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Risk and burden of hospital admissions associated with wildfire-related PM_2·5 in Brazil, 2000–15: a nationwide time-series study

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The Lancet Planetary Health 2021年第9期5卷 e599-e607页

作者： Ye, Tingting Guo, Yuming Chen, Gongbo Yue, Xu Xu, Rongbin Coêlho, Micheline de Sousa Zanotti Stagliorio Saldiva, Paulo Hilario Nascimento Zhao, Qi Li, Shanshan Climate Air Quality Research Unit School of Public Health and Preventive Medicine Monash University Melbourne VIC Australia School of Public Health and Management Binzhou Medical University Yantai China Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment Department of Occupational and Environmental Health School of Public Health Sun Yat-sen University Guangzhou China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment Technology School of Environmental Science and Engineering Nanjing University of Information Science and Technology Nanjing China Department of Pathology Faculty of Medicine University of São Paulo São Paulo Brazil Department of Epidemiology School of Public Health Cheeloo College of Medicine Shandong University Jinan China

Background: In the context of climate change and deforestation, Brazil is facing more frequent and unprecedented wildfires. Wildfire-related PM2·5 is associated with multiple adverse health outcomes;however, the ...

Background: In the context of climate change and deforestation, Brazil is facing more frequent and unprecedented wildfires. Wildfire-related PM_2·5 is associated with multiple adverse health outcomes;however, the magnitude of these associations in the Brazilian context is unclear. We aimed to estimate the association between daily exposure to wildfire-related PM_2·5 and cause-specific hospital admission and attributable health burden in the Brazilian population using a nationwide dataset from 2000 to 2015. Methods: In this nationwide time-series analysis, data for daily all-cause, cardiovascular, and respiratory hospital admissions were collected through the Brazilian Unified Health System from 1814 municipalities in Brazil between Jan 1, 2000, and Dec 31, 2015. Daily concentrations of wildfire-related PM_2·5 were estimated using the 3D chemical transport model GEOS-Chem at a 2·0° latitude by 2·5° longitude resolution. A time-series analysis was fitted using quasi-Poisson regression to quantify municipality-specific effect estimates, which were then pooled at the regional and national levels using random-effects meta-analyses. Analyses were stratified by sex and ten age groups. The attributable fraction and attributable cases of hospital admissions due to wildfire-related PM_2·5 were also calculated. Findings: At the national level, a 10 μg/m³ increase in wildfire-related PM_2·5 was associated with a 1·65% (95% CI 1·51–1·80) increase in all-cause hospital admissions, a 5·09% (4·73–5·44) increase in respiratory hospital admissions, and a 1·10% (0·78–1·42) increase in cardiovascular hospital admissions, over 0–1 days after the exposure. The effect estimates for all-cause hospital admission did not vary by sex, but were particularly high in children aged 4 years or younger (4·88% [95% CI 4·47–5·28]), children aged 5–9 years (2·33% [1·77–2·90]), and people aged 80 years and older (3·70% [3·20–4·20]) compared w

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Asian diversity in human immune cells

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Cell 2025年第8期188卷 2288-2306.e24页

作者： Kock, Kian Hong Tan, Le Min Han, Kyung Yeon Ando, Yoshinari Jevapatarakul, Damita Chatterjee, Ankita Lin, Quy Xiao Xuan Buyamin, Eliora Violain Sonthalia, Radhika Rajagopalan, Deepa Tomofuji, Yoshihiko Sankaran, Shvetha Park, Mi-So Abe, Mai Chantaraamporn, Juthamard Furukawa, Seiko Ghosh, Supratim Inoue, Gyo Kojima, Miki Kouno, Tsukasa Lim, Jinyeong Myouzen, Keiko Nguantad, Sarintip Oh, Jin-Mi Rayan, Nirmala Arul Sarkar, Sumanta Suzuki, Akari Thungsatianpun, Narita Venkatesh, Prasanna Nori Moody, Jonathan Nakano, Masahiro Chen, Ziyue Tian, Chi Zhang, Yuntian Tong, Yihan Tan, Crystal T.Y. Tizazu, Anteneh Mehari Loh, Marie Hwang, You Yi Ho, Roger C. Larbi, Anis Ng, Tze Pin Won, Hong-Hee Wright, Fred A. Villani, Alexandra-Chloé Park, Jong-Eun Choi, Murim Liu, Boxiang Maitra, Arindam Pithukpakorn, Manop Suktitipat, Bhoom Ishigaki, Kazuyoshi Okada, Yukinori Yamamoto, Kazuhiko Carninci, Piero Chambers, John C. Hon, Chung-Chau Matangkasombut, Ponpan Charoensawan, Varodom Majumder, Partha P. Shin, Jay W. Park, Woong-Yang Prabhakar, Shyam Genome Institute of Singapore (GIS) Agency for Science STAR) 60 Biopolis Street Genome Singapore 138672 Singapore Samsung Genome Institute Samsung Medical Center Seoul 06351 South Korea Laboratory for Advanced Genomics Circuit RIKEN Center for Integrative Medical Sciences (IMS) 1-7-22 Suehiro-cho Tsurumi-ku Kanagawa Yokohama 230-0045 Japan Laboratory for Transcriptome Technology RIKEN Center for IMS 1-7-22 Suehiro-cho Tsurumi-ku Kanagawa Yokohama 230-0045 Japan Single-cell omics and Systems Biology of Diseases (scSyBiD) Research Unit Faculty of Science Mahidol University Bangkok 10400 Thailand Department of Microbiology Faculty of Science Mahidol University Bangkok 10400 Thailand John C. Martin Centre for Liver Research and Innovations Sonarpur Kolkata 700150 India Laboratory for Systems Genetics RIKEN Center for IMS 1-7-22 Suehiro-cho Tsurumi-ku Kanagawa Yokohama 230-0045 Japan Department of Statistical Genetics of Medicine Osaka University 2-2 Yamadaoka Osaka Suita 565-0871 Japan Integrated Frontier Research for Medical Science Division Institute for Open and Transdisciplinary Research Initiatives Osaka University 2-2 Yamadaoka Osaka Suita 565-0871 Japan Samsung Advanced Institute for Health Sciences & Technology Sungkyunkwan University Seoul 06351 South Korea Laboratory for Autoimmune Diseases RIKEN Center for IMS 1-7-22 Suehiro-cho Tsurumi-ku Kanagawa Yokohama 230-0045 Japan Department of Biochemistry Faculty of Science Mahidol University Bangkok 10400 Thailand Integrative Computational BioScience Center Mahidol University Nakhon Pathom 73170 Thailand Biotechnology Research and Innovation Council National Institute of Biomedical Genomics West Bengal Kalyani 741251 India Laboratory for Genome Information Analysis RIKEN Center for IMS 1-7-22 Suehiro-cho Tsurumi-ku Kanagawa Yokohama 230-0045 Japan Department of Allergy and Rheumatology of Medicine The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8654 Japan D

The relationships of human diversity with biomedical phenotypes are pervasive yet remain understudied, particularly in a single-cell genomics context. Here, we present the Asian Immune Diversity Atlas (AIDA), a multi-national single-cell RNA sequencing (scRNA-seq) healthy reference atlas of human immune cells. AIDA comprises 1,265,624 circulating immune cells from 619 donors, spanning 7 population groups across 5 Asian countries, and 6 controls. Though population groups are frequently compared at the continental level, we found that sub-continental diversity, age, and sex pervasively impacted cellular and molecular properties of immune cells. These included differential abundance of cell neighborhoods as well as cell populations and genes relevant to disease risk, pathogenesis, and diagnostics. We discovered functional genetic variants influencing cell-type-specific gene expression, which were under-represented in non-Asian populations, and helped contextualize disease-associated variants. AIDA enables analyses of multi-ancestry disease datasets and facilitates the development of precision medicine efforts in Asia and beyond. © 2025 The Authors

关键词： eQTL genetic diversity genetics genomics healthy baseline human diversity immune cells precision medicine single-cell RNA sequencing sub-continental diversity

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Profiling Adaptive Immunity: A Quantitative Framework for Immune Repertoire Dynamics and Clinical Diagnostics

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Fundamental Research 2025年

作者： Yexing Chen Haiwen Ni Yongjie Li Jin Ma Chen Huang Sixian Yang Xiangfei Xie Haitao Lv Min Li Peng Cao State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture Nanjing University of Chinese Medicine Nanjing 210000 China Jiangsu Provincial Medical Innovation Center Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing 210000 China Department of Hematology Affiliated Hospital of Nanjing University of Chinese Medicine The First Clinical College of Nanjing University of Chinese Medicine Nanjing 210000 China Children’s Hospital of Soochow University Suzhou 215000 China Key Laboratory of Quantum Information University of Science and Technology of China Hefei 230000 China Department of Computer Science College of Engineering and Applied Science University of Cincinnati Cincinnati 45221 USA Department of Oncology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Nanjing 210000 China

While immune repertoire(IR) dynamics encode critical disease signatures, existing models fail to capture the non-equilibrium processes that governing clonal selection and somatic hypermutation (SHM). We develop a biophysical framework that mathematically reconstructs IR evolution through energy landscape optimization, where 1) clonal emergence probabilities map to metastable states, 2) repertoire transitions obey non-equilibrium dynamics, and 3) inter-IR distances quantify the distribution transformation costs via optimal transport theory. This model enables macroscopic immune state detection from 10k cells by resolving critical fluctuations in sparse sampling regimes. Experimental validation across murine/human cohorts demonstrates precise unsupervised stratification of immune stages and disease states without prior clinical annotations. By bridging stochastic SHM kinetics with deterministic repertoire shifts, our approach establishes quantitative metrics for tracking immunological trajectories and pathological progression. This paradigm shift from static pattern recognition to dynamic process decoding empowers sensitive immunomonitoring and personalized therapeutic design through ultra-low-input clinical sampling.

关键词： Deductive reasoning Immune repertoire analysis Repertoire shift quantification Early disease screening Systemic immunity inference Kawasaki disease Colorectal cancer

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An Integrated AI-Enabled System Using One Class Twin Cross Learning (OCT-X) for Early Gastric Cancer Detection

arXiv

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arXiv 2025年

作者： Liu, Xian-Xian Wei, Yuanyuan Xu, Mingkun Guo, Yongze Zhang, Hongwei Dong, Huicong Song, Qun Zhao, Qi Luo, Wei Tien, Feng Gao, Juntao Fong, Simon Department of Computer and Information Science University of Macau 999078 China Department of Biomedical Engineering The Chinese University of Hong Kong Shatin999077 Hong Kong Department of Neurology David Geffen School of Medicine University of California Los AngelesCA90095 United States Guangdong Institute of Intelligence Science and Technology Hengqin Zhuhai519031 China Department of Precision Instrument Tsinghua University Beijing100084 China Department of Gastroenterology Affiliated Hospital of Hebei University of Engineering Handan China Institute of Artificial Intelligence Chongqing Technology and Business University CO Chongqing400067 China Cancer Centre Institute of Translational Medicine Faculty of Health Sciences University of Macau Taipa519000 China MoE Frontiers Science Center for Precision Oncology University of Macau Taipa519000 China Institute of Clinical Medicine The First People’s Hospital of Foshan Guangzhou1528000 China Hebei Key Laboratory of Medical Data Science Institute of Biomedical Informatics School of Medicine Hebei University of Engineering Hebei Province Handan056038 China Tsinghua University Beijing China

Early detection of gastric cancer, a leading cause of cancer-related mortality worldwide, remains hampered by the limitations of current diagnostic technologies, leading to high rates of misdiagnosis and missed diagnoses. To address these challenges, we propose an integrated system that synergizes advanced hardware and software technologies to balance speed-accuracy. Our study introduces the One Class Twin Cross Learning (OCT-X) algorithm. Leveraging a novel fast double-threshold grid search strategy (FDT-GS) and a patch-based deep fully convolutional network, OCT-X maximizes diagnostic accuracy through real-time data processing and seamless lesion surveillance. The hardware component includes an all-in-one point-of-care testing (POCT) device with high-resolution imaging sensors, real-time data processing, and wireless connectivity, facilitated by the NI CompactDAQ and LabVIEW software. Our integrated system achieved an unprecedented diagnostic accuracy of 99.70%, significantly outperforming existing models by up to 4.47%, and demonstrated a 10% improvement in multirate adaptability. These findings underscore the potential of OCT-X as well as the integrated system in clinical diagnostics, offering a path toward more accurate, efficient, and less invasive early gastric cancer detection. Future research will explore broader applications, further advancing oncological diagnostics. Code is available at https://***/ liu37972/*** © 2025, CC BY-NC-ND.

关键词： Computer hardware description languages

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Advancing Embodied Intelligence in Robotic-Assisted Endovascular Procedures: A Systematic Review of AI Solutions

arXiv

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arXiv 2025年

作者： Yao, Tianliang Lu, Bo Kowarschik, Markus Yuan, Yixuan Zhao, Hubin Ourselin, Sebastien Althoefer, Kaspar Ge, Junbo Qi, Peng Department of Control Science and Engineering College of Electronic and Information Engineering Shanghai Institute of Intelligent Science and Technology Tongji University Shanghai200092 China Department of Electronic Engineering Faculty of Engineering The Chinese University of Hong Kong 999077 Hong Kong Robotics and Microsystems Center School of Mechanical and Electrical Engineering Soochow University Suzhou215131 China Bavaria Forchheim91301 Germany CREATe Division of Surgery & Interventional Science UCL LondonHA7 4LP United Kingdom School of Biomedical Engineering & Imaging Sciences King’s College London LondonSE1 7EH United Kingdom Centre for Advanced Robotics @ Queen Mary School of Engineering and Materials Science Queen Mary University of London LondonE1 4NS United Kingdom Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases Shanghai200032 China State Key Laboratory of Cardiovascular Diseases Medical Innovation Center Shanghai East Hospital School of Medicine Tongji University Shanghai200092 China

Endovascular procedures have revolutionized the treatment of vascular diseases thanks to minimally invasive solutions that significantly reduce patient recovery time and enhance clinical outcomes. However, the precision and dexterity required during these procedures poses considerable challenges for interventionists. Robotic systems have emerged offering transformative solutions, addressing issues such as operator fatigue, radiation exposure, and the inherent limitations of human precision. The integration of Embodied Intelligence (EI) into these systems signifies a paradigm shift, enabling robots to navigate complex vascular networks and adapt to dynamic physiological conditions. Data-driven approaches, advanced computer vision, medical image analysis, and machine learning techniques, are at the forefront of this evolution. These methods augment procedural intelligence by facilitating real-time vessel segmentation, device tracking, and anatomical landmark detection. Reinforcement learning and imitation learning further refine navigation strategies and replicate experts’ techniques. This review systematically examines the integration of EI principles into robotic technologies, in relation to endovascular procedures. We discuss recent advancements in intelligent perception and data-driven control, and their practical applications in robot-assisted endovascular procedures. By critically evaluating current limitations and emerging opportunities, this review establishes a framework for future developments, emphasizing the potential for greater autonomy and improved clinical outcomes. Emerging trends and specific areas of research, such as federated learning for medical data sharing, explainable AI for clinical decision support, and advanced human-robot collaboration paradigms, are also explored, offering insights into the future direction of this rapidly evolving field. © 2025, CC BY.

关键词： medical robotics

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Remote Blind State Preparation with Weak Coherent Pulses in the Field

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Physical Review Letters 2019年第10期123卷 100503-100503页

作者： Yang-Fan Jiang Kejin Wei Liang Huang Ke Xu Qi-Chao Sun Yu-Zhe Zhang Weijun Zhang Hao Li Lixing You Zhen Wang Hoi-Kwong Lo Feihu Xu Qiang Zhang Jian-Wei Pan Shanghai Branch National Laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of China Shanghai 201315 China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China Hefei Anhui 230026 China Centre for Quantum Information and Quantum Control Department of Electrical & Computer Engineering and Department of Physics University of Toronto Toronto Ontario M5S 3G4 Canada State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China

Quantum computing has seen tremendous progress in past years. Due to implementation complexity and cost, the future path of quantum computation is strongly believed to delegate computational tasks to powerful quantum servers on the cloud. Universal blind quantum computing (UBQC) provides the protocol for the secure delegation of arbitrary quantum computations, and it has received significant attention. However, a great challenge in UBQC is how to transmit a quantum state over a long distance securely and reliably. Here, we solve this challenge by proposing a resource-efficient remote blind qubit preparation (RBQP) protocol, with weak coherent pulses for the client to produce, using a compact and low-cost laser. We experimentally verify a key step of RBQP—quantum nondemolition measurement—in the field test over 100 km of fiber. Our experiment uses a quantum teleportation setup in the telecom wavelength and generates 1000 secure qubits with an average fidelity of (86.9±1.5)%, which exceeds the quantum no-cloning fidelity of equatorial qubit states. The results prove the feasibility of UBQC over long distances, and thus serves as a key milestone towards secure cloud quantum computing.

关键词： Optical quantum information processing Quantum computation Quantum cryptography Quantum optics Quantum protocols Quantum teleportation

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Common Limitations of Image Processing Metrics: A Picture Story

arXiv

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arXiv 2021年

作者： Reinke, Annika Tizabi, Minu D. Sudre, Carole H. Eisenmann, Matthias Rädsch, Tim Baumgartner, Michael Acion, Laura Antonelli, Michela Arbel, Tal Bakas, Spyridon Bankhead, Peter Benis, Arriel Blaschko, Matthew Buettner, Florian Cardoso, M. Jorge Chen, Jianxu Cheplygina, Veronika Christodoulou, Evangelia Cimini, Beth A. Collins, Gary S. Engelhardt, Sandy Farahani, Keyvan Ferrer, Luciana Galdran, Adrian van Ginneken, Bram Glocker, Ben Godau, Patrick Haase, Robert Hamprecht, Fred Hashimoto, Daniel A. Heckmann-Nötzel, Doreen Hirsch, Peter Hoffman, Michael M. Huisman, Merel Isensee, Fabian Jannin, Pierre Kahn, Charles E. Kainmueller, Dagmar Kainz, Bernhard Karargyris, Alexandros Karthikesalingam, Alan Kavur, A. Emre Kenngott, Hannes Kleesiek, Jens Kleppe, Andreas Koehler, Sven Kofler, Florian Kopp-Schneider, Annette Kooi, Thijs Kozubek, Michal Kreshuk, Anna Kurc, Tahsin Landman, Bennett A. Litjens, Geert Madani, Amin Maier-Hein, Klaus Martel, Anne L. Mattson, Peter Meijering, Erik Menze, Bjoern Moher, David Moons, Karel G.M. Müller, Henning Nichyporuk, Brennan Nickel, Felix Noyan, M. Alican Petersen, Jens Polat, Gorkem Rafelski, Susanne M. Rajpoot, Nasir Reyes, Mauricio Rieke, Nicola Riegler, Michael A. Rivaz, Hassan Saez-Rodriguez, Julio Sánchez, Clara I. Schroeter, Julien Saha, Anindo Selver, M. Alper Sharan, Lalith Shetty, Shravya Smeden, Maarten V.A.N. Stieltjes, Bram Summers, Ronald M. Taha, Abdel A. Tiulpin, Aleksei Tsaftaris, Sotirios A. Calster, Ben V.A.N. Varoquaux, Gaël Wiesenfarth, Manuel Yaniv, Ziv R. Jäger, Paul Maier-Hein, Lena Division of Intelligent Medical Systems and HI Helmholtz Imaging Heidelberg Germany Faculty of Mathematics and Computer Science Heidelberg University Heidelberg Germany Division of Intelligent Medical Systems Heidelberg Germany NCT Heidelberg DKFZ University Medical Center Heidelberg Germany MRC Unit for Lifelong Health and Ageing UCL Centre for Medical Image Computing Department of Computer Science University College London London United Kingdom School of Biomedical Engineering and Imaging Science King’s College London London United Kingdom Division of Medical Image Computing Heidelberg Germany Instituto de Cálculo CONICET – Universidad de Buenos Aires Buenos Aires Argentina Centre for Medical Image Computing University College London London United Kingdom McGill University Montréal Canada Division of Computational Pathology Dept of Pathology & Laboratory Medicine Indiana University School of Medicine IU Health Information and Translational Sciences Building Indianapolis United States University of Pennsylvania Richards Medical Research Laboratories FL7 PhiladelphiaPA United States Institute of Genetics and Cancer University of Edinburgh Edinburgh United Kingdom Department of Digital Medical Technologies Holon Institute of Technology Holon Israel European Federation for Medical Informatics Le Mont-sur-Lausanne Switzerland Center for Processing Speech and Images Department of Electrical Engineering KU Leuven Kasteelpark Arenberg 10 - box 2441 Leuven3001 Belgium Frankfurt/Mainz DKFZ UCT Frankfurt-Marburg Germany Heidelberg Germany Goethe University Frankfurt Department of Medicine Germany Goethe University Frankfurt Department of Informatics Germany Frankfurt Cancer Insititute Germany Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. Dortmund Germany Department of Computer Science IT University of Copenhagen Copenhagen Denmark Imaging Platform Broad Institute of MIT and Harvard CambridgeMA United States Centre for St

While the importance of automatic image analysis is continuously increasing, recent meta-research revealed major flaws with respect to algorithm validation. Performance metrics are particularly key for meaningful, objective, and transparent performance assessment and validation of the used automatic algorithms, but relatively little attention has been given to the practical pitfalls when using specific metrics for a given image analysis task. These are typically related to (1) the disregard of inherent metric properties, such as the behaviour in the presence of class imbalance or small target structures, (2) the disregard of inherent data set properties, such as the non-independence of the test cases, and (3) the disregard of the actual biomedical domain interest that the metrics should reflect. This living dynamically document has the purpose to illustrate important limitations of performance metrics commonly applied in the field of image analysis. In this context, it focuses on biomedical image analysis problems that can be phrased as image-level classification, semantic segmentation, instance segmentation, or object detection task. The current version is based on a Delphi process on metrics conducted by an international consortium of image analysis experts from more than 60 institutions worldwide. © 2021, CC BY.

关键词： medical imaging

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Foundation models and intelligent decision-making: Progress, challenges, and perspectives

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Innovation 2025年第6期6卷 100948页

作者： Huang, Jincai Xu, Yongjun Wang, Qi Wang, Qi [Cheems] Liang, Xingxing Wang, Fei Zhang, Zhao Wei, Wei Zhang, Boxuan Huang, Libo Chang, Jingru Ma, Liantao Ma, Ting Liang, Yuxuan Zhang, Jie Guo, Jian Jiang, Xuhui Fan, Xinxin An, Zhulin Li, Tingting Li, Xuefei Shao, Zezhi Qian, Tangwen Sun, Tao Diao, Boyu Yang, Chuanguang Yu, Chenqing Wu, Yiqing Li, Mengxian Zhang, Haifeng Zeng, Yongcheng Zhang, Zhicheng Zhu, Zhengqiu Lv, Yiqin Li, Aming Chen, Xu An, Bo Xiao, Wei Bai, Chenguang Mao, Yuxing Yin, Zhigang Gui, Sheng Su, Wentao Zhu, Yinghao Gao, Junyi He, Xinyu Li, Yizhou Jin, Guangyin Ao, Xiang Zhai, Xuehao Tan, Haoran Yun, Lijun Shi, Hongquan Li, Jun Fan, Changjun Huang, Kuihua Harrison, Ewen Leung, Victor C.M. Qiu, Sihang Dong, Yanjie Zheng, Xiaolong Wang, Gang Zheng, Yu Wang, Yuanzhuo Guo, Jiafeng Wang, Lizhe Cheng, Xueqi Wang, Yaonan Yang, Shanlin Fu, Mengyin Fei, Aiguo Institute of Computing Technology Chinese Academy of Sciences Beijing100190 China Department of Automation Tsinghua University Beijing100084 China Huazhong University of Science and Technology Wuhan430074 China School of Automation Beijing Institute of Technology Beijing100081 China School of Information Science and Engineering Dalian Polytechnic University Dalian116034 China National Engineering Research Center for Software Engineering Peking University Beijing100871 China Department of Oral Implantology Peking University School and Hospital of Stomatology Beijing100081 China Guangzhou511453 China College of Information and Electrical Engineering China Agricultural University Beijing100083 China IDEA Research International Digital Economy Academy Shenzhen518057 China Institute of Automation Chinese Academy of Sciences Beijing100190 China The State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of Automation Chinese Academy of Sciences Beijing100190 China College of Science National University of Defense Technology Changsha410073 China Center for Systems and Control College of Engineering Peking University Beijing100871 China Gaoling School of Artificial Intelligence Renmin University of China Beijing100872 China College of Systems Engineering National University of Defense Technology Changsha410073 China Laboratory for Big Data and Decision National University of Defense Technology Changsha410073 China College of Computing and Data Science Nanyang Technological University Singapore639798 Singapore School of Electrical Engineering Chongqing University Chongqing400044 China Department of Mathematics The University of Hong Kong Hong Kong SAR999077 China School of Food Science and Technology Dalian Polytechnic University Dalian116034 China Centre for Medical Informatics University of Edinburgh EdinburghEH16 4UX United Kingdom Department of Stomatology Peking Union Medical College Hospital Chinese Academ

Intelligent decision-making (IDM) is a cornerstone of artificial intelligence (AI) designed to automate or augment decision processes. Modern IDM paradigms integrate advanced frameworks to enable intelligent agents to make effective and adaptive choices and decompose complex tasks into manageable steps, such as AI agents and high-level reinforcement learning. Recent advances in multimodal foundation-based approaches unify diverse input modalities—such as vision, language, and sensory data—into a cohesive decision-making process. Foundation models (FMs) have become pivotal in science and industry, transforming decision-making and research capabilities. Their large-scale, multimodal data-processing abilities foster adaptability and interdisciplinary breakthroughs across fields such as healthcare, life sciences, and education. This survey examines IDM's evolution, advanced paradigms with FMs and their transformative impact on decision-making across diverse scientific and industrial domains, highlighting the challenges and opportunities in building efficient, adaptive, and ethical decision systems. © 2025 The Authors

关键词： Reinforcement learning

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Small P values may not yield robust findings:an example using REST-meta-PD

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Science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者： Xi-Ze Jia Na Zhao Hao-Ming Dong Jia-Wei Sun Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa Bo-Yu Chen Jun Chen Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito Guo-Guang Fan Federica Di Nardo Yi-Xuan Feng Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay BHorak Xiao Hu Xiao-Fei Hu Biao Huang Pei-Yu Huang Ze-Juan Jia Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu Renaud Lopes Yu-Ting Lou Wei Luo Tara Madhyastha Ni-Ni Mao Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica Hui-Fang Shang James M.Shine Priyank Shukla Tomas Slavicek Xiao-Peng Song Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei Xia Wu Xiao-Jun Xu Lei Yan Jing Yang Wan-Qun Yang Nai-Lin Yao De-Long Zhang Jiu-Quan Zhang Min-Ming Zhang Yan-Ling Zhang Cai-Hong Zhou Chao-Gan Yan Xi-Nian Zuo Mark Hallett Tao Wu Yu-Feng Zang Center for Cognition and Brain Disorders the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou 311121China National Basic Science Data Center Beijing 100190China State Key Laboratory of Cognitive Neuroscience and Learning&McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China School of Information and Electronics Technology Jiamusi UniversityJiamusi 154007China Neuroscience Program Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Department of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The Institute for Biomedical Research and Innovation National Research CouncilMangone CS 87050Italy Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Department of Advanced Medical and Surgery Sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye Center of the 2nd Affiliated Hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310020China Department of Health and Exercise Science Colorado State UniversityFort Collins CO 80523USA Pacific Parkinson’s Research Centre University of British ColumbiaVancouver BC V6E 2M6Canada Department of Medicine(Neurology)University of British Columbia Vancouver BC V6T 1B7Canada Brain and Mind Center The University of SydneySydney NSW 2006Australia Department of Neurology Ulm UniversityUlm 89081Germany Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Department of

Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain *** precise localization of abnormal brain activity,a voxel-level comparison is *** of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].

关键词：帕金森病 precise correction

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The status of the human gene catalogue

arXiv

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arXiv 2023年

作者： Amaral, Paulo Carbonell-Sala, Silvia De La Vega, Francisco M. Faial, Tiago Frankish, Adam Gingeras, Thomas Guigo, Roderic Harrow, Jennifer L. Hatzigeorgiou, Artemis G. Johnson, Rory Murphy, Terence D. Pertea, Mihaela Pruitt, Kim D. Pujar, Shashikant Takahashi, Hazuki Ulitsky, Igor Varabyou, Ales Wells, Christine A. Yandell, Mark Carninci, Piero Salzberg, Steven L. INSPER Institute of Education and Research SP São Paulo Brazil Dr. Aiguader 88 Catalonia Barcelona08003 Spain Department of Biomedical Data Science Stanford University School of Medicine StanfordCA United States Tempus Labs Inc. ChicagoIL United States Nature Genetics San FranciscoCA United States European Molecular Biology Laboratory European Bioinformatics Institute Wellcome Genome Campus Hinxton CambridgeCB10 1SD United Kingdom Department of Functional Genomics Cold Spring Harbor Laboratory Cold Spring HarborNY United States Catalonia Barcelona Spain Centre for Genomics Research Discovery Sciences AstraZeneca Da Vinci Building. Melbourn Science Park RoystonSG8 6HB United Kingdom Universithy of Thessaly Department of Computer Science and Biomedical Informatics Lamia Greece Hellenic Pasteur Institute Athens Greece School of Biology and Environmental Science University College Dublin DublinD04 V1W8 Ireland Conway Institute of Biomedical and Biomolecular Research University College Dublin DublinD04 V1W8 Ireland Department of Medical Oncology Inselspital Bern University Hospital University of Bern Bern3010 Switzerland Department for BioMedical Research University of Bern Bern3008 Switzerland National Center for Biotechnology Information National Library of Medicine National Institutes of Health BethesdaMD20894 United States Center for Computational Biology Johns Hopkins University BaltimoreMD United States Department of Biomedical Engineering Johns Hopkins University BaltimoreMD United States Laboratory for Transcriptome Technology RIKEN Center for Integrative Medical Sciences Kanagawa Yokohama230-0045 Japan Department of Immunology and Regenerative Biology Department of Molecular Neuroscience Weizmann Institute of Science Rehovot76100 Israel Department of Computer Science Johns Hopkins University BaltimoreMD United States Stem Cell Systems Department of Anatomy and Physiology Faculty of Medicine Dentistry and Health Scien

Scientists have been trying to identify all of the genes in the human genome since the initial draft of the genome was published in 2001. Over the intervening years, much progress has been made in identifying protein-coding genes, and the estimated number has shrunk to fewer than 20,000, although the number of distinct protein-coding isoforms has expanded dramatically. The invention of high-throughput RNA sequencing and other technological breakthroughs have led to an explosion in the number of reported non-coding RNA genes, although most of them do not yet have any known function. A combination of recent advances offers a path forward to identifying these functions and towards eventually completing the human gene catalogue. However, much work remains to be done before we have a universal annotation standard that includes all medically significant genes, maintains their relationships with different reference genomes, and describes clinically relevant genetic variants. © 2023, CC BY.

关键词： Genes

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