrepreneurial BioConvergence Seoul National University Seoul 08826 South Korea Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign Urbana IL 61801 USA Nano Systems Institute Seoul National University Seoul 08826 South Korea Interdisciplinary Program in Bioengineering Seoul National University Seoul 08826 South Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology Ulsan 44919 South Korea

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Author Correction: Enhancing untargeted metabolomics using metadata-based source annotation

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Nature biotechnology 2023年第11期41卷 1656页

作者： Julia M Gauglitz Kiana A West Wout Bittremieux Candace L Williams Kelly C Weldon Morgan Panitchpakdi Francesca Di Ottavio Christine M Aceves Elizabeth Brown Nicole C Sikora Alan K Jarmusch Cameron Martino Anupriya Tripathi Michael J Meehan Kathleen Dorrestein Justin P Shaffer Roxana Coras Fernando Vargas Lindsay DeRight Goldasich Tara Schwartz MacKenzie Bryant Gregory Humphrey Abigail J Johnson Katharina Spengler Pedro Belda-Ferre Edgar Diaz Daniel McDonald Qiyun Zhu Emmanuel O Elijah Mingxun Wang Clarisse Marotz Kate E Sprecher Daniela Vargas-Robles Dana Withrow Gail Ackermann Lourdes Herrera Barry J Bradford Lucas Maciel Mauriz Marques Juliano Geraldo Amaral Rodrigo Moreira Silva Flavio Protasio Veras Thiago Mattar Cunha Rene Donizeti Ribeiro Oliveira Paulo Louzada-Junior Robert H Mills Paulina K Piotrowski Stephanie L Servetas Sandra M Da Silva Christina M Jones Nancy J Lin Katrice A Lippa Scott A Jackson Rima Kaddurah Daouk Douglas Galasko Parambir S Dulai Tatyana I Kalashnikova Curt Wittenberg Robert Terkeltaub Megan M Doty Jae H Kim Kyung E Rhee Julia Beauchamp-Walters Kenneth P Wright Maria Gloria Dominguez-Bello Mark Manary Michelli F Oliveira Brigid S Boland Norberto Peporine Lopes Monica Guma Austin D Swafford Rachel J Dutton Rob Knight Pieter C Dorrestein Collaborative Mass Spectrometry Innovation Center University of California San Diego La Jolla CA USA. Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego La Jolla CA USA. Beckman Center for Conservation Research San Diego Zoo Wildlife Alliance Escondido CA USA. Center for Microbiome Innovation Joan and Irwin Jacobs School of Engineering University of California San Diego La Jolla CA USA. Division of Biological Sciences University of California San Diego La Jolla CA USA. Department of Pediatrics School of Medicine University of California San Diego La Jolla CA USA. Bioinformatics and Systems Biology Program University of California San Diego La Jolla CA USA. Division of Rheumatology Allergy & Immunology Department of Medicine University of California San Diego La Jolla CA USA. Division of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN USA. Department of Integrative Physiology University of Colorado Boulder Boulder CO USA. Department of Population Health Sciences University of Wisconsin-Madison Madison WI USA. Servicio Autónomo Centro Amazónico de Investigación y Control de Enfermedades Tropicales Simón Bolívar Puerto Ayacucho Amazonas Venezuela. Department of Pediatrics Billings Clinic Billings MT USA. Department of Animal Science Michigan State University East Lansing MI USA. Department of Pharmacology Ribeirão Preto Medicinal School Center of Research in Inflammatory Diseases University of São Paulo Ribeirão Preto Sao Paolo Brazil. Multidisciplinary Health Institute Federal University of Bahia Vitória da Conquista Bahia Brazil. NPPNS Department of Biomolecular Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo Ribeirão Preto Sao Paolo Brazil. Department of Internal Medicine Ribeirão Preto Medical School Center of Research in Inflammatory Diseases University of São Paulo Ribeirão Preto Sao Paolo Brazil. Department

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Vibration-based classification of road damages: gyroscope data and a simple neural network model

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IOP Conference Series: Earth and Environmental science 2018年第1期195卷

作者： Fergyanto E. Gunawan Herriyandi Benfano Soewito Tuga Mauritsius Nico Surantha Industrial Engineering Department BINUS Graduate Program - Master of Industrial Engineering Bina Nusantara University Jakarta Indonesia 11480 Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta Indonesia 11480 Information Systems Management Department BINUS Graduate Program - Master of Information Systems Management Bina Nusantara University Jakarta Indonesia 11480

A system for automatic detection of road damages is essential for logistics management. At the core of the system lies an algorithm for classification of damages. This work intends to establish such an algorithm. In the current proposal, the algorithm receives data of the probe vehicle rate of rotations, extracts statistics descriptive from the data to produce a feature vector, and finally, feeds the vector to a simple-three-layer neural network to classify the damages. The types of damages are limited to four cases: normal, pothole, speed bump, and expansion joint. For the development, a probe vehicle is used to produce 400 empirical data involving those four damage cases. By using Monte Carlo approach, the established neural network model is evaluated. The results show that the approach is able to classify the cases with 85% accuracy. The study also finds that the rates of pitch and roll to be the determining factors.

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Dense sampling of bird diversity increases power of comparative genomics (vol 587, pg 252, 2020)

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NATURE 2021年第7856期592卷 E24-E24页

作者： Feng, Shaohong Stiller, Josefin Deng, Yuan Armstrong, Joel Fang, Qi Reeve, Andrew Hart Xie, Duo Chen, Guangji Guo, Chunxue Faircloth, Brant C. Petersen, Bent Wang, Zongji Zhou, Qi Diekhans, Mark Chen, Wanjun Andreu-Sanchez, Sergio Margaryan, Ashot Howard, Jason Travis Parent, Carole Pacheco, George Sinding, Mikkel-Holger S. Puetz, Lara Cavill, Emily Ribeiro, Angela M. Eckhart, Leopold Fjeldsa, Jon Hosner, Peter A. Brumfield, Robb T. Christidis, Les Bertelsen, Mads F. Sicheritz-Ponten, Thomas Tietze, Dieter Thomas Robertson, Bruce C. Song, Gang Borgia, Gerald Claramunt, Santiago Lovette, Irby J. Cowen, Saul J. Njoroge, Peter Dumbacher, John Philip Ryder, Oliver A. Fuchs, Jerome Bunce, Michael Burt, David W. Cracraft, Joel Meng, Guanliang Hackett, Shannon J. Ryan, Peter G. Jonsson, Knud Andreas Jamieson, Ian G. da Fonseca, Rute R. Braun, Edward L. Houde, Peter Mirarab, Siavash Suh, Alexander Hansson, Bengt Ponnikas, Suvi Sigeman, Hanna Stervander, Martin Frandsen, Paul B. van der Zwan, Henriette van der Sluis, Rencia Visser, Carina Balakrishnan, Christopher N. Clark, Andrew G. Fitzpatrick, John W. Bowman, Reed Chen, Nancy Cloutier, Alison Sackton, Timothy B. Edwards, Scott V. Foote, Dustin J. Shakya, Subir B. Sheldon, Frederick H. Vignal, Alain Soares, Andre E. R. Shapiro, Beth Gonzalez-Solis, Jacob Ferrer-Obiol, Joan Rozas, Julio Riutort, Marta Tigano, Anna Friesen, Vicki Dalen, Love Urrutia, Araxi O. Szekely, Tamas Liu, Yang Campana, Michael G. Corvelo, Andre Fleischer, Robert C. Rutherford, Kim M. Gemmell, Neil J. Dussex, Nicolas Mouritsen, Henrik Thiele, Nadine Delmore, Kira Liedvogel, Miriam Franke, Andre Hoeppner, Marc P. Krone, Oliver Fudickar, Adam M. Mila, Borja Ketterson, Ellen D. Fidler, Andrew Eric Friis, Guillermo Parody-Merino, Angela M. Battley, Phil F. Cox, Murray P. Lima, Nicholas Costa Barroso Prosdocimi, Francisco Parchman, Thomas Lee Schlinger, Barney A. Loiselle, Bette A. Blake, John G. Lim, Haw Chuan Day, Lainy B. Fuxjager, Matthew J. Baldwin, Maude W. Braun, Michael J. Wirthlin, Morgan Dikow, China National GeneBank BGI-Shenzhen Shenzhen China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China BGI-Shenzhen Shenzhen China Villum Centre for Biodiversity Genomics Section for Ecology and Evolution Department of Biology University of Copenhagen Copenhagen Denmark BGI Education Center University of Chinese Academy of Sciences Shenzhen China MOE Laboratory of Biosystems Homeostasis and Protection Life Sciences Institute Zhejiang University Hangzhou China Department of Neuroscience and Developmental Biology University of Vienna Vienna Austria Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming China James D. Watson Institute of Genome Sciences Hangzhou China UC Santa Cruz Genomics Institute UC Santa Cruz Santa Cruz CA USA Natural History Museum of Denmark University of Copenhagen Copenhagen Denmark Center for Macroecology Evolution and Climate GLOBE Institute University of Copenhagen Copenhagen Denmark Department of Biological Sciences Louisiana State University Baton Rouge LA USA Museum of Natural Science Louisiana State University Baton Rouge LA USA Centre of Excellence for Omics-Driven Computational Biodiscovery (COMBio) Faculty of Applied Sciences AIMST University Kedah Malaysia Section for Evolutionary Genomics The GLOBE Institute Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark Institute of Molecular Biology National Academy of Sciences Yerevan Armenia University Museum Norwegian University of Science and Technology Trondheim Norway Center for Reproductive Medicine The 2nd Affiliated Hospital School of Medicine Zhejiang University Hangzhou China Novogene Durham NC USA Duke University Medical Center Durham NC USA The Rockefeller University New York NY USA Howard Hughes Medical Institute Chevy Chase MD USA Department of Dermatology Medical University of Vienna Vienna Austria

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Applying Standard Independent Verification and Validation (IV&V) Techniques within an Agile Framework: Is there a Compatibility Issue?

Applying Standard Independent Verification and Validation (I...

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International systems Conference

作者： James B. Dabney James D. Arthur Department of Computer Science Virginia Polytechnic Institute and State University Blacksburg Virginia Systems Engineering Program University of Houston - Clear Lake Houston Texas

ISBN: (纸本)9781509046249

Agile methods have gained wide acceptance over the past several years, to the point that they are now a standard management and execution approach for small-scale software development projects. While conventional Agile methods are not generally applicable to large multi-year and mission-critical systems, Agile hybrids are now being developed (such as SAFe) to exploit the productivity improvements of Agile while retaining the necessary process rigor and coordination needs of these projects. From the perspective of Independent Verification and Validation (IV&V), however, the adoption of these hybrid Agile frameworks is becoming problematic. Hence, we find it prudent to question the compatibility of conventional IV&V techniques with (hybrid) Agile practices. This paper documents our investigation of (a) relevant literature, (b) the modification and adoption of Agile frameworks to accommodate the development of large scale, mission critical systems, and (c) the compatibility of standard IV&V techniques within hybrid Agile development frameworks. Specific to the latter, we found that the IV&V methods employed within a hybrid Agile process can be divided into three groups: (1) early lifecycle IV&V techniques that are fully compatible with the hybrid lifecycles, (2) IV&V techniques that focus on tracing requirements, test objectives, etc. are somewhat incompatible, but can be tailored with a modest effort, and (3) IV&V techniques involving an assessment requiring artifact completeness that are simply not compatible with hybrid Agile processes, e.g., those that assume complete requirement specification early in the development lifecycle.

关键词： Independent Verification and Validation Agile

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Galactic transient sources with the Cherenkov Telescope Array Observatory

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Monthly Notices of the Royal Astronomical Society 2025年第1期540卷 205–238页

作者： Abe, K Abe, S Abhir, J Abhishek, A Acero, F Acharyya, A Adam, R Aguasca-Cabot, A Agudo, I Aguirre-Santaella, A Alfaro, J Alfaro, R Alvarez-Crespo, N Alves Batista, R Amans, J-P Amato, E Ambrosi, G Ambrosino, F Angüner, E O Antonelli, L A Aramo, C Arcaro, C Arnesen, T T H Asano, K Ascasibar, Y Aschersleben, J Ashkar, H Augusto Stuani, L Baack, D Backes, M Balazs, C Balbo, M Baquero Larriva, A Barbosa Martins, V Barres de Almeida, U Barrio, J A Barrios-Jiménez, L Batković, I Batzofin, R Baxter, J Becerra González, J Becker Tjus, J Belmont, R Benbow, W Bernete, J Bernlöhr, K Berti, A Bertucci, B Beshley, V Bhattacharjee, P Bhattacharyya, S Bigongiari, C Bissaldi, E Blanch, O Blazek, J Bocchino, F Boisson, C Bolmont, J Bonnoli, G Bonollo, A Bordas, P Bosnjak, Z Bottacini, E Böttcher, M Bradascio, F Bronzini, E Brown, A M Brunelli, G Bulgarelli, A Burelli, I Burger-Scheidlin, C Burmistrov, L Burton, M Buscemi, M Cailleux, J Campoy-Ordaz, A Cantlay, B K Capasso, G Caproni, A Capuzzo-Dolcetta, R Caraveo, P Caroff, S Carosi, A Carosi, R Carquin, E Carrasco, M-S Cascone, E Cassol, F Castaldini, L Castrejon, N Castro-Tirado, A J Cerasole, D Ceribella, G Cerruti, M Chadwick, P M Chaty, S Chen, A W Chernyakova, M Chiavassa, A Chudoba, J Chytka, L Cicciari, G M Cifuentes, A Coimbra Araujo, C H Colapietro, M Conforti, V Contreras, J L Cortina, J Costa, A Costantini, H Cotter, G Cristofari, P Cuevas, O Curtis-Ginsberg, Z D’Aì, A D’Amico, G D’Ammando, F Dai, S Dazzi, F de Bony de Lavergne, M De Caprio, V De Cesare, G De Frondat Laadim, F de Gouveia Dal Pino, E M De Lotto, B De Lucia, M de Martino, D de Menezes, R de Naurois, M de Ona Wilhelmi, E de Souza, V del Peral, L del Valle, M V Delgado, C Dell’aiera, M Della Valle, M della Volpe, D Depaoli, D Devin, J Di Girolamo, T Di Piano, A Di Pierro, F Di Tria, R Di Venere, L Diebold, S Dignam, C Dima, R Dinesh, A Djuvsland, J Dominik, R M Dominis Prester, D Donini, A Dorner, D Dörner, J Doro, M Dubos, C Ducci, L Dwarkadas, V V Ebr, J Eckner, C Egberts, K Einecke, S Elsässer, D Emery Department of Physics Tokai University 4-1-1 Kita-Kaname Hiratsuka Kanagawa 259-1292 Japan Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Kashiwa Chiba 277-8582 Japan ETH Zürich Institute for Particle Physics and Astrophysics Otto-Stern-Weg 5 CH-8093 Zürich Switzerland INFN and Università degli Studi di Siena Dipartimento di Scienze Fisiche della Terra e dell’Ambiente (DSFTA) Sezione di Fisica Via Roma 56 I-53100 Siena Italy Université Paris-Saclay Université Paris Cité CEA CNRS AIM F-91191 Gif-sur-Yvette Cedex France FSLAC IRL 2009 CNRS/IAC E-38205 La Laguna Tenerife Spain University of Alabama Tuscaloosa Department of Physics and Astronomy Gallalee Hall Box 870324 Tuscaloosa AL 35487-0324 USA Université Côte d’Azur Observatoire de la Côte d’Azur CNRS Laboratoire Lagrange UF 06304 Nice France Laboratoire Leprince-Ringuet CNRS/IN2P3 École Polytechnique Institut Polytechnique de Paris F-91120 Palaiseau France Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Martí i Franquès 1 E-08028 Barcelona Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n E-18008 Granada Spain Institute for Computational Cosmology and Department of Physics Durham University South Road Durham DH1 3LE UK Pontificia Universidad Católica de Chile Av. Libertador Bernardo O’Higgins 340 8331150 Santiago Chile Universidad Nacional Autónoma de México Delegación Coyoacán 04510 Ciudad de México Mexico IPARCOS-UCM Instituto de Física de Partículas y del Cosmos and EMFTEL Department Universidad Complutense de Madrid E-28040 Madrid Spain Instituto de Física Teórica UAM/CSIC and Departamento de Física Teórica Universidad Autónoma de Madrid c/ Nicolás Cabrera 13-15 Campus de Cantoblanco UAM E-28049 Madrid Spain LUTH GEPI and LERMA Observatoire de Paris Université PSL Université Paris Cité CNRS 5 place Jules Janssen F-92190 Meudon France INAF – Osservatorio

A wide variety of Galactic sources show transient emission at soft and hard X-ray energies: low- and high-mass X-ray binaries containing compact objects, isolated neutron stars exhibiting extreme variability as magnetars as well as pulsar-wind nebulae. Although most of them can show emission up to MeV and/or GeV energies, many have not yet been detected in the TeV domain by Imaging Atmospheric Cherenkov Telescopes. In this paper, we explore the feasibility of detecting new Galactic transients with the Cherenkov Telescope Array Observatory (CTAO) and the prospects for studying them with Target of Opportunity observations. We show that CTAO will likely detect new sources in the TeV regime, such as the massive microquasars in the Cygnus region, low-mass X-ray binaries with low-viewing angle, flaring emission from the Crab pulsar-wind nebula or other novae explosions, among others. Since some of these sources could also exhibit emission at larger time-scales, we additionally test their detectability at longer exposures. We finally discuss the multiwavelength synergies with other instruments and large astronomical facilities.

关键词： binaries: general stars: magnetars novae cataclysmic variables pulsars: general gamma-rays: general

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Reference Data Based Insights Expand Understanding of Human Metabolomes

SSRN

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SSRN 2020年

作者： Gauglitz, Julia M. Bittremieux, Wout Williams, Candace L. Weldon, Kelly C. Panitchpakdi, Morgan Di Ottavio, Francesca Aceves, Christine M. Brown, Elizabeth Sikora, Nicole C. Jarmusch, Alan K. Martino, Cameron Tripathi, Anupriya Sayyari, Erfan Shaffer, Justin P. Coras, Roxana Vargas, Fernando DeRight Goldasich, Lindsay Schwartz, Tara Bryant, MacKenzie Humphrey, Gregory Johnson, Abigail J. Spengler, Katharina Belda-Ferre, Pedro Diaz, Edgar McDonald, Daniel Zhu, Qiyun Nguyen, Dominic S. Elijah, Emmanuel O. Wang, Mingxun Marotz, Clarisse Sprecher, Kate E. Robles, Daniela Vargas Withrow, Dana Ackermann, Gail Herrera, Lourdes Bradford, Barry J. Marques, Lucas Maciel Mauriz Amaral, Juliano Geraldo Silva, Rodrigo Moreira Veras, Flávio Protaso Cunha, Thiago Mattar Oliveira, Rene Donizeti Ribeiro Louzada-Junior, Paulo Mills, Robert H. Galasko, Douglas Dulai, Parambir S. Wittenberg, Curt Gonzalez, David J. Terkeltaub, Robert Doty, Megan M. Kim, Jae H. Rhee, Kyung E. Beauchamp-Walters, Julia Wright, Kenneth P. Dominguez-Bello, Maria Gloria Manary, Mark Oliveira, Michelli F. Boland, Brigid S. Lopes, Norberto Peporine Guma, Monica Swafford, Austin D. Dutton, Rachel J. Knight, Rob Dorrestein, Pieter C. Collaborative Mass Spectrometry Innovation Center University of California San Diego San DiegoCA92093 United States Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego San DiegoCA92093 United States Department of Computer Science University of Antwerp Antwerpen2020 Belgium Reproductive Sciences Institute for Conservation Research San Diego Zoo Global EscondidoCA92027 United States Center for Microbiome Innovation Joan and Irwin Jacobs School of Engineering University of California San Diego San DiegoCA92093 United States Division of Biological Sciences University of California San Diego San DiegoCA92093 United States Department of Pediatrics School of Medicine University of California San Diego San DiegoCA92093 United States Bioinformatics and Systems Biology Program University of California San Diego San DiegoCA92093 United States Division of Rheumatology Allergy & Immunology Department of Medicine University of California San Diego San DiegoCA92093 United States BioTechnology Institute University of Minnesota Saint PaulMN55108 United States Department of Integrative Physiology University of Colorado Boulder BoulderCO80309 United States Department of Population Health Sciences University of Wisconsin-Madison MadisonWI53726 United States Servicio Autónomo Centro Amazónico de Investigación y Control de Enfermedades Tropicales Simón Bolívar Amazonas Puerto Ayacucho7101 Venezuela Department of Pediatrics Wake Forest School of Medicine Winston-SalemNC27101 United States Department of Animal Science Michigan State University East LansingMI48824 United States Department of Pharmacology School of Medicine of Ribeirao Preto Center of Research in Inflammatory Diseases University of Sao Paulo SP Ribeirao PretoCEP 14049-900 - Brazil Multidisciplinary Health Institute Federal University of Bahia BA Vitória da Conquista45029094 Brazil NPPNS Department of Biomolecular Sciences School of Pharmaceutica

The human metabolome has remained largely unknown, with most studies annotating ~10% of features. In nucleic acid sequencing, annotating transcripts by source has proven essential for understanding gene function. Here we generalize this concept to stool, plasma, urine and other human metabolomes, discovering that food-based annotations increase the interpreted fraction of molecular features 7-fold, providing a general framework for expanding the interpretability of human metabolomic "dark matter." © 2020, The Authors. All rights reserved.

关键词： Nucleic acids

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Applying the MVC EA-IRPM to reporting-guidelines in medicine: A strategy that is a web system 4

Applying the MVC EA-IRPM to reporting-guidelines in medicine...

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4th IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2017

作者： Letouze, Patrick De Souza, J.I.M. Silva, Valeria Martins Climaco, Glaubos Chagas, F.B. Ishihara, Joao Y. Graduate Program of Computational Modeling of Systems Universidade Federal Do Tocantins Quadra 109 Norte Avenida NS-15 Palmas77001-090 Brazil Graduate Program of Systems' Engineering and Computation - PESC Universidade Federal Do Rio de Janeiro Rio de Janeiro Brazil Department of Informatics at the Universidade Federal Do Maranh/ Ao - UFMA Brazil Faculty of Computer Science Faculdade Pitagoras Imperatriz Imperatriz Brazil Faculty of Electrical Engineering Universidade de Brasília Brasília Brazil

ISBN: (纸本)9781509041794

Reporting-Guidelines in Medicine play an important role in promoting the quality of reports in health-related research. For instance, a poorly reported research may induce misinterpretation and inappropriate clinical settings. Basically, three major issues regarding Reporting-Guidelines in Medicine has to be addressed: (1) the existence of lots of reporting guidelines covering a broad spectrum of medical research increases the difficulties when reporting a medical research because it may not be clear which guidelines are applicable, or if all related guidelines are considered;(2) most guideline developers have not described how their guidance was developed, consequently tracking guidelines and features for evaluation, or even for correcting, may be not possible;(3) few guideline developers have evaluated the effectiveness of their guidance, then the real value that the guideline brings to reporting the research is not assured. Hence, we propose a solution to these three issues based on the Model-View-Controller Evolutionary Acquisition Interdisciplinary Research Project Management (MVC EA-IRPM) that is simultaneously a strategy and a web system for the development and management of reporting guidelines. © 2017 IEEE.

关键词： Clinical research

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Framework for selecting the preferred networked computer system for dynamic continuous missions

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CrossTalk 2017年第2期30卷 17-21页

作者： Tolentino, Glenn Tian, Jeff Stracener, Jerrell Command and Control Department Space and Naval Warfare Systems Center Pacific San DiegoCA United States United States School of Computer Science Northwestern Polytechnical University Xi'an China Systems Engineering Program United States

This paper presents a framework for selecting a combination of existing systems to satisfy new, emerging requirements while reusing existing and proven capabilities to ensure mission success. Decision attributes will be considered during the selection process and will be used to measure the networked computer system's effectiveness to accomplish the mission. This approach will enable system stakeholders to make critical, well-informed decisions to address the continuing evolution of missions, threats, budget and technology.

关键词： Budget control

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