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Track 6-Screening of high affinity peptide binders using drop-based microfluidics

Track 6-Screening of high affinity peptide binders using dro...

2016年大连国际微纳流体和微流控芯片大会(2016 International Conference of Microfluidics, Nanofluidics and Lab-On-A-Chip

作者： Naiwen Cui Huidan Zhang Nils Schneider Ye Tao Haruichi Asahara Zhiyi Sun Yamei Cai Stephan A.Koehler Tom F.A.de Greef Alireza Abbaspourrad David A.Weitz Shaorong Chong New England Biolabs Inc.240 County Road Ipswich MA 01938 USA School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 USA Department of Cell Biology Key Laboratory of Cell Biology Ministry of Public Health and Key Laboratory of Medical Cell Biology Ministry of Education China Medical University Shenyang 110001 China Ecole Supé rieure de Biotechnologiede Strasbourg Boulevard Sé bastien Brant 67400 IllkirchFrance School of Mechatronics Engineering Harbin Institute of Technology Harbin 150001China New England Biolabs Inc.240 County Road Ipswich MA 01938 USA School of Pharmacy Second Military Medical University Shanghai 200433 China Institute for Complex Molecular Systems.Department of Biomedical Engineering Eindhoven University of Technology Den Dolech 2.5600 MB Eindhoven The Netherlands School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 USA School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 USA School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 USA Department of Physics Harvard University Cambridge MA02138 USA

Drop-based microfluidics encapsulating protein-encoding DNA molecules can provide a stable linkage between genotype (gene sequence) and phenotype (protein function) for directed protein evolution without using ***, such use of drop-based microfluidics for screening desired protein variants has not been demonstrated with a protein library encoded in DNA molecules.

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ID 310 – Electromyography to protect the facial nerve during minimally invasive cochlear implantation

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Clinical Neurophysiology 2016年第3期127卷 e103-e104页

作者： C. Dür J. Ansó H. Rohrbach C. Stahl D. Ferrario E. Muntane T. Wyss N. Gerber T. Williamson K. Gavaghan B. Bell S. Weber M. Caversaccio Department of ENT Head and Neck Surgery Inselspital University of Bern Switzerland ARTORG Center for Biomedical Engineering University of Bern Switzerland VetSuisse Faculty University of Bern Switzerland Control and Sensing Systems Division CSEM Switzerland Computational Biomechanics ISTB University of Bern Switzerland

Objective In minimally invasive cochlear implantation (MICI) a tunnel is drilled towards the middle ear cavity and the facial nerve (FN) appears exposed in close proximity to the tool (0.3–1.2 mm). No method has been reported to ensure intraoperative FN protection during drilling. A custom designed stimulation probe could enable a safe mechanism for early detection of the facial nerve during MICI. Methods Per subject ( n = 5 sheep), 9 trajectories were drilled with different distances respect to the FN. Stimulus pulses with varying amplitude and duration were applied at 5 different depths. EMG responses were measured in the facial muscles . Measurements of drill to FN distance were achieved through μCT scans of the extracted temporal bones , postoperatively. A sensitivity and specificity analysis was performed for 3 stimulus threshold values (0.3, 0.5, 1 mA). Results 90% of the detections with the bipolar electrodes occurred at the FN boundary. The 1 mA intensity and the monopolar electrode provided early detection of the FN (>0.2 mm). Conclusion The newly developed probe has improved the sensitivity and specificity of FN detection during MICI. The results suggest that an insulated drill with monopolar stimulation at 1 mA would provide an early warning of FN detection above 0.2 mm.

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Investigation of annular gap size for optimizing the dynamic range of MR damper using comsol multiphysics software

Investigation of annular gap size for optimizing the dynamic...

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1st International Materials, Industrial and Manufacturing engineering Conference, MIMEC 2013

作者： Fathima, Sharmila Muthalif, Asan G. A. Raisuddin Khan, Md. Smart Structures Systems and Control Research Laboratory Department of Mechatronics Engineering International Islamic University Malaysia Kuala Lumpur Malaysia

ISBN: (纸本)9783038351832

Magneto-rheological (MR) fluid technology has made it possible to develop reliable, revolutionary vibration control systems for a variety of commercial, medical and military applications. MR fluid shock absorber systems are enabled by versatile MR fluid technology, which allows the system to respond instantly and controllably to varying levels of vibration or shock with simple, robust designs. This paper presents a parametric study of the MR dampers for semi-active vibration control. The influence of gap size of the damper on the viscous stress of the MR fluid is examined. It is inferred from the study that the viscous stress of the MR fluid for different parameters such as gap size influences the dynamic range of MR fluid dampers. The simulated results depict amaximum viscous stress of 1765.441 N/m2 for a gap size of 1.85 mm. The developed dynamic range would allow for smaller size of the device, higher dynamic yield stress and lower power consumption. The simulated results using finite element analysis for the verification of the parametric strategy have been presented. Results of this study shall enhance the design of MR dampers for different control applications. © (2014) Trans Tech Publications, Switzerland.

关键词： Yield stress

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Constrained iterative feedback tuning for robust high-precision motion control 19

Constrained iterative feedback tuning for robust high-precis...

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19th IFAC World Congress on International Federation of Automatic control, IFAC 2014

作者： Van Der Velden, Bart J.C.H. Oomen, Tom Heertjes, Marcel F. Control Systems Technology Group Department of Mechanical Engineering Eindhoven University of Technology Eindhoven Netherlands Mechatronics Technology Development ASML Veldhoven Netherlands

ISBN: (纸本)9783902823625

The aim of this paper is to extend iterative feedback tuning (IFT), which is a data-based approach for controller tuning, with robustness constraints. Hereto a constrained IFT problem is formulated that is solved by introducing a penalty function. Essentially, the gradient estimates decompose into (a) the well-known IFT gradients and (b) the gradients with respect to this penalty function. Experimental results obtained from the motion control systems of an industrial wafer scanner confirm enhanced performance with guaranteed robustness properties. © IFAC.

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REAL-TIME OPTIMIZATION AND control OF 3DOF HELICOPTER SYSTEM VIA EXTREMUM SEEKING ALGORITHM

REAL-TIME OPTIMIZATION AND CONTROL OF 3DOF HELICOPTER SYSTEM...

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Asian control Conference

作者： Safanah M. Ra'afat Shahad S. Ali Rini Akmeliawati Control and Systems Engineering Department University of Technology (UOT) Intelligent Mechatronics System Research Unit International Islamic University Malaysia (IIUM)

ISBN: (纸本)9781479978632

In this paper, a real-time optimized Propotional-Integral-Derivative (PID) controller for a three Degree of Freedom (3DOF) helicopter is proposed. The real-time optimization of the PID controller gains is performed by the extremum seeking algorithm. The system is an under-actuated mechanical system with high nonlinearity and high coupling among its states. Such system is affected by the outside disturbances which may affect the stability of the system and lead to instability. For these reasons, an advanced controller that is capable of tuning the controller gains adaptively to the sudden changes, has the ability of regulation and finding best tracking performance is required. The Extremum Seeking (ES) control is a paradigm that aims to find an extremum value of an unknown nonlinear mapping. Therefore, it will be useful to apply ESC to tune PID controller. Experimental results demonstrate that the tracking errors of elevation and pitch angles are converged to the vicinity of the desired operating points with high robustness.

关键词： Extremum Seeking Optimized PID 3DOF helicopter system Elevation Pitch Online optimization Nonlinear mapping

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Optimization of a Class of Nonlinear Switched systems with Fixed-Levels control Inputs

Optimization of a Class of Nonlinear Switched Systems with F...

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American control Conference

作者： Vadim Azhmyakov Javier Cabrera Martinez Alexander Poznyak Ruthber Rodriguez Serrezuela Faculty of Electronics Biomedical Engineering and Mechatronics University of Antonio Narino Neiva 410001 Republic of Colombia Department of Automatic Control CINVESTAV A.P. 14-740 Av. I.P.N. no. 2508 C.P. 07360 Mexico D.F. Mexico

ISBN: (纸本)9781479917730

This paper is devoted to a consistent numerical method for Optimal control Problems (OCPs) associated with a specific class of nonlinear systems. We study dynamic models equipped with the piecewise constant (fixed-level) control inputs. The presented formalism also includes some switched dynamic models. We develop an implementable control algorithm for the above-mentioned classes of switched-type OCPs, study convexity characteristics and discuss some key properties of the proposed numeric scheme. We also consider a computational example. The computational scheme we propose is based on the Armijo-type projected gradient methodology.

关键词： nonlinear switched systems dynamic models Numerical methods Computer algorithms computational scheme

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Orientation Estimation Using Visual and Inertial Sensors

Orientation Estimation Using Visual and Inertial Sensors

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IEEE International Conference on Information and Automation

作者： Yinlong Zhang Wei Liang Yang Li Haibo An Jindong Tan Key Lab of Networked Control Systems Shenyang Institute of Automation Chinese Academy of Sciences Department of Mechanical Aerospace and Biomedical Engineering University of Tennessee

ISBN: (纸本)9781467391054

This paper presents an orientation estimate scheme using monocular camera and inertial measurement units (IMUs). Unlike the traditional wearable orientation estimation methods, our proposed approach combines both of these two modalities in a novel pattern. Firstly, two visual correspondences between consecutive frames are selected that not only meet the requirement of descriptor similarity constraint, but satisfy the locality constraints, which is under the assumption that the correspondence will be taken as an inlier if their nearest-neighbor feature-point counterparts are within the predefined thresholds with respect to the objective feature-point counterpart. Secondly, these two selected correspondences from visual sensor and quaternions from inertial sensor are jointly employed to derive the initial body poses. Thirdly, a coarse-to-fine procedure proceeds in removing visual false matches and estimating body poses iteratively using Expectation Max-imization (EM). Ultimately, the optimal orientation estimation is achieved. Experimental results validate that our proposed method is effective and well suited for wearable orientation estimate.

关键词： Orientation Estimate Inertial Measurement Unit Monocular Camera Nearest Neighbor locality constraint

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Automated transitions between walking and running in legged robots 19

Automated transitions between walking and running in legged ...

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19th IFAC World Congress on International Federation of Automatic control, IFAC 2014

作者： Shahbazi, M. Lopes, G.A.D. Babuška, R. Delft Center for Systems and Control Delft University of Technology Mekelweg 2 Delft2628 CD Netherlands Department of Mechatronics Engineering Faculty of New Sciences and Technologies University of Tehran Iran

ISBN: (纸本)9783902823625

This paper addresses the synthesis of controllers for walk-to-run transition (WRT) and run-to-walk transition (RWT) in legged robots with adjustable leg compliance. Inspired by human kinematics, we propose a detailed procedure for the WRT and RWT in an adjustable-stiffness spring and mass model, and derive control parameters that ensure effective gait transitions. The WRT is achieved by modulating the compliance of the leg in a piecewise constant way during the transition stride. In the RWT, in addition to the leg compliance, we modulate the touchdown angle of attack. The merits of the approach proposed are demonstrated via a simulation that incorporates the control of walking, followed by a transition to running with first increasing and then decreasing speed, and finally a transition back to walking. © IFAC.

关键词： Robots

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Balancing a legged robot using state-dependent riccati equation control 19

Balancing a legged robot using state-dependent riccati equat...

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19th IFAC World Congress on International Federation of Automatic control, IFAC 2014

作者： Najafi, E. Lopes, G.A.D. Babuška, R. Delft Center for Systems and Control Delft University of Technology Mekelweg 2 Delft2628 CD Netherlands Department of Mechatronics Engineering Faculty of New Sciences and Technologies University of Tehran Iran

ISBN: (纸本)9783902823625

In this paper, we propose a nonlinear control approach for balancing underactuated legged robots. For the balancing task, the robot is modeled as a generalized version of a Segway. The control design is based on the State-Dependent Riccati Equation (SDRE) approach. The domain of attraction of the SDRE controller is compared to the domain of attraction of a linear quadratic controller. Using a simulation example of a four-legged robot balancing on its hind legs, we show that the SDRE controller gives a reasonably large domain of attraction, even with realistic level constraints on the control input, while the linear quadratic controller is unable to stabilize the system. © IFAC.

关键词： controllers

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Erratum to: The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species

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Genome biology 2017年第1期18卷 11页

作者： Alexie Papanicolaou Marc F Schetelig Peter Arensburger Peter W Atkinson Joshua B Benoit Kostas Bourtzis Pedro Castañera John P Cavanaugh Hsu Chao Christopher Childers Ingrid Curril Huyen Dinh HarshaVardhan Doddapaneni Amanda Dolan Shannon Dugan Markus Friedrich Giuliano Gasperi Scott Geib Georgios Georgakilas Richard A Gibbs Sarah D Giers Ludvik M Gomulski Miguel González-Guzmán Ana Guillem-Amat Yi Han Artemis G Hatzigeorgiou Pedro Hernández-Crespo Daniel S T Hughes Jeffery W Jones Dimitra Karagkouni Panagiota Koskinioti Sandra L Lee Anna R Malacrida Mosè Manni Kostas Mathiopoulos Angela Meccariello Monica Munoz-Torres Shwetha C Murali Terence D Murphy Donna M Muzny Georg Oberhofer Félix Ortego Maria D Paraskevopoulou Monica Poelchau Jiaxin Qu Martin Reczko Hugh M Robertson Andrew J Rosendale Andrew E Rosselot Giuseppe Saccone Marco Salvemini Grazia Savini Patrick Schreiner Francesca Scolari Paolo Siciliano Sheina B Sim George Tsiamis Enric Ureña Ioannis S Vlachos John H Werren Ernst A Wimmer Kim C Worley Antigone Zacharopoulou Stephen Richards Alfred M Handler Hawkesbury Institute for the Environment Western Sydney University Sydney Australia. Justus-Liebig-University Giessen Institute for Insect Biotechnology 35394 Giessen Germany. Department of Biological Sciences Cal Poly Pomona Pomona CA 91768 USA. Department of Entomology and Center for Disease Vector Research University of California Riverside Riverside CA 92521 USA. Interdepartmental Graduate Program in Genetics Genomics & Bioinformatics University of California Riverside Riverside CA 92521 USA. Department of Biological Sciences University of Cincinnati Cincinnati OH 45221 USA. Insect Pest Control Laboratory Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture Seibersdorf Vienna Austria. Department of Environmental and Natural Resources Management University of Patras Agrinio Greece. Department of Environmental Biology Centro de Investigaciones Biológicas CSIC 28040 Madrid Spain. Human Genome Sequencing Center Department of Human and Molecular Genetics Baylor College of Medicine 77030 Houston TX USA. National Agricultural Library USDA 20705 Beltsville MD USA. Georg-August-Universität Göttingen Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie 37077 Göttingen Germany. Department of Biology University of Rochester 14627 Rochester NY USA. Department of Biological Sciences Wayne State University 48202 Detroit MI USA. Department of Biology and Biotechnology University of Pavia 27100 Pavia Italy. USDA-ARS Pacific Basin Agricultural Research Center 96720 Hilo HI USA. DIANA-Lab Department of Electrical & Computer Engineering University of Thessaly 382 21 Volos Greece and Hellenic Pasteur Institute 11521 Athens Greece. Department of Entomology University of Illinois at Urbana-Champaign 61801 Urbana IL USA. Department of Biological Sciences Oakland University 48309 Rochester MI USA. Department of Biochemistry and Biotechnology University of Thessaly Larissa Greece. Department of Biology Univer

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