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Gamma entrainment frequency affects mood, memory and cognition: an exploratory pilot study

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Brain informatics 2020年第1期7卷 1-12页

作者： Sharpe, Ryan L. S. Mahmud, Mufti Kaiser, M. Shamim Chen, Jianhui Department of Computer Science Nottingham Trent University NottinghamNG11 8NS United Kingdom Medical Technology Innovation Facility Nottingham Trent University NottinghamNG11 8NS United Kingdom Institute of Information Engineering Jahangirnagar University Savar Dhaka1342 Bangladesh Beijing Key Laboratory of MRI and Brain Informatics Beijing University of Technology Beijing100124 China Beijing International Collaboration Base on Brain Informatics and Wisdom Services Beijing China

Here we provide evidence with an exploratory pilot study that through the use of a Gamma 40 Hz entrainment frequency, mood, memory and cognition can be improved with respect to a 9-participant cohort. Participants constituted towards three binaural entrainment frequency groups: the 40 Hz, 25 Hz and 100 Hz. Participants attended a total of eight entrainment frequency sessions twice over the duration of a 4-week period. Additionally, participants were assessed based on their cognitive abilities, mood as well as memory, where the cognitive and memory assessments occurred before and after a 5-min binaural beat stimulation. The mood assessment scores were collected from sessions 1, 4 and 8, respectively. With respect to the Gamma 40 Hz entrainment frequency population, we observed a mean improvement in cognitive scores, elevating from 75% average to 85% average upon conclusion of the experimentation at weak statistical significance (α = 0.10, p = 0.076). Similarly, memory score improvements at a greater significance (α = 0.05, p = 0.0027) were noted, elevating from an average of 87% to 95%. In pertinence to the mood scores, a negative correlation across all populations were noted, inferring an overall increase in mood due to lower scores correlating with elevated mood. Finally, correlation analysis revealed a stronger R2 value (0.9838) within the 40 Hz group between sessions as well as mood score when compared across the entire frequency group cohort. © 2020, The Author(s).

关键词： Population statistics

Tigc-Net: Transformer-Improved Graph Convolution Network for Spatio-Temporal Prediction

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SSRN

SSRN 2022年

作者： Chen, Kai Yang, Chunfeng Zhou, Zhengyuan Liu, Yao Ji, Tianjiao Sun, Weiya Chen, Yang School of Cyber Science and Engineering Southeast University Nanjing210096 China Key Laboratory of Computer Network and Information Integration Southeast University Ministry of Education Nanjing210096 China The College of Software Engineering Southeast University Nanjing210096 China Laboratory of Image Science and Technology The School of Computer Science and Engineering Southeast University Nanjing210096 China Jiangsu Key Laboratory of Molecular and Functional Imaging Department of Radiology Zhongda Hospital Southeast University Nanjing210009 China Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing School of Computer Science and Engineering Southeast University Nanjing210096 China NHC Key Laboratory of Medical Virology and Viral Diseases National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Beijing Institute of Tracking and Communication Technology Beijing100094 China

Modeling spatio-temporal sequences is an important topic yet challenging for existing neural networks. Most of the current spatio-temporal sequence prediction methods usually capture features separately in temporal and spatial dimensions or employ multiple mutually independent local spatio-temporal graphs to represent a spatio-temporal sequence. The first kind of method mentioned above is difficult to mine the complex spatio-temporal correlations, while the other is limited for the accuracy of long-term predictions. To handle these issues, this paper proposes a Transformer-Improved Graph Convolution Network for spatio-temporal prediction. Specifically, the temporal location encoding method is exploited to derive the spatio-temporal characteristics of the sequence utilizing a spatio-temporal feature fusion network. In addition, a spatio-temporal attention network is developed to enhance the spatio-temporal correlation of the sequence, and the dynamic spatial features of sequence are further extracted through the adaptive graph convolution network. A private dataset and a public dataset are employed to demonstrate the performance of the proposed TIGC-Net. The qualitative and quantitative results show that the proposed TIGC-Net can extract dynamic spatiotemporal properties more effectively, enhance the spatio-temporal correlation of sequences and improve the prediction accuracy compared with four stateof-the-art. © 2022, The Authors. All rights reserved.

关键词： Convolution

A comparison for patch-level classification of deep learning methods on transparent environmental microorganism images: From convolutional neural networks to visual transformers

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arXiv 2021年

作者： Yang, Hechen Li, Chen Zhang, Jinghua Zhao, Peng Chen, Ao Zhao, Xin Jiang, Tao Grzegorzek, Marcin Microscopic Image and Medical Image Analysis Group MBIE College Northeastern University Shenyang110169 China Environmental Engineering Department Northeastern University Shenyang110169 China School of Control Engineering Chengdu University of Information Technology Chengdu610225 China Institute of Medical Informatics University of Luebeck Luebeck Germany

Nowadays, analysis of Transparent Environmental Microorganism Images (T-EM images) in the field of computer vision has gradually become a new and interesting spot. This paper compares different deep learning classification performance for the problem that T-EM images are challenging to analyze. We crop the T-EM images into 8×8 and 224×224 pixel patches in the same proportion and then divide the two different pixel patches into foreground and background according to ground truth. We also use four convolutional neural networks and a novel ViT network model to compare the foreground and background classification experiments. We conclude that ViT performs the worst in classifying 8 × 8 pixel patches, but it outperforms most convolutional neural networks in classifying 224 × 224 pixel patches. Copyright © 2021, The Authors. All rights reserved.

关键词： Convolutional neural networks

Touchstone benchmark: are we on the right way for evaluating AI algorithms for medical segmentation? 24

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Touchstone benchmark: are we on the right way for evaluating...

Proceedings of the 38th International Conference on Neural information Processing Systems

作者： Pedro R. A. S. Bassi Wenxuan Li Yucheng Tang Fabian Isensee Zifu Wang Jieneng Chen Yu-Cheng Chou Saikat Roy Yannick Kirchhoff Maximilian Rokuss Ziyan Huang Jin Ye Junjun He Tassilo Wald Constantin Ulrich Michael Baumgartner Klaus H. Maier-Hein Paul Jaeger Yiwen Ye Yutong Xie Jianpeng Zhang Ziyang Chen Yong Xia Zhaohu Xing Lei Zhu Yousef Sadegheih Afshin Bozorgpour Pratibha Kumari Reza Azad Dorit Merhof Pengcheng Shi Ting Ma Yuxin Du Fan Bai Tiejun Huang Bo Zhao Haonan Wang Xiaomeng Li Hanxue Gu Haoyu Dong Jichen Yang Maciej A. Mazurowski Saumya Gupta Linshan Wu Jiaxin Zhuang Hao Chen Holger Roth Daguang Xu Matthew B. Blaschko Sergio Decherchi Andrea Cavalli Alan L. Yuille Zongwei Zhou Department of Computer Science Johns Hopkins University and Department of Pharmacy and Biotechnology University of Bologna and Center for Biomolecular Nanotechnologies Istituto Italiano di Tecnologia Department of Computer Science Johns Hopkins University NVIDIA Division of Medical Image Computing German Cancer Research Center (DKFZ) and Helmholtz Imaging German Cancer Research Center (DKFZ) ESAT-PSI KU Leuven Division of Medical Image Computing German Cancer Research Center (DKFZ) and Faculty of Mathematics and Computer Science Heidelberg University Division of Medical Image Computing German Cancer Research Center (DKFZ) and Faculty of Mathematics and Computer Science Heidelberg University and HIDSS4Health - Helmholtz Information and Data Science School for Health Shanghai Jiao Tong University Shanghai Artificial Intelligence Laboratory Division of Medical Image Computing German Cancer Research Center (DKFZ) Division of Medical Image Computing German Cancer Research Center (DKFZ) and Pattern Analysis and Learning Group Department of Radiation Oncology Heidelberg University Hospital Helmholtz Imaging German Cancer Research Center (DKFZ) and Interactive Machine Learning Group (IML) DKFZ School of Computer Science and Engineering Northwestern Polytechnical University Australian Institute for Machine Learning The University of Adelaide College of Computer Science and Technology Zhejiang University Hong Kong University of Science and Technology (Guangzhou) Hong Kong University of Science and Technology (Guangzhou) and Hong Kong University of Science and Technology Faculty of Informatics and Data Science University of Regensburg Faculty of Electrical Engineering and Information Technology RWTH Aachen University Faculty of Informatics and Data Science University of Regensburg and Fraunhofer Institute for Digital Medicine MEVIS Electronic & Information Engineering School Harbin Institute of Technology (Shenzhen) Shanghai Jiao Tong University and Beijing Academy of Artificial Intelligence (BAAI) S

ISBN: (纸本)9798331314385

How can we test AI performance? This question seems trivial, but it isn't. Standard benchmarks often have problems such as in-distribution and small-size test sets, oversimplified metrics, unfair comparisons, and short-term outcome pressure. As a consequence, good performance on standard benchmarks does not guarantee success in real-world scenarios. To address these problems, we present Touchstone, a large-scale collaborative segmentation benchmark of 9 types of abdominal organs. This benchmark is based on 5,195 training CT scans from 76 hospitals around the world and 5,903 testing CT scans from 11 additional hospitals. This diverse test set enhances the statistical significance of benchmark results and rigorously evaluates AI algorithms across out-of-distribution scenarios. We invited 14 inventors of 19 AI algorithms to train their algorithms, while our team, as a third party, independently evaluated these algorithms. In addition, we also evaluated pre-existing AI frameworks—which, differing from algorithms, are more flexible and can support different algorithms—including MONAI from NVIDIA, nnU-Net from DKFZ, and numerous other open-source frameworks. We are committed to expanding this benchmark to encourage more innovation of AI algorithms for the medical domain.

关键词：

EDMAE: An Efficient Decoupled Masked Autoencoder for Standard View Identification in Pediatric Echocardiography

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arXiv 2023年

作者： Liu, Yiman Han, Xiaoxiang Liang, Tongtong Dong, Bin Yuan, Jiajun Hu, Menghan Liu, Qiaohong Chen, Jiangang Li, Qingli Zhang, Yuqi Department of Pediatric Cardiology Shanghai Children's Medical Center School of Medicine Shanghai Jiao Tong University Shanghai200127 China Shanghai200127 China Shanghai Key Laboratory of Multidimensional Information Processing School of Communication and Electronic Engineering East China Normal University Shanghai200241 China School of Health Science and Engineering University of Shanghai for Science and Technology Shanghai200093 China Shanghai Minhang Center for Disease Control and Prevention Shanghai201101 China School of Medical Instruments Shanghai University of Medicine and Health Sciences Shanghai201318 China

This paper introduces the Efficient Decoupled Masked Autoencoder (EDMAE), a novel self-supervised method for recognizing standard views in pediatric echocardiography. EDMAE introduces a new proxy task based on the encoderdecoder structure. The EDMAE encoder is composed of a teacher and a student encoder. The teacher encoder extracts the potential representation of the masked image blocks, while the student encoder extracts the potential representation of the visible image blocks. The loss is calculated between the feature maps output by the two encoders to ensure consistency in the latent representations they extract. EDMAE uses pure convolution operations instead of the ViT structure in the MAE encoder. This improves training efficiency and convergence speed. EDMAE is pre-trained on a large-scale private dataset of pediatric echocardiography using self-supervised learning, and then fine-tuned for standard view recognition. The proposed method achieves high classification accuracy in 27 standard views of pediatric echocardiography. To further verify the effectiveness of the proposed method, the authors perform another downstream task of cardiac ultrasound segmentation on the public dataset CAMUS. The experimental results demonstrate that the proposed method outperforms some popular supervised and recent self-supervised methods, and is more competitive on different downstream tasks. Copyright © 2023, The Authors. All rights reserved.

关键词： Pediatrics

Enhancing Diagnostic Precision in Gastric Bleeding through Automated Lesion Segmentation: A Deep DuS-KFCM Approach

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arXiv 2024年

作者： Liu, Xian-Xian Xu, Mingkun Wei, Yuanyuan Qin, Huafeng Song, Qun Fong, Simon Tien, Feng Luo, Wei Gao, Juntao Zhang, Zhihua Siu, Shirley The Department of Computer and Information Science University of Macau 999078 China Guangdong Institute of Intelligence Science and Technology Zhuhai519031 China Department of Biomedical Engineering The Chinese University of Hong Kong Shatin999077 China Department of Neurology David Geffen School of Medicine University of California Los AngelesCA90095 United States The School of Computer Science and Information Engineering Chongqing Technology and Business University Chongqing400067 China Institute of Artificial Intelligence Chongqing Technology and Business University Chongqing400067 China Hebei Key Laboratory of Medical Data Science Institute of Biomedical Informatics School of Medicine Hebei University of Engineering Hebei Province Handan056038 China The director of the Institute of Clinical Medicine The First People’s Hospital of Foshan Guangzhou510060 China Tsinghua University California Beijing100084 China Beijing Institute of Genomics Chinese Academy of Sciences Beijing100101 China Centre for Artificial Intelligence Driven Drug Discovery Macao Polytechnic University Rua de Luís Gonzaga Gomes 999078 China

Timely and precise classification and segmentation of gastric bleeding in endoscopic imagery are pivotal for the rapid diagnosis and intervention of gastric complications, which is critical in life-saving medical procedures. Traditional methods grapple with the challenge posed by the indistinguishable intensity values of bleeding tissues adjacent to other gastric structures. Our study seeks to revolutionize this domain by introducing a novel deep learning model, the Dual Spatial Kernelized Constrained Fuzzy C-Means (Deep DuS-KFCM) clustering algorithm. This Hybrid Neuro-Fuzzy system synergizes Neural Networks with Fuzzy Logic to offer a highly precise and efficient identification of bleeding regions. Implementing a two-fold coarse-to-fine strategy for segmentation, this model initially employs the Spatial Kernelized Fuzzy C-Means (SKFCM) algorithm enhanced with spatial intensity profiles and subsequently harnesses the state-of-the-art DeepLabv3+ with ResNet50 architecture to refine the segmentation output. Through extensive experiments across mainstream gastric bleeding and red spots datasets, our Deep DuS-KFCM model demonstrated unprecedented accuracy rates of 87.95%, coupled with a specificity of 96.33%, outperforming contemporary segmentation methods. The findings underscore the model’s robustness against noise and its outstanding segmentation capabilities, particularly for identifying subtle bleeding symptoms, thereby presenting a significant leap forward in medical image processing. © 2024, CC BY.

关键词： medical image processing

A comprehensive review of image analysis methods for microorganism counting: From classical image processing to deep learning approaches

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arXiv 2021年

作者： Zhang, Jiawei Li, Chen Rahaman, Md Mamunur Yao, Yudong Ma, Pingli Zhang, Jinghua Zhao, Xin Jiang, Tao Grzegorzek, Marcin Microscopic Image and Medical Image Analysis Group College of Medicine and Biological Information Engineering Northeastern University Shenyang110169 China Department of Electrical and Computer Engineering Stevens Institute of Technology Hobo-kenNJ07030 United States School of Resources and Civil Engineering Northeastern University Shenyang110004 China School of Control Engineering Chengdu University of Information Technology Chengdu610225 China Institute of Medical Informatics University of Luebeck Luebeck23538 Germany

Microorganisms such as bacteria and fungi play essential roles in many application fields, like biotechnique, medical technique and industrial domain. Microorganism counting techniques are crucial in microorganism analysis, helping biologists and related researchers quantitatively analyze the microorganisms and calculate their characteristics, such as biomass concentration and biological activity. However, traditional microorganism manual counting methods, such as plate counting method, hemocytometry and turbidimetry, are time-consuming, subjective and need complex operations, which are difficult to be applied in large-scale applications. In order to improve this situation, image analysis is applied for microorganism counting since the 1980s, which consists of digital image processing, image segmentation, image classification and suchlike. Image analysis-based microorganism counting methods are efficient comparing with traditional plate counting methods. In this article, we have studied the development of microorganism counting methods using digital image analysis. Firstly, the microorganisms are grouped as bacteria and other microorganisms. Then, the related articles are summarized based on image segmentation methods. Each part of the article is reviewed by methodologies. Moreover, commonly used image processing methods for microorganism counting are summarized and analyzed to find common technological points. More than 144 papers are outlined in this article. In conclusion, this paper provides new ideas for the future development trend of microorganism counting, and provides systematic suggestions for implementing integrated microorganism counting systems in the future. Researchers in other fields can refer to the techniques analyzed in this paper. © 2021, CC0.

关键词： Image segmentation

Smart Insole: A Gait Analysis Monitoring Platform Targeting Parkinson Disease Patients Based on Insoles

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arXiv 2022年

作者： Boucharas, Dimitrios G. Androutsos, Christos Gkois, George Tsakanikas, Vassilis D. Pezoulas, Vasileios C. Manousos, Dimitrios Skaramagkas, Vasileios Chatzaki, Chariklia Kontogiannis, Stathis Spandonidis, Christos Pantazis, Alexandros K. Tachos, Nikolaos S. Tsiknakis, Manolis Fotiadis, Dimitrios I. The Unit of Medical Technology and Intelligent Information Systems Department of Materials Science and Engineering University of Ioannina IoanninaGR-45110 Greece Crete HeraklionGR-70013 Greece Biomedical Informatics and eHealth Laboratory Department of Electrical and Computer Engineering Hellenic Mediterranean University Estavromenos Crete HeraklionGR-71004 Greece The Department of Electric and Computer Engineering Hellenic Mediterranean University Crete HeraklionGR-71004 Greece PD Neurotechnology Ltd IoanninaGR-45110 Greece Prisma Electronics SA P.Faliro AthensGR-17564 Greece Crete HeraklionGR-70013 Greece Biomedical Research Institute FORTH IoanninaGR-45110 Greece The Unit of Medical Technology and Intelligent Information Systems University of Ioannina IoanninaGR-45110 Greece

During the preceding decades, human gait analysis has been the center of attention for the scientific community, while the association between gait analysis and overall health monitoring has been extensively reported. Technological advances further assisted in this alignment, resulting in access to inexpensive and remote healthcare services. Various assessment tools, such as software platforms and mobile applications, have been proposed by the scientific community and the market that employ sensors to monitor human gait for various purposes ranging from biomechanics to the progression of functional recovery. The framework presented herein offers a valuable digital biomarker for diagnosing and monitoring Parkinson’s disease that can help clinical experts in the decision-making process leading to corrective planning or patient-specific treatment. More accurate and reliable decisions can be provided through a wide variety of integrated Artificial Intelligence algorithms and straightforward visualization techniques, including, but not limited to, heatmaps and bar plots. The framework consists of three core components: the insole pair, the mobile application, and the cloud-based platform. The insole pair deploys 16 plantar pressure sensors, an accelerometer, and a gyroscope to acquire gait data. The mobile application formulates the data for the cloud platform, which orchestrates the component interaction through the web application. Utilizing open communication protocols enables the straightforward replacement of one of the core components with a relative one (e.g., a different model of insoles), transparently from the end user, without affecting the overall architecture, resulting in a framework with the flexibility to adjust its modularity. © 2022, CC BY.

关键词： Computer architecture

Constructing Epidermal Rete Ridges Using Composite Hydrogel to Enhance Multiple Signaling Pathways for the Maintenance of Epidermal Stem Cell Niche

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SSRN

SSRN 2023年

作者： Shen, Zhizhong Liu, Zixian Sun, Lei Li, Meng Han, Lu Wang, Jianming Wu, Xunwei Sang, Shengbo Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception College of Information and Computer Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System the Ministry of Education Taiyuan University of Technology Taiyuan030024 China Shanxi Research Institute of 6D Artificial Intelligence Biomedical Science Taiyuan030031 China General Hospital of TISCO North Street Xinghualing District Taiyuan030809 China Engineering Laboratory for Biomaterials and Tissue Regeneration Ningbo Stomatology Hospital Savaid Stomatology School Hangzhou Medical College Ningbo China Department of Tissue Engineering and Regeneration School and Hospital of Stomatology Cheeloo College of Medicine Shandong University Shandong Key Laboratory of Oral Tissue Regeneration Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration Shandong Jinan China Cutaneous Biology Research Center Massachusetts General Hospital Harvard Medical School BostonMA United States

The undulating microstructure rete ridge (RR) located at the junction between the dermis and epidermis plays a crucial role in improving skin mechanical properties and maintaining skin homeostasis. However, the investigation of RR microstructures are usually neglected in current tissue engineering for skin regeneration. Here, to create an epidermal model with RR microstructures, keratinocytes were inoculated onto a patterned GelMA-PEGDA hydrogel constructed using molding technology. Furthermore, grafting acryloylated Arg-Gly-Asp (RGD) peptides on the hydrogel surface significantly improved cell adhesion, fusion, and development. RT-PCR, Western blot, and immunofluorescence staining confirmed that cells on RR microstructures exhibited higher gene and protein expression associated with epidermal stem cells. RNA sequencing analysis of cells on RR microstructure showed higher gene expression profiles related to stem cell maintenance, basement membrane formation, and epidermal development. Furthermore, RT-PCR analysis of epidermal models of various dimensions demonstrated that smaller microstructures were more conducive to epidermal stem cell marker gene expression, which is analogous to human skin. Overall, we have successfully developed a method for integrating RR microstructures into an epidermal model that mimics natural skin to maintain epidermal stem cell niche, providing a valuable reference for researching skin regeneration within the fields of tissue engineering and regenerative medicine. © 2023, The Authors. All rights reserved.

关键词： Microstructure