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An Effective Analysis and Exploration of Cutting-Edge Machine Learning for Protein Structure and Sequence Prediction

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SN computer Science 2024年第6期5卷 1-12页

作者： Alam, Afaque Kumar, Mukesh Department of Computer Science and Engineering National Institute of Technology Patna

When processing large amounts of data, proteins play a key role in biological processes. Protein structure prediction relies on a procedure called relevant feature selection. To accomplish classification, a feature selection technique must first identify the most important features inside the massive dataset. The proposed methods improve protein structure prediction by providing data from the protein identification and sequencing process. Here we present a novel method for predicting protein structure using PSI sequencing. Gibbs Entropy Simulated Forging is used to pick important properties from a protein dataset. Gibbs Entropy is used to quickly locate the important amino acid properties from the massive dataset. The big data protein is sequenced using the Edman Firefly Optimization procedure after the appropriate features have been identified. A firefly's light intensity is calculated with the use of an objective function. Selected amino acid characteristics are ordered by light intensity rating. As a result, it is put to use in the fast and precise formation of protein sequences. This results in improved accuracy when sequencing proteins and a shorter sequencing time when determining each peptide's amino acid sequence. Accuracy and recall in the GESF algorithm procedure have increased while protein sequencing has required less time. The protein sequence is then constructed by applying Edman Firefly Optimization to a subset of characteristics. To improve protein correctness with little efforts investment, peptide residues are sequenced using EFO. Several large protein datasets are used to conduct an experimental evaluation in terms of precision, recall, false positive rate (FPR), sequencing accuracy (SQR), and sequencing time. The findings demonstrate that GESF-EFO improves upon existing methods of protein sequencing in the context of massive datasets. © The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd. 2024.

关键词： Accuracy EFO GESF SA ST

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Computation of Graph Fourier Transform Centrality Using Graph Filter

IEEE Open Journal of Circuits and Systems

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IEEE Open Journal of Circuits and Systems 2024年 5卷 69-80页

作者： Tseng, Chien-Cheng Lee, Su-Ling National Kaohsiung University of Science and Technology Department of Computer and Communication Engineering Kaohsiung824005 Taiwan Chang Jung Christian University Department of Computer Science and Information Engineering Tainan711301 Taiwan

In this paper, the computation of graph Fourier transform centrality (GFTC) of complex network using graph filter is presented. For conventional computation method, it needs to use the non-sparse transform matrix of graph Fourier transform (GFT) to compute GFTC scores. To reduce the computational complexity of GFTC, a linear algebra method based on Frobenius norm of error matrix is applied to convert the spectral-domain GFTC computation task to vertex-domain one such that GFTC can be computed by using polynomial graph filtering method. There are two kinds of designs of graph filters to be studied. One is the graph-aware method;the other is the graph-unaware method. The computational complexity comparison and experimental results show that the proposed graph filter method is more computationally efficient than conventional GFT method because the sparsity of Laplacian matrix is used in the implementation structure. Finally, the centrality computations of social network, metro network and sensor network are used to demonstrate the effectiveness of the proposed GFTC computation method using graph filter. © 2020 IEEE.

关键词： Complex networks

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Secure data authentication and access control protocol for industrial healthcare system

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Journal of Ambient Intelligence and Humanized Computing 2023年第5期14卷 4853-4864页

作者： Gupta, Daya Sagar Mazumdar, Nabajyoti Nag, Amitava Singh, Jyoti Prakash Department of Computer Science and Engineering Rajiv Gandhi Institute of Petroleum Technology Jais UP Amethi229304 India Department of Information Technology Indian Institute of Information Technology Allahabad Prayagraj India Department of Computer Science and Engineering Central Institute of Technology Kokrajhar BTR Kokrajhar India Department of Computer Science and Engineering National Institute of Technology Patna Patna India

Because of recent COVID-19 epidemic, the Internet-of-Medical-Things (IoMT) has acquired a significant impetus to diagnose patients remotely, regulate medical equipment, and track quarantined patients via smart electronic devices installed at the patient’s end. Nevertheless, the IoMT confronts various security and privacy issues, such as entity authentication, confidentiality, and integrity of health-related data, among others, rendering this technology vulnerable to different attacks. To address these concerns, a number of security procedures based on traditional cryptographic approaches, such as discrete logarithm and integer factorization problems, have been developed. All of these protocols, however, are vulnerable to quantum attacks. This paper, in this context, presents a data authentication and access control protocol for IoMT systems that can withstand quantum attacks. A comprehensive formal security assessment demonstrates that the proposed algorithm can endure both current and future threats. In terms of data computing, transmission, and key storage overheads, it also surpasses other related techniques. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： Authentication

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Drug-Target Interactions Prediction Based on Signed Heterogeneous Graph Neural Networks

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Chinese Journal of Electronics 2024年第1期33卷 231-244页

作者： Ming CHEN Yajian JIANG Xiujuan LEI Yi PAN Chunyan JI Wei JIANG College of Information Science and Engineering Hunan Normal University School of Computer Science Shaanxi Normal University Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Computer Science Department BNU-HKBU United International College

Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.

关键词： Drug-target interactions Signed heterogeneous network Link sign prediction Graph neural networks

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Securing Autonomous UAV Cluster With Blockchain-Based Threshold Key Management System Utilizing Crypto-Asset and Multisignature

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IEEE Transactions on Mobile Computing 2025年第7期24卷 5765-5778页

作者： Kharjana, Mebanjop Sahana, Subhas Chandra Saha, Goutam North-Eastern Hill University Department of Information Technology Shillong793022 India National Institute of Technology Department of Computer Science and Engineering Durgapur713209 India

Unmanned aerial vehicles deployed in remote locations rely on self-governed key management for their protection. However, conventional key management depends on a centralized ground-based station or single vehicle. Such a system is vulnerable to compromised certificate authority problems and single-points-of-failure. This paper proposed to resolve these vulnerabilities using a blockchain-based threshold key management system. The proposed system utilized blockchain’s concepts of crypto-asset and multisignature. Keys are defined as crypto-assets to improve their management in the blockchain network. Multisignature facilitates collaboration during key management based on a threshold value. The threshold value is also configurable to meet systems’ security and performance requirements. The proposed system secured the process of re-enforcement, sub-clustering, re-merging, and inter-cluster migration. Security analysis revealed that the proposed system complied with most key management security guidelines. The custom signature module used to authenticate intra-cluster communication was also verified as safe. Threats to the cluster were identified, assessed for risk, and mitigated accordingly. Performance analysis found that both AODV and DSDV routing protocols offer consistent performance but DSDV prevailed during the worst-case network scenario. The paper finally identified research gaps, including the requirement for an optimized mechanism for collecting consent signatures. © 2002-2012 IEEE.

关键词： Blockchains Autonomous aerial vehicles Security Authentication Drones Public key Mobile computing Smart contracts Collaboration Global Positioning System

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A Network Model to Study the Underlying Characteristics of Phishing Sites

IEEE Networking Letters

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IEEE Networking Letters 2024年第1期6卷 46-49页

作者： Gayen, Avijit Santra, Sukriti Dey, Ayush Jana, Angshuman Indian Institute of Information Technology Guwahati Department of Computer Science and Engineering Guwahati781015 India Swami Vivekanda University Department of Computer Science and Engineering Kolkata700121 India Techno India University Department of Computer Science and Engineering Kolkata700091 India

In the rapidly evolving landscape of cyber threats, phishing continues to be a prominent vector for cyberattacks, posing significant risks to individuals, organizations and information systems. This letter delves into a comprehensive analysis of phishing sites, focusing on their distinctive characteristics through the lens of network perspectives. In this letter, we study the underlying characteristics of phishing sites from the hyperlinked connectivity perspectives. In this letter, we have used a phishing site dataset available at Mendeley data. As the dataset does not contain any hyperlinked information, We further collect the hyperlinks in each site and store that information in a JSON file. We further analyze the hyperlinks and the various features of those sites. The initial study reveals that though the Phishing sites mimic the original legitimate sites to trap people in their sites, it has distinct differences from the perspective of structural connectivity as well as the content of sites. © 2019 IEEE.

关键词： Data mining

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Multi Attention Convolutional Sparse Coding U-Net for Enhanced Land-Use and Land-Cover Segmentation Using Hyperspectral Images

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Sensing and Imaging 2025年第1期26卷 1-32页

作者： Yele, Vijaykumar P. Badhe, Namdeo Baban Alegavi, Sujata Sedamkar, R.R. Department of Electronics & Telecommunication Engineering Thakur College of Engineering and Technology Maharashtra Mumbai400101 India Department of Information Technology Thakur College of Engineering and Technology Maharashtra Mumbai400101 India Department of Internet of Things Thakur College of Engineering and Technology Maharashtra Mumbai400101 India Department of Computer Engineering Thakur College of Engineering and Technology Maharashtra Mumbai400101 India

The process of segmentation of hyperspectral images involves dividing the image into various categories by interpreting the spectral data which in turn enhances the accuracy of environmental, urban, and agricultural monitoring. Most existing land-cover land-use segmentation models have operational inefficiencies due to limitations such as high memory consumption, complicated computing processes, and weak scalability with the architectural complexities hindering the performance across different datasets and tasks. In response to this, a Multi Attention Convolutional sparse coding U-network Feed-forward Network (MACUFN) is developed as a multi-layered and advanced solution for segmentation. The Gaussian Adaptive Bilateral Median Filtering (GABMF) is very effective at noise reduction while still maintaining sharp edges. Moreover, the Adaptive Particle Swarm Dandelion Optimization (APSDO) technique underpins the proposed segmentation model’s parameters processing, which allows for proper management of hyperspectral images in different datasets enhancing precision and consistency beyond the existing approaches. The proposed system demonstrates remarkable performance, achieving accuracy across all the datasets as 99.97%, 99.98%, 99.94%, and 99.35% on Indian Pines, Pavia University, Salinas, and EuroSat respectively. The proposed model enhances the accuracy as well as the efficiency of land-cover segmentation and overcomes the drawbacks faced by current land-cover segmentation models. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.

关键词： Image segmentation

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Deep learning based RAGAE-SVM for Chronic kidney disease diagnosis on internet of health things platform

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Multimedia Tools and Applications 2024年 1-39页

作者： Kandukuri, Prabhakar Abdul, Ashu Kumar, Kuchipudi Prasanth Sreenivas, Velagapudi Ramesh, G. Gundu, Venkateswarlu Department of Artificial Intelligence and Machine Learning Chaitanya Bharathi Institute of Technology Telangana Hyderabad500075 India Department of Computer Science and Engineering SRM University Andhra PradeshNeerukonda Mangalagiri 522503 India Department of Computer Science & amp Engineering Koneru Lakshmaiah Education Foundation Andhra PradeshVaddeswaram 522302 India Department of Computer Science and Engineering SRK Institute of Technology Andhra Pradesh Vijayawada521108 India Department of Computer Science and Engineering Gokaraju Rangaraju Institute of Engineering and Technology TelanganaBachupally Hyderabad500090 India Department of Computer Science and Engineering Koneru Lakshmaiah Education Foundation Andhra PradeshVaddeswaram 522302 India

Chronic kidney disease (CKD) is a prominent disease that causes loss of functionality in the kidney. Doctors can now more easily gather patient health status data due to the growth of the Internet of Health Things (IoHT). The IoHT data contains a huge number of redundant data, making it challenging to predict CKD disease quickly and accurately. In healthcare applications like feature-based classification, a variety of disease diagnosis systems were used to address this problem. Current disease detection algorithms suffer from imbalanced dataset processing, low-accuracy feature learning, and high computational power requirements. Thus, deep learning-based clinical decision support systems have been developed to solve these complexities. To remove outliers from medical data, data collected with IoHT devices is first pre-processed using an enhanced K-means clustering technique. The Synthetic Minority over Sampling Technique is used to balance data because the IoHT dataset is highly imbalanced. The classifier detects anomalies in less time because of the implemented processing step. The balanced CKD dataset is then presented for use with a novel classifier called Residual Attention-Gated Autoencoder with Support Vector Machine. In order to improve accurate detection, the adopted classifier can learn and extract features. The proposed method results in an increased accuracy of 99.43% within 70.1 s of computation time. The mean intersection of the union and kappa coefficient of the proposed method is 98.15% and 98.1%, respectively. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.

关键词： Classification (of information)

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Electrochemical sensor for dopamine detection based on multiwalled carbon nanotube/molybdenum disulfide quantum dots with machine learning integration and anti-interference capability

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Tungsten 2025年第1期7卷 137-151页

作者： Geethukrishnan Onkar Apte Kiran Kumar Tadi Energy Electrodics and Electrocatalysis (EEE) Lab Department of Chemistry School of Advanced Sciences Vellore Institute of Technology School of Computer Science and Engineering Vellore Institute of Technology

The precise detection and measurement of dopamine（DA）,a crucial neurotransmitter in the human body,plays a significant role in diagnosing,preventing,and treating neurological diseases associated with its levels.A highly sensitive DA electrochemical sensor was constructed by combining molybdenum disulfide quantum dots（MSQDs） with multiwalled carbon nanotubes（MWCNTs）.The MSQDs were synthesized using the shear exfoliation *** sensors consist of MSQDs with Mo-S edge catalytic centers for the DA redox reaction,and MWCNTs amplify the sensor *** linearity of the sensor for the detection of DA was tested in the presence of ascorbic acid(AA,50 μmol·L-1) and uric acid(UA,200 μmol·L-1),and exhibited linearity from 2 to 966 μmol·L-1of DA with 0.097 μA(mol·L-1)-1sensitivity and a low limit of detection of0.6 μmol·L-1（the ratio between signal and noise,S/N=3）.Moreover,the sensitivity and selectivity of the sensor were also studied using *** is no increase in amperometric current after adding the most potentially interfering *** sensor was successfully applied to recover DA in human blood sera ***,machine learning algorithms were operated to aid in the near-precise detection of DA in the heterogeneous mixture containing AA and *** algorithms facilitate the identification and quantification of DA amidst coexisting interferents,including AA,that are commonly present in biological matrices.

关键词： Dopamine MoS_2 Biosensor Multiwalled carbon nanotubes Machine learning Complex mixture

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Noise Robust Audio Spoof Detection Using Hybrid Feature Extraction and LCNN

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SN computer Science 2024年第4期5卷 425页

作者： Joshi, Sanil Dua, Mohit Department of Computer Engineering National Institute of Technology Kurukshetra India

In recent times, Voice Controlled Devices (VCD) have become an important part of our life. However, these devices are vulnerable to replay attacks. Hence, to address the issue, this paper proposes an Automatic Speaker Verification (ASV) system that uses hybrid feature extraction technique at front end and Light Convolutional Neural Network (LCNN) at back end. The proposed hybrid feature extraction techniques involve three different combinations that are;Frequency Domain Linear Prediction (FDLP) with Gammatone Cepstral Coefficients (GTCC), FDLP with Mel Frequency Cepstral Coefficients (MFCC) and GTCC with MFCC. Hence, the work proposes FDLP + GTCC-LCNN, FDLP + MFCC-LCNN and GTCC + MFCC-LCNN based ASV systems. The training and evaluation of all the systems is performed on state-of-the-art Voice Spoofing Detection Corpus (VSDC) that contains original audio samples (0PR), single order replay (1PR) recorded audios, and multi order replay (2PR) recorded audio samples. The obtained results reveal that the proposed FDLP + GTCC-LCNN based system outperforms the other two proposed systems. It gives 0.43 and 0.52% Equal Error Rate (ERR) in 1PR and 2PR attacks, respectively. In order to check the performance of proposed system in noisy environment, Additive White Gaussian Noise (AWGN), Babble and Street Noise are mixed with the audio samples of VSDC dataset at 5, 10 and 15 dB. It can be concluded from attained results that the proposed system gives good results under both clean and noisy multi order replay attack environments. © The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd. 2024.

关键词： ASV AWGN Babble Hybrid feature extraction LCNN VSDC

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