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Stable IL- 1β-Activation in an Inflammasome Signalling Model Depends on Positive and Negative Feedbacks and Tight Regulation of Protein Production

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IEEE/ACM transactions on computational biology and bioinformatics 2019年第2期16卷 627-637页

作者： Fernando Lopez-Caamal Heinrich J Huber Chemical Engineering Department Universidad de Guanajuato Noria Alta s/n Guanajuato Guanajuato México Institute for Automation Engineering (IFAT) Laboratory for Systems Theory and Automatic Control Otto-von-Guericke University Magdeburg Magdeburg Germany

INTRODUCTION:NLRP3-dependent inflammasome signalling is a key pathway during inflammatory processes and its deregulation is implicated in several diseases. NLRP3-inflammasome pathway activation leads to the rapid, phosphorylation-driven NF$\kappa$κB-pathway signalling, subsequently proceeds via slower transcription/translation process for producing pro-enzymes, and finally leads to the medium-speed enzymatic activation of the central inflammatory mediator IL-$1\beta$1β[1] . We here were interested in how the timing of the rate-limiting step of transcription/translation and the presence of a positive and negative auto-regulation would pose conditions for meaningful and stable IL-$1\beta$1β-activation. METHODS:We extracted the essential topology of the inflammasome pathway network using a linear chain of first-order reaction and a second-order reaction for inhibitory feedback. We then performed an analytical treatment of the resulting ODE set to obtain closed-form formulae. We therefore looked for the steady states and characterized their stability by using a Jacobian-based, local analysis. We employed the Small Gain Theorem from control Theory as recently applied by us [2] and the Gershgorin Circle Theorem to obtain mathematically exact conditions for a positive ON state and stabilities for ON and OFF steady states. RESULTS:We identified an ON- and one OFF- steady state whose properties we characterized in terms of the kinetic parameters by closed-form formulae. We found that under the assumption of a first-order information flow through the network, the existence of a biologically reasonable ON steady state required the simultaneous presence of the positive and the negative feedback. Assuming non-competitivity between IL-$1\beta$1β entities binding to different receptors, we found that a minimum kinetics for protein production is required to sustain a steady state with IL-$1\beta$1β activation. Assuming competitivity between IL-$1\beta$1β entities introduced additio

关键词： Steady State Proteins Biological System Modeling Negative Feedback Production Mathematical Model NLRP 3 Inflammasome IL-1 Z_$\beta$_Z β Interleukin 1 Local Stability Analysis Steady States Stability Positive Feedback Negative Feedback Synthetic Biology

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ESND: An embedding-based framework for signed network dismantling

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Expert systems with Applications 2025年 289卷

作者： Chenwei Xie Chuang Liu Cong Li Xiu-Xiu Zhan Xiang Li Research Center for Complexity Sciences Hangzhou Normal University Hangzhou 311121 China Department of Electronic Engineering School of Information Science and Technology Adaptive Networks and Control Lab Fudan University Shanghai 200433 China College of Media and International Culture Zhejiang University Hangzhou 310058 China Research Institute of Intelligent Complex Systems Fudan University Shanghai 200433 China

Network dismantling aims to maximize the disintegration of a network by removing a specific set of nodes or edges and is applied to various tasks in various domains, such as cracking down on crime organizations, delaying the propagation of rumors, and blocking the transmission of viruses. Most of the current network dismantling methods are tailored for unsigned networks, which only consider the connection between nodes without evaluating the nature of the relationships, such as friendship/hostility, enhancing/repressing, and trust/distrust. We here propose an embedding-based algorithm, namely ESND, to solve the signed network dismantling problem. The algorithm generally iterates the following four steps, i.e., giant component detection, network embedding, node clustering, and removal node selection. To illustrate the efficacy and stability of ESND, we conduct extensive experiments on six signed network datasets as well as null models, and compare the performance of our method with baselines. Experimental results consistently show that the proposed ESND is superior to the baselines and displays stable performance with the change in the network structure. Additionally, we examine the impact of sign proportions on network robustness via ESND, observing that networks with a high ratio of negative edges are generally easier to dismantle than networks with high positive edges.

关键词： Network dismantling Node clustering Node embedding Signed network

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Distributed delay model of the McKeithan’s network

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IFAC-PapersOnLine 2019年第7期52卷 33-38页

作者： György Lipták Katalin M. Hangos Process Control Research Group Systems and Control Laboratory Computer and Automation Research Institute Hungarian Academy of Sciences P.O. Box 63 H-1518 Budapest Hungary Department of Electrical Engineering and Information Systems University of Pannonia Veszprém Hungary

In this paper CRNs containing linear reaction chains with multiple joint complexes were considered in order to obtain an equivalent reduced order delayed CRN model with distributed time delays. For this purpose, our earlier method (Lipták and Hangos (2018)) for decomposing the chains of linear reactions with multiple joint complexes was used together with the "linear chain trick". An analytical expression for the kernel function of the distributed delay was also derived from the reaction rate coefficients of the linear reaction chains. Our approach was demonstrated using the example of the well known McKeithan’s network model of kinetic proofreading.

关键词： Process control Delay Chemical Reaction Networks

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Comparing APPRAISE-RS/TDApp and Clinical Practice Guidelines for ADHD Treatment Recommendations: Impact of Patient Complexity

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Neuroscience Applied 2024年 3卷

作者： X. Castells Ò. Raya B. López D. Ramírez R. Cunill D. Serrano I. Andreu E. Baykova Universitat de Girona Translational Medicine and Decision Sciences Laboratory TransLab. Department of Medical Sciences Girona Spain University of Girona Control Engineering and Intelligent Systems eXiT- Girona Spain University of Girona Control Engineering and Intelligent Systems eXiT Girona Spain Service of Clinical Pharmacology Vall d’Hebron Barcelona Hospital Campus Barcelona Spain Sant Joan de Deu-Numancia Health Park Acute patients unit Barcelona Spain Institute of Health Care ICS-IAS Acute patients unit Girona Spain Institute of Health Care ICS-IAS CSMIJ Gironès i Pla de l'Estany Girona Spain Institute of Health Care ICS-IAS CSMIJ La Selva Blanes- Girona Spain

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Investigation on the influence of nozzle orifice position under conditions of ultra-high pressure multi-pulse injection and PCCI combustion

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AIP Conference Proceedings 2024年第1期3086卷

作者： Pop-Paul Ewphun Tsuyoshi Nagasawa Hidenori Kosaka Susumu Sato National Energy Technology Center (ENTEC) National Science and Technology Development Agency (NSTDA) 111 Thailand Science Park Paholyothin Rd. Khlong Nueng Khlong Luang Pathum Thani 12120 Thailand Department of Systems and Control Engineering Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo 152-8552 Japan

The compression ignition engine has the highest thermal efficiency compared to other internal combustion engines. However, combustion also results in significant amounts of soot and NOx emissions. Soot and NOx emissions can be reduced simultaneously by adopting premixed charge compression ignition (PCCI) combustion. Unfortunately, PCCI combustion is difficult to manage in terms of ignition time and has a restricted operating range. The combination of ultra-high injection pressure and multi-pulse injection shows the promise of controlling PCCI combustion, reducing emissions and improving thermal efficiency. Unfortunately, increased impingement from ultra-high injection pressure reduces thermal efficiency due to increased impingement. The penetration of the spray must be decreased in order to address this problem. By applying an offset orifice nozzle, the problem can be solved. An offset orifice nozzle was created by moving the orifice aliment from the sac’s center to the periphery of the sac in the direction of the swirl. The offset orifice nozzle was given a counter bore design to maintain the same constant orifice length as the regular nozzle. The experiments were conducted on a single-cylinder engine both with and without optical access. Three equally distributed main injection pulses at varied injection pressures from 150 to 350 MPa were used. An advanced rate of heat release was provided by the offset orifice nozzle. The offset orifice nozzle, however, produces a slightly greater flame temperature with a wider flame area. Additionally, it offers a broader, more intense OH* chemiluminescence region, particularly for the 2nd and 3rd injections.

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Robust Stabilization of T-S Fuzzy Stochastic Descriptor systems via Integral Sliding Modes

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IEEE TRANSACTIONS ON CYBERNETICS 2018年第9期48卷 2736-2749页

作者： Li, Jinghao Zhang, Qingling Yan, Xing-Gang Spurgeon, Sarah K. Institute of Systems Science State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Shenyang China Instrumentation Control and Embedded Systems Research Group School of Engineering and Digital Arts University of Kent Canterbury U.K. Department of Electronic and Electrical Engineering University College London London U.K.

This paper addresses the robust stabilization problem for T-S fuzzy stochastic descriptor systems using an integral sliding mode control paradigm. A classical integral sliding mode control scheme and a nonparallel distributed compensation (Non-PDC) integral sliding mode control scheme are presented. It is shown that two restrictive assumptions previously adopted developing sliding mode controllers for Takagi-Sugeno (T-S) fuzzy stochastic systems are not required with the proposed framework. A unified framework for sliding mode control of T-S fuzzy systems is formulated. The proposed Non-PDC integral sliding mode control scheme encompasses existing schemes when the previously imposed assumptions hold. Stability of the sliding motion is analyzed and the sliding mode controller is parameterized in terms of the solutions of a set of linear matrix inequalities which facilitates design. The methodology is applied to an inverted pendulum model to validate the effectiveness of the results presented.

关键词： Integral sliding mode control inverted pendulum nonparallel distributed compensation (Non-PDC) robust stabilization Takagi-Sugeno (T-S) fuzzy stochastic descriptor systems

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Synchronous data collection measuring system using a single-chip computer

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IFAC-PapersOnLine 2019年第27期52卷 68-73页

作者： Jiří Czebe Pavel Šuránek Jiří Tůma Stanislav Žiaran Department of Control Systems and Instrumentation Faculty of Mechanical Engineering VSB-TUO Ostrava Czech Republic Department of Control Systems and Instrumentation Faculty of Mechanical Engineering VSB- TUO Ostrava Czech Republic Institute of Applied Mechanics and Mechatronics Faculty of Mechanical Engineering Slovak University of Technology Bratislava Slovakia

Paper deals with synchronous data collection using a single-chip computer. It states an essential description of a measurement system’s feedback, which consists of two lasers and two encoders. Description of the whole measuring chain, with a brief introduction of a measurement unit, follows. The next part focuses on a firmware description of the measurement unit (measuring and communication processed) and communication peripherals and an external LAN module. Enhancement of the whole process using DMA controller and communication techniques with used sensors or modules. Finally, synchronous data collection is presented to ensure the proper functionality of the whole measuring system with the best possible measurement results.

关键词： Embedded systems Microprocessors Industry automation Data acquisition

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Analysis and Classification of Low Head Hydro Power Based on Advanced Morphological Approach

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Journal of Physics: Conference Series 2021年第1期2096卷

作者： D L Rakov Department of technological processes and systems control Mechanical Engineering Research Institute of the Russian Academy of Sciences (IMASH RAN) Moscow Russia

The paper discusses hydrokinetic systems low head hydro power as an element renewable resource. In the paper a review of the existing and upcoming orthogonal and axial turbines schemes is outlined. Based on a morphological approach comprehensive survey of various schemes and qualitative comparison, is presented. The proposed engineering solutions reduce the structure weight and the processability increases. These factors lead to a decrease in the cost. The engineering solutions under consideration are designed to operate in low-pressure flows, regardless of their direction. Thanks to these features, the scope of their use expands. They can be used both in high tide and in the use of the sea currents kinetic energy.

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FSD-10: A dataset for competitive sports content analysis

arXiv

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arXiv 2020年

作者： Liu, Shenglan Liu, Xiang Huang, Gao Feng, Lin Hu, Lianyu Jiang, Dong Zhang, Aibin Liu, Yang Qiao, Hong Faculty of Electronic Information and Electrical Engineering Dalian University of Technology Dalian Liaoning116024 China Faculty of Tsinghua University of Technology Beijing China State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing100190 China

Action recognition is an important and challenging problem in video analysis. Although the past decade has witnessed progress in action recognition with the development of deep learning, such process has been slow in competitive sports content analysis. To promote the research on action recognition from competitive sports video clips, we introduce a Figure Skating Dataset (FSD-10) for finegrained sports content analysis. To this end, we collect 1484 clips from the worldwide figure skating championships in 2017-2018, which consist of 10 different actions in men/ladies programs. Each clip is at a rate of 30 frames per second with resolution 1080 × 720. These clips are then annotated by experts in type, grade of execution, skater info,.etc. To build a baseline for action recognition in figure skating, we evaluate state-of-the-art action recognition methods on FSD-10. Motivated by the idea that domain knowledge is of great concern in sports field, we propose a keyframe based temporal segment network (KTSN) for classification and achieve remarkable performance. Experimental results demonstrate that FSD-10 is an ideal dataset for benchmarking action recognition algorithms, as it requires to accurately extract action motions rather than action poses. We hope FSD-10, which is designed to have a large collection of finegrained actions, can serve as a new challenge to develop more robust and advanced action recognition models. Copyright © 2020, The Authors. All rights reserved.

关键词： Sports

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Author Correction: Transboundary cooperation in infrastructure operation generates economic and environmental co-benefits in the Lancang-Mekong River Basin

Nature Water

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Nature Water 2024年 602页

作者： Yang Yu Jinyu Gao Shiruo Hu Bo Liu Jianshi Zhao Yan Bo Andrea Castelletti Patrice Dumas Ximing Cai Junguo Liu Taher Kahil Yoshihide Wada Feng Zhou State Key Laboratory of Hydroscience and Engineering Department of Hydraulic Engineering Tsinghua University Beijing China Rural Revitalization Finance Department China Construction Bank Beijing China Centralized Control Center Yalong River Hydropower Development Company Chengdu China Sino-France Institute of Earth Systems Science Laboratory for Earth Surface Processes College of Urban and Environmental Sciences Peking University Beijing China Department of Electronics Information and Bioengineering Politecnico di Milano Milan Italy Institute of Environmental Engineering ETH Zurich Zurich Switzerland Centre International de Recherche sur l’Environnement et le Développement Nogent sur Marne France Department of Civil and Environmental Engineering University of Illinois at Urbana‐Champaign Champaign IL USA School of Environmental Science and Engineering Southern University of Science and Technology Shenzhen China International Institute for Applied Systems Analysis Laxenburg Austria National Key Laboratory of Water Disaster Prevention Jiangsu Province Engineering Research Center of Watershed Geospatial Intelligence College of Geography and Remote Sensing Hohai University Nanjing China Institute of Carbon Neutrality Laboratory for Earth Surface Processes College of Urban and Environmental Sciences Peking University Beijing China Southwest United Graduate School Kunming China

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